Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

作     者：Qishan Wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei Lijun Chen Qishan Wang;Bin Liu;Xianping Li;Junying Zhao;Zongshen Zhang;Weicang Qiao;Xinyue Wei;Lijun Chen

作者机构：School of BioengineeringDalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Dairy Health for Maternal and ChildBeijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of DairyBeijing Sanyuan Foods Co.Ltd.Beijing 100163China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第3期

页      面：1258-1270页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083203[工学-农产品加工及贮藏工程] 

基　　金：supported by the National Natural Science Foundation of China (32072191) Daxing District Major Scientific and Technological Achievements Transformation Project (2020006) Beijing Innovation Team Project of Livestock Industry Technology System Beijing Science and Technology Special Project (Z201100002620005) 

主　　题：Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis 

摘      要：The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are ***,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral *** 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical *** results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid ***,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and ***,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase ***,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.