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Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study

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Biomedical and Environmental Sciences 2014年第9期27卷 707-717页

作者： LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei Department of Epidemiology Secondary Military Medical University Department of Urology Changhai HospitalSecond Military Medical University Department of Urology Zhongshan HospitalFudan University Department of Urology Changzheng HospitalSecond Military Medical University Center for Disease Control and Prevention of Zhabei District Department of pathology Changhai HospitalSecond Military Medical University Center for Disease Control and Prevention of Yangpu District Department of Genitourinary Medical Oncology-research University of TexasMD Anderson Cancer Center Houston77030USA

Objective To study the risk environmental and psycho-social factors associated to prostate cancer （PCa） in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios （OR） and 95% confidence intervals （95% CI） for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa （0R=0.39, 95% CI： 0.28-0.53; 0R=0.59, 95% Cl： 0.40-0.87, respectively）. Family history of PCa （0R=7.16, 95% CI： 2.01-25.49）, history of prostate diseases （0R=2.28, 95% Cl： 1.53-3.41）, alcohol consumption （0R=1.97, 95% CI： 1.33-2.90）, red meat consumption （0R=1.74, 95% CI： 1.20-2.52）, barbecued （0R=2.29, 95% CI： 1.11-4.73） or fried （0R=2.35, 95% CI： 1.24-4.43） foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks （0R=1.61, 95% CI： 2.00-2.59）, marital separation （0R=1.94, 95% CI： 1.29-2.91）, self-contained suffering {0R=2.37, 95% CI： 1.58-3.55）, and high sensitivity to the personal comments （0R=1.73, 95% CI： 1.18-2.54） were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population.

关键词： Case-control study Lifestyle Dietary factors Psycho-social factors Prostate cancer

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Isolation and identification of Salmonella from curry samples and its sensitivity to commercial antibiotics and aqueous extracts of Camelia sinensis(L.) and Trachyspermum ammi(L.)

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 266-269页

作者： Thanes Gunasegaran Xavier Rathinam Marimuthu Kasi Kathiresan Sathasivam Sasidharan Sreenivasan Sreeramanan Subramaniam Department of Biotechnology Faculty of Applied SciencesAIMST UniversitySemeling08100 BedongKedah Darul AmanMalaysia Institute for research in Molecular Medicine(INFORMM) Universiti Sains Malaysia 11800 PenangMalaysia School of Biological Sciences Universiti Sains Malaysia11800 PenangMalaysia

Objective:To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant ***:Salmonella was isolated from the curry samples by standard microbiological methods and was confirmed by biochemical *** antibiotic susceptibility test was conducted by disc diffusion method using commercially available antibiotics such as ampicillin,tetracycline,chloramphenicol,kanamycin,and *** addition,the susceptibility of the food-borne Salmonella was also evaluated against the aqueous extracts of Camelia sinensis(L.) Theaceae(tea leaves) and the Trachyspermum ammi(L.) Apiaceae(ajwain or omum seeds).Results:Out of fifty curry samples,only seven samples were identified to have Salmonella *** Salmonella isolates showed a significant drug resistance pattern except for *** plant extracts showed a considerable antibacterial activity against the isolates,indicating the presence of antimicrobial principle which can be exploited after complete pharmacological ***:The present study demonstrates the occurrence of Salmonella in the curry samples,and shows significant drug resistance against most of the commercially available antibiotics,except *** effect of the plant extracts against the food-bone Salmonella suggests that dietary including medicinal herbs would be one strategy to manage food borne pathogens.

关键词： Food-borne Salmonella Drug resistance Plant extracts Curry samples Camelia sinensis Trachyspermum ammi Commercial antibiotics

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Electrically focus-tuneable ultrathin lens for high-resolution square subpixels

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Light(Science & Applications) 2020年第1期9卷 1066-1078页

作者： Sehong Park Gilho Lee Byeongho Park Youngho Seo Chae bin Park Young tea Chun Chulmin Joo Junsuk Rho Jong Min Kim James Hone Seong Chan Jun School of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Electrical Engineering Division Engineering DepartmentUniversity of Cambridge9 JJ Thomson AvenueCambridge CB3 OFAUK Department of Electronic Material Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohang 37673Republic of Korea Institute for Convergence research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Mechanical Engineering Columbia University500 West 120th StreetMudd 220New YorkNY 10027USA

Owing to the tremendous demands for high-resolution pixel-scale thin lenses in displays,we developed a graphenebased ultrathin square subpixel lens(USSL)capable of electrically tuneable focusing(ETF)with a performance competitive with that of a typical mechanical refractive *** fringe field due to a voltage bias in the graphene proves that our ETF-USSL can focus light onto a single point regardless of the wavelength of the visible light—by controlling the carriers at the Dirac point using radially patterned graphene layers,the focal length of the planar structure can be adjusted without changing the curvature or position of the lens.A high focusing efficiency of over 60% at a visible wavelength of 405 nm was achieved with a lens thickness of <13 nm,and a change of 19.42% in the focal length with a 9% increase in transmission was exhibited under a driving *** design is first presented as an ETF-USSL that can be controlled in pixel units of flat panel displays for visible *** can be easily applied as an add-on to high resolution,slim displays and provides a new direction for the application of multifunctional autostereoscopic displays.

关键词： visible driving competitive

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原代培养猪冠状动脉平滑肌的电压依赖和钙激活钾通道(英文)

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泸州医学院学报 2001年第5期24卷 415-424页

作者：曾晓荣 Yutaka Nakaya Isao Inoue 泸州医学院心肌电生理研究室泸州646000 The Sedond Department of Internal Medicine School of MedicineTokushima University Institute for Enzyme research Tokushima University

目的 :研究原代培养的猪冠状动脉平滑肌电压依赖性和钙激活外向钾通道的特性。方法 :离子通道电流采用膜片钳技术进行记录。结果 :在内面向外式膜片构型 ,当膜内外K+ 浓度梯度类似生理状态时 ,该通道单位电导值约为 10 0pS ,而当膜内外... 详细信息

目的 :研究原代培养的猪冠状动脉平滑肌电压依赖性和钙激活外向钾通道的特性。方法 :离子通道电流采用膜片钳技术进行记录。结果 :在内面向外式膜片构型 ,当膜内外K+ 浓度梯度类似生理状态时 ,该通道单位电导值约为 10 0pS ,而当膜内外K+ 浓度为对称的 140mM浓度时 ,该通道单位电导值约为 2 70pS。其平均电流显示该通道具时间和电压依赖性激活特性 ,而无任何时间和电压依赖性失活特性。另外 ,通道的开放时间常数和开放概率随除极及胞内Ca2 + 的增加而显著增加。通过用EGTA降低胞浆内Ca2 + 浓度 ,可使外向电流抑制。动力学分析显示通道激活时存在一种开放状态和至少两种关闭状态。四乙胺 (tea)可在胞外侧阻断该电流 ,但高达 15mM的 4-氨基吡啶 (4-AP)在胞内外都对通道无影响。在全细胞构型 ,对细胞膜进行除极可引出宏观外向电流。随着细胞的除极 ,该电流的激活时间常数逐渐缩短 ,并显示快速激活动力学特性。结论 :在原代培养的猪冠状动脉平滑肌上存在有电压依赖和Ca2 + 激活的K+ 选择性离子通道。该类通道具有非常高的单位电导值 ,除极时快速开放 ,对胞内Ca2 + 高度敏感。

关键词：血管平滑肌膜片钳钙激活性钾通道激活动力学失活原代培养

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Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer

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Acta Pharmaceutica Sinica B 2020年第3期10卷 399-413页

作者： Puvanesswaray Ramakrishnan Wei Mee Loh Subash CBGopinath Srinivasa Reddy Bonam Ismail M.Fareez Rhanye Mac Guad Maw Shin Sim Yuan Seng Wu Ageing and Age-Associated Disorders research Group Faculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Depanment of Pharmacology Faculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia School of Bioprocess Engineering Universiti Malaysia PerlisArau 02600Malaysia Institute of Nano Electronic Engineering Universiti Malaysia PerlisKangar 01000Malaysia UMR 7242 CNRS-University of StrasbourgBiotechnology and Cell Signaling/Laboratory of Excellence MedalisIllkirch 67400France Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia Department of Biomedical Science and Therapeutics Faculty of Medicine and Health ScienceUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversity of MalayaKuala Lumpur 50603Malaysia Department of Biochemistry Faculty of Medicine Bioscience and NursingMAHSA UniversitySelangor 42610Malaysia

Activated pancreatic stellate cells(PSCs)have been widely accepted as a key precursor of excessive pancreatic fibrosis,which is a crucial hallmark of chronic pancreatitis(CP)and its formidable associated disease,pancreatic cancer(PC).Hence,anti-fibrotic therapy has been identified as a novel therapeutic strategy for treating CP and PC by targeting *** of the anti-fibrotic agents have been limited to phaseⅠ/Ⅱclinical trials involving vitamin analogs,which are abundant in medicinal plants and have proved to be promising for clinical *** use of phytomedicines,as new anti-fibrotic agents,has been applied to a variety of complementary and alternative *** aim of this review was to present a focused update on the selective new potential anti-fibrotic agents,including curcumin,resveratrol,rhein,emodin,green tea catechin derivatives,metformin,eruberin A,and ellagic acid,in combating PSC in CP and PC *** aimed to describe the mechanism(s)of the phytochemicals used,either alone or in combination,and the associated molecular *** of them were tested in PC models with similar mechanism of actions,and curcumin was tested *** research may explore the issues of bioavailability,drug design,and nano-formulation,in order to achieve successful clinical outcomes with promising activity and tolerability.

关键词： Pancreatic stellate cells Anti-fibrotic Chronic pancreatitis Pancreatic cancer Phytochemicals Curcumin Resverastrol Rhein Emodin Green tea catechin

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Heart failure and chronic obstructive pulmonary disease: Two for tea or tea for two?

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World Journal of Cardiology 2010年第10期2卷 305-307页

作者： Stanislav Suskovic Mitja Kosnik Mitja Lainscak Department for Clinical Audit University Clinic for Respiratory and Allergic Diseases Golnik University Clinic for Respiratory and Allergic Diseases Golnik Division of Cardiology University Clinic for Respiratory and Allergic Diseases Golnik Applied Cachexia research Department of Cardiology Charité Campus Virchow-Klinikum

A combination of chronic obstructive pulmonary disease (COPD) and heart failure (HF) is common yet it is inadequately and rarely recognized. Because of the similar clinical manifestations, comorbidity is frequently not considered and appropriate diagnostic tests are not performed. It is very important that a combination of COPD and HF is recognized as these patients have a worse prognosis than patients with an individual disease. When present, COPD should not prevent the use of life-saving therapy in patients with HF, particularly β-blockers. Despite clear evidence of the safety and tolerability of cardioselective β-blockers in COPD patients, these drugs remain grossly underprescribed and underdosed. Routine spirometry and echocardiography in HF and COPD patients, respectively, is therefore warranted to improve current clinical practice.

关键词： Heart failure Chronic obstructive pulmonary disease Spirometry β blocker Inflammation

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Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats

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World Journal of Gastroenterology 2020年第17期26卷 2064-2081页

作者： Yu Wang Hei-Ying Jin Ming-Zhi Fang Xiao-Feng Wang Hao Chen Shu-Liang Huang De-Song Kong Min Li Xiu Zhang Yu Sun Shui-Ming Wang Department of Oncology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Department of Colorectal Surgery The Second Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina National Center of Colorectal Disease Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Department of Pathology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Scientific research Administration Department Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Endoscopy Center Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210001Jiangsu ProvinceChina Origin Bioscience Inc Nanjing 210000Jiangsu ProvinceChina

BACKGROUND Epigallocatechin gallate(EGCG)is a polyhydroxy phenolic compound extracted from tea and its antitumor effect has received widespread *** explored the inhibitory effect of EGCG on dimethylhydrazine(DMH)-induced colorectal cancer(CRC)using a rat model,predicted the interaction between EGCG and CRC target genes using a database,and explained the EGCG associated target pathways and mechanisms in *** To understand the inhibitory mechanisms of EGCG on CRC cell proliferation and identify its pharmacological targets by network pharmacology *** DMH(40 mg/kg,s.c.,twice weekly for eight weeks)was used to induce CRC in *** model establishment,the rats were administered with EGCG(50,100,or 200 mg/kg,p.o.,once daily for eight weeks)and killed 12 and 20 wk after the start of the *** of aberrant crypt foci and tumor was studied by histological *** network pharmacology analysis,candidate and collective targets of EGCG and CRC were identified,and Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes analyses were used to predict the pathways altered by *** At week 12,high-dose EGCG treatment significantly reduced the tumor formation rate,total number of tumors,cancerous and non-cancerous tumors,tumor volume,ascites formation,and aberrant crypt foci *** week 20,all three doses of EGCG were ***-eight collective targets of EGCG and CRC were identified,of which 28 genes were dysregulated in *** Encyclopedia of Genes and Genomes and GO analyses showed that the dysregulated genes were enriched in hsa05210(CRC),hsa04115(p53 signaling pathway),and hsa04151(PI3K-Akt signaling pathway),GO:0043124(negative regulation of I-kappaB kinase/NF-kappaB signaling pathway),GO:0043409(negative regulation of mitogen-activated protein kinase cascade),and GO:2001244(positive regulation of intrinsic apoptotic signaling pathway)*** EGCG inhibits the formation of DMH-induced CRC

关键词： Epigallocatechin gallate Dimethylhydrazine Colorectal cancer Aberrant crypt foci Mitogen-activated protein kinase The Cancer Genome Atlas

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A review of pharmacological activity and application potential in food of tea polyphenols

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TMR Pharmacology research 2023年第1期3卷 3-13页

作者： Zhan Li Wang Li Zhi-Yong Liang Xian-Jun Liu Hao Li Zhan-Dong Li School of Biological and Food Engineering Jilin Engineering Normal UniversityChangchun 130052China School of Life Science Tonghua Normal UniversityTonghua 134001China Qingdao Haoda Marine Biotech Co. Ltd.Qingdao 266100China Measurement Biotechnique research Center Jilin Engineering Normal UniversityChangchun 130052China

tea polyphenols(TP)is a class of polyhydroxy compounds isolated from *** biological and medical studies have shown that TP has many pharmacological activities,such as anti-inflammatory,anti-virus,anti-oxidation,anti-tumor and ***,these substances can be used as a potential drug component to positively guide the occurrence and development of certain ***,because of the activities of TP,such as anti-oxidation and anti-bacteria,it can be applied in food preservation,color preservation,deodorization,and treatment of food processing *** on the research progress of TP in recent years,this paper summarizes the pharmacological activities of TP and expounds on its application potential in the field of *** order to provide a theoretical reference for the research,development and utilization of TP.

关键词： tea polyphenols pharmacological activities food application potential

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Phytotherapy and psoriasis:Complementary and alternative medications

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World Journal of Dermatology 2014年第4期3卷 86-91页

作者： Sami A Gabr Ahmad H Alghadir Department of Anatomy Faculty of MedicineMansoura University Rehabilitation research Chair King Saud University Department of Rehabilitation Science College of Applied Medical Sciences King Saud University

Psoriasis comprises severe skin problems affects on quality of patient's life. It affects 2% of the general population with age before 35 years old. Most potent and cheap psoriatic drugs are still largely unavailable. Recently, as aresult of the apparent side effects of chemical drugs, treatments of herbal origin gains the popularity among patients with skin disorders especially those for psoriasis. In this review, the uses of complementary and alternative medications of various topical herbal formulae with different potency against psoriasis was greatly assessed. Modified Psoriasis scoring systems were performed as evident of improvement when various topical herbal formula including traditional chinese medicine ingredients such as Camptotheca acuminate, Oleum horwathiensis, Capsaicin, furocoumarins, Curcumin, and Tars were used against psoriasis. Also, plant extracts of Aleo Vera, and green tea were reported in topical form for the treatment of psoriasis. Most studies indicated a variety of biological activities of used herbs depending on their chemical constituents. This versatile range of biological activities explaining,the apparent benefits of these herbs in monitoring of psoriasis.

关键词： Psoriasis Herbal medicine Skin disorders Chinese herbal medicine Traditional chinese medicine

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Changes of Ca^2+ activated potassium channels and cellular proliferation in autogenous vein grafts

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Journal of Medical Colleges of PLA(China) 2003年第5期18卷 317-320页

作者：钱济先宋胜云马保安范清宇 Orthopedics Oncology Institute & Orthopedics Surgery Center of Chinese PLA.Tangdu Hospital Fourth Military Medical UniversityXi'an 710038China Department of Surgery Baoshan Hospital of Yunnan General Armed Polices ForcesBaoshan 678000China Orthopedics Oncology Institute & Orthopedics Surgery Center of Chinese PLA.Tangdu Hospital Fourth Military Medical UniversityXi'an 710038Chinabjective: To investigate changes of Ca2+ activated potassium channels ( KCa) in autogenous vein grafts. Methods: Contraction of venous ring was measured by means of perfusion in vitro. The intimal rabbits proliferation of vascular and proliferation of cultured smooth muscle cells ( vascular smooth muscle cells VSMCs) were observed by the means of computerised image analysis and MTT method respectively. Furthermore whole cell mode of patch clamp was used to record KCa of VSMCs isolated from autogenous vein grafts. Results: One week after transplantation there were no significant differences of contraction and intimal relative thickness between autogenous vein grafts and control. Contraction and intimal relative thickness of autogenous vein graft were significantly increased 2 weeks after transplantation (P < 0. 05 n = 8 vs control) and they was more enhanced 4 weeks after vein transplantation ( P < 0. 01 n =8 vs control ). TEA( blocker of Ca2+ activated potassium channels) increased MTT A490 nm value of VSMCs from femoral vein in a dose dependent manner(P<0. 05 n =8). KCa current density was significantly attenuated in VSMCs from autogenous vein grafts (1-4) week after transplantation (P < 0. 05 n =5). Conclusion: KCa is inhibited in autogenous vein graft which account for vasospasm and intimal proliferation.

Objective: To investigate changes of Ca2+ activated potassium channels (KCa) in autogenous vein grafts. Methods: Contraction of venous ring was measured by means of perfusion in vitro. The intimal rabbits proliferation of vascular and proliferation of cultured smooth muscle cells(vascular smooth muscle cells, VSMCs)were observed by the means of computerised image analysis and MTT method respectively. Furthermore, whole cell mode of patch clamp was used to record KCa of VSMCs isolated from autogenous vein grafts. Results: One week after transplantation there were no significant differences of contraction and intimal relative thickness between autogenous vein grafts and control. Contraction and intimal relative thickness of autogenous vein graft were significantly increased 2 weeks after transplantation (Ptea(blocker of Ca2+ activated potassium channels)increased MTT A490 nm value of VSMCs from femoral vein in a dose dependent manner(P<0.05, n=8). KCa current density was significantly attenuated in VSMCs from autogenous vein grafts (1-4) week after transplantation(P<0.05, n=5).Conclusion: KCa is inhibited in autogenous vein graft, which account for vasospasm and intimal proliferation.

关键词： autogenous vein graft intimal proliferation vasospasm Ca2+ activated potassium channel vascular smooth muscle cell

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