Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer

作     者：Puvanesswaray Ramakrishnan Wei Mee Loh Subash CBGopinath Srinivasa Reddy Bonam Ismail M.Fareez Rhanye Mac Guad Maw Shin Sim Yuan Seng Wu Puvanesswaray Ramakrishnan;Wei Mee Loh;Subash C.B.Gopinath;Srinivasa Reddy Bonam;Ismail M.Fareez;Rhanye Mac Guad;Maw Shin Sim;Yuan Seng Wu

作者机构：Ageing and Age-Associated Disorders Research GroupFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Depanment of PharmacologyFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia School of Bioprocess EngineeringUniversiti Malaysia PerlisArau 02600Malaysia Institute of Nano Electronic EngineeringUniversiti Malaysia PerlisKangar 01000Malaysia UMR 7242CNRS-University of StrasbourgBiotechnology and Cell Signaling/Laboratory of Excellence MedalisIllkirch 67400France Department of Oral Biology and Biomedical SciencesFaculty of DentistryMAHSA UniversitySelangor 42610Malaysia Department of Biomedical Science and TherapeuticsFaculty of Medicine and Health ScienceUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of Pharmaceutical Life SciencesFaculty of PharmacyUniversity of MalayaKuala Lumpur 50603Malaysia Department of Biochemistry Faculty of MedicineBioscience and NursingMAHSA UniversitySelangor 42610Malaysia 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第3期

页      面：399-413页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by two research university grants,from University of Malaya(grant No.GPF002C-2018,Malaysia) MAHSA University(grant No.RP165-05/19,Malaysia) 

主　　题：Pancreatic stellate cells Anti-fibrotic Chronic pancreatitis Pancreatic cancer Phytochemicals Curcumin Resverastrol Rhein Emodin Green tea catechin 

摘      要：Activated pancreatic stellate cells(PSCs)have been widely accepted as a key precursor of excessive pancreatic fibrosis,which is a crucial hallmark of chronic pancreatitis(CP)and its formidable associated disease,pancreatic cancer(PC).Hence,anti-fibrotic therapy has been identified as a novel therapeutic strategy for treating CP and PC by targeting *** of the anti-fibrotic agents have been limited to phaseⅠ/Ⅱclinical trials involving vitamin analogs,which are abundant in medicinal plants and have proved to be promising for clinical *** use of phytomedicines,as new anti-fibrotic agents,has been applied to a variety of complementary and alternative *** aim of this review was to present a focused update on the selective new potential anti-fibrotic agents,including curcumin,resveratrol,rhein,emodin,green tea catechin derivatives,metformin,eruberin A,and ellagic acid,in combating PSC in CP and PC *** aimed to describe the mechanism(s)of the phytochemicals used,either alone or in combination,and the associated molecular *** of them were tested in PC models with similar mechanism of actions,and curcumin was tested *** research may explore the issues of bioavailability,drug design,and nano-formulation,in order to achieve successful clinical outcomes with promising activity and tolerability.