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Minimally invasive treatment of hepatic hemangioma by transcatheter arterial embolization combined with microwave ablation:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7154-7162页

作者： Lei-Zhi Wang Kun-Peng Wang Jing-Gang Mo Guo-Yu Wang Chong Jin Hao Jiang Yi-Fu Feng Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina Department of Radiology Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina Department of Hepatobiliary Surgery Taizhou Central Hospital(Affiliated Hospital of Taizhou University)Taizhou 510000Zhejiang ProvinceChina

BACKGROUND Hepatic hemangioma is the most common benign tumor of the ***,patients with large hemangiomas that cause compression symptoms or that are at risk of rupture may need further *** is necessary to explore additional minimally invasive and personalized treatment options for *** SUMMARY A 47-year-old woman was diagnosed with a right hepatic hemangioma for more than 10 *** contrast-enhanced computed tomography(CT)and contrast-enhanced ultrasound revealed that there was a large hemangioma in the right liver,with a size of approximately 95 mm×97 mm×117 *** to the patient's refusal of surgical treatment,hepatic artery embolization was performed in the first *** 25 d of liver protection treatment,the liver function indexes decreased to normal ***,ultrasound-guided microwave ablation of the giant hepatic hemangioma was *** days after the treatment,hepatobiliary ultrasonography showed that the hemangioma of the right liver was smaller than the previous size(the volume was reduced by approximately 30%).Then the patient was discharged from the *** year after discharge,CT showed that the hepatic hemangioma had shrunk by about 80%CONCLUSION Transcatheter arterial embolization combined with microwave ablation is a safe and effective minimally invasive treatment for hepatic hemangioma.

关键词： Hepatic hemangioma Transcatheter arterial embolization Microwave ablation Minimally invasive treatment Case report

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Adult duodenal intussusception with horizontal adenoma: A rare case report

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World Journal of Clinical Cases 2020年第15期8卷 3314-3319页

作者： Kun-Peng Wang Hao Jiang Can Kong Lie-Zhi Wang Guo-Yu Wang Jing-Gang Mo Chong Jin Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina Department of Radiology Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina

BACKGROUND Adult duodenal intussusception rarely occurs,and the majority of duodenal adenomas are located in the descending part of the ***,adenomas in the horizontal part of the duodenum presenting as duodenal intussusception in adults are extremely *** SUMMARY A 36-year-old man complained of abdominal pain for 13 *** analysis showed *** resonance cholangiopancreatography and computed tomography revealed a tumor in the horizontal part of the duodenum as the main finding,leading to duodeno-duodenal *** obvious abnormalities were found on endoscopy or upper gastrointestinal *** was diagnosed with duodenal intussusception secondary to duodenal *** showed duodeno-duodenal intussusception and a tumor in the horizontal part of the duodenum near the ascending *** pathology revealed tubular-villous adenoma with low-grade glandular intraepithelial neoplasia(local high-grade intraepithelial neoplasia).He was discharged without *** This case highlights that rational use of computed tomography,magnetic resonance cholangiopancreatography,endoscopy and upper gastrointestinal radiography for preoperative diagnosis and timely surgery is an effective strategy for the treatment of adult duodenal intussusception with duodenal masses.

关键词： Adult duodenal intussusception Duodenal adenoma Horizontal part of the duodenum Intestinal obstruction Case report

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Intestinal gangrene secondary to congenital transmesenteric hernia in a child misdiagnosed with gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5294-5301页

作者： Xi-Xi Zheng Kun-Peng Wang Chao-Mei Xiang Chong Jin Peng-Fei Zhu Teng Jiang Shi-Hui Li Yong-Zhi Lin Department of Pediatric Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina

BACKGROUND Congenital transmesenteric hernia in children is a rare and potentially fatal form of internal abdominal hernia,and no specific clinical symptoms can be observed ***,this condition is not widely known among clinicians,and it is easily misdiagnosed,resulting in disastrous *** SUMMARY This report presents the case of a 13-year-old boy with a chief complaint of abdominal pain and vomiting and a history of duodenal *** patient was misdiagnosed with gastrointestinal bleeding and treated conservatively at ***,the patient’s symptoms were aggravated and he presented in a shock-like *** tomography revealed a suspected internal hernia,extensive small intestinal obstruction,and massive effusion in the abdominal and pelvic *** exploration found a small mesenteric defect approximately 3.5 cm in diameter near the ileocecal valve,and there was about 1.8 m of herniated small intestine that was treated by resection and *** patient recovered well and was followed for more than 5 years without developing short bowel *** In this report,we review the pathogenesis,presentation,diagnosis,and treatment of congenital transmesenteric hernia in children.

关键词： Congenital transmesenteric hernia Children Gastrointestinal bleeding Intestinal gangrene Case report

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Clinical practice of rapid antigen tests for SARS-CoV-2 Omicron variant:A single-center study in China

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Virologica Sinica 2022年第6期37卷 842-849页

作者： Mengyuan Chen Jiaqin Xu Lingjun Ying Miaoguo Cai Tao-Hsin Tung Kai Zhou Yufen Zheng Xiaojie Bi Jing Wang Xi Tu Bo Shen Dongqing Lv Department of Laboratory Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Hepatology and Infectious Diseases Center Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Department of Radiation Oncology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Evidence-based Medicine Center Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Department of Respiratory and Critical Diseases Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China

Responding to the fast-spreading SARS-CoV-2 Omicron variant, to improve screening efficiency, rapid antigen tests(RATs) were first added as a supplementary detection method in China in mid-March, 2022. What and how big a role RATs should play need to be supported by clinical data. Here, RAT performance and relevant factors in comparison with nucleic acid amplification tests(NAATs) were assessed in Omicron-infected inpatients. From the NAAT results, nasopharyngeal swabs(NPs) performed better than oropharyngeal swabs(OPs). RATs tested on NAAT positive NPs performed better than those with OP-positive samples. The RAT positivity rate was strongly associated with high levels of N and OFR1ab genes, especially in NPs where patients also had significantly longer hospital stays and shorter days from symptom onset to RAT testing. Self-performed RATs had a detection accuracy that was comparable to professionally performed RATs when the subjects were well guided. The antigen negative rate of the studied patients was 100% at discharge. These findings suggest that, in addition to a supplementary detection role, RATs can be an important strategy for evaluating the disease progression of Omicron-infected inpatients. This study provides important clinical data to support better rules regarding RATs under China’s COVID-19 prevention and control policy.

关键词： SARS-CoV-2 Omicron variant Rapid antigen tests(RATs) Dynamic zero-COVID policy COVID-19 progression evaluation

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Constructing Nanoscale Topology on the Surface of Microfibers Inhibits Fibroblast Fibrosis

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Advanced Fiber Materials 2022年第5期4卷 1219-1232页

作者： Yongjie Jiao Xiaojing Li Jinjie Chen Chaojing Li Laijun Liu Xingxing Liu Fujun Wang Guang Chen Lu Wang Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai 201620China Healthcare Department of taizhou hospital Affiliated to Wenzhou Medical University(Zhejiang Province taizhou hospital) Taizhou 317000China Department of Vascular Surgery Taizhou Hospital Affiliated to Wenzhou Medical University(Zhejiang Province Taizhou Hospital)Taizhou 317000China

Fibrosis is a common problem in soft tissue regeneration,often caused by the differentiation of fibroblasts into *** of the nanoscale topology that regulates the mechanical transduction of cells,nanofibers or nanoparticles are commonly used to modulate fibroblast ***,the strength of nanofibers is insufficient,and the physi-ological toxicity of nanoparticles still remains to be *** this study,self-induced crystallization was used to construct nano-protrusions on the random and aligned polycaprolactone microfibers to regulate the behavior of *** results revealed that the mechanical properties of microfibers with a nanoscale topology were *** staining manifested that nano-protrusions impeded the activation of integrins and vinculins,thereby inhibiting the nuclear transfer of Yes-associated protein,resulting in a decrease in the expression ofα-smooth muscle *** topology of microfibers hampered the activation of the Rho/ROCK signalling *** general,we used a simple process to con-struct a fibrous scaffold with a micro-nano multilevel *** structure can hinder the transformation of fibroblasts into myofibroblasts on both random and aligned fibers,which is expected to prevent fibrosis.

关键词： Electrospinning Topology Fibroblast Fibrosis

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Left abdominal wall proliferative myositis resection and patch repair:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1922-1928页

作者： Ren-Wei Xing Han-Qiu Nie Xian-Fei Zhou Fang-Fang Zhang Yong-Hua Mou Department of Hepatobiliary Surgery Taizhou Municipal HospitalTaizhou 318000Zhejiang ProvinceChina Department of Pathology Taizhou Municipal HospitalTaizhou 318000Zhejiang ProvinceChina

BACKGROUND Proliferative myositis is a rare benign tumor that is typically self-limiting and does not become *** can be cured by simple resection without reported *** to its rapid growth,hard structure and ill-defined borders,it can however be mistaken for malignant tumors such as *** SUMMARY We investigate the case of a 64-year-old male with proliferative myositis of the abdominal wall,who was preoperatively administered a needle aspiration biopsy and given a simple excision and patch *** then compared it with other similar cases to determine the effectiveness of this treatment *** Resection with follow-up observation has shown to be an effective treatment method for proliferative *** avoid unnecessarily extended or destructive resection,a thorough and conclusive diagnosis is crucial,which requires adequate imaging and pathological knowledge.

关键词： Proliferative myositis Sarcoma Abdominal wall Patch repair Case report

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Rare recurrent gallstone ileus: A case report

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World Journal of Clinical Cases 2020年第10期8卷 2023-2027页

作者： Hao Jiang Chong Jin Jing-Gang Mo Lie-Zhi Wang Lei Ma Kun-Peng Wang Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina

BACKGROUND The management of recurrent gallstone ileus(GSI)is unsatisfactory,and there is no consensus on how to reduce the incidence of recurrent *** SUMMARY A 79-year-old man presented to the Emergency Department of our hospital complaining of abdominal *** abdominal computed tomography(CT)scan revealed cholecystolithiasis,intrahepatic bile duct dilatation,gas accumulation,small intestinal obstruction,and circular high-density shadow in the intestinal *** surgery revealed that the small intestine had extensive adhesions,unclear gallbladder exposure,obvious adhesions,and difficult *** obstruction was located 70 cm between the ileum and the ileocecum,which was incarcerated by gallstones,and a simple enterolithotomy was carried *** the third day after the operation,he had passed gas and defecated and had begun a liquid *** the fifth day after the operation,he suddenly experienced abdominal distension and *** CT examination revealed recurrent GSI,and the diameter of the stone was approximately 2.0 cm(consistent with the shape of cholecystolithiasis on the abdominal CT scan before the first operation).The patient’s symptoms were not significantly relieved after conservative *** the ninth day after the operation,emergency enterolithotomy was performed again along the original surgical *** the twentieth day after the second operation,the patient fully recovered and was discharged from the *** We believe that a thorough examination of the bowel and gallbladder for gallstones based on preoperative imaging during surgery and removal of them as far as possible on the premise of ensuring the safety of patients are an effective strategy to reduce the recurrence of GSI.

关键词： Recurrent gallstone ileus Enterolithotomy Cholecystectomy Cholecystolithotomy Case report

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MED12 mutations in human diseases

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Protein & Cell 2013年第9期4卷 643-646页

作者： Hua Wang Qin Shen Li-hua Ye Jun Ye Jiangsu taizhou People’s hospital Taizhou 225300China taizhou Maternal and Children’s Health-Care Center Taizhou 225300China

The Mediator Complex plays key roles in activating gene transcription in *** of RNA polymerase II transcription subunit 12 homolog(MED12)is a subunit of the Mediator Complex and regu-lates the activity of the ***12 is involved in a variety of cellular activities,and mutations in MED12 gene impair MED12 activities and are associated with several diseases,including Opitz-Kaveggia syndrome,Lujan syndrome,uterine leiomyomas and prostate *** review will discuss the bio-logical function of MED12 and the relationship between MED12 mutations and diseases.

关键词： diseases complex. MED1

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Cryoballoon pulmonary vein isolation and left atrial appendage occlusion prior to atrial septal defect closure: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3872-3878页

作者： Yu-Cheng Wu Mei-Xiang Wang Ge-Cai Chen Zhong-Bao Ruan Qing-Qing Zhang Department of Cardiology Taizhou People’s HospitalTaizhou 225300Jiangsu ProvinceChina Department of Endocrinology Taizhou People’s HospitalTaizhou 225300Jiangsu ProvinceChina

BACKGROUND In patients who suffer from both atrial fibrillation(AF)and atrial septal defect(ASD),cryoballoon pulmonary vein isolation(PVI),sequential left atrial appendage(LAA)occlusion and ASD closure could be a strategy for effective prevention of stroke and right heart *** SUMMARY A 65-year-old man was admitted to our institution due to recurrent episodes of palpitations and shortness of breath for 2 years,which had been worsening over the last 48 *** had a history of AF,ASD,coronary heart disease with stent implantation and *** and laboratory examinations showed no *** score of CHA2DS2VASc was 3,and HAS-BLED was *** revealed a 25-mm secundum *** vein(PV)and LAA anatomy were assessed by cardiac computed *** mapping with 10-pole Lasso catheter was performed following ablation of all four PVs with complete *** the cryoballoon PVI,the patient underwent LAA occlusion under transesophageal echocardiographic ***,a 34-mm JIYI ASD occlude device was implanted.A follow-up transesophageal echocardiography at 3 mo showed proper position of both devices and neither thrombi nor leakage was *** Sequential cryoballoon PVI and LAA occlusion prior to ASD closure can be performed safely in AF patients with ASD.

关键词： Atrial fibrillation Atrial septal defect Cryoballoon Pulmonary vein isolation Left atrial appendage occlusion Case report

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Metachronous isolated penile metastasis from sigmoid colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第31期10卷 11658-11664页

作者： Guo-Lin Yin Jiang-Bo Zhu Cheng-Lin Fu Ru-Liang Ding Jun-Miao Zhang Qian Lin Department of Urology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Pathology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Anorectology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina

BACKGROUND Sigmoid colon adenocarcinoma has a high incidence among gastrointestinal tumors,and it very rarely metastasizes to the *** literature reports that the prognosis after penile metastasis is generally poor,with a median survival of about 9 *** isolated metastasis to the penis originating from sigmoid colon adenocarcinoma has not been reported so ***,we report a case of sigmoid colon adenocarcinoma with isolated penile metastasis occurring 2 years after *** mass was pathologically confirmed as metastatic adenocarcinoma,and oral chemotherapy with capecitabine was given after *** tumor did not recur during the 2-year follow-up *** SUMMARY A 79-year-old man presented to the urology department with"a mass located at the root of the penis since 1 mo".Enhanced computed tomography(CT)examination suggested a 12 mm×10 mm×9 mm nodule at the root of the right penile corpus ***,pulmonary,and abdominal CT;and bone scan did not show any tumorigenic *** carcinoembryonic antigen(CEA)level was slightly elevated(6.01 ng/mL,reference value 0-5 ng/mL).The patient had undergone laparoscopic radical sigmoidectomy for sigmoid colon cancer 2 years *** postoperative pathology showed moderately differentiated adenocarcinoma of the sigmoid colon,and the stage was *** penile mass was removed under general *** postoperative pathology showed adenocarcinoma,and immunohistochemistry showed CDX2(+),CK20(+),and Villin(+).Based on the medical history,he was diagnosed with penile metastasis from sigmoid colon *** CEA level returned to normal(3.34 ng/mL)4 d after *** chemotherapy with capecitabine was given subsequently,and tumor recurrence was not found during the 2-year follow-up *** To our knowledge,this is a rare case of metachronous isolated penile metastasis from sigmoid colon *** penis is a potential site of metastasis of colon adenocarcinoma,an

关键词： Colon adenocarcinoma Penis Metastases Metachronous Adenocarcinoma Case report

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