MED12 mutations in human diseases

作     者：Hua Wang Qin Shen Li-hua Ye Jun Ye 

作者机构：Jiangsu Taizhou People’s HospitalTaizhou 225300China Taizhou Maternal and Children’s Health-Care CenterTaizhou 225300China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第9期

页      面：643-646页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：diseases complex. MED1 

摘      要：The Mediator Complex plays key roles in activating gene transcription in *** of RNA polymerase II transcription subunit 12 homolog(MED12)is a subunit of the Mediator Complex and regu-lates the activity of the ***12 is involved in a variety of cellular activities,and mutations in MED12 gene impair MED12 activities and are associated with several diseases,including Opitz-Kaveggia syndrome,Lujan syndrome,uterine leiomyomas and prostate *** review will discuss the bio-logical function of MED12 and the relationship between MED12 mutations and diseases.