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Invitro pharmacodynamicstudyof ceftobiprole,vancomycin,linezolid and daptomycin against staphylococcal bloodstream infections

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 83-84页

作者：李玲琴 State Key Lab Infect Dis Diag&Treat1st Affil HospZhejiang Univ Med SchHangzhou 310003

Objective To evaluate the antibacterial efficacy of ceftobiprole,vancomycin,linezolid,and daptomycin against Staphylococcus aureus(SAU)and coagulasenegative Staphylococcus(CNS)bloodstream infections,which can provide a reference for clinical *** A total of 1777 strains of staphylococci were isolated from blood culture of 51 hospitals within the Blood Bacterial Resistant Investigation Collaborative System(BRICS)from January to December in *** dilution method was used to assess the minimum inhibitoryyconcentrations(MIC)of ceftobiprole,vancomycin,linezolid and daptomycin on ***,the probability of target attainment(PTA)and cumulative fraction of response(CFR)of these medications in varied dosage regimens were predicted using Monte Carlo *** Ceftobiprole demonstrated significant antibacterial activity againstmethicillinresistant Staphylococcus aureus(MRSA),the MICso and MICoo were 0.500 and 1.000 mg/L,respectively,and the MIC range was≤0.060 to 4.000 mg/***,the ceftobiprole-resistance rate of SAU was 0.1%(1/1073),but the resistance rate of CNS was 7.7%(54/704).

关键词： dosage Blood infections

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun Liu Shangde Guo Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

Single-center retrospective analysis of efficacy and safety of daratumumab plus dexamethasone for light chain amyloidosis nephropathy

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 112-113页

作者：薛韩 Kidney Dis Center 1st Affil HospZhejiang Univ Med Sch Instit Nephrol Zhejiang UnivZhejiang Prov Key LabKidney Dis Prev & Treat Technol Res

Objective To analyze the efficacy and safety of daratumumab plus dexamethasone in the treatment of renal injury patients with light chain amyloidosis,and to provide clinical *** It was a single center retrospective observational *** clinical data before and after daratumumab treatment of renal injury patients with light chain amyloidosis treated with daratumumab plus dexamethasone from December 2021 to August 2022 were retrospectively collected.

关键词： diagnosis endoscopic treatment

Relationship between killer cell immunoglobulin-like receptor genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome patients after anti-retroviral therapy

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 25-25页

作者：梅馨尹 Public Health Dept Guangxi Med Univ&Guangxi AIDS Prev&Treat Key LabNanning 530000

Objective To analyze the relationship between killer cell immunoglobulin-like receptor (KIR) genes and immune reconstitution failure in human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) patients after anti-retroviral therapy (ART).Methods HIV/AIDS patients receiving ART for≥1 year who attended the AIDS outpatient clinics of Wuming Hospital of Guangxi Medical University and People’s Hospital of Mashan from May 2007 to December 2019 were included.

关键词： killer immunodeficiency patients

The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer’s disease

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Neural Regeneration Research 2023年第5期18卷 947-954页

作者： Yi-Ge Wu Li-Juan Song Li-Jun Yin Jun-Jun Yin Qing Wang Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Zhejiang Chinese Medical University HangzhouZhejiang ProvinceChina Institute of Brain Science/Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases/Medical School Shanxi Datong UniversityDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes;these events have become a significant and promising area of research. In this review, we summarize the effects of microglial polarization and crosstalk with other cells in the central nervous system in the treatment of Alzheimer’s disease. Our literature search found that phenotypic changes occur continuously in Alzheimer’s disease and that microglia exhibit extensive crosstalk with astrocytes, oligodendrocytes, neurons, and penetrated peripheral innate immune cells via specific signaling pathways and cytokines. Collectively, unlike previous efforts to modulate microglial phenotypes at a single level, targeting the phenotypes of microglia and the crosstalk with other cells in the central nervous system may be more effective in reducing inflammation in the central nervous system in Alzheimer’s disease. This would establish a theoretical basis for reducing neuronal death from central nervous system inflammation and provide an appropriate environment to promote neuronal regeneration in the treatment of Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid biomarker central nervous system cytokines diabetes inflammation microglia neuroinflammation phagocytosis tau

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

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Neural Regeneration Research 2022年第12期17卷 2623-2631页

作者： Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma Research Center of Neurobiology The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Datong Fifth People’s HospitalDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of *** are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple *** studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin ***,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative *** increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell *** review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs *** review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based *** from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases.

关键词： Alzheimer’s disease cell-based therapy central nervous system cells fasudil immunocytes multiple sclerosis Parkinson’s disease pericytes Rho kinase inhibitor Rho-associated kinases

Potential of G-CSF supplementation to counter the neutrophil effects of standard PEG-IFNα plus ribavirin combination therapy for treating HCV-related cirrhosis

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China Medical Abstracts(Internal Medicine) 2013年第3期30卷 173-174页

作者：孙素梅 Infect Dis Diag treat Center PLATangdu Hosp4th Milit Med Univ

Objective To investigate the effects of the granulocyte colony stimulating factor (G-CSF) with pegylated interferon alpha (PEC-IFNα) plus ribavirin (RBV) and PEG-IFNαreduction in the treatment of the compensatory he... 详细信息

关键词： ribavirin cirrhosis neutrophil interferon granulocyte colony treating recurrence stimulating sustained

关爱, 从了解开始——访解放军总医院神经内科医学部吴士文教授

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健康世界 2024年第4期31卷 69-71页

作者：本刊编辑部吴士文不详解放军总医院神经内科医学部国际神经肌肉病治疗协会(treat-NMD)组织全球数据系统出版委员会中国研究型医院学会神经科学专业委员会中国医师协会神经内科医师分会中华医学会神经病学分会

近年来,有这样一个患病群体越来越受到大家关注,患者往往表现为肢体乏力、运动困难、肌肉萎缩或"肉跳"等,症状不一,"像雾、像雨又像风",易被忽视。患者病情每况愈下,经过反复就医最终确诊为神经肌肉疾病。中华医学会《健康世界》邀请解... 详细信息

近年来,有这样一个患病群体越来越受到大家关注,患者往往表现为肢体乏力、运动困难、肌肉萎缩或"肉跳"等,症状不一,"像雾、像雨又像风",易被忽视。患者病情每况愈下,经过反复就医最终确诊为神经肌肉疾病。中华医学会《健康世界》邀请解放军总医院神经内科医学部吴士文教授为我们介绍这类罕见病,以及近年来疾病里程碑式的诊疗进展。

关键词：神经肌肉疾病中华医学会神经内科罕见病肌肉萎缩诊疗进展医学部解放军总医院

Analysis of lens status of 4 452 medical radiation workers in a city

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China Medical Abstracts (Internal Medicine) 2022年第4期 209-210页

作者：杨勇 Dept Occup Health & Radiol Health Hangzhou Prev & Treat Occup Dis Hosp

Objective To understand the lens condition of radiation workers in a city,explore the factors affecting lens opacity,and to provide basis for strengthening the radiation protection management of radiation *** In December 2020,according to the national radiation health monitoring project,the occupational health examination data of radiation workers in an occupational health examination institution in a city from December 2018 to November 2020 were collected,

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