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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering research Center of Precision Diagnostics and Therapeutics development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Twisted Pair Cable Fault Diagnosis via Random Forest Machine Learning

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Computers, Materials & Continua 2022年第6期71卷 5427-5440页

作者： N.B.Ghazali F.C.Seman K.Isa K.N.Ramli Z.Z.Abidin S.M.Mustam M.A.Haek A.N.Z.Abidin A.Asrokin Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn MalaysiaBatu PahatJohor tm research&development CyberjayaMalaysia

Applying the fault diagnosis techniques to twisted pair copper cable is beneficial to improve the stability and reliability of internet access in Digital Subscriber Line(DSL)Access Network *** network performance depends on the occurrence of cable fault along the copper ***,most of the telecommunication providers monitor the network performance degradation hence troubleshoot the present of the fault by using commercial test gear on-site,which may be resolved using data analytics and machine learning *** paper presents a fault diagnosis method for twisted pair cable fault detection based on knowledge-based and data-driven machine learning *** DSL Access Network is emulated in the laboratory to accommodate VDSL2 Technology with various types of cable fault along the cable distance between 100 m to 1200 ***,the line operation parameters and loop line testing parameters are collected and used to ***,the feature transformation,a knowledge-based method,is utilized to pre-process the fault ***,the random forests algorithms(RFs),a data-driven method,are adopted to train the fault diagnosis classifier and regression algorithm with the processed fault ***,the proposed fault diagnosis method is used to detect and locate the cable fault in the DSL Access Network *** results show that the cable fault detection has an accuracy of more than 97%,with less minimum absolute error in cable fault localization of less than 11%.The proposed algorithm may assist the telecommunication service provider to initiate automated cable faults identification and troubleshooting in the DSL Access Network System.

关键词： Twisted pairs random forest machine learning cable fault DSL

PARAMETER ESTIMATION OF ENGINEERING TURBULENCE MODEL

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Acta Mechanica Sinica 2001年第4期17卷 302-309页

作者：钱炜棋蔡金狮 China Aerodynamics research&development Center Mianyang 621000 China

A parameter estimation algorithm is introduced and used to determine the parameters in the standard k-epsilon two equation turbulence model (SKE). It can be found from the estimation results that although the parameter estimation method is an effective method to determine model parameters, it is. difficult to obtain a set of parameters for SKE to suit all kinds of separated flow and a modification of the turbulence model structure should be considered. So, a new nonlinear k-e two-equation model (NNKE) is put forward in this paper and the corresponding parameter estimation technique is applied to determine the model parameters. By implementing the NNKE to solve some engineering turbulent flows, it is shown that NNKE is more accurate and versatile than SKE. Thus, the success of NNKE implies that the parameter estimation technique may have a bright prospect in engineering turbulence model research.

关键词： turbulence model parameter estimation k-epsilon two-equation model

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Investigation of calcium phosphate (CaP) tribofilms from commercial automatic transmission fluids (ATFs) and their correlation with antishudder performance

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Friction 2020年第5期8卷 882-892页

作者： Zechao DI Jingjing XU Yang LIU Yu JIANG Dongsheng HUANG Haitao CUI Zhongguo LIU Zhiyu ZHAO Shaohui LI Dalian Lubricating Oil research&development Institute PetroChinaDalian 116032China

The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATFs). Here, four commercial ATFs were evaluated with a disc-on-disc tribometer to study tribofilm formation on steel surfaces and the effects of tribofilms on the friction properties. The chemical composition, stoichiometry, structure, and thickness of the tribofilms were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS). Calcium phosphate (CaP) tribofilms form on the friction surface with all ATFs, which contributes to their antishudder characteristics. The thickness and surface coverage of CaP tribofilms are positively correlated with their antishudder properties.

关键词： tribofilm commercial ATF antishudder hydroxyapatite

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Experimental studies of water hammer in propellant feed system of reaction control system

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Propulsion and Power research 2018年第1期7卷 52-59页

作者： Avanish Kumar P.Satya Prasad M.Raghavendra Rao Defence research&development Laboratory HyderabadTelangana 500058India

Water hammer pressure transient produces large dynamic forces which can damage the pipes and other assemblies in the feed line of a reaction control system(RCS).It has led to the failure of pressure transducers monitoring the manifold pressure in the feed line of ***,water hammer studies have been carried out to understand its effect in feed *** system has been simplified to develop a mathematical model and experiments have been carried out at extensive *** mathematical model was developed considering pipe of uniform c/s and moving liquid-gas *** experimental studies have been done using water as working medium instead of actual *** studies showed that rate of pressurization have a very critical role on the water hammer *** studies have been also carried out to study the effect of density,friction and initial liquid column length on water hammer amplitude.

关键词： Water hammer Reaction control system(RCS) Propellant feed system Experimental study Testing

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic research Center of Excellence for Ecological Security and Green development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Chinese Medicine,Which Targets Body's Response State,Is An Effective Way to Treat Epidemic Infectious Diseases

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Chinese Journal of Integrative Medicine 2022年第2期28卷 168-175页

作者： YUAN Bing Hong Kong Modern Chinese Medicine research&development Center Hong Kong SARChina

In the fight against epidemic infectious diseases in the past 2,000 years,Chinese medicine(CM)has gradually developed a complete response system including diagnosis and *** focal point of CM in the treatment of infectious diseases is the personalized response state to pathogen,which is a treatment method consistent with the personalized concept of precision *** with the methods of directly killing or inactivating pathogens,which are used in modern medicine,CM is an effective treatment modality that has a wider range of points of action in the human *** remarkable effects achieved while treating SARS in 2003 and the current coronavirus disease 2019(COVID-19)pneumonia and the history of the effective responses to epidemics in the past 2,000 years have fully demonstrated the effectiveness of CM in treating infectious *** article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods,which will reacquaint the world with *** improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases.

关键词： COVID-19 coronavirus infectious disease epidemic Chinese medicine SARS-CoV-2

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Record-breaking bifunctional oxygen electrocatalyst accomplished by a data-driven approach for zinc-air batteries

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Journal of Energy Chemistry 2025年第1期100卷 144-145页

作者： Deviprasath Chinnadurai Zhi Wei Seh Institute of Materials research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)

Rechargeable zinc-air batteries(ZABs) have recently drawn great attention in energy research due to their high theoretical capacity,low costs, and inherently safe nature [1–3]. However, the sluggish cathode reactions necessitate the development of bifunctional oxygen electrocatalysts with lower ΔE indicator values. The ΔE indicator is commonly employed to quantitatively evaluate the electrocatalytic activity of a bifunctional oxygen electrocatalyst,representing the overall overpotential from oxygen reduction reaction(ORR) to oxygen evolution reaction(OER).

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Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics

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Burns & Trauma 2020年第1期8卷 388-396页

作者： Daniel G.Metcalf Philip G.Bowler Science&Technology Research&DevelopmentConvaTec Ltd.DeesideFlintshireUK

Background:Hard-to-heal wounds are often compromised by the presence of *** presents an infection risk,yet traditional antimicrobial wound care products and systemic antibiotics are often used despite the uncertainty of therapeutic success and wound *** aim of this study was to investigate the clinical impact of a next-generation anti-biofilm Hydrofiber wound dressing(AQUACEL Ag+Extra[AQAg+E])in hard-to-heal wounds that had previously been treated unsuccessfully with traditional silver-,iodine-or polyhexamethylene biguanide(PHMB)-containing dressings and products and/or systemic ***:Clinical case study evaluations of the anti-biofilm dressing were conducted,where deteriorating or stagnant wounds were selected by clinicians and primary dressings were replaced by the anti-biofilm dressing for up to 4 weeks,or as deemed clinically appropriate,with monitoring via case report *** data was stratified for cases where traditional silver-,iodine-or PHMBcontaining products,or systemic antibiotics,had been used prior to the introduction of the antibiofilm ***:Sixty-five cases were identified for inclusion,wounds ranging in duration from 1 week to 20 years(median:12 months).In 47(72%)cases the wounds were stagnant,while 15(23%)were deteriorating;3 wounds were not *** an average of 4.2 weeks of management with the anti-biofilm dressing(range:1–11 weeks),in 11(17%)cases the wounds had healed(*** wound closure),40(62%)wounds improved,9(14%)wounds remained the same and 5(8%)wounds ***:The introduction of this anti-biofilm dressing into protocols of care that had previously involved wound management with traditional antimicrobial products and/or antibiotics was shown to facilitate improvements in the healing status of most of these hard-to-heal *** containing proven anti-biofilm technology,in combination with antimicrobial silver and exudate management technology,appear to b

关键词： Antibiotics Antimicrobials AQUACEL Ag+Extra Biofilm Dressings Iodine Hard-to-heal wounds Polyhexamethylene biguanide Silver