Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer
作者机构：Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University
出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))
年 卷 期：2025年
核心收录：
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学]
基 金：supported by the National Natural Science Foundation of China (22277087, 32071373, 52125304, and 32330060) the Key Research & Development Program of Jiangsu Province (BE2020763 and BE2022724) the Jiangsu Specially-Appointed Professor Program the National Key R&D Program of China (2022YFA1206000) the Gusu Innovation and Entrepreneurship Leading Talent Plan (ZXL2022508) the Project of State Key Laboratory of Radiation Medicine and Protection Soochow University (GZN1202301) the Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University (YXY2303024) the China Postdoctoral Science Foundation (2023TQ0234) the Jiangsu Province Excellent Postdoctoral Program (2023ZB296) the Postdoctoral Fellowship Program of CPSF (GZC20231897) the Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD)
摘 要：Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.
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