检索结果-南通市图书馆

Age and genotype dependent erythropoietin protection in COVID-19

World Journal of Stem Cells 2021年第10期13卷 1513-1529页

作者： Konstantinos I Papadopoulos Warachaya Sutheesophon Somjate Manipalviratn Tar-Choon Aw Department of Research and Development THAI StemLifeBangkok 10310Thailand Laboratory Department THAI StemLifeBangkok 10310Thailand Department of Reproductive Endocrinology Jetanin Institute for Assisted ReproductionBangkok 10330Thailand Department of Laboratory Medicine Changi General HospitalSingapore 529889Singapore Department of Medicine National University of SingaporeSingapore 119228Singapore

Erythropoietin(EPO)is the main mediator of erythropoiesis and an important tissue protective hormone that appears to mediate an ancestral neuroprotective innate immune response mechanism at an early *** the young brain is threatened-prematurity,neonatal hyperbilirubinemia,malaria-EPO is hypersecreted disproportionately to any concurrent anemic *** eons of severe malarial selection pressure,neuroprotective EPO augmenting genetic determinants such as the various hemoglobinopathies,and the angiotensin converting enzyme(ACE)I/D polymorphism,have been positively *** malarial and other cerebral threats abate and the young child survives to adulthood,EPO *** high ACE and angiotensin II(Ang II)levels through the ACE D allele in adulthood may then become detrimental as witnessed by epidemiological *** ubiquitous renin angiotensin system(RAS)influences theα-klotho/fibroblast growth factor 23(FGF23)circuitry,and both are interconnected with *** we propose that at a young age,EPO augmenting genetic determinants through ACE D allele elevated Ang II levels in some or HbE/beta thalassemia in others would increase EPO levels and shield against coronavirus disease 2019,akin to protection from malaria and dengue *** evolution may use ACE2 as a“bait”for severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)to gain cellular entry in order to trigger an ACE/ACE2 imbalance and stimulate EPO hypersecretion using tissue RAS,uncoupled from hemoglobin *** subjects without EPO augmenting genetic determinants at any age,ACE2 binding and internalization upon SARS-CoV-2 entry would trigger an ACE/ACE2 imbalance,and Ang II oversecretion leading to protective EPO *** children,low nasal ACE2 Levels would beneficially augment this imbalance,especially for those without protective genetic *** the other hand,in predisposed adults with the ACE D allele,ACE/ACE2 imbalance,may lead to uncontrolled RAS overactiv

关键词： Erythropoietin Angiotensin converting enzyme Angiotensin II Hemoglobinopathy Malaria Coronavirus disease 2019 Fibroblast growth factor 23

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful lifestyle modifications may underlie umbilical cordmesenchymal stromal cell effects in type 2 diabetes mellitus

引用

World Journal of Diabetes 2023年第3期14卷 347-351页

作者： Alexandra Papadopoulou Konstantinos I Papadopoulos Occupational and Environmental Health Services Feelgood LundLund 22363SkåneSweden Department of Research and Development THAI StemLife Co.Ltd.Bangkok 10310BangkokThailand

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a grave threat to human *** efforts to relieve its detrimental effects are acutely *** sine qua non in T2DM management is consistent adherence to a prudent lifestyle and nutrition,combined with aerobic and resistance exercise regimens,together repeatedly shown to lead to complete reversal and even longterm ***-adherence to the above lifestyle adjustments condemns any treatment effort and ultimately the patient to a grim *** is thus imperative that every study evaluating the effects of innovative interventions in T2DM objectively compares the novel treatment modality to lifestyle modifications,preferably through double-blind controlled randomization,before claiming efficacy.

关键词： Type 1 diabetes mellitus Type 2 diabetes mellitus Human umbilical cord mesenchymal stem cells Diabetes remission Diabetes reversal Lifestyle modifications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Too hard to die:Exercise training mediates specific and immediate SARS-CoV-2 protection

引用

World Journal of Virology 2022年第2期11卷 98-103页

作者： Konstantinos I Papadopoulos Warachaya Sutheesophon Tar-Choon Aw thai stemlife Bangkok 10310BangkokThailand Laboratory THAI StemLifeBangkok 10310BangkokThailand Laboratory Medicine Changi General HospitalSingapore 529889SingaporeSingapore Department of Medicine National University of SingaporeSingapore 119228SingaporeSingapore

Several mechanisms may explain how exercise training mechanistically confers protection against coronavirus disease 2019(COVID-19).Here we propose two new perspectives through which cardiorespiratory fitness may protect against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).Physical exercise-activated adenosine monophosphate(AMP)-activated protein kinase(AMPK)signaling induces endothelial nitric oxide(NO)synthase(eNOS),increases NO bio-availability,and inhibits palmitoylation,leading to specific and immediate SARS-CoV-2 *** signaling also induces angiotensin 1-7 release and enhances eNOS activation thus further mediating cardio-and ***,a myokine released from skeletal muscles during aerobic exercise,also participates in the AMPK/Akt-eNOS/NO pathway,protects mitochondrial functions in endothelial cells,and antagonizes renin angiotensin system proinflammatory action leading to reductions in genes associated with severe COVID-19 ***,all the above findings point to the fact that increased AMPK and irisin activity through exercise training greatly benefits molecular processes that mediate specific,immediate,and delayed SARS-CoV-2 *** regular physical activity levels is a safe and affordable lifestyle strategy against the current and future pandemics and may also mitigate against obesity and cardiometabolic disease *** more because a moving target is harder to kill.

关键词： Adenosine monophosphate-activated protein kinase Irisin Physical exercise Nitric oxide Endothelial nitric oxide synthase Severe acute respiratory syndrome coronavirus-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation:implications for innovative type 2 diabetes mellitus management

引用

世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1334-1340页

作者： Konstantinos I Papadopoulos Alexandra Papadopoulou Tar-Choon Aw Department of R&D THAI StemLifeBangkok 10310Thailand Occupational and Environmental Health Services Feelgood LundLund 223-63SkåneSweden Department of Laboratory Medicine Changi General HospitalSingapore 529889SingaporeSingapore Department of Medicine National University of SingaporeSingapore 119228SingaporeSingapore

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a threat to human *** understanding of its pathogenesis is acutely needed in order to devise innovative,preventative,and potentially curative pharmacological ***(miRNA),are small,non-coding,one-stranded RNA molecules,that can target and silence around 60%of all human genes through translational ***-155 is an ancient,evolutionarily well-conserved miRNA,with distinct expression profiles and multifunctionality,and a target repertoire of over 241 genes involved in numerous physiological and pathological processes including hematopoietic lineage differentiation,immunity,inflammation,viral infections,cancer,cardiovascular conditions,and particularly diabetes ***-155 Levels are progressively reduced in aging,obesity,sarcopenia,and ***,the loss of coordinated repression of multiple miR-155 targets acting as negative regulators,such as C/EBPβ,HDAC4,and SOCS1 impacts insulin signaling,deteriorating glucose homeostasis,and causing insulin resistance(IR).Moreover,deranged regulation of the renin angiotensin aldosterone system(RAAS)through loss of Angiotensin II Type 1 receptor downregulation,and negated repression of ETS-1,results in unopposed detrimental Angiotensin II effects,further promoting ***,loss of BACH1 and SOCS1 repression abolishes cytoprotective,anti-oxidant,anti-apoptotic,and anti-inflam matory cellular pathways,and promotesβ-cell *** contrast to RAAS inhibitor treatments that further decrease already reduced miR-155 Levels,strategies to increase an ailing miR-155 production in T2DM,e.g.,the use of metformin,mineralocorticoid receptor blockers(spironolactone,eplerenone,finerenone),and verapamil,alone or in various combinations,represent current treatment *** the future,direct tissue delivery of miRNA analogs is likely.

关键词： Angiotensin II Angiotensin II type 1 receptor Arginase 2 L-type calcium channel Mineralocorticoid receptor MiRNA-155 Renin-angiotensin aldosterone system Type 1/2 diabetes mellitus Verapamil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：