Too hard to die:Exercise training mediates specific and immediate SARS-CoV-2 protection

作     者：Konstantinos I Papadopoulos Warachaya Sutheesophon Tar-Choon Aw 

作者机构：THAI StemLifeBangkok 10310BangkokThailand LaboratoryTHAI StemLifeBangkok 10310BangkokThailand Laboratory MedicineChangi General HospitalSingapore 529889SingaporeSingapore Department of MedicineNational University of SingaporeSingapore 119228SingaporeSingapore 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2022年第11卷第2期

页      面：98-103页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Adenosine monophosphate-activated protein kinase Irisin Physical exercise Nitric oxide Endothelial nitric oxide synthase Severe acute respiratory syndrome coronavirus-2 

摘      要：Several mechanisms may explain how exercise training mechanistically confers protection against coronavirus disease 2019(COVID-19).Here we propose two new perspectives through which cardiorespiratory fitness may protect against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).Physical exercise-activated adenosine monophosphate(AMP)-activated protein kinase(AMPK)signaling induces endothelial nitric oxide(NO)synthase(eNOS),increases NO bio-availability,and inhibits palmitoylation,leading to specific and immediate SARS-CoV-2 *** signaling also induces angiotensin 1-7 release and enhances eNOS activation thus further mediating cardio-and ***,a myokine released from skeletal muscles during aerobic exercise,also participates in the AMPK/Akt-eNOS/NO pathway,protects mitochondrial functions in endothelial cells,and antagonizes renin angiotensin system proinflammatory action leading to reductions in genes associated with severe COVID-19 ***,all the above findings point to the fact that increased AMPK and irisin activity through exercise training greatly benefits molecular processes that mediate specific,immediate,and delayed SARS-CoV-2 *** regular physical activity levels is a safe and affordable lifestyle strategy against the current and future pandemics and may also mitigate against obesity and cardiometabolic disease *** more because a moving target is harder to kill.