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Shared changes in angiogenic factors across gastrointestinal vascular conditions:A pilot study

World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第3期11卷 40-47页

作者： Atiyekeogbebe R Douglas Grainne Holleran Sinead M Smith Deirdre McNamara tagg research centre School of MedicineTrinity College DublinDublin D24Ireland

BACKGROUND Neovascularisation is common to a variety of gastrointestinal(GI)disorders with differing aetiologies and presentations;usually affecting adults above 60 *** angiogenic factors modulated by disease specific elements could be a common denominator and represent novel diagnostic and therapeutic *** yet,assessment of angiogenic factors across several GI vascular disorders associated with recurrent bleeding and anaemia has not been *** To assess serum levels of angiogenic factors in several intestinal vascular *** A case control study was performed in Tallaght University Hospital in patients with endoscopically proven small bowel angiodysplasia(SBA),portal hypertensive gastropathy(PHG),gastric antral vascular ectasia(GAVE)and nonbleeding,non-anaemic *** enzyme-linked immunosorbent assay,concentrations of Angiopoietin 1(Ang-1),Ang-2 and vascular endothelial growth factor(VEGF)were measured from 2 serum tubes of blood following informed *** relative expression of Ang-1 and Ang-2 and Ang-1/2 ratio was calculated and compared between *** analysis was applied using a t-test,and a P value of<0.05 was considered *** To date 44 samples were tested:10 SBA,11 PHG,8 GAVE and 15 *** age 60(range 20-85)years and 20(45%)were *** were significantly younger(49 years vs 66 years,P=0.0005).There was no difference in VEGF levels between the groups(P=0.6).SBA,PHG and GAVE Ang-1 levels were similar and were significantly lower than controls,(P=0.0002,95%CI:241 to 701).Ang-2 levels were statistically higher in PHG and GAVE groups compared to controls(P= 0.01, 95%CI: 77.8 to 668) and as a result, also had a lower Ang-1/2 ratioscompared to controls. While SBA Ang-2 levels were higher than controls, this didnot reach statistical significance. Neither age nor haemoglobin level, which wassimilar between disease groups, could explain the difference. In addition, themedian Ang-1/A

关键词： Gastric antral vascular ectasia Portal hypertensive gastropathy Angiodysplasia Angiopoietins Angiogenic factors Recurrent bleeding

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肠杆菌科细菌耐药：机制和临床意义

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英国医学杂志中文版 2017年第12期20卷 715-729页

作者： Iredell Jon Brown Jeremy tagg Kaitlin 张静(译者) 赵丽娜(译者) 喻玮(译者) 尉骁(译者) 牛天水(译者) 黄晨(译者) 肖婷婷(译者) 肖永红(审校者) Westmead Institute for Medical research University of Sydney and Marie Bashir Institute Sydney NSW Australia Department of Microbiology Institute of Clinical Pathology and Medical Research Sydney 浙江大学医学院附属第一医院

肠杆菌科细菌对抗生素的耐药，尤其是对β-内酰胺类药物，主要是由携带可以持续表达药物修饰酶的单一基因传播所致。现代细菌耐药的流行经历了从强烈而普遍存在的选择压力伴随着“天然”耐药（例如诱导型染色体酶、膜通透性降低和药物... 详细信息

肠杆菌科细菌对抗生素的耐药，尤其是对β-内酰胺类药物，主要是由携带可以持续表达药物修饰酶的单一基因传播所致。现代细菌耐药的流行经历了从强烈而普遍存在的选择压力伴随着“天然”耐药（例如诱导型染色体酶、膜通透性降低和药物外排），到与可移动的基因库相互协同的转变。以这种方式，耐药性比以前任何时候都更易于为导致脓毒症的常见病原菌，

关键词：肠杆菌科细菌耐药性

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Improved measurement of electron antineutrino disappearance at Daya Bay

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Chinese Physics C 2013年第1期37卷 1-20页

作者：安丰鹏安琪白景芝 A.B.Balantekin H.R.Band W.Beriguete M.Bishai S.Blyth R.L.Brown 曹国富曹俊 R.Carr W.T.Chan 常劲帆 Y.Chang C.Chasman 陈和生 H.Y.Chen 陈申见陈少敏陈潇聪陈晓辉陈晓苏陈羽陈义学 J.J.Cherwinka 朱明中 J.P.Cummings 邓子艳丁雅韵 M.V.Diwan E.Draeger 杜小峰 D.Dwyer W.R.Edwards S.R.Ely 方绍东付金煜付在伟葛良全 R.L.Gi11 M.Gonchar 龚光华宫辉 Y.A.Gornushkin 顾文强关梦云郭新恒 R.W.Hackenburg R.L.Hahn S.Hans 郝慧峰何苗贺青 K.M.Heeger 衡月昆 P.Hinrichs Y.K.Hor Y.B.Hsiung B.z.Hu 胡涛黄翰雄 H.z.Huang 黄性涛 P.Huber V.Issakov z.Isvan D.E.Jaffe S.Jetter 季筱璐季向盼姜海静焦健斌 R.A.Johnson 康丽 S.H.Kettell M.Kramer 关健强郭文伟郭人能 C.Y.Lai 赖万昌 W.H.Lai K.Lau L.Lebanowski J.Lee 雷瑞霆 R.Leitner 梁干庄梁嘉怡 C.A.Lewis 李飞李高嵩李秋菊李卫东李小波李小男李学潜李仪李志斌梁昊林政儒 C.L.Lin S.K.Lin 林延畅凌家杰 J.M.Link L.Littenberg B.R.Littlejohn D.W.Liu 刘金昌刘江来刘颖彪陆昌国路浩奇陆永康 K.B.Luk 马秋梅马续波马骁妍马宇蒨 K.T.McDonald M.C.McFarlane R.D.McKeown Y.Meng D.Mohapatra Y.Nakajima J.Napolitano D.Naumov I.Nemchenok 倪浩然 W.K.Ngai 聂阳波宁哲 J.P.Ochoa-Ricoux A.Olshevski S.Patton V.Pec J.C.Peng L.E.Piilonen L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero B.Roskovec 阮锡超邵贝贝师恺 H.Steiner 孙功星孙吉良 N.tagg 谭耀豪 H.K.Tanaka 唐晓 H.Themann Y.Torun S.Trentalange O.Tsai K.V.Tsang R.H.M.Tsang C.E.Tull Y.C.Tung B.Viren V.Vorobe1 C.H.Wang 王灵淑王玲玉王龙泽王萌王乃彦王瑞光 W.Wang 王玺王贻芳王喆王铮王志民 D.M.Webber 魏瀚宇魏亚东温良剑 K.Whisnant C.G.White L.Whitehead Y.Williamson T.Wise H.L.H.Wong E.T.Worcester F.F.Wu 吴群习建博夏冬梅邢志忠徐建一徐晶徐吉磊徐晔薛涛杨长根杨雷叶梅 M.Yeh Y.S.Yeh B.L.Young 于泽源占亮 C.Zhang 章飞虹张家文张清民张书华张一纯张银鸿张一心张志坚张子平张智勇赵洁赵庆旺赵豫斌郑磊钟玮丽周莉周祖英庄红林邹佳恒 Institute of High Energy Physics Chinese Academy of Sciences University of Science and Technology of China University of Wisconsin Brookhaven National Laboratory National United University California Institute of Technology Nanjing University Department of Engineering Physics Tsinghua University Chinese University of Hong Kong Shenzhen Univeristy North China Electric Power University Siena College Department of Physics Illinois Institute of Technology Lawrence Berkeley National Laboratory Department of Physics University of California Department of Physics University of Illinois at Urbana-Champaign Chengdu University of Technology Joint Institute for Nuclear research Shanghai Jiao Tong University Beijing Normal University Joseph Henry Laboratories Princeton University Center for Neutrino Physics Virginia Tech Department of Physics National Taiwan University Institute of Physics National Chiao-Tung University China Institute of Atomic Energy University of California Shandong University School of Physics Nankai University University of Cincinnati Dongguan University of Technology Department of Physics The University of Hong Kong Department of Physics University of Houston Charles University Faculty of Mathematics and Physics Sun Yat-Sen(Zhongshan)University College of William and Mary Rensselaer Polytechnic Institute China Guangdong Nuclear Power Group Iowa State University Xi'an Jiaotong University

We report an improved measurement of the neutrino mixing angle θ13 from the Daya Bay Reactor Neutrino Experiment. We exclude a zero value for sin22θ13 with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GWm th were detected in six antineutrino detectors deployed in two near （flux-weighted baselines of 470 m and 576 m） and one far （1648 m） underground experimental halls. Using 139 days of data, 28909 （205308） electron antineutrino candidates were detected at the far hall （near halls）. The ratio of the observed to the expected number of antineutrinos assuming no oscillations at the far hall is 0.944± 0.007（stat.） ± 0.003（syst.）. An analysis of the relative rates in six detectors finds sin22θ13=0.089± 0.010（stat.）±0.005（syst.） in a three-neutrino framework.

关键词： neutrino oscillation neutrino mixing reactor Daya Bay

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