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CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promote long-range resection of double strand breaks

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CRL4Wdr70 facilitates chromatin recruitment of Exo1 to promo...

Chemotherapy suppresses SHH gene expression via a specific enhancer

2014年第七届中国模式真菌研讨会

作者：曾鸣 Laifeng Ren Ken'Ichi Mizuno Konstantinos Nestoras Haibin Wang Zizhi Tang Xiaobo Wang Liandi Guo Daochun Kong Qun He Lilin Du Antony M.Carr Cong Liu sussex centre for genome damage and stability centre School of Life SciencesUniversity of Sussex West China Second University Hospital Sichuan University

Homologous recombination(HR)is important for repairing potentially lethal DNA double strand breaks(DSBs)in the context of *** are resected by the combination action of the Mrell-Rad50-Nbsl(MRN),Ctpl,Exol and Rqhl-Top3-Dna2 factors to form the ssDNA substrates which initiate *** these DNA processing enzymes navigate nucleosome-packaged DNA remains poorly *** find that the fission yeast DCAF protein,Wdr70,is recruited to DSBs in complex with Ddbl and the Cullin4 ubiquitin ligase(CRL4).CRL4recruitment stimulates H2B lysine 119 mono-ubiquitination(uH2B)of chromatin both proximal

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Journal of Genetics and Genomics 2023年第1期50卷 27-37页

作者： Yafei Zhang Jianqiong Lin Kaibin Yang Zhicao Yue Department of Cell Biology and Medical Genetics International Cancer Centerand Guangdong Key Laboratory for Genome Stability and Disease PreventionShenzhen University Medical SchoolShenzhenGuangdong 518060China

Sonic hedgehog(SHH)signaling is a key regulator of embryonic development and tissue homeostasis that is involved in gastrointestinal(GI)cancer *** of SHH gene expression is a paradigm of long-range enhancer *** the classical chemotherapy drug 5-fluorouracil(5FU)as an example,here we show that SHH gene expression is suppressed by *** is downstream of immediate early genes(IEGs),including Early growth response 1(Egr1).A specific 139 kb upstream enhancer is responsible for its *** down EGR1 expression or blocking its binding to this enhancer renders SHH unresponsive to *** further demonstrate that down-regulation of SHH expression does not depend on 5FU’s impact on nucleotide metabolism or DNA damage;rather,a sustained oxidative stress response mediates this rapid *** enhancer is present in a wide range of tumors and normal tissues,thus providing a target for cancer chemotherapy and its adverse effects on normal *** propose that SHH is a stress-responsive gene downstream of IEGs,and that traditional chemotherapy targets a specific enhancer to suppress its expression.

关键词： Sonic hedgehog Chemotherapy Immediate early genes EGR1 5-Fluorouracil

RNF126 Quenches RNF168 Function in the DNA damage Response

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 428-438页

作者： Lianzhong Zhang Zhenzhen Wang Ruifeng Shi Xuefei Zhu Jiahui Zhou Bin Peng Xingzhi Xu College of Life Sciences Capital Normal University Faculty of Life Sciences Tangshan Normal College Guangdong Key Laboratory for genome stability & Disease Prevention Shenzhen University Health Science Center

DNA damage response(DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin and ubiquitin-like modi?cations play an important role in DDR, from signaling DNA damage to mediating DNA repair. In this report, we found that the E3 ligase ring ?nger protein 126(RNF126) was recruited to UV laser micro-irradiation-induced stripes in a RNF8-dependent manner. RNF126 directly interacted with and ubiquitinated another E3 ligase, RNF168. Overexpression of wild type RNF126, but not catalytically-inactive mutant RNF126(CC229/232 AA), diminished ubiquitination of H2 A histone family member X(H2AX),and subsequent bleomycin-induced focus formation of total ubiquitin FK2, TP53-binding protein1(53 BP1), and receptor-associated protein 80(RAP80). Interestingly, both RNF126 overexpression and RNF126 downregulation compromised homologous recombination(HR)-mediated repair of DNA double-strand breaks(DSBs). Taken together, our ?ndings demonstrate that RNF126 negatively regulates RNF168 function in DDR and its appropriate cellular expression levels are essential for HR-mediated DSB repair.

关键词： DNA repair DNA damage response Ubiquitination RNF126 RNF8 RNF168

Circular RNAs:implications of signaling pathways and bioinformatics in human cancer

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Cancer Biology & Medicine 2023年第2期20卷 104-128页

作者： Fan Hu Yin Peng Xinmin Fan Xiaojing Zhang Zhe Jin Guangdong Provincial Key Laboratory of genome stability and Disease Prevention and Regional Immunity and Diseases Department of PathologySchool of Basic Medical SciencesMedical SchoolShenzhen UniversityShenzhen 518060China

Circular RNAs(circRNAs)form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic *** RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes,such as transcriptional regulation and *** serve predominantly as microRNA sponges,RNA-binding proteins,and templates for *** importantly,circRNAs are involved in cancer progression,and may serve as promising biomarkers for tumor diagnosis and *** traditional experimental methods are usually time-consuming and laborious,substantial progress has been made in exploring potential circRNA-disease associations by using computational models,summarized signaling pathway data,and other ***,we review the biological characteristics and functions of circRNAs,including their roles in ***,we focus on the signaling pathways associated with carcinogenesis,and the status of circRNA-associated bioinformatics ***,we explore the potential roles of circRNAs as prognostic biomarkers in cancer.

关键词： circRNA cancer signaling pathway database bioinformatics

Self-consistent assessment of Li^(+) ion cathodes:Theory ***

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Journal of Energy Chemistry 2021年第8期30卷 229-241,I0006页

作者： Hongjie Xu Weidong Xiao Zhuo Wang Junhua Hu Guosheng Shao School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China centre for International Cooperation on Designer Low-carbon&Environmental Materials(CDLCEM) Zhengzhou UniversityZhengzhou 450001China Zhengzhou Materials genome Institute(ZMGI) Zhengzhou 450100China

Transition metal oxide cathodes such as layered Li Co O_(2),spinel Li Mn_(2)O_(4) and olivine Li Fe PO4 have been commercialized for several decades and widely used in the rechargeable Li-ion batteries(LIBs).While great theoretical efforts have been made using the density functional theory(DFT)method,leading to insightful understanding covering materials stability and functional properties,the lack of consistency in choices of functionals and/or convergence criteria makes it somewhat difficult to compare *** is therefore highly useful to assess these established systems towards self-consistency,thus offering a reliable working basis for theoretical formulation of novel *** in this work,we have carried out systematic DFT calculations on the basis of recently established framework covering both thermodynamic stability,functional properties and associated *** have been made in selfconsistent selection of exchange-correlation(XC)functionals in terms of dependable accuracy with affordable computational cost,which is essential for high-throughput first-principles *** outcome of the current work on three established cathode systems is in very good agreement with experimental data,and the methodology is to provide a solid basis for designing novel cathode materials without using costing non-local exchange-correlation functionals for structure-energy calculations.

关键词： Li-ion batteries Intercalation-type oxide cathodes Ab initio approaches Self-consistency Density functional theory

Ataxin-10 is involved in Golgi membrane dynamics

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Journal of Genetics and Genomics 2017年第11期44卷 549-552页

作者： Jie Tian Yingxin Shi Shanshan Nai Qizhi Geng Leiliang Zhang Gong-Hong Wei Xingzhi Xu Jing Li Beijing Key Laboratory of DNA damage Response College of Life Sciences Capital Normal University Molecular & Environmental Plant Sciences Texas A&M UniversityCollege Station MOH Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College Biocenter Oulu Faculty of Biochemistry and Molecular MedicineUniversity of Oulu Guangdong Key Laboratory of genome stability & Disease Prevention Shenzhen University School of Medicine

Cytokinesis is the final stage of cell division that generates two daughter cells（Fededa and Gerlich,2012）.The textbook version di-vides the plant and animal cell cytokinesis into two *** cells form a mid-zone phrag... 详细信息

关键词： Ataxin-10 Golgi membrane dynamics

Stable all-solid-state battery enabled with Li_(6.25)PS_(5.25)Cl_(0.75) as fast ion-conducting electrolyte

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Journal of Energy Chemistry 2021年第2期30卷 147-154,I0006页

作者： Weidong Xiao Hongjie Xu Minjie Xuan Zhiheng Wu Yongshang Zhang Xiangdan Zhang Shijie Zhang Yonglong Shen Guosheng Shao School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina centre for International Cooperation on Designer Low-carbon Environmental Materials(CDLCEM) Zhengzhou UniversityZhengzhou 450001HenanChina Zhengzhou Materials genome Institute(ZMGI) Zhengzhou 450100HenanChina

All-solid-state batteries(ASSB) with lithium anode have attracted ever-increasing attention towards developing safer batteries with high energy *** great advancement has been achieved in developing solid electrolytes(SE) with superb ionic conductivity rivalling that of the current liquid technology,it has yet been very difficult in their successful application to ASSBs with sustaining rate and cyclic *** in this work,we have realized a stable ASSB using the Li_(6.25)PS_(5.25)Cl_(0.75) fast ionconducting electrolyte together with LiNbO_3 coated LiCoO_2 as cathode and lithium foil as the *** effective diffusion coefficient of Li-ions in the battery is higher than 10^(-12) cm~2 s^(-1),and the significantly enhanced electrochemical matching at the cathode-electrolyte interface was essential to enable long-term stability against high oxidation potential,with the LCO@LNO/Li_(6.25)PS_(5.25)Cl_(0.75)/Li battery to retain 74.12% capacity after 430 cycles at 100 μA cm-2 and 59.7% of capacity after 800 cycles at 50 μA cm^(-2),at a high charging cut-off voltage of 4.2 *** demonstrates that the Li_(6.25)PS_(5.25)Cl_(0.75) can be an excellent electrolyte for the realization of stable ASSBs with high-voltage cathodes and metallic lithium as anode,once the electrochemical compatibility between cathode and electrolyte can be addressed with a suitable buffer coating.

关键词： All-solid-state batteries Sulfide electrolyte Li_(6.25)PS_(5.25)Cl_(0.75) LiNbO_(3)coating Lithium anode Long-term stability

Enabling Argyrodite Sulfides as Superb Solid-State Electrolyte with Remarkable Interfacial stability Against Electrodes

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Energy & Environmental Materials 2022年第3期5卷 852-864页

作者： Hongjie Xu Guoqin Cao Yonglong Shen Yuran Yu Junhua Hu Zhuo Wang Guosheng Shao School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China State centre for International Cooperation on Designer Low-Carbon&Environmental Materials(CDLCEM) Zhengzhou UniversityZhengzhou 450001China Zhengzhou Materials genome Institute(ZMGI) Building 2Zhongyuanzhigu Xingyang 450100China

While argyrodite sulfides are getting more and more attention as highly promising solid-state electrolytes(SSEs)for solid batteries,they also suffer from the typical sulfide setbacks such as poor electrochemical compatibility with Li anode and high-voltage cathodes and serious sensitivity to humid air,which hinders their practical ***,we have devised an effective strategy to overcome these challenging shortcomings through modification of chalcogen chemistry under the guidance of theoretical *** resultant Li_(6.25)PS_(4)O_(1.25)Cl_(0.75)delivered excellent electrochemical compatibility with both pure Li anode and high-voltage LiCoO_(2)cathode,without compromising the superb ionic conductivity of the pristine ***,the current SSE also exhibited highly improved stability to oxygen and humidity,with further advantage being more insulating to *** remarkably enhanced compatibility with electrodes is attributed to in situ formation of helpful electrolyte–electrode *** formation of in situ anode–electrolyte interphase(AEI)enabled stable Li plating/stripping in the Li|Li_(6.25)PS_(4)O_(1.25)Cl_(0.75)|Li symmetric cells at a high current density up to 1 mA cm^(-2)over 200 h and 2 mA cm^(-2)for another 100 *** in situ amorphous nano-film cathode–electrolyte interphase(CEI)facilitated protection of the SSE from decomposition at elevated ***,the synergistic effect of AEI and CEI helped the LiCoO_(2)|Li_(6.25)PS_(4)O_(1.25)Cl_(0.75)|Li full-battery cell to achieve markedly better cycling stability than that using the pristine Li_(6)PS_(5)Cl as SSE,at a high area loading of the active cathode material(4 mg cm^(-2))in type-2032 coin *** work is to add a desirable SSE in the argyrodite sulfide family,so that high-performance solid battery cells could be fabricated without the usual need of strict control of the ambient atmosphere.

关键词： al oying chemistry argyrodite sulfide compatibility with high-voltage cathode and lithium anode fast solid lithium ion conductor resilience to humid air

Characterization of immunogenic cell death-related genes predicting prognosis in colon adenocarcinoma

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Medical Data Mining 2024年第4期7卷 19-27页

作者： Jie Chen Hong-Yi Zhou Fu-Yi Xie Laboratory centre Li Huili HospitalNingbo Medical CentreNingbo 315040China Department of Anorectal Surgery Li Huili HospitalNingbo Medical CentreNingbo 315040China

Background:Colon adenocarcinoma(COAD)is a gastrointestinal malignancy with a high mortality *** have confirmed the role of immunogenic cell death(ICD)in different cancer ***,there is a lack of research on ICD-related genes(ICD-RGs)in *** study aimed to examine the impact of ICD-RGs on COAD and their interaction with the immune ***:Using data from The Cancer genome Atlas and Gene Expression Omnibus databases,we identified 107 ICD-RGs in *** a one-way Cox regression analysis,we examined the relationship between these ICD-RGs and overall survival in ***:Following the regression analyses,we identified 14 overall survival-related ***,we examined the predictive impact of the ICD-RGs using the least absolute shrinkage and selection operator regression analysis and developed a nine-genes prognostic *** Cancer genome Atlas and Gene Expression Omnibus datasets were used for training and ***-Meier analysis was used to confirm that the high-risk group had a lower survival rate than the low-risk ***,following a multifactorial analysis,we created a prognostic nomogram that integrated clinical data and risk ***:The nine-genes model exhibits robust stability and can provide valuable insights for guiding the development of tumor immunotherapy strategies and personalized drug selection for patients with COAD.

关键词： colon adenocarcinoma least absolute shrinkage and selection operator prognosis immunogenic cell death-related genes