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Towards standardizing retinal optical coherence tomography angiography:a review

Light(Science & Applications) 2022年第4期11卷 520-541页

作者： Danuta M.Sampson Adam M.Dubis Fred K.Chen Robert J.Zawadzki David D.Sampson surrey biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at Moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. Department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. Department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. surrey biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

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Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length

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Eye and Vision 2024年第5期10卷 18-27页

作者： Deepaysh D.C.S.Dutt Seyhan Yazar Jason Charng David A.Mackey Fred K.Chen Danuta M.Sampson Centre for Ophthalmology and Visual Science(Incorporating Lions Eye Institute) The University of Western AustraliaPerthWAAustralia Garvan Institute of Medical Research SydneyAustralia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVICAustralia Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVICAustralia surrey biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildfordUK Institute of Ophthalmology University College LondonLondonUK Lions Eye Institute 2 Verdun StreetNedlandsWA 6009Australia

Background:To generate and validate a method to estimate axial length estimated(AL_(est))from spherical equivalent(SE)and corneal curvature[keratometry(K)],and to determine if this AL_(est)can replace actual axial length(AL_(act))for correcting transverse magnification error in optical coherence tomography angiography(OCTA)images using the Littmann-Bennett ***:Data from 1301 participants of the Raine Study Gen2-20 year follow-up were divided into two datasets to generate(n=650)and validate(n=651)a relationship between AL,SE,and *** developed formula was then applied to a separate dataset of 46 participants with AL,SE,and K measurements and OCTA images to estimate and compare the performance of AL_(est)against AL_(act)in correcting transverse magnification error in OCTA images when measuring the foveal avascular zone area(FAZA).Results:The formula for AL_(est)yielded the equation:AL_(est)=2.102K−0.4125SE+7.268,R^(2)=*** was good agreement between AL_(est)and AL_(act)for both study *** mean difference[standard deviation(SD)]between FAZA corrected with AL_(est)and AL_(act)was 0.002(0.015)mm^(2)with the 95%limits of agreement(LoA)of−0.027 to 0.031 mm^(2).In comparison,mean difference(SD)between FAZA uncorrected and corrected with AL_(act)was−0.005(0.030)mm^(2),with 95%LoA of−0.064 to 0.054 mm^(2).Conclusions:AL_(act)is more accurate than AL_(est)and hence should be used preferentially in magnification error correction in the clinical *** corrected with AL_(est)is comparable to FAZA corrected with AL_(act),while FAZA measurements using images corrected with AL_(est)have a greater accuracy than measurements on uncorrected ***,in the absence of AL_(act),clinicians should use AL_(est)to correct for magnification error as this provides for more accurate measurements of fundus parameters than uncorrected images.

关键词： OCTA Keratometry Spherical equivalent Axial length Littmann-Bennett formula

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