Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length

作     者：Deepaysh D.C.S.Dutt Seyhan Yazar Jason Charng David A.Mackey Fred K.Chen Danuta M.Sampson 

作者机构：Centre for Ophthalmology and Visual Science(Incorporating Lions Eye Institute)The University of Western AustraliaPerthWAAustralia Garvan Institute of Medical ResearchSydneyAustralia OphthalmologyDepartment of SurgeryUniversity of MelbourneEast MelbourneVICAustralia Centre for Eye Research AustraliaRoyal Victorian Eye and Ear HospitalEast MelbourneVICAustralia Surrey BiophotonicsCentre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildfordUK Institute of OphthalmologyUniversity College LondonLondonUK Lions Eye Institute2 Verdun StreetNedlandsWA 6009Australia 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2024年第10卷第5期

页      面：18-27页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：The Raine Foundation, Ophthalmic Research Institute of Australia (DMS, FKC) Bayer Global Ophthalmology Awards Program (FKC) National Health and Medical Research Council (FKC) Telethon-Perth Children's Hospital Research Fund (DMS, FKC) 

主　　题：OCTA Keratometry Spherical equivalent Axial length Littmann-Bennett formula 

摘      要：Background:To generate and validate a method to estimate axial length estimated(AL_(est))from spherical equivalent(SE)and corneal curvature[keratometry(K)],and to determine if this AL_(est)can replace actual axial length(AL_(act))for correcting transverse magnification error in optical coherence tomography angiography(OCTA)images using the Littmann-Bennett ***:Data from 1301 participants of the Raine Study Gen2-20 year follow-up were divided into two datasets to generate(n=650)and validate(n=651)a relationship between AL,SE,and *** developed formula was then applied to a separate dataset of 46 participants with AL,SE,and K measurements and OCTA images to estimate and compare the performance of AL_(est)against AL_(act)in correcting transverse magnification error in OCTA images when measuring the foveal avascular zone area(FAZA).Results:The formula for AL_(est)yielded the equation:AL_(est)=2.102K−0.4125SE+7.268,R^(2)=*** was good agreement between AL_(est)and AL_(act)for both study *** mean difference[standard deviation(SD)]between FAZA corrected with AL_(est)and AL_(act)was 0.002(0.015)mm^(2)with the 95%limits of agreement(LoA)of−0.027 to 0.031 mm^(2).In comparison,mean difference(SD)between FAZA uncorrected and corrected with AL_(act)was−0.005(0.030)mm^(2),with 95%LoA of−0.064 to 0.054 mm^(2).Conclusions:AL_(act)is more accurate than AL_(est)and hence should be used preferentially in magnification error correction in the clinical *** corrected with AL_(est)is comparable to FAZA corrected with AL_(act),while FAZA measurements using images corrected with AL_(est)have a greater accuracy than measurements on uncorrected ***,in the absence of AL_(act),clinicians should use AL_(est)to correct for magnification error as this provides for more accurate measurements of fundus parameters than uncorrected images.