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Efficacy of a Topical Aromatic Rub (Vicks VapoRub<sup>®</sup>) on Effects on Self-Reported and Actigraphically Assessed Aspects of sleep in Common Cold Patients

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Open Journal of Respiratory Diseases 2017年第2期7卷 83-101页

作者： Nayantara Santhi David Ramsey Gill Phillipson David Hull Victoria L. Revell Derk-Jan Dijk surrey sleep research centre School of Biosciences and Medicine Faculty of Health and Medical Sciences University of Surrey Surrey UK The Procter & Gamble Company Mason Business Center Mason Montgomery Road Mason OH USA Procter & Gamble Greater London Innovation Centre Whitehall Lane Egham Surrey UK surrey-Clinical research centre Department of Clinical and Experimental Medicine School of Biosciences and Medicine Faculty of Health and Medical Sciences University of Surrey Surrey UK

Common cold sufferers frequently report sleep disruption during the symptomatic period of infections. We examined the effects of treatment with a topical aromatic pharmaceutical ointment (Vicks VapoRub?), on associated sleep disturbances. The effects of Vicks VapoRub? versus placebo (petrolatum ointment) on subjective and objective measured sleep parameters were assessed in an exploratory study of 100 common cold patients, in a randomized, single blind, controlled, two-arm, parallel design study. The primary efficacy variable was subjective sleep quality measured with the SQSQ (Subjective Quality of sleep Questionnaire). Additional measures included, ease of falling asleep and depth of sleep (measured with a post-sleep Visual Analog Scale), total sleep time, sleep onset latency, activity score, percentage of sleep, sleep efficiency (measured with actigraphy and SQSQ) and sleep quality index measured with a modified Karolinska sleep Diary (KSD). The primary endpoint, “How was the quality of your sleep last night?” showed a statistically significant difference in change from baseline in favour of VapoRub treatment (p = 0.0392) versus placebo. Positive effects of VapoRub versus placebo were also observed for “How refreshed did you feel upon waking up?” (p = 0.0122) (SQSQ), “Did you get enough sleep?” (p = 0.0036) (KSD), “How was it to get up?” (p = 0.0120) (KSD) and “Do you feel well-rested?” (p = 0.0125) (KSD). No statistically significant changes from baseline versus placebo were detected in the Actiwatch endpoints. Vicks VapoRub? when applied before retiring to bed can reduce subjective sleep disturbances during a common cold. The results of this exploratory study support the belief among patients that the use of VapoRub improves subjective sleep quality during common cold which was associated with more refreshing sleep.

关键词： Upper Respiratory Tract Infection Common Cold VapoRub sleep Disturbance Aromatic Oils

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Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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Journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie Ella Miller Claire Lawrence Rebecca J Beeken Abigail Fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life sleepTagedAPTARAEnd

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Open-Label Real-World Pharmacy Purchaser Study of Two Fixed-Dose Combination OTC Cold Treatments;Wick MediNait, Wick DayMed Capsules or a Combination of Both

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Open Journal of Respiratory Diseases 2018年第3期8卷 43-62页

作者： Gillian Phillipson David Ramsey Sue Aspley Ingo Fietze Procter&Gamble International Operations Geneva Business CenterGenevaSwitzerland Procter&Gamble Health Care MasonOHUSA Procter&Gamble Technical centres Ltd. SurreyUK Center of sleep Medicine Charité—Universitatsmedizin BerlinBerlinGermany

Acute upper respiratory tract infections, i.e. common colds cause multiple symptoms and affect adults on average 2 - 4 times a year and children 6 - 8 times per year. Thousands of non-prescription, over-the-counter products are used by sufferers, aimed at relieving the various both er some symptoms such as cough, nasal congestion, sore throat, etc. This study evaluated real-world effectiveness of Wick MediNait or Wick DayMed medicines alone and together in a combination as a day and night treatment regimen. Adult cold sufferers were recruited in pharmacy by pharmacy staff following self-purchase of either Wick MediNait, Wick DayMed capsules, or the combination of DayMed and MediNait. Participants completed online questionnaires before and after product use (evening of the first day for DayMed and the morning after using MediNait at bedtime). For the primary endpoint “Wick MediNait was effective at relieving my symptoms”, there was a statistically significant difference (p < 0.0001) in the users who Strongly Agreed or Agreed vs. Neither Agreed or Disagreed, Disagreed or Strongly Disagreed. Further, all symptoms evaluated (cough, runny nose, nasal congestion, fever, headache, sore throat, muscle aches and pains, sneezing) were statistically improved after MediNait and DayMed alone and when both were used, and users were satisfied with both treatments. All treatments were well tolerated with minimal adverse event reporting. The diurnal use of DayMed capsules combined with the nocturnal use of MediNait allows cold sufferers to efficiently self-manage their symptom relief throughout the day and night.

关键词： Wick MediNait Real-World Use User Satisfaction Observational Cold Symptom Relief sleep Quality

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丛集性头痛作者给Litwin和Malhotra的回信

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英国医学杂志中文版 2015年第3期18卷 177-178页

作者： Alexander D Nesbitt Peter J Goadsby 沈航 surrey sleep research centre University of Surrey Guildford Surrey GU2 7XP UK Department of Neurology University of California SanFraneiseo CA 94115 USA 北京协和医院神经科

我们欢迎Litwin和Malhotra医生给出的痛性眼科情况列表，它们可能与丛集性头痛单次发作的一些元素类似。我们也同意，有这些情况的患者可能不止一次经历这些症状。他们的建议——神经影像检查是必要的，以排除丛集性头痛样的疼痛的继发... 详细信息

我们欢迎Litwin和Malhotra医生给出的痛性眼科情况列表，它们可能与丛集性头痛单次发作的一些元素类似。我们也同意，有这些情况的患者可能不止一次经历这些症状。他们的建议——神经影像检查是必要的，以排除丛集性头痛样的疼痛的继发性原因——在我们的原稿中是存在的。可是，这种情况极不寻常，即头痛反复的、非常刻板的发作，天天发作至少每天1次，仅持续15分钟到3小时，发作聚集在一起构成持续数周的丛集期。丛集性头痛发作不出现视力减退或视觉光晕效应，但在大约一半的患者中会引起单侧畏光。

关键词：丛集性答复作者头痛

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