Efficacy of a Topical Aromatic Rub (Vicks VapoRub<sup>®</sup>) on Effects on Self-Reported and Actigraphically Assessed Aspects of Sleep in Common Cold Patients

作     者：Nayantara Santhi David Ramsey Gill Phillipson David Hull Victoria L. Revell Derk-Jan Dijk 

作者机构：Surrey Sleep Research Centre School of Biosciences and Medicine Faculty of Health and Medical Sciences University of Surrey Surrey UK The Procter & Gamble Company Mason Business Center Mason Montgomery Road Mason OH USA Procter & Gamble Greater London Innovation Centre Whitehall Lane Egham Surrey UK Surrey-Clinical Research Centre Department of Clinical and Experimental Medicine School of Biosciences and Medicine Faculty of Health and Medical Sciences University of Surrey Surrey UK 

出 版 物：《Open Journal of Respiratory Diseases》 (呼吸病期刊（英文）)

年 卷 期：2017年第7卷第2期

页      面：83-101页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Upper Respiratory Tract Infection Common Cold VapoRub Sleep Disturbance Aromatic Oils 

摘      要：Common cold sufferers frequently report sleep disruption during the symptomatic period of infections. We examined the effects of treatment with a topical aromatic pharmaceutical ointment (Vicks VapoRub?), on associated sleep disturbances. The effects of Vicks VapoRub? versus placebo (petrolatum ointment) on subjective and objective measured sleep parameters were assessed in an exploratory study of 100 common cold patients, in a randomized, single blind, controlled, two-arm, parallel design study. The primary efficacy variable was subjective sleep quality measured with the SQSQ (Subjective Quality of Sleep Questionnaire). Additional measures included, ease of falling asleep and depth of sleep (measured with a post-sleep Visual Analog Scale), total sleep time, sleep onset latency, activity score, percentage of sleep, sleep efficiency (measured with actigraphy and SQSQ) and sleep quality index measured with a modified Karolinska Sleep Diary (KSD). The primary endpoint, “How was the quality of your sleep last night? showed a statistically significant difference in change from baseline in favour of VapoRub treatment (p = 0.0392) versus placebo. Positive effects of VapoRub versus placebo were also observed for “How refreshed did you feel upon waking up? (p = 0.0122) (SQSQ), “Did you get enough sleep? (p = 0.0036) (KSD), “How was it to get up? (p = 0.0120) (KSD) and “Do you feel well-rested? (p = 0.0125) (KSD). No statistically significant changes from baseline versus placebo were detected in the Actiwatch endpoints. Vicks VapoRub? when applied before retiring to bed can reduce subjective sleep disturbances during a common cold. The results of this exploratory study support the belief among patients that the use of VapoRub improves subjective sleep quality during common cold which was associated with more refreshing sleep.