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Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1787-1795页

作者： Jiao-Jie Xue Su-Tian Hu Chong-Chong Wang Zhi-Chong Chen Shi-Yao Cheng Shu-Qi Yu Hua-Jing Peng Yi-Tao Zhang Wei-Jie Zeng Department of Cardiovascular Internal Medicine Sun Yat-sen University Sixth Affiliated HospitalGuangzhou 510655Guangdong ProvinceChina Department of Cardiovascular Internal Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Department of Ultrasound Fuwai HospitalChinese Academy of Medical Sciences ShenzhenShenzhen 518052Guangdong ProvinceChina Department of Kidney Internal Medicine Sun Yat-sen University First Affiliated HospitalGuangzhou 510062Guangdong ProvinceChina

BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular *** which,ventricular arrhythmia is a prevalent clinical *** suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal *** To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving *** We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor *** patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated hospital of sun Yat-sen University from January 2018 to June ***,41 general healthy age-matched and sexmatched controls were *** were categorized into survival and non-survival *** primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of *** ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P35/24 h to all-cause mortality,and NSVT was associated with ***,neither PVC burden nor NSVT independently predicted outcomes according to multivariate *** Patients with gastrointestinal tumors exhibited elevated ***>35/24 h and NSVT detected by 24-h ambulatory ECG were prognos

关键词： Ventricular arrhythmia Gastrointestinal tumor Major adverse cardiovascular events Prognostic Surgery

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Ocular decompression retinopathy after phacoemulsification in a patient with primary acute angleclosure glaucoma undergoing chemotherapy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 397-400页

作者： Yi-Lin Chen Xiao-Nan Yang Ying-Li Liu Wen-Tao Li Li-Jun Huo Department of Ophthalmology the First Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

Dear Editor,Ocular decompression retinopathy(ODR),which manifests as diffuse retinal hemorrhage occurring abruptly in multiple locations,including the subretinal,intraretinal,and preretinal spaces,is a rare complication after glaucoma surgery and is caused by sudden,iatrogenic lowering of intraocular pressure(IOP).Implicated procedures include glaucoma drainage implantation,trabeculectomy,iridotomy,and even cataract surgery[1].One report described a case of ocular decompression management following uncomplicated cataract surgery with no posterior capsular rupture or other intraoperative complications[2].Here,we report a rare case of ODR triggered by phacoemulsification and the use of systemic chemotherapeutic drugs in a patient with primary acute angleclosure glaucoma(PACG).The case not only improves our understanding of potential side effects of chemotherapeutic drugs on ophthalmic surgery but may also serve as a reference for clinicians in the management of patients with glaucoma with similar medical histories.

关键词： glaucoma decompression drugs

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Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3865-3874页

作者： Zhi-Jie Wu Bing Lan Jian Luo Ayniyazi Ameti Hui Wang Qiong-Yu Hu Department of General Surgery(Colorectal Surgery) The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Anesthesiology Kashgar First People’s HospitalKashgar 844000Xinjiang Uygur Autonomous RegionChina Department of Anesthesiology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Identifying patients with peritoneal metastasis(PMs)of colorectal cancer(CRC)who will benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is crucial before *** and nutritional indicators play essential roles in cancer development and *** To investigate the association of preoperative inflammatory and nutritional markers with prognosis in patients with *** We included 133 patients diagnosed with CRC-PM between July 2012 and July ***’demographics,overall survival(OS),and preoperative inflammatory and nutritional markers were *** Kaplan-Meier method and log-rank test were used to estimate *** Of the 133 patients,94(70.6%)had normal hemoglobin(Hb)and 54(40.6%)had a high neutrophil-to-lymphocyte ratio(NLR).The median OS(mOS)was significantly lower for patients with high NLR(7.9 months)than for those with low NLR(25.4 months;P=0.002).Similarly,patients with normal Hb had a longer mOS(18.5 months)than those with low Hb(6.3 months;P<0.001).Multivariate analysis identified age,carbohydrate antigen 199 levels,NLR,Hb,and peritoneal cancer index as independent predictors of *** on these findings,a nomogram was constructed,which demonstrated a good capacity for prediction,with a C-index of 0.715(95%confidence interval:0.684-0.740).Furthermore,the 1-and 2-year survival calibration plots showed good agreement between predicted and actual OS *** areas under the curve for the 1-and 2-year survival predictions of the nomogram were 0.6238 and 0.6234,*** High NLR and low Hb were identified as independent predictive risk factors for poor prognosis in patients with *** established nomogram demonstrated high accuracy in predicting OS for patients with CRC-PM,indicating its potential as a valuable prognostic tool for this patient population.

关键词： Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio Hemoglobin Prognosis Overall survival

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Prognostic value of neutrophil-to-lymphocyte ratio in end-stage liver disease:A meta-analysis

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World Journal of Hepatology 2024年第3期16卷 477-489页

作者： Xiang-Hao Cai Yun-Ming Tang Shu-Ru Chen Jia-Hui Pang Yu-Tian Chong Hong Cao Xin-Hua Li Department of Infectious Disease Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)is commonly utilized as a prognostic indicator in end-stage liver disease(ESLD),encompassing conditions like liver failure and decompensated ***,some studies have contested the prognostic value of NLR in *** To investigate the ability of NLR to predict *** Databases,such as Embase,PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure,Weipu,and Wanfang,were comprehensively searched to identify studies published before October 2022 assessing the prognostic ability of NLR to predict mortality in patients with *** sizes were calculated using comprehensive meta-analysis software and SATAT *** A total of thirty studies involving patients with end-stage liver disease(ESLD)were included in the *** the pooled results of eight studies,it was observed that the Neutrophil-to-Lymphocyte Ratio(NLR)was significantly higher in non-survivors compared to survivors(random-effects model:standardized mean difference=1.02,95%confidence interval=0.67-1.37).Additionally,twenty-seven studies examined the associations between NLR and mortality in ESLD patients,reporting either hazard ratios(HR)or odds ratios(OR).The combined findings indicated a link between NLR and ESLD mortality(randomeffects model;univariate HR=1.07,95%CI=1.05-1.09;multivariate HR=1.07,95%CI=1.07-1.09;univariate OR=1.29,95%CI=1.18-1.39;multivariate OR=1.29,95%CI=1.09-1.49).Furthermore,subgroup and meta-regression analyses revealed regional variations in the impact of NLR on ESLD mortality,with Asian studies demonstrating a more pronounced *** Increased NLR in patients with ESLD is associated with a higher risk of mortality,particularly in Asian *** is a useful prognostic biomarker in patients with ESLD.

关键词： Neutrophil-to-lymphocyte ratio End stage liver diseases Prognosis Meta-analysis Mortality

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Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huang Jian-Yun Peng Hai-Yi Long Xian Zhong Yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical Ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 IU/mL as Pos group(n=200)and40 U/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

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Local Climate Change Induced by Urbanization on a South China Sea Island

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Journal of Tropical Meteorology 2024年第1期30卷 11-19页

作者：郝宇李磊陈柏纬孙伟戴永久 School of Atmospheric Sciences Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yatsen UniversityZhuhaiGuangdong 519082 China Guangdong Provincial Observation and Research Station for Climate Environment and Air Quality Change in the Pearl River Estuary ZhuhaiGuangdong 519082 China Key Laboratory of Tropical Atmosphere-Ocean System Ministry of EducationSun Yat-sen UniversityZhuhaiGuangdong 519082 China Guangdong Provincial Marine Meteorology Science Data Center Guangzhou 510640 China Hong Kong Observatory KowloonHongkong 999077 China Meteorological Bureau of Sansha City SanshaHainan 573199 China

The South China Sea is a hotspot for regional climate *** the past 40 years,considerable improvement has been made in the development and utilization of the islands in the South China Sea,leading to a substantial change in the land-use of the ***,research on the impact of human development on the local climate of these islands is *** study analyzed the characteristics of local climate changes on the islands in the South China Sea based on data from the Yongxing Island Observation Station and ERA5 ***,the influence of urbanization on the local climate of the South China Sea islands was explored in this *** findings revealed that the 10-year average temperature in Yongxing Island increased by approximately 1.11℃from 1961 to 2020,and the contribution of island development and urbanization to the local warming rate over 60 years was approximately 36.2%.The linear increasing trend of the annual hot days from 1961–2020 was approximately 14.84 days per *** diurnal temperature range exhibited an increasing trend of 0.05℃per decade,whereas the number of cold days decreased by 1.06days per *** rapid increase in construction on Yongxing Island from 2005 to 2021 led to a decrease in observed surface wind speed by 0.32 m s^(-1)per ***,the number of days with strong winds decreased,whereas the number of days with weak winds ***,relative humidity exhibited a rapid decline from 2001 to 2016 and then *** study also found substantial differences between the ERA5 re-analysis and observation data,particularly in wind speed and relative humidity,indicating that the use of re-analysis data for climate resource assessment and climate change evaluation on island areas may not be feasible.

关键词： local climate climate change Yongxing Island a South China Sea island climate change induced by urbanization

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The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan Hailin Tang Lewei Zhu Yutian Zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

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Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of Gastroenterology 2024年第5期30卷 440-449页

作者： Yue Deng Ya Jiang Tong Jiang Ling Chen Hai-Jun Mou Bi-Guang Tuo Guo-Qing Shi Department of Gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also *** were allocated to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was *** average cost and other related economic factors were g

关键词： Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

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Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

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Bio-Design and Manufacturing 2024年第1期7卷 88-103页

作者： Shuang Huang Shantao Zheng Mengyi He Chuanjie Yao Xinshuo Huang Zhengjie Liu Qiangqiang Ouyang Jing Liu Feifei Wu Hang Gao Xi Xie Hui-jiuan Chen State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China The First Affiliated hospital of sun Yat-Sen University Guangzhou 510080China Pazhou Lab Guangzhou 510335China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

关键词： Multiplexed microfilament electrode cluster Physiological ion sensing Subcutaneous and brain experiment Wearable platform for multi-ion detection Continuous real-time monitoring system

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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