检索结果-南通市图书馆

Detailed sedimentary facies of a sandstone reservoir in the eastern zone of the sulige gas field, Ordos Basin

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mining Science and Technology 2010年第6期20卷 891-897,903页

作者： LI Yijun ZHAO Yong YANG Renchao FAN Aiping LI Fuping sulige gas field research center Changqing Oilfield Company Xi "an 710018 China College of Geological Science and Engineering Shandong University of Science and Technology Qingdao 266510 China

Given sustaining exploration, the eastern zone of the sulige gas field may soon become a key area of exploitation. In order to explore its genesis, types and distribution of the reservoir sandstones in the eastern zone of this gas field, we focused in our study on the provenance and detailed sedimentary facies of sandstone of the He8 （the eighth part of the Shihezi formation, Permian system） and Shanxil （the first part of the Shanxi formation, Permian system） members, based on core observations, analyses in petrography, granularity and logging. The results show that： 1） the sandstone provenance of Shanxil and He8 in the eastern zone of the sulige gas field is from the north of the Ordos Basin, characterized by dual directions from the north and northeast. 2） The He8 and Shanxil members were deposited in a fluvial-delta sedimentary system. The He8 was mainly deposited in braided rivers, in- cluding braided channels, channel bars, levee and floodplain sub-environments, whereas the Shanxil Member was deposited in braided rivers and deltas, including braided channels, channel bars, floodplains, tributaries and inter-tributary sub-environments. 3） Sedimentary facies bands migrated in drastic fashion towards the basin from the Shanxil to the He8 Member. Base levels of sedi- mentation generally present a trend of small increases in-amplitude, large decreasing amplitudes and slow and gradual Increases. 4） The continuity of the reservoir sandbodies along the source direction is better than that perpendicular to the direction. Compared with Shanxil, both dimensions and continuity of the sandbodies in He8 are better from which we conclude that it is the most fa- vorable part of the reservoir.

关键词： Ordos Basin sulige gas field Permian sandstone reservoir detailed sedimentary facies

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Exosomes:the next-generation therapeutic platform for ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang Stroke center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience research center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering research center of Stem Cells Translational Medicine ShanghaiChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

Basin-Scale Sand Deposition in the Upper Triassic Xujiahe Formation of the Sichuan Basin, Southwest China: Sedimentary Framework and Conceptual Model

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2013年第1期24卷 89-103页

作者：谭秀成夏青松陈景山李凌刘宏罗冰夏吉文杨家静 State Key Laboratory of Oil and gas Geology and Exploitation Southwest Petroleum University School of Resource and Environment Southwest Petroleum University research Institute of Exploration and Development PetroChina Southwest Oil and Gas Field Company Branch of Shunan gas field PetroChina Southwest Oil and Gas Field Company

The Upper Triassic Xujiahe （须家河） Formation in the Sichuan （四川） Basin, Southwest China is distinctive for the basin-scale sand deposition. This relatively rare sedimentary phenomenon has not been well interpreted. Here we addressed this issue by discussing sedimentary framework and conceptual model. Analysis of sedimentary setting implied that the basin received transgression during the deposition. It had multiple provenance supplies and river networks, as being surrounded by old- lands in multiple directions including the north, east and south. Thus, the basin was generally charac-terized by coastal and widely open and shallow lacustrine deposition during the Late Triassic Xujiahe period. This is similar to the modern well-known Poyang （鄱阳） Lake. Therefore, we investigated the framework and conceptual model of the Sichuan Basin during the Xujiahe period with an analogue to the Poyang Lake. Results show that the conceptual model of the deposition can be divided into transgressive and regressive stages. The first, third and fifth mem- bers of the formation are in transgressive stage and the deposits are dominated by shore and shallow lacustrine mud. In contrast, the deposition is mainly of braided river channel sand deposits during the regressive stage, mainly including the second, fourth and sixth members of the formation. The sand deposited in almost the entire basin because of the lateral migration and forward moving of the cross networks of the braided rivers. The multiple alternations of short and rapid transgression and relatively long regression are beneficial to the basin-scale sand deposition. Thus, the main channel of the braided river and its extensional areas are favorable for the development of hydrocarbon reservoir. This provides practical significance to the reservoir evaluation and exploration. In addition, the results also justify the relatively distinctive sedimentary phenomenon in the study area and may also have im- plications for understanding the

关键词： basin-scale sand deposition coastal and widely open lake sedimentary framework sedimentary conceptual model channel of braided river Upper Triassic Xujiahe Formation Sichuan Basin.

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第2期20卷 483-484页

作者： Yun Li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Evaluation of the combined influence of geological layer property and in-situ stresses on fracture height growth for layered formations

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第5期21卷 3222-3236页

作者： Peng Tan Zhao-Wei Chen Liu-Ke Huang Qing Zhao Sha-Rui Shao CNPC Engineering Technology R&D Company Limited National Engineering research center for Oil&gas Drilling and Completion Technology School of Civil Engineering and Geomatics Southwest Petroleum University Shale gas research Institute Southwest Oil&Gas Field Company

Fracture geometry is important when stimulating low-permeability reservoirs for natural gas or oil production. The geological layer(GL) properties and contrasts in in-situ stress are the two most important parameters for determination of the vertical fracture growth extent and containment in layered rocks. However, the method for assessing the cumulative impact on growth in height remains ambiguous. In this research, a 3D model based on the cohesive zone method is used to simulate the evolution of hydraulic fracture(HF) height in layered reservoirs. The model incorporates fluid flow and elastic deformation, considering the friction between the contacting fracture surfaces and the interaction between fracture components. First, an analytical solution that was readily available was used to validate the model. Afterwards, a quantitative analysis was performed on the combined impacts of the layer interface strength, coefficient of interlayer stress difference, and coefficient of vertical stress *** results indicate that the observed fracture height geometries can be categorized into three distinct regions within the parametric space: blunted fracture, crossed fracture, and T-shaped ***, the results explained the formation mechanism of the low fracture height in the deep shale reservoir of the Sichuan Basin, China, as well as the distinction between fracture network patterns in mid-depth and deep shale reservoirs.

关键词： Deep shale Hydraulic fracturing HF propagation Fracture interaction Cohesive zone method

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第6期20卷 1699-1700页

作者： Seyed Mojtaba Hosseini Soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada Manitoba Multiple Sclerosis research center WinnipegMBCanada Children Hospital research Institute of Manitoba WinnipegMBCanada

Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).

关键词： peroxidation Fischer injury