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Journal of Environmental Sciences 2017年第5期29卷 157-163页

作者： Lakshmi Pethakamsetty Kalyani Kothapenta Hanumanta Rao Nammi Lakshmi Kalyani Ruddaraju Pratap Kollu Soon Gil Yoon Sri Venkata Narayana Pammi Department of Microbiology College of Science and Technology Andhra University Visakhapatnam 530003 India DST-PURSE programme Advanced Analytical Laboratory Andhra University Visakhapatnam 530003 India Sri Vishnu College of pharmacy Department of Pharmaceutical Technology Vishnupur Bhimavaram A.P. 530041 India DST-INSPIRE Faculty Department of Metallurgical Engineering & Materials Science Indian Institute of Technology Bombay Mumbai 400076 India Department of Materials Science and Engineering Chungnam National University Daeduk Science Town 305-764 Daejeon South Korea

The current research study focuses to formulate the biosynthesized silver nanoparticles for the first time from silver acetate using methanolic root extracts of Diospyros sylvatica,a member of family Ebenaceae. TEM analysis revealed the average diameter of Ag NPs around 8 nm which is in good agreement with the average crystallite size（10 nm）calculated from X-ray Diffraction（XRD）analysis. Further the study has been extended to the antimicrobial activity against test pathogenic Gram（＋）ve,Gram（-）ve bacterial and fungal strains. The bioinspired Ag-NP showed promising activity against all the tested bacterial strains and the activity was enhanced with increased dosage levels

关键词： Root extract Silver nanoparticles Antimicrobial properties

What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness

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World Journal of Rheumatology 2015年第2期5卷 108-126页

作者： Jéssica Barreto dos Santos Juliana de Oliveira Costa Haliton Alves de Oliveira Junior Lívia Lovato Pires Lemos Vnia Eloisa de Araújo Marina Amaral de Avila Machado Alessandra Maciel Almeida Francisco de Assis Acurcio Juliana Alvares Postgraduate programme in Medicines and Pharmaceutical Assistance College of PharmacyFederal University of Minas GeraisAv.Presidente Antonio Carlos College of pharmacy Federal University of Minas GeraisAv.Presidente Antonio Carlos Department of Social pharmacy College of PharmacySUS Collaborating Centre-CCATESFederal University of Minas GeraisAv.Presidente Antonio Carlos College of Medicine Federal University of Minas GeraisAv.Prof.Alfredo Balena

AIM:To evaluate the effectiveness of the biological disease-modifying antirheumatic drugs(b DMARD) in the treatment of rheumatoid arthritis through a systematic review of observational ***:The studies were searched in the Pub Med,EMBASE,Cochrane Controlled Trials Register and LILACS databases(until August 2014),in the grey literature and conducted a manual *** assessed criteria of effectiveness included the EULAR,the disease activity score(DAS),the Clinical Disease Activity Index,the Simplified Disease Activity Index,the American College of Rheumatology and the Health Assessment *** meta-analysis was performed with Review Manager 5.2 software using a random effects model.A total of 35 studies were included in this ***:The participants anti-tumor necrosis factor inhibitors(TNF) nave,who used adalimumab(P = 0.0002) and etanercept(P = 0.0006) exhibited greater good EULAR response compared to the participants who used *** difference was detected between adalimumab and etanercept(P = 0.05).The participants who used etanercept exhibited greater remission according to DAS28 compared to the participants who used infliximab(P = 0.01).No differences were detected between adalimumab and infliximab(P = 0.12) or etanercept(P = 0.79).Better results were obtained with b DMARD associated with methotrexate than with b DMARD *** good EULAR response and DAS 28 was better for combination with methotrexate than b DMARD monotherapy(P = 0.03 e P < 0.00001).In cases of therapeutic failure,the participants who used rituximab exhibited greater DAS28 reduction compared to those who used anti-TNF agents(P = 0.0002).The participants who used etanercept achieved greater good EULAR response compared to those who did not use that drug(P = 0.007).Studies that assessed reduction of the CDAI score indicated the superiority of abatacept over rituximab(12.4 vs +1.7) and anti-TNF agents(7.6 vs 8.3).The present systematic review with meta-analys

关键词： Systematic review Meta-analysis Effecti-veness Biological disease-modifying antirheumatic drugs Rheumatoid arthritis

Modifying current thin-film microextraction(TFME)solutions for analyzing prohibited substances:Evaluating new coatings using liquid chromatography

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Journal of Pharmaceutical Analysis 2022年第3期12卷 470-480页

作者： Łukasz Sobczak Dominika Kołodziej Krzysztof Gorynski Bioanalysis Scientific Group Faculty of PharmacyCollegium Medicum in Bydgoszcz at Nicolaus Copernicus University in Torun85-089BydgoszczPoland

For identifying and quantifying prohibited substances,solid-phase microextraction(SPME)continues to arouse interest as a sample preparation ***,the practical implementation of this method in routine laboratory testing is currently hindered by the limited number of coatings compatible with the ubiquitous high-performance liquid chromatography(HPLC)*** octadecyl(C18)and polydimethylsiloxane/divinylbenzene ligands are currently marketed for this *** address this situation,the present study evaluated 12 HPLC-compatible coatings,including several chemistries not currently used in this *** stationary phases of SPME devices in the geometry of thin filmcoated blades were prepared by applying silica particles bonded with various functional ligands(C18,octyl,phenyl-hexyl,3-cyanopropyl,benzenesulfonic acid,and selected combinations of these),as well as unbonded silica,to a metal *** of these chemistries have not been previously used as microextraction *** 48 most commonly misused substances were selected to assess the extraction efficacy of each coating,and eight desorption solvent compositions were used to optimize the desorption *** samples were analyzed using an HPLC system coupled with triple quadrupole tandem mass *** evaluation enables selection of the best-performing coatings for quantifying prohibited substances and investigates the relationship between extraction efficacy and the physicochemical characteristics of the ***,using the most suitable coatings is essential for trace-level analysis of chemically diverse prohibited substances.

关键词： Sample preparation Solid-phase microextraction Thin-film microextraction Prohibited substances Drugs of abuse High-performance liquid chromatography

A pilot study on prevalence and cure rate of tuberculosis in selected areas of Malabar 2006-07.

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 64-67页

作者： Dilip C Saraswathi R Christapher PV Prasanth NV Sanal Dev Al Shifa College o pharmacy KizhatturPerinthalmannaKerala.Pin-679325

Objective:To study the prevalence and cure rate of tuberculosis(TB) and the people affected by TB in selected areas,considering different factors like age,sex,percentage of people affected,dosage forms,role of hospitals, and patient ***:A detailed survey was carried out in and around Perinthalmanna and Wayanad(Urban and Rural) to understand the burden and overall trend of TB in our locality and how effective our TB control *** than 250 treatment cards were collected from the Government hospitals and TB ***:In the study,at Perinthalmanna and Wayanad,out of 250 TB patients it was found that males is more susceptible than females,rural area accounting for the greater proportion of TB patients. Greater proportion were affected with pulmonary than extra pulmonary *** incidence of tuberculosis in different age groups varied according to the *** proportion in both rural and urban areas were belonging to categoryⅡfollowed by categoryⅢ.Conclusion:The nature and magnitude of TB is more in rural area than urban area mainly because of the lack of awareness of the severity of disease and improper follow up of preventive *** study suggests that the combined and committed efforts of government,non government organizations,medical and paramedical professional and society is required at large,to reach all patients and ensure that they receive high quality care.

关键词： Directly observed treat short course(DOTS) Multi drug resistant tuberculosis(MDR -TB) Revised national TB control programme(RNTCP)

Biased activity of soluble guanylyl cyclase:the Janus face of thymoquinone

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Acta Pharmaceutica Sinica B 2017年第4期7卷 401-408页

作者： Charlotte Detremmerie Paul M.Vanhoutte Susan Leung Department of Pharmacology and pharmacy and State Key Laboratory for Pharmaceutical Biotechnology Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

The natural compound thymoquinone, extracted from Nigella sativa(black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endotheliumindependent vasodilator effects in isolated rat aortae and pulmonary arteries, depending in part on activation of adenosine triphosphate-sensitive potassium channels and inhibition of voltage-dependent calcium channels. The compound also improves endothelial dysfunction in mesenteric arteries of ageing rodents and in aortae of rabbits treated with pyrogallol, by inhibiting oxidative stress. Serendipitously,thymoquinone was found to augment contractions in isolated arteries with endothelium of both rats and pigs. The endothelium-dependent augmentation it causes counterintuitively depends on biased activation of soluble guanylyl cyclase(sGC) producing inosine 3',5'-cyclic monophosphate(cyclic IMP) rather than guanosine 3',5'-cyclic monophosphate. This phenomenon shows a striking mechanistic similarity to the hypoxic augmentation previously observed in porcine coronary arteries. The cyclic IMP preferentially produced under thymoquinone exposure causes an increased contractility of arterial smooth muscle by interfering with calcium homeostasis. This brief review summarizes the vascular pharmacology of thymoquinone, focussing in particular on how the compound causes endothelium-dependent contractions by biasing the activity of sGC.

关键词： Thymoquinone Endothelium-dependentcontraction Nitric oxide Soluble guanylyl cyclase Cyclic IMP NADPH:quinone oxidoreductase

Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis

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Chinese Chemical Letters 2017年第8期28卷 1751-1754页

作者： Ben-Hou Zhang Jing-Jing Kong Yang Huang Yue-Guang Lou Xiao-Fei Li Chun-Yang He School of pharmacy Zunyi Medical UniversityZunyi 563003China Dafeng Marine Industrial Institute of Nanjing Tech University Yancheng 224145China

In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing commercial available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science.

关键词： Uracils Uracil Nucleosides Blue LED Photoredox catalysis Perfluoroalkylation

Injecting drug use: A vector for the introduction of new hepatitis C virus genotypes

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World Journal of Gastroenterology 2015年第38期21卷 10811-10823页

作者： Simona Ruta Costin Cernescu Carol Davila University of Medicine and pharmacy Stefan S. Nicolau Institute of Virology Stefan S. Nicolau Institute of Virology

Hepatitis C virus(HCV) genotypes' monitoring allows real-time insight into the dynamic changes that occur in the global epidemiological picture of HCV infection. Intravenous drug use is currently the primary driver for HCV transmission in developed and developing countries. The distribution of HCV genotypes/subtypes differs significantly between people who inject drugs(PWID) and the general population. HCV genotypes that previously exhibited a limited geographical distribution(3a,4) are becoming more prevalent in this high-risk group. Immigration from HCV-endemic countries and the evolving networks of HCV transmission in PWID influence HCV genotypes distribution in Europe. Social vulnerabilities(e.g.,unemployment,homelessness,and limited access to social and healthcare insurances systems) are important triggers for illicit drug use,which increases the associated risks of HCV infection and the frequent emergence of less prevalent genotypes. Genotype/subtype determination bears important clinical consequences in the progression of liver disease,susceptibility to antiviral therapies and the emergence of resistance-associated variants. An estimated half of the chronically HCV-infected PWID are unaware of their infection,and only one in ten of those diagnosed enter treatment. Nevertheless,PWID exhibit high response rates to new antiviral regimens,and the level of HCV reinfection is unexpectedly low. The focus of the healthcare system must be on the early detection and treatment of infection,to avoid late presentations that are associated with high levels of viremia and liver fibrosis,which may diminish the therapeutic success rate.

关键词： Hepatitis C Hepatitis C virus genotypes Intravenou

Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 500-506页

作者： Urve Paaver Ivo Laidmae Hélder A.Santos Jouko Yliruusi Jaan Aruvali Karin Kogermann Jyrki Heinamaki Faculty of Medicine Department of PharmacyUniversity of TartuNooruse150411 TartuEstonia Faculty of pharmacy Division of Pharmaceutical Chemistry and TechnologyUniversity of HelsinkiViikinkaari 5EFI-00014HelsinkiFinland Institute of Ecology and Earth Sciences University of TartuRavila 14a50411 TartuEstonia

Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols.

关键词： Electrospinning Plant sterol β-sitosterol Nanofibers Solid-state properties Dissolution

Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody:Pilot study

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 361-368页

作者： Adriana Ciocalteu Adrian Saftoiu Daniel Pirici Claudia-Valentina Georgescu Tatiana Cartana Dan Ionut Gheonea Lucian Gheorghe Gruionu Cosmin Gabriel Cristea Gabriel Gruionu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy of Craiova Department of Research Methodology University of Medicine and Pharmacy of Craiova Department of Pathology Emergency County Hospital Department of Mechanical Engi-neering University of Craiova Edwin Steele Laboratory of Tumor Biology Department of Radiation OncologyMassachusetts General HospitalHarvard Medical School

AIM: To evaluate neoangiogenesis in patients with colon cancer by two fluorescently labeled antibodies on fresh biopsy samples imaged with confocal laser endomicroscopy(CLE).METHODS: CLE is an imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular *** important question in validating tumor angiogenesis is what proportion of the tumor vascular network is represented by preexisting parent tissue vessels and newly formed ***105(endoglin) represents a proliferation-associated endothelial cell adhesion *** contrast to panendothelial markers,such as CD31,CD105 is preferentially expressed in activated endothelial cells that participate in ***,we evaluated CD105 and CD31 expression from samples of ten patients with primary rectal adenocarcinoma,using a dedicated endomicroscopy system.A imaging software was used to obtain the Z projection of the confocal serial images from each biopsy sample previously combined into *** density and vessel diameters were measured within two 50 μm x 475 μm rectangular regions of interest centered in the middle of each image in the horizontal and vertical *** results were averaged over all the patients and were expressed as the mean ± ***: The use of an anti-CD105 antibody was found to be suitable for the detection of blood vessels in colon *** anti-CD31 antibodies stained blood vessels in both normal and pathologic colon equally,CD105 expression was observed primarily in malignant lesions,with little or no expression in the vessels of the normal mucosa(244.21 ± 130.7 vessels/mm3 in only four patients).The average diameter of antiCD105 stained vessels was 10.97 ± 0.6 μm in tumor tissue,and the vessel density was 2787.40 ± 134.8 vessels/*** using the anti-CD31 antibody,the average diameter of vessels in the normal colon tissue was 7.67 ± 0.5 μm and the vessel density was 3191.60 ± 387.8 vessels/mm3,while in the tumors w

关键词： Rectal cancer Neoangiogenesis Confocal laser endomicroscopy Panendothelial markers Anti-CD105 antibody

Noninvasive assessment of alcoholic liver disease using unidimensional transient elastography(Fibroscan~)

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World Journal of Gastroenterology 2015年第42期21卷 11914-11923页

作者： Monica Lupsor-Platon Radu Badea Department of Medical Imaging Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor Iuliu Hatieganu University of Medicine and Pharmacy

Unidimensional transient elastography(TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the factors that may influence the result of fibrosis prediction, and last but not least, on its potential use in assessing the steatosis degree. Therefore, this field is far from being exhausted and deserves more attention. Further studies are required, on large groups of biopsied patients, in order to find answers to all the remaining questions in this field.

关键词： Transient elastography Alcoholic liver disease Fib