Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol

作     者：Urve Paaver Ivo Laidmae Hélder A.Santos Jouko Yliruusi Jaan Aruvali Karin Kogermann Jyrki Heinamaki 

作者机构：Faculty of MedicineDepartment of PharmacyUniversity of TartuNooruse150411 TartuEstonia Faculty of PharmacyDivision of Pharmaceutical Chemistry and TechnologyUniversity of HelsinkiViikinkaari 5EFI-00014HelsinkiFinland Institute of Ecology and Earth SciencesUniversity of TartuRavila 14a50411 TartuEstonia 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第4期

页      面：500-506页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This study is supported by the European Social Fund’s Doctoral Studies and Internationalisation Programme DoRa.The work is part of the ETF Grant Project No.ETF7980 and IUT-34-18 Project.Kerly Kustavus is kindly acknowledged for drawing the chemical structures of plant sterols.Dr.Korbinian Löbmann is kindly acknowledged for providing the Mercury files for the theoretical XRPD pattern calculations.Dr.H.A.Santos acknowledges financial support from the Academy of Finland(Decision No.252215) 

主　　题：Electrospinning Plant sterol β-sitosterol Nanofibers Solid-state properties Dissolution 

摘      要：Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols.