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Mechanisms underlying the role of endoplasmic reticulum stress in the placental injury and fetal growth restriction in an ovine gestation model

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Journal of animal Science and Biotechnology 2024年第1期15卷 201-217页

作者： Hao Zhang Xia Zha Yi Zheng Xiaoyun Liu Mabrouk Elsabagh Hongrong Wang Honghua Jiang Mengzhi Wang laboratory of Metabolic Manipulation of Herbivorous animal nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China joint International Research laboratory of Agriculture and Agri‑Product Safety Ministry of Education of ChinaYangzhou UniversityYangzhou 225009P.R.China Department of animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNiğde Omer Halisdemir UniversityNigde 51240Turkey Department of nutrition and Clinical nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China state key laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural Reclamation ScienceShihezi 832000China

Background Exposure to bisphenol A(BPA),an environmental pollutant known for its endocrine-disrupting properties,during gestation has been reported to increase the risk of fetal growth restriction(FGR)in an ovine model of *** hypothesized that the FGR results from the BPA-induced insufficiency and barrier dysfunction of the placenta,oxidative stress,inflammatory responses,autophagy and endoplasmic reticulum stress(ERS).However,precise mechanisms underlying the BPA-induced placental dysfunction,and subsequently,FGR,as well as the potential involvement of placental ERS in these complications,remain to be *** In vivo experiment,16 twin-pregnant(from d 40 to 130 of gestation)Hu ewes were randomly distributed into two groups(8 ewes each).One group served as a control and received corn oil once a day,whereas the other group received BPA(5 mg/kg/d as a subcutaneous injection).In vitro study,ovine trophoblast cells(OTCs)were exposed to 4 treatments,6 replicates *** OTCs were treated with 400μmol/L BPA,400μmol/L BPA+0.5μg/m L tunicamycin(Tm;ERS activator),400μmol/L BPA+1μmol/L 4-phenyl butyric acid(4-PBA;ERS antagonist)and DMEM/F12 complete medium(control),for 24 *** In vivo experiments,pregnant Hu ewes receiving the BPA from 40 to 130 days of pregnancy experienced a decrease in placental efficiency,progesterone(P4)level and fetal weight,and an increase in placental estrogen(E2)level,together with barrier dysfunctions,OS,inflammatory responses,autophagy and ERS in type A *** vitro experiment,the OTCs exposed to BPA for 24 h showed an increase in the E2 level and related protein and gene expressions of autophagy,ERS,pro-apoptosis and inflammatory response,and a decrease in the P4 level and the related protein and gene expressions of antioxidant,anti-apoptosis and barrier ***,treating the OTCs with Tm aggravated BPA-induced dysfunction of barrier and endocrine(the increased E2 level and decreased P4 level),OS,inflamm

关键词： Autophagy Bisphenol A Endoplasmic reticulum stress Fetal growth restriction Inflammatory responses Sheep

Effects of solid-state fermentation product of yeast supplementation on liver and intestinal health,and resistance of common carp(Cyprinus carpio)against spring viraemia carp virus

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animal nutrition 2024年第3期18卷 408-418页

作者： Mengxin Wang Dongmei Xia Lijuan Yu Qiang Hao Mingxu Xie Qingshuang Zhang Yajie Zhao Delong Meng Yalin Yang Chao Ran Tsegay Teame Zhen Zhang Zhigang Zhou China-Norway joint Lab on Fish Gut Microbiota Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Hubei key laboratory of animal nutrition and Feed Science Wuhan Polytechnic UniversityWuhan 430000China key laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Tigray Agricultural Research institute Mekelle Agricultural Research CenterMekelleTigray 251Ethiopia

This study aimed to investigate the effects of solid-state fermentation products of yeast(SFPY)on liver and intestinal health and disease resistance of common carp(Cyprinus carpio).A total of 200 common carp with an initial average weight of 2.55±0.004 g were divided into 5 groups(4 replications per group and 10 fish per replication),and were fed with one of five diets,including a control diet and 4 diets supplemented with 2‰(Y2),3‰(Y3),4‰(Y4),or 5‰(Y5)SFPY,respectively,for 8 *** indicated that,the addition of SFPY to the diet of common carp did not affect the growth performance or survival rate of fish(P=0.253).Interestingly,with the addition of SFPY,the triacylglycerol(TAG)content of the liver presented a linear decreasing tendency(P=0.004),with significantly decreased in Y4 and Y5 groups(P=0.035)compared with *** lipopolysaccharide(LPS)content and diamine oxidase(DAO)activity presented a negative linear relationship with the addition of SFPY(P=0.015,P=0.030),while serum lipopolysaccharide binding protein(LBP)content first decreased and then increased(P<0.001).The total antioxidant capacity(T-AOC)in the intestine of fish increased continuously with increasing SFPY supplementation(P=0.026),reaching the highest level in Y5 *** villus height in all experimental groups were significantly higher than that in the control group(P<0.001).Furthermore,compared to the control,adding 3‰SFPY to the control diet of common carp significantly increased the relative abundance of Fusobacteria(P=0.018)and decreased that of Proteobacteria(P=0.039)at phylum level,and increased the relative abundance of Cetobacterium(P=0.018)and decreased that of Shewanella(P=0.013)at genus *** with the control,the relative mRNA expression level of spring viraemia of carp virus N protein(SVCV-n)in the kidney was lower than that of the control group without significance and bottomed out in Y4 group(P=0.138).In conclusion,dietary SFPY enhanced the SVCV resistance capa

关键词： Yeast Solid-state fermentation product Probiotic Immunity Gut microbiota Common carp

Excessive level of dietary insect protein negatively changed growth metabolomic and transcriptomic profiles of largemouth bass(Micropterus salmoides)

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animal nutrition 2024年第2期17卷 397-407页

作者： Hao Sun Wenjing Dong Guanglun He Yong Long Yuanfa He Yongjun Chen Shimei Lin College of Fisheries Southwest University College of Fisheries Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education) Southwest University state key laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences

Hermetia illucens(HI) meal is a promising substitute for fish meal(FM) in the feeds of farmed ***, the impacts of dietary HI meal on largemouth bass(LMB) remain unknown. In this study, we formulated three isonitrogenous and isolipid diets with 0%(HI0, control), 20%(HI20) and 40%(HI40) of FM substituted by HI meal. A total of 270 juvenile largemouth bass with an initial body weight of10.02 ± 0.03 g were used(30 fish per tank). After an 80-day feeding trial, the fish fed with the HI40 diet demonstrated decreased growth performance and protein efficiency ratio(PER), and increased liver oxidative indices and lipid accumulation compared to the control(P joint transcriptomic-metabolomic analyses revealed that the pathways such as one carbon pool by folate, propanoate metabolism and alpha-linolenic acid metabolism were disturbed by high dietary HI meal. In summary, our data revealed the candidate genes, metabolites and biological pathways that account for the adverse effects of high HI meal diet on the growth and health of LMB.

关键词： Hermetia illucens Growth Transcriptome Metabolomic effect Micropterus salmoides

The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan Wang Mengqi Qu Yuhai Bi William J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping Zhang George F.Gao International joint Research Center of National animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS key laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu laboratory Zhengzhou 450046China University of Chinese Academy of sciences Beijing 100049China NHC key laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China state key laboratory of animal nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

iTRAQ quantitative analysis of plasma proteome changes of cow from pregnancy to lactation

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Journal of Integrative Agriculture 2015年第7期14卷 1407-1413页

作者： MA Lu BU Deng-pan YANG Yong-xing YAN Su-mei WANG Jia-qi Inner Mongolia Agricultural University state key laboratory of animal nutrition/caas-icraf joint laboratory on agroforestry and sustainable animal husbandry/institute of animal sciences Chinese Academy of Agricultural Sciences Synergetic Innovation Center of Food Safety and nutrition Northeast Agricultural University

Dairy cows undergo tremendous changes in physiological, metabolism and the immune function from pregnancy to lac- tation that are associated with cows being susceptible to metabolic and infectious diseases. The objective of this study is to investigate the changes of plasma proteome on 21 d before expected calving and 1 d after calving from dairy cows using an integrated proteomic approach consisting of minor abundance protein enrichment by ProteoMiner beads, protein labeling by isobaric tags for relative and absolute quantification, and protein identification by liquid chromatography coupled with tandem mass spectrometry. Nineteen proteins were changed around the time of calving. These proteins were asso- ciated with response to stress, including acute-phase response and defense response, based on the proteins annotation. In particular, three up-regulated proteins after calving including factor V, a2-antiplasmin and prothrombin were assigned into the complement and coagulation pathway. These results may provide new information in elucidating host response to lactation and parturition stress, and inflammatory-like conditions at the protein level. Differential proteins may serve as potential markers to regulate the lactation and parturition stress in periparturient dairy cows.

关键词： dairy cow periparturient plasma proteomic quantitative analysis

Dietary energy sources and levels shift the multi-kingdom microbiota and functions in the rumen of lactating dairy cows

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Journal of animal Science and Biotechnology 2020年第4期11卷 1073-1088页

作者： Tansol Park Lu Ma Ying Ma Xiaoqiao Zhou Dengpan Bu Zhongtang Yu Department of animal sciences The Ohio State UniversityColumbusOHUSA The state key laboratory of animal nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijingP.R.China caas-icraf joint Lab on agroforestry and sustainable animal husbandry BeijingP.R.China.

Background: Dietary energy source and level in lactation diets can profoundly affect milk yield and *** dietary effects on lactation performance are underpinned by alteration of the rumen microbiota, of which bacteria, archaea, fungi, and protozoa may vary differently. However, few studies have examined all the four groups of rumen microbes. This study investigated the effect of both the level and source of dietary energy on rumen bacteria, archaea, fungi, and protozoa in the rumen of lactating dairy cows. A 2 × 2 factorial design resulted in four dietary treatments: low and high dietary energy levels(LE: 1.52–1.53;and HE: 1.71–1.72 Mcal/kg dry matter) and two dietary energy sources(GC: finely ground corn;and SFC: steam-flaked corn). We used a replicated 4 × 4 Latin square design using eight primiparous Chinese Holstein cows with each period lasting for 21 d. The rumen microbiota was analyzed using metataxonomics based on kingdom-specific phylogenetic markers [16 S r RNA gene for bacteria and archaea, 18 S r RNA gene for protozoa, and internally transcribed spacer 1(ITS1) for fungi] followed with subsequent functional prediction using ***: The GC resulted in a higher prokaryotic(bacterial and archaeal) species richness and Faith's phylogenetic diversity than SFC. For the eukaryotic(fungi and protozoa) microbiota, the LE diets led to significantly higher values of the above measurements than the HE diets. Among the major classified taxa, 23 genera across all the kingdoms differed in relative abundance between the two dietary energy levels, while only six genera(none being protozoal)were differentially abundant between the two energy sources. Based on prokaryotic amplicon sequence variants(ASVs) from all the samples, overall functional profiles predicted using PICRUSt2 differed significantly between LE and HE but not between the two energy sources. Fish Taco analysis identified Ruminococcus and Coprococcus as the taxa potentially contributing

关键词： Corn processing method Dietary energy level Functional profiles Multi-kingdom Rumen microbiota

Heat stress impacts the multi-domain ruminal microbiota and some of the functional features independent of its effect on feed intake in lactating dairy cows

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Journal of animal Science and Biotechnology 2022年第6期13卷 1902-1916页

作者： Tansol Park Lu Ma Shengtao Gao Dengpan Bu Zhongtang Yu Department of animal sciences The Ohio State UniversityColumbusOHUSA Department of animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-doRepublic of Korea state key laboratory of animal nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193People’s Republic of China caas-icraf joint Lab on agroforestry and sustainable animal husbandry Beijing 100193People’s Republic of China

Background:Heat stress(HS)affects the ruminal microbiota and decreases the lactation performance of dairy *** HS decreases feed intake,the results of previous studies were confounded by the effect of HS on feed *** study examined the direct effect of HS on the ruminal microbiota using lactating Holstein cows that were pair-fed and housed in environmental chambers in a 2×2 crossover *** cows were pair-fed the same amount of identical total mixed ration to eliminate the effect of feed or feed *** composition and structure of the microbiota of prokaryotes,fungi,and protozoa were analyzed using metataxonomics and compared between two thermal conditions:pair-fed thermoneutrality(PFTN,thermal humidity index:65.5)and HS(87.2 for daytime and 81.8 for nighttime).Results:The HS conditions altered the structure of the prokaryotic microbiota and the protozoal microbiota,but not the fungal *** stress significantly increased the relative abundance of Bacteroidetes(primarily Gram-negative bacteria)while decreasing that of Firmicutes(primarily Gram-positive bacteria)and the Firmicutes-toBacteroidetes *** genera were exclusively found in the heat-stressed cows and thermal control *** co-occurrence and mutual exclusion between some genera were also found exclusively for each thermal *** stress did not significantly affect the overall functional features predicted using the 16S rRNA gene sequences and ITS1 sequences,but some enzyme-coding genes altered their relative abundance in response to ***:Overall,HS affected the prokaryotes,fungi,and protozoa of the ruminal microbiota in lactating Holstein cows to a different extent,but the effect on the structure of ruminal microbiota and functional profiles was limited when not confounded by the effect on feed ***,some genera and co-occurrence were exclusively found in the rumen of heat-stressed *** effects should be attributed to the direct effect

关键词： Functional profiles Heat stress Microbiome Multi-kingdom Network analysis Ruminal microbiota

MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells

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animal nutrition 2022年第3期10卷 319-328页

作者： Fang Wang Jürgen van Baal Lu Ma Xuejun Gao Jan Dijkstra Dengpan Bu state key laboratory of animal nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China animal nutrition Group Wageningen University and ResearchWageningen6708WDthe Netherlands College of animal Science Yangtze UniversityJingzhou434020China joint laboratory on Integrated Crop-Tree-Livestock Systems of the Chinese Academy of Agricultural sciences(caas) Ethiopian Institute of Agricultural Research(EIAR)and World Agroforestry Center(ICRAF)Beijing100193China

Myotonic dystrophy-related Cdc42-binding kinase alpha(MRCKα)is an integral component of signaling pathways controlling vital cellular processes,including cytoskeletal reorganization,cell proliferation and cell *** this study,we investigated the physiological role of MRCKα in milk protein and fat production in dairy cows,which requires a dynamic and strict organization of the cytoskeletal network in bovine mammary epithelial cells(BMEC).Within a selection of 9 Holstein cows,we found that both mRNA and protein expression of MRCKα in the mammary gland were upregulated during lactation and correlated positively(r>0.89)with the mRNA and protein levels of *** positive correlations(r>0.79)were found in a primary culture of BMEC stimulated with prolactin for 24 *** these cells,silencing of MRCKα decreased basal b-casein,sterol-regulatory element binding protein(SREBP)-1 and cyclin D1 protein level,phosphorylation of mTOR,triglyceride secretion,cell number and viabilitydwhile overexpression of MRCKα displayed the reversed ***,silencing of MRCKα completely prevented the stimulatory action of prolactin on the same *** data demonstrate that MRCKα is a critical mediator of prolactin-induced lactogenesis via stimulation of the mTOR/SREBP1/cyclin D1 signaling pathway.

关键词： Myotonic dystrophy-related Cdc42-binding kinase alpha Bovine mammary gland Prolactin Mechanistic target of rapamycin Sterol regulatory element-binding protein-1 Cyclin D1

Milk selenium content and speciation in response to supranutritional selenium yeast supplementation in cows

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animal nutrition 2021年第4期7卷 1087-1094页

作者： Lingling Sun Gentao Liu Dongmei Xu Zhaohai Wu Lu Ma Sanz-Fernandez M.Victoria Lance H.Baumgard Dengpan Bu state key laboratory of animal nutrition Institute of Animal Sciences of Chinese Academy of Agricultural SciencesBeijing 100193China Comparative Physiology Group Subdireccion General de Investigacion y Tecnologia(SGIT)Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)Madrid 28040Spain Department of animal Science Iowa State UniversityAmes 50014USA caas-icraf joint Lab on agroforestry and sustainable animal husbandry Beijing 100193China Hunan Co-Innovation Center of animal Production Safety CICAPSChangshaHunan 410128China

The effects of selenium(Se)yeast supplementation on performance,blood biochemical and antioxidant parameters,and milk Se content and speciation were ***-six mid-lactation Holstein dairy cows were randomly assigned to 1 of 3 treatments:1)control(basal diet containing Se at 0.11 mg/kg DM),2)basal diet+0.5 mg supplemental Se/kg DM(SY-0.5),and 3)basal diet+5 mg supplemental Se/kg DM(SY-5).Selenium was supplemented as Se *** trial consisted of a 1-week pretrial period and an 8-week experimental *** somatic cell score decreased with SY-5 supplementation(P0.05).The serum Se concentration increased with the increasing levels of Se yeast supplementation(P<0.05),however,blood biochemical parameters showed few treatment *** antioxidant capacity of dairy cows was improved with Se yeast supplementation reflected in increased serum glutathione peroxidase activity(P<0.05)and total antioxidant capacity(P=0.08),and decreased malondialdehyde concentration(P<0.05).Milk total Se concentration increased with Se dose(P<0.05).Also,the selenomethionine concentration increased with Se dose from 13.0±0.7 pg/kg in control to 33.1±2.1 pg/kg in SY-0.5 and 530.4±17.5 pg/kg in SY-5 cows(P<0.05).Similarly,selenocystine concentration increased from 15.6±0.9μg/kg in control and 18.9±1.1 pg/kg in SY-0.5 to 22.2±1.5 pg/kg in SY-5 cows(P<0.05).In conclusion,Se yeast is a good organic Se source to produce Se-enriched cow milk with increased Se species including selenomethionine and *** results can provide useful information on milk Se species when a high dose Se yeast was supplemented in the cow diet.

关键词： Dairy cow Selenium yeast Selenium speciation Milk performance