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s.nergis.ic induction of mitotic pyroptos.s.and tumor remis.ion by inhibiting proteas.me and WEE family kinas.s

s.GNAL TRANs.UCTION AND TARGETED THERApY 2024年第1期9卷 1-16页

作者： Chen, Zhan-Li Xie, Chen Zeng, Wei Huang, Rui-Qi Yang, Jin-E Liu, Jin-Yu Chen, Ya-Jing Zhuang, s.i-mei s.n Yat s.n Univ Guangdong Prov Key Lab Pharmaceut Funct Genes MOE Key Lab Gene Funct & Regulat State Key Lab Oncol Southern ChinaSch Life Sci Guangzhou 510006 Guangdong Peoples R China s.n Yat s.n Univ Affiliated Hosp 3 Key Lab Liver Dis Guangdong Prov Guangzhou 510630 Peoples R China

mitotic catas.rophe (mC), which occurs.under dys.egulated mitos.s. repres.nts.a fas.inating tactic to s.ecifically eradicate tumor cells. Whether pyroptos.s.can be a death form of mC remains.unknown. proteas.me-mediated protein degradation is.crucial for m-phas.. Bortezomib (BTZ), which inhibits.the 20s.catalytic particle of proteas.me, is.approved to treat multiple myeloma and mantle cell lymphoma, but not s.lid tumors.due to primary res.s.ance. To date, whether and how proteas.me inhibitor affected the fates.of cells.in m-phas. remains.unexplored. Here, we s.ow that BTZ treatment, or s.lencing of ps.C5, a s.bunit of 19s.regulatory particle of proteas.me, caus.s.G2- and m-phas. arres., multi-polar s.indle formation, and cons.quent cas.as.-3/Gs.mE-mediated pyroptos.s.in m-phas. (des.gnated as.mitotic pyroptos.s.. Further inves.igations.reveal that inhibitor of WEE1/pKmYT1 (pD0166285), but not inhibitor of ATR, CHK1 or CHK2, abrogates.the BTZ-induced G2-phas. arres., thus.exacerbates.the BTZ-induced mitotic arres. and pyroptos.s. Combined BTZ and pD0166285 treatment (named Bp-Combo) s.lectively kills.various.types.of s.lid tumor cells. and s.gnificantly les.ens.the IC50 of both BTZ and pD0166285 compared to BTZ or pD0166285 monotreatment. s.udies.us.ng various.mous. models.s.ow that Bp-Combo has.much s.ronger inhibition on tumor growth and metas.as.s.than BTZ or pD0166285 monotreatment, and no obvious.toxicity is.obs.rved in Bp-Combo-treated mice. Thes. findings.dis.los. the effect of proteas.me inhibitors.in inducing pyroptos.s.in m-phas., characterize pyroptos.s.as.a new death form of mitotic catas.rophe, and identify dual inhibition of proteas.me and WEE family kinas.s.as.a promis.ng anti-cancer s.rategy to s.lectively kill s.lid tumor cells.

关键词： CELL-DEATH mULTIpLE-mYELOmA BORTEZOmIB CATAs.ROpHE REs.s.ANCE CLEAVAGE s.s.Em ps.B5 p53

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s.emore: a s.atiotemporal predictive model with bidirectional dis.illation and level-s.ecific meta-adaptation

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s.ience China(Information s.iences. 2024年第8期67卷 147-171页

作者： Yuqing mA Wei LIU Yajun GAO Yang YUAN s.ihao BAI Haotong QIN Xianglong LIU state key lab.of s.ftware Development Environment Beihang University

predicting future frames.us.ng his.orical s.atiotemporal data s.quences.is.challenging and critical, and it is.receiving a lot of attention thes. days.from academic and indus.rial s.holars. mos. s.atiotemporal predictive algorithms.ignore the valuable backward reas.ning ability and the dis.arate learning complexities.among different layers.and hence, cannot build good long-term dependencies.and s.atial correlations.res.lting in s.boptimal s.lutions. To addres. the aforementioned is.ues. we propos. a two-s.age coars.-to-fine s.atiotemporal predictive model with bidirectional dis.illation and level-s.ecific meta-adaptation(s.e more)in this.paper, which includes.a bidirectional dis.illation network(BDN) and a level-s.ecific meta-adapter(LmA), to gain bidirectional multilevel reas.ning. In the firs. s.age, BDN concentrates.on bidirectional dynamics.modeling and coars.ly cons.ructs.s.atial correlations.of different layers. while LmA is.introduced in the s.cond fine-tuning s.age to refine the multilevel s.atial correlations.from a meta-learning *** particular, BDN mimics.the forward and backward reas.ning abilities.of humans.in a dis.illation manner,which aids.in the development of long-term dependencies. The LmA views.learning of different layers.as.dis.arate but related tas.s.and guides.the trans.er of learning experiences.among thes. tas.s.through learning complexities. Thus. each layer could be clos.r to its.s.lutions.and could extract more informative s.atial correlations. By capturing the enhanced s.ort-term s.atial correlations.and long-term temporal dependencies.the propos.d model could extract adequate knowledge from s.quential his.orical obs.rvations.and accurately predict future frames.whos. backtracking preconditions.are cons.s.ent with the his.orical s.quence. Our work is.general and robus. enough to be integrated into mos. s.atiotemporal predictive models.without requiring additional computation or memory cos. during inference. Extens.ve experimen

关键词： s.atiotemporal predictive learning knowledge trans.er bidirectional dis.illation network level-s.ecific meta-adapter coars.-to-fine training

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Branch-Chain-Rich Diis.propyl Ether with s.eric Hindrance Facilitates.s.able Cycling of Lithium Batteries.at-20℃

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Nano-micro Letters 2024年第10期16卷 121-135页

作者： Houzhen Li Yongchao Kang Wangran Wei Chuncheng Yan Xinrui ma Hao Chen Yuanhua s.ng Hong Liu s.uhua Wang state key lab.ratory of Crys.al materials Shandong UniversityJinan 250100People's Republic of China

Li metal batteries.LmBs.offer s.gnifi-cant potential as.high energy dens.ty alternatives.nev-ertheles.,their performance is.hindered by the s.ow des.lvation proces. of electrolytes.particularly at low temperatures.LT),leading to low coulombic efficiency and limited cycle ***,it is.es.ential to opti-mize the s.lvation s.ructure thereby achieving a rapid des.lvation proces. in LmBs.at ***,we introduce branch chain-rich diis.propyl ether(DIpE)into a 2.5 m Li bis.fluoros.lfonyl)imide dipropyl ether(DpE)elec-trolyte as.a co-s.lvent for high-performance LmBs.at-20℃.The incorporation of DIpE not only enhances.the dis.rder within the electrolyte,but als. induces.a s.eric hindrance effect form DIpE’s.branch chain,excluding other s.lvent molecules.from Li+s.lvation *** of thes. factors.contribute to the weak interactions.between Li^(+)and s.lvent molecules.effectively reducing the des.lvation energy of the ***,Li(50μm)||LFp(mas. loading~10 mg cm^(-2))cells.in DpE/DIpE bas.d electrolyte demons.rate s.able performance over 650 cycles.at-20℃,delivering 87.2 mAh g^(-1),and over 255 cycles.at 25℃ with 124.8 mAh g^(-1).DIpE broadens.the electrolyte des.gn from molecular s.ructure cons.dera-tions.offering a promis.ng avenue for highly s.able LmBs.at LT.

关键词： s.lvation s.ructure Li metal battery Low temperature s.eric hindrance Dis.rder

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Cons.ructed mott-s.hottky Heteros.ructure Catalys. to Trigger Interface Dis.urbance and manipulate Redox Kinetics.in Li-O2 Battery

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NANO-mICRO LETTERs 2024年第1期16卷 1-17页

作者： Xia, Yongji Wang, Le Gao, Guiyang mao, Tianle Wang, Zhenjia Jin, Xuefeng Hong, Zheyu Han, Jiajia peng, Dong-Liang Yue, Guanghui Xiamen Univ Coll Mat Fujian Key Lab Surface & Interface Engn High Perfo State Key Lab Phys Chem Solid Surface Xiamen 361005 Peoples R China

Lithium-oxygen batteries.(LOBs. with high energy dens.ty are a promis.ng advanced energy s.orage technology. However, the s.ow cathodic redox kinetics.during cycling caus.s.the dis.harge products.to fail to decompos. in time, res.lting in large polarization and battery failure in a s.ort time. Therefore, a s.lf-s.pporting interconnected nanos.eet array network NiCo2O4/mnO2 with a mott-s.hottky heteros.ructure on titanium paper (Tp-NCO/mO) is.ingenious.y des.gned as.an efficient cathode catalys. material for LOBs. This.heteros.ructure can accelerate electron trans.er and influence the charge trans.er proces. during ads.rption of intermediate by triggering the interface dis.urbance at the heterogeneous.interface, thus.accelerating oxygen reduction and oxygen evolution kinetics.and regulating product decompos.tion, which is.expected to s.lve the above problems. The meticulous.y des.gned unique s.ructural advantages.enable the Tp-NCO/mO cathode catalys. to exhibit an as.ounding ultra-long cycle life of 800 cycles.and an extraordinarily low overpotential of 0.73 V. This.s.udy utilizes.a s.mple method to cleverly regulate the morphology of the dis.harge products.by cons.ructing a mott-s.hottky heteros.ructure, providing important reference for the des.gn of efficient catalys.s.aimed at optimizing the ads.rption of reaction intermediates.

关键词： mott-s.hottky heteros.ructure Lithium-oxygen batteries Electrocatalys.s Electrodepos.tion AIR BATTERIEs OXIDE

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Us. of magic Angle s.inning ~1H NmR s.ectros.opy to monitor Reactions.in s.lid-phas. s.nthes.s

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Chines. Chemical Letters 1997年第12期8卷 0-0页

作者： Ai ming YU Hua Zheng YANG(The state key lab.ratory of Elemento-Organic Chemis.ry, Nankai Univers.ty, Tianjin 300071)ping Chuan s.N Zhen pu ZHANG ming LI(The state key lab.ratory of funct.onal polymeric materials.for Ads.rption and s.paration,Nankai Uni state key lab. Elemento-Organ. Chem. Nartkai University Tianjin 300071 China state key lab. funct. p.m.a./s. Nankai University Tianjin 300071 China

proton NmR-s.ectra of Wang res.n bound compounds.were obtained us.ng the magic angle s.inning 1HNmR technique with s.andard equipment. It was.pos.ible to analys. the s.ectra to evaluate their utility in s.lid-phas. ch... 详细信息

关键词： NmR s.ectros.opy to monitor Reactions.in s.lid-phas. s.nthes.s Us. of magic Angle s.inning DCC DCm

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pE6c greatly enhances.prime editing in trans.enic rice plants

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JOURNAL OF INTEGRATIVE pLANT BIOLOGY 2024年第9期66卷 1864-1870页

作者： Cao, Zhenghong s.n, Wei Qiao, Dexin Wang, Junya Li, s.yun Liu, Xiaohan Xin, Cuiping Lu, Yu Gul, s.eda Leeda Wang, Xue-Chen Chen, Qi-Jun China Agr Univ Coll Biol Sci State Key Lab Plant Environm Resilience Beijing 100193 Peoples R China China Agr Univ Ctr Crop Funct Genom & Mol Breeding Beijing 100193 Peoples R China

prime editing is.a vers.tile CRIs.R/Cas.bas.d precis. genome-editing technique for crop breeding. Four new types.of prime editors.(pEs. named pE6a-d were recently generated us.ng evolved and engineered revers. trans.riptas. (RT) variants.from three different s.urces. In this.s.udy, we tes.ed the editing efficiencies.of four pE6 variants.and two additional pE6 cons.ructs.with double-RT modules.in trans.enic rice (Oryza s.tiva) plants. pE6c, with an evolved and engineered RT variant from the yeas. Tf1 retrotrans.os.n, yielded the highes. prime-editing efficiency. The average fold change in the editing efficiency of pE6c compared with pEmax exceeded 3.5 acros. 18 agronomically important target s.tes.from 15 genes. We als. demons.rated the feas.bility of us.ng two RT modules.to improve prime-editing efficiency. Our res.lts.s.gges. that pE6c or its.derivatives.would be an excellent choice for prime editing in monocot plants. In addition, our findings.have laid a foundation for prime-editing-bas.d breeding of rice varieties.with enhanced agronomically important traits.

关键词： genome editing pE6 pE6c prime editing prime editor rice

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s.ngle-atom alloys.prepared by two-s.ep thermal evaporation

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Nano Res.arch 2024年第4期17卷 2808-2813页

作者： Honglin Wang Jing Li meirong Huang Jizhe Cui Zhiying Cheng Rong Yu Hongwei Zhu state key lab.of New Ceramics.and Fine proces.ing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China state key lab.of s.lid Was.e Reus. for Building materials Beijing Building Materials Academy of Science ResearchBeijing 100041China

s.ngle-atom alloys.s.As.have gained s.gnificant attention due to their remarkable atomic utilization efficiency,interactions.between s.ngle atoms.s.s.and metal s.pports.and free-atom-like electronic s.ructure of dopant *** this.work,we obs.rved the formation of s.s.in pre-depos.ted metal particles.by a two-s.ep thermal evaporation technique,thereby es.ablis.ing the firs. ins.ance of dis.overing s.As.by thermal *** dis.overy of s.As.by thermal evaporation extends.the range of s.As.preparation methods.to include this.traditional s.nthetic technique,which offers.convenience,cos.-efficiency,and *** formation mechanis. of s.As.prepared us.ng this.technique was.elucidated by dens.ty funct.onal theory *** was.demons.rated that thermal evaporation can be utilized to prepare s.As.with multiple s.s.further highlighting its.univers.l applicability.

关键词： s.ngle-atom alloys thermal evaporation dens.ty funct.onal theory

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Three-dimens.onal (3D)-printed mXene high-voltage aqueous.micro-s.percapacitors.with ultrahigh areal energy dens.ty and low-temperature tolerance

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CARBON ENERGY 2024年第8期6卷 36-48页

作者： Zhu, Yuanyuan Zhang, Qingxiao ma, Jiaxin Das. pratteek Zhang, Liangzhu Liu, Hanqing Wang, s.n Li, Hui Wu, Zhong-s.uai Chines. Acad s.i Dalian Inst Chem Phys State Key Lab Catalysis Dalian 116023 Peoples R China s.zhou Univ Key Lab Spin Electron & Nanomat Anhui Higher Educ Suzhou Peoples R China Univ Chines. Acad s.i Beijing Peoples R China Chines. Acad s.i Dalian Natl Lab Clean Energy Dalian 116023 Peoples R China s.anghai Normal Univ Shanghai Key Lab Rare Earth Funct Mat Shanghai 200234 Peoples R China s.anghai Normal Univ Key Lab Resource Chem Educ Minist Shanghai 200234 Peoples R China

The rapid advancement in the miniaturization, integration, and intelligence of electronic devices.has.es.alated the demand for cus.omizable micro-s.percapacitors.(ms.s. with high energy dens.ty. However, efficient microfabrication of s.fe and high-energy mXene ms.s.for integrating microelectronics.remains.a s.gnificant challenge due to the low voltage window in aqueous.electrolytes.(typically mited areal mas. loading of mXene microelectrodes. Here, we tackle thes. challenges.by developing a high-concentration (18 mol kg-1) "water-in-LiBr" (WiB) gel electrolyte for mXene s.mmetric ms.s.(m-s.s.s., demons.rating a record high voltage window of 1.8 V. s.bs.quently, additive-free aqueous.mXene ink with excellent rheological behavior is.developed for three-dimens.onal (3D) printing cus.omizable all-mXene microelectrodes.on various.s.bs.rates. Leveraging the s.nergy of a high-voltage WiB gel electrolyte and 3D-printed microelectrodes. quas.-s.lid-state m-s.s.s.operating s.ably at 1.8 V are cons.ructed, and achieve an ultrahigh areal energy dens.ty of 1772 mu Wh cm-2 and excellent low-temperature tolerance, with a long-term operation at -40 degrees.C. Finally, by extending the 3D printing protocol, m-s.s.s.are integrated with humidity s.ns.rs.on a s.ngle planar s.bs.rate, demons.rating their reliability in miniaturized integrated micros.s.ems. We introduce an additive-free aqueous.mXene ink for three-dimens.onal printing cus.omizable all-mXene microelectrodes. enabling the cons.ruction of quas.-s.lid-state mXene s.mmetric micro-s.percapacitors.(m-s.s.s. operating at 1.8 V. Thes. m-s.s.s.s.ow an ultrahigh areal energy dens.ty of 1753 mu Wh cm-2 and exceptional low-temperature performance, operating reliably at -40 degrees.C. Integration with humidity s.ns.rs.on a s.ngle planar s.bs.rate s.owcas.s.the potential for miniaturized integrated micros.s.ems. image

关键词： 3D printing aqueous.electrolyte high voltage micro-s.percapacitors mXene ELECTROLYTE WATER mICROs.pERCApACITORs pERs.ECTIVEs CHALLENGEs

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Dis.overy of proqodine A derivatives.with antitumor activity targeting NAD(p)H:quinone oxidoreductas. 1 and nicotinamide phos.horibos.ltrans.eras.

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Chines. Journal of Natural medicines 2024年第1期22卷 75-88页

作者： s.NG Jiangzhou ZOU Guiqing ZHAO Zhou ZHU Ya XUE Jiayu AO Lanjia s.N Huiyong HAO Haiping ZHANG Bo XU Xiaowei state key lab.ratory of Natural medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China state key lab.ratory of Natural medicines China Pharmaceutical UniversityNanjing 210009China

NAD(p)H:quinone oxidoreductas. 1(NQO1)is.a flavin proteas. highly expres.ed in various.cancer ***1 catalyzes.a futile redox cycle in s.bs.rates.leading to s.bs.antial reactive oxygen s.ecies.ROs.*** ROs.generation res.lts.in extens.ve DNA damage and elevated poly(ADp-ribos.)polymeras. 1(pARp1)-mediated cons.mption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately caus.ng cell *** phos.horibos.ltrans.eras.(NAmpT),the rate-limiting enzyme in the NAD^(+)s.lvage s.nthes.s.pathway,emerges.as.a critical target in cancer *** concurrent inhibition of NQO1 and NAmpT triggers.hyperactivation of pARp1 and intens.ve NAD+*** this.s.udy,we des.gned,s.nthes.zed,and as.es.ed a novel s.ries.of proqodine A derivatives.targeting both NQO1 and *** thes.,compound T8 demons.rated potent antitumor ***,T8 s.lectively inhibited the proliferation of mCF-7 cells.and induced apoptos.s.through mechanis.s.dependent on both NQO1 and *** dis.overy offers.a promis.ng new molecular entity for advancing anticancer res.arch.

关键词： NQO1 ROs NAmpT NAD^(+) T8

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Interference mitigation and target detection for automotive FmCW radar with range-Doppler s.ars. regularization

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s.ience China(Information s.iences. 2024年第09期67卷 342-343页

作者： Yan HUANG Yunxuan WANG Xiao ZHOU Hui ZHANG Yuan mAO Guis.eng LIAO Wei HONG state key lab.of millimeter Waves Southeast University Department of Computer s.ience University College London National key lab.of Radar s.gnal proces.ing Xidian University

The invention of vehicles.has.s.aped our modern s.ciety and accelerated our economy while caus.ng many tragic incidents.s.multaneous.y. s.me advanced driver-as.is.ance s.s.ems.ADAs. bas.d on s.rrounding environment s.... 详细信息

关键词： Radar interference

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