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Effects of supplementation with vitamin D on glucose metabolism during pregnancy: a systematic review and meta-analysis of randomized controlled trials

Effects of supplementation with vitamin D on glucose metabol...

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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Jianqiong Zheng Hongping Zhang HaiYing Chen Bingbing Zheng Zhenzhen Zheng Jie Yang Congcong Sun Liang Zheng Hao Ying department of Obstetrics and Gynecology Wenzhou people's Hospital the Third Clinical Institute Affiliated to Wenzhou Medical University department of Obstetrics Shanghai First Maternity and Infant Hospital Tongji University School of Medicine department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's Hospital The Third Clinical Institute Affiliated to Wenzhou Medical University department of Cardiovascular medicine Research Center for Translational Medicine Shanghai East HospitalTongji University School of Medicine

Background: Vitamin D has an important role in glucose metabolism and the associated hormones and metabolites in pregnant women, however its specific effect of vitamin D supplementation during pregnant time remains unclear. The present meta-analysis describes the effect of varying doses of vitamin D supplementation on glucose metabolism in pregnant ***: A literature search was conducted using PubMed, EMBASE, Web of Science, and Cochrane databases. The revised Jadad’s scale was used to evaluate the quality of each trial. Two reviewers independently performed a quality assessment of each study included. A random effects model was used to calculate the pooled ***: A total of 641 participants from 9 studies were pooled into our meta-analysis(intervention group: 320, control group: 321). Results from numerous populations(with and without GDM), suggest that vitamin D supplementation significantly reduced FPG, insulin, HOMA-IR, and HOMA-B in pregnant women with GDM [SMD=-0.87,-0.73,-0.68,-0.52, 95%CI:(-1.32,-0.42),(-1.01,-0.44),(-1.08,-0.28),(-0.92,-0.13), z= 3.76, 5.02, 3.34, 2.60, P= 0.00, 0.00, 0.00, 0.01, respectively]. Similarly, vitamin D supplementation significantly decreased insulin, HOMA-IR, and HOMA-B in pregnant women without GDM [SMD=-1.73,-2.52,-2.48, 95%CI:(-2.80,-0.65),(-2.52,-0.66),(-2.48,-0.67), z= 3.15, 3.34, 3.42, P = 0.00, 0.00, 0.00, respectively]. When vitamin D doses were varied,(low, moderate, high dosage group) the results fluctuated accordingly. There was no significant effect on glucose metabolism in the low dosage group. Moderate dosage of vitamin D supplementation significantly reduced FPG, insulin, HOMA-IR, and HOMA-B [SMD =-0.92,-0.97,-0.65,-0.48, 95%CI :(-1.44,-0.41),(-1.62,-0.32),(-1.13,-0.18),(-0.95,-0.02), z= 3.49, 2.91, 2.68, 2.02, P = 0.00, 0.00, 0.01, 0.04, respectively]. Similarly, high doses of vitamin D supplementation significantly reduced insulin, HOMA-IR, and HOMA-B [SMD=-1.13,-1.10,-1.09, 95%CI:(-1.51,-0.74

关键词： vitamin D glucose metabolism pregnant women meta-analysis randomized controlled trial

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The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021

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Cancer Communications 2021年第8期41卷 747-795页

作者： Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China department of Gastric Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001P.R.China department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310006P.R.China department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025P.R.China department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001P.R.China department of Medical Oncology Fujian Cancer HospitalFuzhouFujian 350000P.R.China department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030P.R.China Cancer Center of The First hospital of Jilin university ChangchunJilin 130021P.R.China department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Endoscopy Center Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142P.R.China department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuan

There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the eastern and Western *** Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it *** into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in *** 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric *** on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant *** the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant *** value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been *** the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided.

关键词： adjuvant chemotherapy Chinese Society of Clinical Oncology(CSCO) diagnosis gastric cancer immunotherapy neoadjuvant radiotherapy surgery targeted therapy

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ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling

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Journal of Molecular Cell Biology 2020年第5期12卷 337-344页

作者： Pengcheng Ma Ning-Ning Song Xiaoning Cheng Liang Zhu Qiong Zhang Long long Zhang Xiangcai Yang Huishan Wang Qinghua Kong Deli Shi Yu-Qiang Ding Bingyu Mao State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain SciencesFudan UniversityShanghai 200032China Affiliated hospital of Guangdong Medical university Zhanjiang 524001China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650223China Key Laboratory of Arrhythmias Ministry of Education of ChinaEast Hospitaland Department of Anatomy and NeurobiologyCollaborative Innovation Center for Brain ScienceTongji University School of MedicineShanghai 200092China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650203China department of Laboratory Animal Science Fundan UniversityShanghai 200032China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Present address:department of Clinical Laboratory The Affiliated Hospital of KMUSTMedical FacultyKunming University of Science and TechnologyKunming 650032China

ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and ***4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli *** we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal *** showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in *** data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.

关键词： ZC4H2 RNF220 spinal cord patterning Gli signaling

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China shanghai Key Laboratory of Maternal Fetal medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Apalutamide for patients with metastatic castrationsensitive prostate cancer in east Asia:a subgroup analysis of the TITAN trial

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Asian Journal of Andrology 2022年第2期24卷 161-166页

作者： Byung Ha Chung Jian Huang Zhang-Qun Ye Da-Lin He Hirotsugu Uemura Gaku Arai Choung Soo Kim Yuan-Yuan Zhang Yusoke Koroki SuYeon Jeong Suneel Mundle Spyros Triantos Sharon McCarthy Kim N Chi Ding-Wei Ye department of Urology Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-roGangnam-guSeoul 135-271Korea Sun Yat-Sen Memorial hospital Sun Yat-sen UniversityGuangzhou 510120China Wuhan tongji hospital Tongji Medical CollegeWuhan 430030China First Affiliated hospital of Xi’an Jiaotong university Xi’an 719054China Kindai university hospital Ōsakasayama 589-8511Japan Dokkyo Medical university Saitama Medical Center Saitama 2-1-50Japan Asian Medical Center University of UlsanSeoul 138-040Korea Janssen Medical Affairs department Beijing 100025China Janssen Medical Affairs department Tokyo 101-0065Japan Janssen Medical Affairs department Seoul 140-012Korea Janssen Global Medical Affairs department HorshamPA 08869USA Janssen Research and Development Spring HousePA 19477USA Janssen Research and Development RaritanNJ 08869USA BC Cancer and Vancouver Prostate Centre VancouverBC V5Z 1G1Canada Fudan university shanghai Cancer Center Shanghai 200032China

Ethnicity might be associated with treatment outcomes in advanced prostate *** study aimed to evaluate the efficacy and safety of androgen deprivation therapy(ADT)combined with apalutamide in east Asians with metastatic castration-sensitive prostate cancer(mCSPC).The original phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial was conducted at 260 sites in 23 *** subgroup analysis included patients enrolled in 62 participating centers in China,Japan,and *** progression-free survival(PFS),time to prostate-specific antigen(PSA)progression,and PSA changes from baseline were compared between groups in the east Asian *** intent-to-treat east Asian population included 111 and 110 participants in the apalutamide and placebo groups,*** 24-month radiographic PFS rates were 76.1%and 52.3%in the apalutamide and placebo groups,respectively(apalutamide vs placebo:hazard ratio[HR]=0.506;95%confidence interval[CI],0.302–0.849;P=0.009).Median time to PSA progression was more favorable with apalutamide than placebo(HR=0.210;95%CI,0.124–0.357;Peast Asian subgroup of the TITAN trial are consistent with the global results.

关键词： apalutamide east Asia metastasis prostatic neoplasm survival

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Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

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Precision Clinical medicine 2023年第2期6卷 67-80页

作者： Jiachao Xiong Guodong Chen Zhixiao Liu Xuemei Wu Sha Xu Jun Xiong Shizhao Ji Minjuan Wu department of Histology and Embryology Naval Military Medical UniversityShanghai 200433China department of Plastic Surgery Shanghai East HospitalTongji University School of MedicineShanghai 200120China Institute of Translational medicine Naval Military Medical UniversityShanghai 200433China department of Burn Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

Objectives Alopecia areata(AA)is an autoimmune-related non-cicatricial alopecia,with complete alopecia(AT)or generalized alopecia(AU)as severe forms of ***,there are limitations in early identification of AA,and intervention of AA patients who may progress to severe AA will help to improve the incidence rate and prognosis of severe *** We obtained two AA-related datasets from the gene expression omnibus database,identified the differentially expressed genes(DEGs),and identified the module genes most related to severe AA through weighted gene co-expression network *** enrichment analysis,construction of a protein–protein interaction network and competing endogenous RNA network,and immune cell infiltration analysis were performed to clarify the underlying biological mechanisms of severe ***,pivotal immune monitoring genes(IMGs)were screened through multiple machine-learning algorithms,and the diagnostic effectiveness of the pivotal IMGs was validated by receiver operating *** A total of 150 severe AA-related DEGs were identified;the upregulated DEGs were mainly enriched in immune response,while the downregulated DEGs were mainly enriched in pathways related to hair cycle and skin *** IMGs(LGR5,SHISA2,HOXC13,and S100A3)with good diagnostic efficiency were *** an important gene of hair follicle stem cells stemness,we verified in vivo that LGR5 downregulation may be an important link leading to severe *** Our findings provide a comprehensive understanding of the pathogenesis and underlying biological processes in patients with AA,and identification of four potential IMGs,which is helpful for the early diagnosis of severe AA.

关键词： alopecia areata immune response machine learning immune monitoring genes diagnosis

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Low Concordance Between Blood Pressures Measured in Periodic Health Examinations and in a Workplace-Based Hypertension Management Program

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Phenomics 2022年第6期2卷 419-429页

作者： Jun-Xiang Chen Yan-Feng Zhou Tingting Geng Simiao Chen Shuohua Chen Guodong Wang Yan-Bo Zhang Yi Wang Zhou-Zheng Tu Gang Liu Shouling Wu An Pan department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and Technology13 Hangkong RoadWuhan 430030HubeiChina Heidelberg Institute of Global Health Faculty of Medicine and University HospitalHeidelberg University44883 HeidelbergGermany department of Cardiology Kailuan General HospitalNorth China University of Science and Technology57 Xinhua East RoadTangshan 063000HebeiChina department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and SafetySchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430040HubeiChina

Poor adherence to standard protocols of blood pressure(BP)measurement in routine clinical practice leads to higher readings than“research-quality”*** this phenomenon exists in periodic health examinations was *** aimed to explore the concordance between BP measurements in periodic health examinations and those measured following a standard measurement *** used data from the Kailuan Study,an ongoing longitudinal cohort study in China,of which participants received biennial health examinations in health management *** addition,BPs were measured following standard protocols in a workplace-based hypertension management program nested in the Kailuan *** compared BP readings of the same person between the two settings using generalized linear mixed-effects models.A total of 3988 men(the mean age was 44.9 years)had at least two BP measurements both in health examinations and management program with a time interval between the two settings that less than 90 *** mean systolic blood pressures(SBP)and diastolic blood pressures(DBP)in health examinations were 4.2(95%CI 3.9–4.5)mm Hg and 3.3(95%CI 3.1–3.5)mm Hg higher than those in the management program,***–Altman analyses showed the wide agreement inter-vals ranging from-27.7-to 36.5-mm Hg for SBP and-18.3-to 24.7-mm Hg for *** conclusion,BP measurements in periodic health examinations were generally higher than BPs measured following a standard *** findings highlight the importance of standard BP measurement to avoid overestimation of hypertension prevalence and treatment initiation.

关键词： Hypertension Physical examination Blood pressure determination Guideline adherence

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DJ-1 is dispensable for human stem cell homeostasis

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Protein & Cell 2019年第11期10卷 846-853页

作者： Fang Cheng Si Wang Moshi Song Zunpeng Liu Ping Liu Lei Wang Yanjiang Wang Qian Zhao Kaowen Yan Piu Chan Weiqi Zhang Jing Qu Guang-Hui Liu National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China department of Neurology Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Safeguard!ng cellular redox homeostasis is crucial for maintaining organism health and preventing *** stress,often characterized by decreased mitochondrial integrity and increased reactive oxygen species(ROS)product!on,disrupts proteostasis and genomic stability,which may eventually lead to cellular decomposition(Oh et al.,2014).Stem cells(such as mesenchymal stem cells,MSCs,and neural stem cells,NSCs)are susceptible to various external and internal stresses,and their dysfunction con tributes to aging and agin g-related ***,it is of importance to elucidate the complex signaling networks regulated by oxidative stress in stem *** redox signaling has been implicated in multiple cellular processes,how the redox system functions in various human stem cells is unclear.

关键词： PARKINSONS-DISEASE CHCHD2 MUTATIONS REGULATOR

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Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial

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Cancer Communications 2021年第9期41卷 889-903页

作者： Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021P.R.China department of Oncology Yibin Second People’s HospitalYibinSichuan 644000P.R.China department of Oncology Liuzhou People’s HospitalLiuzhouGuangxi 545006P.R.China department of Thoracic Oncology Fujian Provincial Cancer HospitalFuzhouFujian 350014P.R.China Oncology department the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233030P.R.China department of Oncology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510030P.R.China department of Internal medicine Linyi Cancer HospitalLinyiShandong 276002P.R.China department of Thoracic Surgery the Affiliated Cancer Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510095P.R.China department of Internal medicine-Oncology/department of thoracic oncology Henan Chest HospitalZhengzhouHenan 450003P.R.China The Second department of Radiotherapy Wuwei Cancer Hospital of Gansu ProvinceWuweiGansu 730000P.R.China department of Oncology the People’s Hospital of Jiangsu ProvinceNanjingJiangsu 210000P.R.China Respiratory medicine department Shanghai East HospitalShanghai 200120P.R.China The Second department of Internal medicine-Oncology Xuzhou Central HospitalXuzhouJiangsu 221009P.R.China Oncology department Tangshan People’s HospitalTangshanHebei 063001P.R.China Respiratory medicine department West China Hospital of Sichuan UniversityChengduSichuan 610041P.R.China Thoracic Surgery the Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515051P.R.China Internal medicine-Oncology Hunan Cancer HospitalChangshaHunan 410013P.R.China department of Oncology Xiangyang Central HospitalXiangyangHubei 441021P.R.China Respiratory department Lishui Central HospitalLishuiZ

Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or *** primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and *** study was registered in Clinical ***(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)*** of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)*** responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,*** stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY010

关键词： anti-angiogenesis anti-VEGF monoclonal antibody avastin bevacizumab biosimilar nonsmall cell lung cancer LY01008 vascular endothelial growth factor

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Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique

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National Science Review 2023年第4期10卷 19-21页

作者： Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang Ruijin hospital Shanghai Jiao Tong University College of Life Science and Technology Guangxi University Beijing Institute of Genomics Chinese Academy of Sciences Children's hospital of Chongqing Medical university Wuxi School of medicine Jiangnan University School of Biology and Biological Engineering South China University of Technology department of Physics School of ScienceTianjin University School of Pharmaceutical Sciences Wuhan University Institute of Botany Chinese Academy of Sciences Institut Pasteur of shanghai Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences School of Life Sciences Sun Yat-sen University Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of medicine and Health Sciences University College Sedaya International School of medicine South China University of Technology department of Medical Genetics Capital Institute of Pediatrics School of Life Science and Technology Harbin Institute of Technology department of Biochemistry Abdul Wali Khan University Xiangya hospital Central South University department of Computer Science City University of Hong Kong College of Life Science and Technology Foshan University South China Sea Institute of Oceanology Chinese Academy of Sciences College of Ecology Lanzhou University School of Life Sciences and Technology Tongji University School of Life Sciences Peking University Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Science South China Agricultural University Institute of Neuroscience Chinese Academy of Sciences School of Life Sciences East China Normal University Nanjing university of Aeronautics and Astronautics Wenzhou Institute University of Chinese Academy of Sciences Institute of Systems Biomedicine Shanghai Jiao Tong University tongji Medical College Huazhong University of Science and Technology School of Life Sciences Xiamen University Division of Life Science and department of

Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic’ that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19.

关键词： SARS-COV-2 ORIGIN

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