DJ-1 is dispensable for human stem cell homeostasis

作     者：Fang Cheng Si Wang Moshi Song Zunpeng Liu Ping Liu Lei Wang Yanjiang Wang Qian Zhao Kaowen Yan Piu Chan Weiqi Zhang Jing Qu Guang-Hui Liu 

作者机构：National Laboratory of BiomacromoleculesCAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Advaneed Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Department of NeurologyDaping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Genomic and Precision MedicineBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100049China Institute for Stem cell and RegenerationChinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell TherapyShanghai East HospitalTongji University School of MedicineShanghai 200120China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2019年第10卷第11期

页      面：846-853页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2017YFA0102802) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100) Major Program of Development Fund for Shanghai Zhangjiang National In novati on Demonstrati on Zone(ZJ2018-ZD-004) the National Key Research and Development Program of China(2018YFC2000100,2015CB964800,2017 YFA0103304,2018YFA0107203,2017YFA0504000,2019YFA0110100) the National Natural Science Foundation of China(Grant Nos.81625009,91749202,91749123,31671429,81671377,81771515,31601158,81701388,81601233,31601109,81822018,8187022&81801399,31801010,81801370,81861168034,81921006,81922027,31900523,81901432,31900524,81901433) Beijing Natural Science Foundation(Z190019) Beijing Municipal Commission of Health and Family Planning(PXM2018_026283_000002) Advan ced Inn ovation Center for Human Brain Protectio n(3500-1192012) the State Key Laboratory of Membrane Biology and Youth Innovation Promotion Association,CAS(to LW) 

主　　题：PARKINSONS-DISEASE CHCHD2 MUTATIONS REGULATOR 

摘      要：Dear Editor,Safeguard!ng cellular redox homeostasis is crucial for maintaining organism health and preventing *** stress,often characterized by decreased mitochondrial integrity and increased reactive oxygen species(ROS)product!on,disrupts proteostasis and genomic stability,which may eventually lead to cellular decomposition(Oh et al.,2014).Stem cells(such as mesenchymal stem cells,MSCs,and neural stem cells,NSCs)are susceptible to various external and internal stresses,and their dysfunction con tributes to aging and agin g-related ***,it is of importance to elucidate the complex signaling networks regulated by oxidative stress in stem *** redox signaling has been implicated in multiple cellular processes,how the redox system functions in various human stem cells is unclear.