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Gut microbiome:A revolution in typeⅡdiabetes mellitus

World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana Department of orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： TypeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

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Scoliocorrector Fatma-UI for correction of adolescent idiopathic scoliosis: Development, effectivity, safety and functional outcome

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World Journal of Orthopedics 2024年第1期15卷 61-72页

作者： Phedy Phedy Ismail Hadisoebroto Dilogo Wresti Indriatmi Sugeng Supriadi Marcel Prasetyo Fitri Octaviana Zairin Noor Doctoral Program in Medical Sciences Faculty of Medicine University of IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Department of orthopaedic and Traumatology Universitas IndonesiaJakarta 10430DKI JakartaIndonesia Department of Dermatology and Venereology Faculty of MedicineUniversity of IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Faculty of Mechanical Engineering University of IndonesiaDepok 16424Jawa BaratIndonesia Department of Radiology University of IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Department of Neurology Faculty of MedicineUniversity of IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Research Center for Osteoporosis Department of Orthopaedic and TraumatologyLambung Mangkurat UniversityBanjarmasin 70123Kalimantan SelatanIndonesia

BACKGROUND Adolescent idiopathic scoliosis remains a major problem due to its high incidence,high risk,and high *** of the aims of the management in scoliosis is to correct the *** techniques are available to correct scoliosis deformity;however,they are all far from ideal to achieve three-dimensional correction in *** To develop a set of tools named Scoliocorrector Fatma-UI(SCFUI)to aid threedimensional correction and to evaluate the efficacy,safety,and functional *** This study consists of two *** the first stage,we developed the SCFUI and tested it in finite element and biomechanical *** second stage was a single-blinded randomized clinical trial to evaluate the SCFUI compared to direct vertebral rotation(DVR).Forty-four subjects with adolescent idiopathic scoliosis were randomly allocated into the DVR group(n=23)and SCFUI group(n=21).Radiological,neurological,and functional outcome was compared between the *** Finite element revealed the maximum stress of the SCFUI components to be between 31.2-252 *** analysis revealed the modulus elasticity of SCFUI was 9561324±633277 *** groups showed improvement in Cobb angle and sagittal profile,however the rotation angle was lower in the SCFUI group(11.59±7.46 vs 18.23±6.39,P=0.001).Neurological and functional outcome were comparable in both *** We concluded that SCFUI developed in this study resulted in similar coronal and sagittal but better rotational correction compared to *** safety and functional outcomes were also similar to DVR.

关键词： Adolescent idiopathic scoliosis Scoliocorrector Fatma-UI Scoliosis surgery Posteromedial translation Direct vertebral rotation

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Effectiveness and safety of electroacupuncture analgesia in controlling intraoperative pain and hemodynamics during total thyroidectomy:A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 165-171页

作者： Dong Phuong Tran Quoc Dung Nguyen Ninh Khac Nguyen Van Hong Pham Senior specialist Clinic National Hospital of AcupunctureHanoi10000Vietnam Vietnam National Association of Acupuncture Hanoi10000Vietnam Department of Training and Science National Hospital of AcupunctureHanoi10000Vietnam

Objective:To evaluate the effectiveness and safety of electroacupuncture in conjunction with additional medications in providing analgesia and stabilizing hemodynamic parameters during total ***:This randomized controlled trial included 100 patients who underwent a total thyroidectomy between October 2022 and October 2023 at the Vietnam National Hospital of *** patients were randomized into two *** electroacupuncture analgesia(EA)group received EA stimulation at five acupuncture points:Hegu(LI 4),Neiguan(PC 6),Shuitu(ST 10),Quepen(ST 12),and Yifeng(SJ 17),while the control group received a bilateral superficial cervical plexus *** outcomes included the level of analgesia and perioperative vital signs in both ***,pain thresholds and serum b-endorphin levels were measured before and after electroacupuncture in the EA ***:Complete analgesia(Level A)was attained in 86%and 76%of the patients in the EA and control groups,respectively,with no significant difference between the two groups(P¼1.00).In the EA group,the mean pain threshold after receiving EA doubled(648.7(77.4)g/s vs.305.3(45.3)g/s,P<.001),and the mean serum b-endorphin level increased by approximately 13.5 pg/mL(P<.001).All patients remained hemodynamically stable throughout the ***:EA,in conjunction with additional medications that stimulate five acupuncture points,LI 4,PC 6,ST 10,ST 12,and SJ 17,was well tolerated and effectively maintained a suitable level of analgesia and hemodynamic stability during total thyroidectomy.

关键词： Electroacupuncture Acupuncture analgesia Graves'disease Thyroidectomy Thyroid surgery b-Endorphin

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Early Treatment Outcome of Humeral Shaft Fracture Non-Union in Adults: Comparative Study of Plating versus Interlocking Nailing

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Health 2024年第4期16卷 371-381页

作者： Abdullallahi Bello Galadima Lukman Olalekan Ajiboye Muhammad Nuhu Salihu Isha Nurudeen Orthopedics and Trauma Department Usmanu Danfodiyo University/Teaching Hospital Sokoto Nigeria Department of orthopaedics and Trauma University of Abuja Abuja Nigeria Orthopedic Department National Orthopaedic Hospital Dala Nigeria

Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is a major problem in this part of the world. This non-union is a major treatment challenge with increased cost of care and morbidity in this part of the world. Humeral shaft non-union can be treated with locked intra-medullary nailing (LIMN) or dynamic compression plating (DCP). Study on comparison of these methods of fixation in this part of the world is scarce in literature search, hence the reason for this study. Objective: The objectives of this study are: (1) to compare early clinical outcome following fixation of humeral shaft fracture nonunion with DCP versus LIMN;(2) to compare the time of radiologic fracture union of DCP with LIMN;(3) to compare complications following fixation of humeral shaft fracture nonunion with DCP versus LIMN. Patients and Methods: This was a randomized control study done for 2 years in which fifty adult patients with humeral shaft non-union were recruited. The patients were grouped into 2 (P = DCP & N = LIMN). Forty five of the patients completed the follow up periods of the study and then analyzed. The P group had ORIF with DCP while the N group had ORIF with LIMN. Both groups had grafting with cancellous bones. Each patient was followed up for a period of 6 months at the time which radiographic union is expected. Any patient without clinical and/or radiographic evidence of union after six months of surgery was diagnosed as having recurrent non-union. The data generated was analyzed using SPSS Version 23. The results were presented in charts and tables. The paired t-test was used while considering p value Result: Forty five patients completed follow up. There was a male preponderance (4:1), right humerus predominated (3:2). Motor vehicular accidents were the commonest cause of the fractures (62%). Most non-union fractur

关键词： Humeral Shaft Non-Union Dynamic Compression Plating Locked Intra-Medullary Nailing Early Treatment Outcome Early Outcome

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Tapir health and conservation medicine

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Integrative Zoology 2012年第4期7卷 331-345页

作者： Paulo Rogerio MANGINI Emilia Patrícia MEDICI Renata Carolina FERNANDES-SANTOS Lowland Tapir Conservation Initiative IPÊ-Institute for Ecological ResearchNazaréPaulistaSão PauloBrazil Brazilian Institute for Conservation Medicine-TRÍADE RecifePernambucoBrazil IUCN/SSC Tapir specialist group(TSG) GlandSwitzerland IUCN/SSC Wildlife Health specialist group(WHSG) New YorkNYUSA IUCN/SSC Peccary specialist group(PSG) GlandSwitzerland Escola Superior de Conservação Ambiental e Sustentabilidade(ESCAS/IPÊ) NazaréPaulistaSão PauloBrazil IUCN/SSC Conservation Breeding specialist group(CBSG) Brazil NetworkCampo GrandeBrazil

Tapirs have unique nutritional needs,as well as anatomical,physiological,behavioral and ecological adapta-tions that must be considered when managing their health,both in the wild and in *** about how tapirs live in their natural habitats can provide crucial knowledge to prevent many of the health problems found in captivity such as infectious and parasitic diseases,reproductive issues and nutritional and behavior-al ***,proper management in captivity can significantly contribute to in situ conservation *** medicine is a science created to address the global health crisis that jeopardizes biodiver-sity causing imbalances among ecosystem,human,animal and vegetal *** this context,common threats to tapir health and conservation,such as isolated and small populations surrounded by human activity,chemical pollution,domestic animals and their pathogenic agents,need to be better *** manuscript provides information about the health of tapirs both in captivity and in the wild and aims to encourage tapir conservation-ists worldwide to gather information about pathogen and disease dynamics and manifestation,as well as impli-cations for tapir conservation.

关键词： captive management conservation medicine tapirs wildlife health

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The coexistence of Baird’s tapir (Tapirus bairdii) and indigenous hunters in northeastern Honduras

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Integrative Zoology 2012年第4期7卷 429-438页

作者： Marc DUNN Nereyda ESTRADA Derek A.SMITH Department of Geography and Environmental Studies Carleton UniversityOttawaOntarioCanada International Union for Conservation of Nature(IUCN)Honduras Tapir specialist group TegucigalpaHonduras

The Baird’s tapir(Tapirus bairdii)is a popular game species throughout Central America,particularly among in-digenous populations,and is currently *** on Miskitu hunting was conducted over 4 months in a remote region in northeastern Honduras that overlaps with the Río Plátano Biosphere *** hunting zone was mapped together with hunters and interviews were conducted with elders and other community mem-bers about tapir *** show that tapir harvesting is targeted toward specific habitats at specific times of *** rates for one year suggest that tapir hunting in the area exceeds estimates of maximum sustain-able ***,field surveys reveal the presence of tapir within 1 km of the community,and its harvest tends to be nearby,in both forested and agricultural landscapes,suggesting that the animal has not been depleted in the *** appears that the existence of forest areas adjacent to the hunting zone that do not experi-ence hunting,together with the anthropogenic habitats created through shifting cultivation,are factors that help explain the presence of tapirs in the *** article concludes with a discussion regarding the potential posi-tive role of indigenous hunters in tapir conservation throughout its distribution range.

关键词： Baird’s tapir Honduras indigenous hunting Miskitu Río Plátano Biosphere Reserve

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Alien mammals in Europe:updated numbers and trends,and assessment of the effects on biodiversity

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Integrative Zoology 2012年第3期7卷 247-253页

作者： Piero GENOVESI Lucilla CARNEVALI Anna ALONZI Riccardo SCALERA Institute for Environmental Protection and Research RomeItaly International Union for Conservation of Nature Species Survival CommissionInvasive Species Specialist Group(IUCN/SSC ISSG)ValbyDenmark

This study provides an updated picture of mammal invasions in Europe,based on detailed analysis of information on introductions occurring from the Neolithic to recent *** assessment considered all information on species introductions,known extinctions and successful eradication campaigns,to reconstruct a trend of alien mammals’establishment in the *** a comparative analysis of the data on introduction,with the information on the impact of alien mammals on native and threatened species of Europe,the present study also provides an objective assessment of the overall impact of mammal introductions on European biodiversity,including information on impact *** results of this assessment confirm the constant increase of mammal invasions in Europe,with no indication of a reduction of the rate of *** study also confirms the severe impact of alien mammals,which directly threaten a significant number of native species,including many highly threatened *** results could help to prioritize species for response,as required by international conventions and obligations.

关键词： impact indicators invasive species Red List threatened species

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Population viability analysis: using a modeling tool to assess the viability of tapir populations in fragmented landscapes

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Integrative Zoology 2012年第4期7卷 356-372页

作者： Emília Patrícia MEDICI Arnaud Leonard Jean DESBIEZ Lowland Tapir Conservation Initiative IPÊ-Institute for Ecological ResearchNazaréPaulistaSão PauloBrazil IUCN/SSC Tapir specialist group(TSG) GlandSwitzerland Escola Superior de Conservação Ambiental e Sustentabilidade(ESCAS/IPÊ) NazaréPaulistaSão PauloBrazil IUCN/SSC Conservation Breeding specialist group(CBSG) Brazil NetworkCampo GrandeMSBrazil Royal Zoological Society of Scotland EdinburghScotland

A population viability analysis(PVA)was conducted of the lowland tapir populations in the Atlantic Forest of the Pontal do Paranapanema region,Brazil,including Morro do Diabo State Park(MDSP)and surrounding forest *** from the model projected that the population of 126 tapirs in MDSP is likely to per-sist over the next 100 years;however,200 tapirs would be required to maintain a viable ***-ity analysis showed that sub-adult mortality and adult mortality have the strongest influence on the dynamics of lowland tapir *** road-kill has a major impact on the MDSP tapir population and can lead to population *** modeling showed that dispersal of tapirs from MDSP to the surrounding fragments can be detrimental to the overall metapopulation,as fragments act as ***,the model showed that under certain conditions the maintenance of the metapopulation dynamics might be determinant for the persistence of tapirs in the region,particularly in the smaller *** establishment of corridors con-necting MDSP to the forest fragments models resulted in an increase in the stochastic growth rate,making ta-pirs more resilient to threats and catastrophes,but only if rates of mortality were not increased when using *** PVA showed that the conservation of tapirs in the Pontal region depends on:the effective protection of MDSP;maintenance and,whenever possible,enhancement of the functional connectivity of the landscape,reducing mortality during dispersal and threats in the unprotected forest fragments;and neutralization of all threats affecting tapirs in the smaller forest fragments.

关键词： Atlantic Forest fragmentation lowland tapir minimum viable population population viability analysis

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Cellular modulation by the mechanical cues from biomaterials for tissue engineering

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Biomaterials Translational 2021年第4期2卷 323-342页

作者： Qiang Wei Shenghao Wang Feng Han Huan Wang Weidong Zhang Qifan Yu Changjiang Liu Luguang Ding Jiayuan Wang Lili Yu Caihong Zhu Bin Li Department of orthopaedic Surgery Orthopaedic InstituteThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu ProvinceChina China orthopaedic Regenerative Medicine group(CORMed) HangzhouZhejiang ProvinceChina

Mechanical cues from the extracellular matrix(ECM)microenvironment are known to be significant in modulating the fate of stem cells to guide developmental processes and maintain bodily *** engineering has provided a promising approach to the repair or regeneration of damaged *** are fundamental in cell-based regenerative *** artificial ECM that mimics the mechanical properties of native ECM would greatly help to guide cell functions and thus promote tissue *** this review,we introduce various mechanical cues provided by the ECM including elasticity,viscoelasticity,topography,and external stimuli,and their effects on cell ***,we discuss the underlying principles and strategies to develop natural or synthetic biomaterials with different mechanical properties for cellular modulation,and explore the mechanism by which the mechanical cues from biomaterials regulate cell function toward tissue *** also discuss the challenges in multimodal mechanical modulation of cell behaviours and the interplay between mechanical cues and other microenvironmental factors.

关键词： cell behaviour mechanical cues multi-modal stiffness viscoelasticity

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Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru MJ Naidu Ravi Teja Mundluru Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Madhan Jeyaraman Department of orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

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