检索结果-南通市图书馆

PACK-CXL *** therapy for bacterial,fungal,and mixed infectious keratitis:a prospective randomized phase 3 trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2024年第1期10卷 10-20页

作者： Farhad Hafezi Mohammed Hosny Rohit Shetty Boris Knyazer Shihao Chen Qinmei Wang Hassan Hashemi Emilio A.Torres‑Netto 无 center for Applied Biotechnology and Molecular Medicine(CABMM) University of ZurichZurichSwitzerland ELZA Institute DietikonSwitzerland. Faculty of Medicine University of GenevaGenevaSwitzerland Department of Ophthalmology Medical University of WenzhouWenzhouChina USC Roski Eye Institute University of Southern California Los AngelesLos AngelesUSA Department of Ophthalmology University of CairoCairoEgypt Narayana Nethralaya Eye Hospital and the Postgraduate Institute of Ophthal‑mology BangaloreIndia Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael Noor Ophthalmology Research center Noor Eye HospitalTehranIran University Hospital Zurich ZurichSwitzerland. the PACK-CXL Working Group

Background:Infectious keratitis is a major cause of global *** tested whether standalone photoactivated chromophore corneal cross-linking(PACK-CXL)may be an efective frst-line treatment in early to moderate infectious keratitis,compared with standard antimicrobial ***:This is a randomized,controlled,multinational phase 3 clinical *** in fve centers in Egypt,India,Iran,Israel,and China,aged≥18 years,with infectious keratitis of presumed bacterial,fungal,or mixed origin,were randomly assigned(1:1)to PACK-CXL,or antimicrobial *** measures included healing,defned as time to re-epithelialization of the corneal epithelial defect in the absence of infammatory activity in the anterior chamber and clearance of stromal *** success was defned as the complete resolution of signs of ***:Between July 21,2016,and March 4,2020,participants were randomly assigned to receive PACK-CXL(n=18)or antimicrobial therapy per American Academy of Ophthalmology(AAO)guidelines(n=21).No participants were lost to *** eyes were excluded from the epithelialization time analysis due to treatment failure:two in the antimicrobial therapy group,and two in the PACK-CXL *** rates were 88.9%(16/18 patients)in the PACK-CXL group and 90.5%(19/21 patients)in the medication *** was no signifcant diference in time to complete corneal re-epithelialization(P=0.828)between both treatment ***:PACK-CXL may be an alternative to antimicrobial drugs for frst-line and standalone treatment of early to moderate infectious keratitis of bacterial or fungal origin.

关键词： Photoactivated chromophore Corneal cross-linking Infectious keratitis Corneal melting PACK-CXL

New results on the safety of laparoscopic sleeve gastrectomy bariatric procedure for type 2 diabetes patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2019年第2期10卷 78-86页

作者： Ohad Guetta Alex Vakhrushev Oleg Dukhno Amnon Ovnat Gilbert Sebbag Department General Surgery B Soroka University Medical Center

BACKGROUND It has been established that bariatric surgery,including laparoscopic sleeve gastrectomy(LSG),has a positive impact on type 2 diabetes mellitus(T2DM).However,less frequently T2DM is reported as a risk factor for complications with this type of *** To evaluate the safety of LSG in *** A retrospective cohort study was conducted over patients admitted for LSG from January 2008 to May *** was collected through digitized *** deviation from normal postoperative care within the first 60 d was defined as an early complication,and further categorized into mild or *** Nine hundred eighty-four patients underwent LSG,among these 143(14.5%)were diagnosed with *** were 19 complications in the T2DM group(13.3%)compared to 59 cases in the non-T2DM(7.0%).Out of 19 complications in the T2DM group,12 were mild(8.4%)and 7 were severe(4.9%).Compared to the non-T2DM group,patients had a higher risk for mild complications(Odds-ratio 2.316,CI:1.163-4.611,P=0.017),but not for severe ones(P=0.615).An increase of 1% in hemoglobin A1c levels was associated with a 40.7% increased risk for severe complications(P=0.013,CI:1.074-1.843)but not for mild *** Our data suggest that LSG is relatively safe for patients with *** preoperative control of hemoglobin A1c level will lower the complications rate has to be prospectively studied.

关键词： Bariatric surgery Laparoscopic sleeve gastrectomy Type 2 diabetes Complications Morbidity Hemoglobin A1c Fasting plasma glucose Clavien-Dindo classification

Risk factors for an atherothrombotic event in patients with diabetic macular edema treated with intravitreal injections of bevacizumab

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第9期13卷 1411-1416页

作者： Alon Tiosano Aviel Hadad Noam Yanculovic Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeer Sheva 84101Israel

AIM:To identify risk factors for an atherothrombotic event(ATE)among patients who were treated for diabetic macular edema(DME)with intravitreal bevacizumab ***:This retrospective study enrolled all consecutive patients with DME who were treated by intravitreal bevacizumab from 2009 through 2016 in a single *** were divided into one group treated by bevacizumab and subsequently had an ATE and a second group also treated by bevacizumab and did not have an ***:A total of 455 patients with DME were ***-two of the patients had an ATE.A multivariate model adjusted for age,gender,smoking,body mass index,hemoglobin A1c(HbA1c),duration of diabetes,creatinine,and blood pressure revealed an increased risk for ATE in the patients with diabetic duration of more than 13 y,a systolic blood pressure over 153.5 mm Hg at first treatment,or having been treated by more than 4 intravitreal bevacizumab ***,patients that had an ATE within 3 mo from the last intravitreal treatment underwent more bevacizumab injections(5.2±3.4 vs 3.07±1.86;P153.5 mm Hg,a history of diabetic mellitus for more than 13 y,and treatment with more than 4 intravitreal bevacizumab *** factors need to be borne in mind when bevacizumab is being considered in the management of patients with DME.

关键词： atherothrombotic event bevacizumab diabetic macular edema

Erdheim chester-A rare disease with unique endoscopic features

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第25期20卷 8309-8311页

作者： Gil Ben-yaakov Daniela Munteanu Ignacio Sztarkier Alexer Fich Doron Schwartz Institute of Gastroenterology and Hepatology Soroka University Medical Center Faculty of Health Science Ben Gurion University of the NegevBeer sheva 84101Israel Institute of Pathology Soroka University Medical Center Faculty of Health Science Ben Gurion University of the Negev Beer sheva 84101 Israel

Erdheim-Chester disease(ECD) is a rare inflammatory syndrome in which systemic infiltration of non-Langerhans cell histiocytes occurs in different sites. Both the etiology and pathophysiology of ECD are unknown, but CD68 positive CD 1a/S100 negative cells are characteristic. The presentation of ECD differs according to the involved organs. This case report describes a patient with ECD and the gastrointestinal manifestations and unique endoscopic appearance as seen in gastroscopy and colonoscopy with histological proof of histiocyte infiltration of the lamina propria. The clinical and endoscopic findings of this unique case, to our knowledge, were never described before, so were the features of the gastrointestinal involvement in this disease.

关键词： Erdheim chester Histiocytes Lamina propria Colon Stomach

Manipulation of the intestinal microbiome-a slow journey to primetime

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第21期11卷 4975-4988页

作者： Ofra Kriger-Sharabi Stephen D H Malnick David Fisher Institute of Gastroenterology Assuta Medical CenterAshdod 7747629Israel Department of Internal Medicine Kaplan Medical CenterRehovot 76100Israel Department of Endocrinology Soroka Medical CenterBeer Sheva POB 151Israel

The gut microbiota has important functions in the regulation of normal body *** of the microbiota are being increasingly linked to various disease *** microbiome has been manipulated via the administration of stool from animals or humans,for more than 1000 ***,fecal microbiota transplantation can be performed via endoscopic administration of fecal matter to the duodenum or colon or via capsules of lyophilized *** recently fecal microbial transplantation has been shown to be very effective for recurrent Clostridoides difficile infection(CDI).In addition there is some evidence of efficacy in the metabolic syndrome and its hepatic manifestation,metabolic associated fatty liver disease(MAFLD),irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).We review the current literature regarding the microbiome and the pathogenesis and treatment of CDI,MAFLD,IBS and IBD.

关键词： Gut microbiota Fecal microbiota transplantation Clostridoides difficile Metabolic associated fatty liver disease Irritable bowel syndrome Inflammatory bowel disease

How expensive is inflammatory bowel disease? A critical analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第43期14卷 6641-6647页

作者： Selwyn Odes Inflammatory Bowcl Diseases Unit Department of Gastroenterology and HcpatologySoroka Medical Center and Ben Gurion University of the NcgevPO Box 151Beer Sheva 84101Israel

Economic analysis of chronic diseases is required for proper allocation of resources and understanding costeffectiveness studies of new therapies. Studies on health care cost of ulcerative colitis （UC） and Crohn＇s disease （CD） are reviewed here. These studies were carried out in various countries with disparate health care systems. In the United States, data were often modeled or retrieved from large insurance schemes. Surgery and in-patient hospitalization accounted for over half the outlay on UC and CD. Fistulous disease in CD and parenteral nutrition were very costly. In Canada, overall charges were lower than in the United States, but there too, surgical costs were relatively high. In European studies, economic data were abstracted directly from patients＇ files. One pan-European study examined the outlay on UC and CD in a community-based prospective inception cohort followed for 10 years. Overall costs in Europe were lower than in the United States. Surgery, hospitalization, year of follow-up, disease phenotype in CD and ASCA-positivity impacted significantly on costs. In all studies, the cost data were right skewed, aminosalicylates were expensive drugs, and biological agents the most expensive; moreover indirect costs were not calculated. Infliximab raised costs considerably in CD, but there were no long-term followup studies, so that the cost-benefit of biological agents remains unknown. In conclusion, costs of managing UC and CD vary by country, surgery, genotype and several other factors. The most important question for further research is whether the biological therapies are cost-effective in the long-term.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Cost-analysis medical economics

Regulation of spermatogenesis by paracrine/autocrine testicular factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2004年第3期6卷 259-268页

作者： Mahmoud Huleihel Eitan Lunenfeld Department of Microbiology and Immunology and BGU Cancer Research center Faculty of Health Sciences Ben-Gurion University of the NegevBeer-ShevaIsraelDepartment of Obstetrics and GynecologySoroka University Medical Center Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael

Spermatogenesis is a complex process regulated by endocrine and testicular paracrine/autocrine factors. Gonadotropins are involved in the regulation of several testicular paracrine factors, mainly of the IL-1 family and testicular hormones. Testicular cytokines and growth factors (such as IL-1, IL-6, TNF, IFN-γ, LIF and SCF) were shown to affect both the germ cell proliferation and the Leydig and Sertoli cells functions and secretion. Cytokines and growth factors are produced by immune cells and in the interstitial and seminiferous tubular compartments by various testicular cells, including Sertoli, Leydig, peritubular cells, spermatogonia, differentiated spermatogonia and even spermatozoa. Corresponding cytokine and growth factor receptors were demonstrated on some of the testicular cells. These cytokines also control the secretion of the gonadotropins and testosterone in the testis. Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis. Thus, the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility.

关键词： spermatogenesis paracrine autocrine cytokine growth factor

Parental acceptability of the watchful waiting approach in pediatric acute otitis media

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Pediatrics 2016年第2期5卷 198-205页

作者： Arnon Broides Olga Bereza Noga Lavi-Givon Yariv Fruchtman Eli Gazala Eugene Leibovitz Pediatric Emergency Department Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Family Medicine Department Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Pediatric Infectious Disease Unit Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Child Health Community center Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev

AIM: To determine parental knowledge about acute otitis media(AOM) and its antibiotic therapy, antibiotic resistance and the willingness to comply with the watchful waiting(WW) approach in primary care settings in southern ***: The study was conducted in 3 primary care clinics and the pediatric emergency room of soroka University medical center. Questionnaires(20 questions on education background, previous AOM experience, knowledge on antimicrobial resistance and attitude vs the WW approach) were filled by 600 parents(150 at each centers) of children < 6 years of ***: Mothers represented 69% of parents; 2% had an education of < 10 school years, 46% had high-school education and 17% had an academic degree. 69% parents reported previous experience with AOM and 56% thought that antibiotics represent the only treatment for AOM. Knowledge on bacterial resistance to antibiotics was reported by 57% of the parents; 86% parents were willing to accept/probably accept the WW approach for their children. Logistic regression analysis revealed a significant association between parental education and knowledge about bacterial resistance to antibiotics and that previous experience with AOM was significantly associated with reluctance to accept the WW approach. More parents with knowledge on bacterial resistance were willing to accept the WW approach compared with parents without such knowledge. No correlation was found between the education level and willingness to accept the WW approach. CONCLUSION: A significant correlation was found between previous parental education and experience with AOM and the knowledge about antibiotic use, bacterial resistance and acceptance of the WW approach.

关键词： Acute otitis media Children Antibiotics Parents Watchful waiting Bacteria Resistance

Decompressive Craniectomy for Posterior Reversible Encephalopathy Syndrome (PRES): Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2015年第5期4卷 169-174页

作者： Amit Azriel Israel Melamed Ilan Shelef Yuval Sufaro Micky Gidon Vladimir Merkin Alexandr Shtreizent Avi Cohen Department of Neurosurgery Soroka Medical Center Be’er-Sheva Israel Diagnostic Imaging Institute Soroka Medical Center Be’er-Sheva Israel Department of Neurosurgery The Royal Melbourne Hospital Melbourne Australia

Background: Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinical-neuroradiological syndrome with an unclear pathophysiology. Correlation between PRES and the use of immunosuppressant drugs have previously been described, as well as correlation between elevated blood pressure and PRES. Characteristic brain MRI manifestations include hyperintense lesions on T2 and FLAIR (fluid-attenuated inversion recovery) images. PRES is usually reversible within a short period of time after discontinuation of the presumably offending drug. Some cases of PRES might complicate with intracranial hemorrhage, refractory status epilepticus or expansive vasogenic brain edema (also regarded as “tumefactive” PRES). Methods: We present a case of a young man diagnosed with Hodgkin’s lymphoma, following a laparotomy due to cecal volvulus. The patient received glucocorticoids and elevated blood pressure values were recorded. Brain imaging studies were performed due to generalized epileptic seizures, demonstrating neuroradiological findings consistent with PRES. Neurological and neuroradiological deterioration was noted, necessitating urgent neurosurgical intervention. A complete neurological and functional rehabilitation was achieved. Conclusion: The uncommon cases of complicated PRES should be taken under consideration whenever clinical deterioration is noted following the diagnosis of PRES. Early neuroradiological evaluation should be sought, together with aggressive medical and surgical treatment in cases of life threatening mass effect.

关键词： PRES Posterior Reversible Encephalopathy Syndrome Brain Edema Craniectomy