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The impact of central and obstructive respiratory events on cerebral oxygenation in adults with sleep disordered breathing

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Journal of Innovative Optical Health Sciences 2023年第6期16卷 43-52页

作者： Ramin Khatami Dominik Gnaiger Gordana Hügli Ming Qi Zhongxing Zhang center for sleep Medicine Sleep Research and Epileptology Clinic Barmelweid AGBarmelweidSwitzerland Barmelweid Academy Clinic Barmelweid AGBarmelweidSwitzerland Department of Neurology Inselspital Bern University Hospital and University of BernBernSwitzerland

Obstructive sleep apnea(OSA)and central sleep apnea(CSA)are two main types of sleep disordered breathing(SDB).While the changes in cerebral hemodynamics triggered by OSA events have been well studied using near-infrared spectroscopy(NIRS),they are essentially unknown in CSA in ***,in this study,we compared the changes in cerebral oxygenation between OSA and CSA events in adult patients using *** tissue oxygen saturation(StO_(2))in 13 severe SDB patients who had both CSA and OSA events was measured using frequency-domain *** changes in cerebral StO_(2)desaturation and blood volume(BV)in the¯rst hour of natural sleep were compared between different types of respiratory events(i.e.,277 sleep hypopneas,161 OSAs and 113 CSAs)with linear mixed-effect models controlling for *** respiratory events occurred during non-rapid eye movement(NREM)*** found that apnea events induced greater cerebral desaturations and BV°uctuations compared to hypopneas,but there was no difference between OSA and *** results suggest that cerebral autoregulation in our patients are still capable to counteract the pathomechanisms of apneas,in particularly the negative intrathoracic pressure(ITP)caused by OSA *** larger BV°uctuations in OSA compared to CSA should be observed due to the negative ITP that reduces cardiac stroke volume and leads to lower systematic blood *** study suggests that OSA and CSA may have similar impact on cerebral oxygenation during NREM sleep in adult patients with SDB.

关键词： Near-infrared spectroscopy cerebral autoregulation sleep apnea

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Gut microbiota modulating intestinal stem cell differentiation

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World Journal of Stem Cells 2024年第6期16卷 619-622页

作者： Lin He Chen Zhu Xiang-Feng Zhou Shu-E Zeng Le Zhang Kuan Li Department of Alcohol and Drug Dependence Treatment The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Department of Physical Education Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Department of Geriatric Psychiatry The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina sleep Medicine center The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina

Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut ***,when this disordered proliferation continues,it induces the ISC to enter a cancerous *** gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained ***-biota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors,while in steady state,differentiated colono-cytes are able to break down such metabolites,thereby protecting stem cells at the gut *** the future,the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.

关键词： Intestinal stem cells Gut microbiota Gut stem niche Microenvironment Probiotics

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Dopamine Control of REM sleep and Cataplexy

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Neuroscience Bulletin 2022年第12期38卷 1617-1619页

作者： Chujun Zhang Luyan Huang Min Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Jiao Tong University School of Medicine Afliated Sixth People’s Hospital Shanghai 200233China Shanghai Key Laboratory of sleep disordered breathing Shanghai 200233China

The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.

关键词： Dopamine sleep neural

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sleep disordered breathing Asian ***

Sleep Disordered Breathing Asian ***

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华东地区睡眠医学新进展高级研修班

作者： Edward J.Morgan Hawaii School of sleep Medicine and Technology September 2002

＜正＞Evidence-Based Medicine Residents are not correct unless there is evidence Attendings are not correct unless there is evidence Professors are not correct unless there iS evidence

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Muscle energy technique for chronic obstructive pulmonary disease:A feasibility study

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Journal of Integrative Medicine 2023年第3期21卷 245-253页

作者： Danielle A.Baxter Meaghan E.Coyle Catherine J Hill Christopher Worsnop Johannah L.Shergis School of Health and Biomedical Sciences Royal Melbourne Institute of Technology UniversityBundooraVictoria 383Australia Department of Physiotherapy Austin HealthHeidelbergVictoria 3084Australia Institute for breathing and sleep HeidelbergVictoria 3084Australia

Objective:This study aimed to investigate the feasibility of implementing a manual therapy technique(muscle energy technique,MET)protocol in a hospital pulmonary rehabilitation(PR)program for patients with moderate to severe chronic obstructive pulmonary disease(COPD).Methods:Participants aged 40 years and over,with moderate to severe COPD,were recruited into this 12-week *** primary outcome measures were feasibility(acceptability of the intervention and attendance/adherence to the trial)and safety(adverse events,AEs).All participants received the MET and PR *** and assessors were ***-standardized MET was delivered on 6 occasions(a maximum of once per week)at the hospital directly before a PR *** undertook PR sessions as per the hospital program at a frequency of two days per week for 8 *** were contacted 4 weeks after their final MET treatment via a telephone call to assess acceptability of the ***:Thirty-three participants were enrolled,with a median age of 74 years(range 45-89 years).The median number of MET sessions that participants attended was 5(range O-6)out of a possible 6 sessions(83%attendance).At follow-up,participants overwhelmingly enjoyed the MET treatment with some subjectively reporting improved *** were no major AEs related to the intervention,with the majority of AEs classified as expected events related to COPD ***:It is feasible to implement a manual therapy protocol using MET as an adjunct to PR in a hospital *** rates were satisfactory and there were no AEs related to the MET component of the intervention.

关键词： Manual therapy Pulmonary rehabilitation Chronic obstructive pulmonary disease

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Sodium glucose cotransporter 2 inhibitors:New horizon of the heart failure pharmacotherapy

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World Journal of Cardiology 2021年第9期13卷 464-471页

作者： Ryo Naito Takatoshi Kasai Department of Cardiovascular Biology and Medicine Cardiovascular Respiratory Sleep MedicineJuntendo University Graduate School of MedicineTokyo 113-8421Japan Department of Cardiovascular Biology and Medicine Cardiovascular Respiratory Sleep MedicineJuntendo University Graduate School of MedicineSleep and Sleep Disordered Breathing CenterJuntendo University HospitalTokyo 113-8421Japan

Sodium-glucose cotransporter 2(SGLT2)inhibitors have gained momentum as the latest class of antidiabetic agents for improving glycemic ***-scale clinical trials have reported that SGLT2 inhibitors reduced cardiovascular outcomes,especially hospitalization for heart failure in patients with type 2 diabetes mellitus who have high risks of cardiovascular *** evidence has indicated that beneficial effects can be observed regardless of the presence or absence of type 2 diabetes ***,the Food and Drug Administration approved these agents specifically for treating patients with heart failure and a reduced ejection *** has been concluded that canagliflozin,dapagliflozin,empagliflozin,or ertugliflozin can be recommended for preventing hospitalization associated with heart failure in patients with type 2 diabetes and established cardiovascular disease or those at high cardiovascular *** the present review,we explore the available evidence on SGLT2 inhibitors in terms of the cardioprotective effects,potential mechanisms,and ongoing clinical trials that may further clarify the cardiovascular effects of the agents.

关键词： Sodium glucose cotransporter 2 inhibitors Heart failure Clinical trials Potential mechanisms Diuretics

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Removal of biofilm is essential for long-term ventilation tuberetention

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World Journal of Clinical Cases 2020年第9期8卷 1592-1599页

作者： Qiang Ma Hui Wang Zheng-Nong Chen Ya-Qin Wu Dong-Zhen Yu Peng-Jun Wang Hai-Bo Shi Kai-Ming Su Department of Otorhinolaryngology–Head&Neck Surgery the Sixth People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 200233China Shanghai Key Laboratory of sleep disordered breathing Shanghai 200233China

BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 *** address this issue,we aimed to determine a new method for long-term retention of the ventilation *** To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation *** A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube *** patients were randomly divided into two groups:Control group and treatment *** in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm *** conventional ventilation tubes were placed in this *** measures were tube position and *** retention time and any complications were *** Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the *** tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.

关键词： Tympanostomy tubes Biofilm Complication management Long-term retention Ménière disease Refractory otitis media with effusion

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A novel POU domain class 3 transcription factor 4 mutation causes X-linked non-syndromic hearing loss in a Chinese family

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Chinese Medical Journal 2019年第18期132卷 2251-2253页

作者： Hong-Min Wu Hui-Qun Jie Hui Wang Ya-Qin Wu Zheng-Nong Chen Ya-Zhi Xing Ji-Ping Wang Hai-Bo Shi Shan-Kai Yin Department of Otolaryngology Sixth People’s Hospital Shanghai Jiao Tong University Otolaryngology Institute of Shanghai Jiao Tong University Shanghai 200233 China Shanghai Key Laboratory of sleep disordered breathing Shanghai 200233 China

To the Editor: POU domain class 3 transcription factor 4 or BRN-4 (POU3F4) is a causative gene of non-syndromic X-linked hearing loss (HL), which is characterized by inner ear anomalies. To date, six X-linked non-syndromic HL loci (DFNX1-6) have been mapped to chromosome X and five of these genes have been identified: phosphoribosyl pyrophosphate synthetase 1 (PRPS1)(DFNX1, OMIM: 304500), POU3F4 (DFNX2, OMIM: 304400),[1] small muscle protein, X-linked (SMPX)(DFNX4, OMIM: 300066), apoptosis-inducing factor, mitochondria-associated, 1 (AIFM1)(DFNX5, OMIM: 300614), and collagen, type IV alpha-6 (COL4A6)(DFNX6, OMIM;300914). POU3F4 mutation accounts for nearly 50% of all cases of DFNX.

关键词： hearing loss phosphoribosyl pyrophosphate muscle protein

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Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants

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Research 2022年第2期2022卷 5-24页

作者： Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministryof Education)Shanghai jiao Tong University1954 Huashan RoadShanghai 200030China Biomedical Sciences Insttuteof Qingdao University(Qingdao Branch of SJTU Bio-X Institutes) Qingdao University Qingdao 266003China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Key Laboratory of sleep disordered breathing Shanghai liao Tong University Afliated Sixth People's Hospital.ShanghaiChina The First Afiliated Hospital of Zhengzhou Universily Zhengzhou 450052China Deparment of Psychiary First Teaching Hospital of Xinjiang Medical UniversitUrumqi 830046China

SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H *** acid mutations are enriched in the spike protein of SARS *** plays a crucial role in cell ***,the impact of these mutations on protein structure and function is *** the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein ***,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using *** clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta *** that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein *** analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 ***,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 *** findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants.

关键词： globally similarity finding

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Is Smoking a Risk Factor of Hypertension within Obstructive sleep Apnea Patients

Is Smoking a Risk Factor of Hypertension within Obstructive ...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病...

作者： Lijun Jiang Zhihao Quan Jianhong Liu Yuping Xie Zhijian Lei Bifang Liang Hualin Tang sleep-disordered breathing center of Guangxi People’s Hospital of Guangxi Zhuang Autonomous Region

Objective To explore the possible relationship between smoking and hypertension within the obstructive sleep apnea patients. Methods Subjects aged over 18 years were recruited from May 2009 to July 2012 inGuangxi Zhuang Autonomous Region People’s *** polysomnography(PSG) was performed for each *** measurements,such as height,weight,were measured before *** habits were quantified by using retrospective

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