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Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes

World Journal of Gastroenterology 2014年第48期20卷 18121-18130页

作者： Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone IEMEST Euro-Mediterranean Institute of Science and Technology 90139 Palermo Italy Department of Experimental Biomedicine and Clinical Neurosciences Section of Histology University of Palermo 90133 Palermo Italy AOUP "P Giaccone" School of Medicine University of Palermo 90139 Palermo Italy Fondazione Istituto S. Raffaele-G. Giglio Gastroenterology and Endoscopy Unit Cefalù 90146 Italy Unit of Surgery "Clinica Torina" 9010Palermo Italy Deparment of Anatomy Cell Biology and Physiology American University of Beirut Beirut 1107-2020 Lebanon Department of Biomedical Sciences Oakland University William Beaumont School of Medicine Rochester MI 48309 United States

Patients with inflammatory bowel disease (IBD) have an increased risk of 10%-15% developing colorectal cancer (CRC) that is a common disease of high economic costs in developed countries. The CRC has been increasing in recent years and its mortality rates are very high. Multiple biological and biochemical factors are responsible for the onset and progression of this pathology. Moreover, it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health. The gut microflora, or microbiota, has an extensive diversity both quantitatively and qualitatively. In utero, the intestine of the mammalian fetus is sterile. At birth, the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms, ultimately developing into a stable community, with marked variations in microbial composition between individuals. The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora (dysbiosis). The healthy human gut harbours about 10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract. The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC. In healthy subjects, the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature, competition between different bacterial strains, peristalsis and drugs can influence the intestinal microenvironment. The microbiota exerts diverse physiological functions to include: growth inhibition of pathogenic microorganisms, synthesis of compounds useful for the trophism of colonic mucosa, regulation of intestinal lymphoid tissue and synthesis of amino acids. Furthermore, mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity. Changes in the microbiota composition are mainly influenced

关键词： Dismicrobism Inflammatory bowel disease Colorectal Cancer Dysbiosis Eubiosis Heat shock proteins

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Infuence of gut microbiome on the human physiology

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Systems Microbiology and Biomanufacturing 2022年第2期2卷 217-231页

作者： Aakriti Srivastava Muhil Raj Prabhakar Anee Mohanty Sumer Singh Meena Department of Biotechnology Dr.B.R.Ambedkar National Institute of TechnologyJalandharPunjab 144011India

Trillions of microbes harbor the gastrointestinal tract and co-exist peacefully with the human *** diversity and composition among individuals depend upon human age,diet,and environmental *** dynamic population of the gut microbiome,majorly consisting of Bacteroidetes and Firmicutes,forms a complex ecological *** collective metabolic activities and interaction of gut microbiota with the host exert a marked infuence on human *** gut microbiota help to perform various functions,such as maintenance of intestinal mucosal integrity,production of antimicrobial peptides,protection against foreign invaders,and immunity *** addition,they also provide essential nutrients,such as enzymes and vitamins,and also take part in metabolite synthesis,which infuences both cognitive and behavioral functions of the human *** equilibrium among gut microorganisms,and between the microbes and intestinal interface of the host allows the maintenance of benefcial *** alteration or dysbiosis in gut microbial composition,due to a sedentary lifestyle or intake of an unbalanced diet,plays a crucial role in the development of diseases like systemic infammation,insulin resistance,auto-immune and metabolic *** review summarizes our current understanding of the gut microbial organization,its importance in the fundamental biological processes and the pathogenesis of various human diseases and infections,and also the prognostic,diagnostic,and therapeutic potential of the gut microbiota.

关键词： Gut microbiota microorganisms Gastrointestinal tract Digestive system Nutrition Metabolism

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Effects of CO_2 Compression and Decompression Rates on the physiology of microorganisms

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Chinese Journal of Chemical Engineering 2005年第1期13卷 140-143页

作者：刘秀凤张宝泉李天铎 School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Department of Chemical Engineering Shandong institute of Light Industry Jinan 250100 China

The influence of compression and decompression rates of carbon dioxide on the physiology of Absidia coerufea and Saccharomyces cerevisiae was investigated. Besides parameters such as pressure, temperature, exposure time, water content, and initial pH, the influence of either compression or decompression rate on the biological behavior of microorganisms was quite essential. For both microorganisms studied, an optimal rate for either compression or decompression process exists due to the integrated effect of pressure, exposure time as well as compression or decompression speed. The decompression rate has no significant effect on cell's viability after 180 min exposure in compressed CO_2 because almost all the microorganisms were died before decompression.

关键词： viability biological activity Absidia coerulea Saccharomyces cerevisiae supercritical CO_2

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Genome-Wide Analysis of Gene Expression in Stationary Phase and Genetic Characterization of Stationary-Phase-Dependent Halocin Gene Expression in the Haloarchaeon Haloferax mediterranei

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Journal of Genetics and Genomics 2013年第8期40卷 441-444页

作者： Xiaoqing Liu Lei Wang Jingfang Liu Lei Cai Hua Xiang State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of Sciences University of Chinese Academy of Sciences

The stationary phase of microbial growth is a very complex state regulated by various environmental and physiological factors. An intensive study of stationary phase could promote a comprehensive understanding of the complete life cycle of microorganisms, and may provide important insights into their adaptation to harsh and nutrient-depleted conditions. Although the underlying mechanisms have been weU-studied in bacteria and yeasts （Herman, 2002; Navarro Llorens et al., 2010）, less is known about this growth phase in archaea yet. The haloarchaeon Haloferax mediterranei has served as a good model for studying haloarchaeal physiology and metabolism for several decades because of its accelerated growth, remarkable metabolic ability and genomic stability （Han et al., 2012）. During stationary phase, H. mediterranei can produce halocin H4 （Cheung et al.,

关键词： Genome-Wide Analysis of Gene Expression in Stationary Phase and Genetic Characterization of Stationary-Phase-Dependent Halocin Gene Expression in the Haloarchaeon Haloferax mediterranei KEGG BRE gene down

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Production and Characterization of New Fibrinolytic Protease from Mucor subtillissimus UCP 1262 in Solid-State Fermentation

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Advances in Enzyme Research 2015年第3期3卷 81-91页

作者： Thiago Pajeu Nascimento Amanda Emmanuelle Sales Camila Souza Porto Romero Marcos Pedrosa Brandao Galba Maria Campos Takaki Jose Antonio Couto Teixeira Tatiana Souza Porto Ana Lucia Figueiredo Porto Center for Biological Sciences Federal University of PernambucoRecifeBrazil Department of Morphology and Animal physiology Federal Rural University of PernambucoRecifeBrazil Center for Research in Environmental Sciences Catholic University of PernambucoRecifeBrazil institute for Biotechnology and Bioengineering Centre of Biological EngineeringUniversity of MinhoCampus of GualtarBragaPortugal Academic Unit of Garanhuns Federal Rural University of PernambucoGaranhunsBrazil

Fibrinolytic enzymes have received attention regarding their medicinal potential for thrombolytic diseases, a leading cause of morbidity and mortality worldwide. Various natural enzymes purified from animal, plant and microbial sources have been extensively studied. The aim of this work was to produce fibrinolytic protease by solid state fermentation using agro industrial substrates. Rhizopus arrhizus var. arrhizus UCP 1295 and Mucor subtillissimus UCP 1262 filamentous fungi species isolated from soil of Caatinga-PE, Brasil, were used as producer microorganisms. Wheat bran was shown to be the best substrate for the production of the enzyme and by using a 23 full factorial design the main effects and interactions of the quantity of the substrate wheat bran, moisture and temperature on the fibrinolytic enzyme production and protease were evaluated. The best results for fibrinolytic and protease activities, 144.58 U/mL and 48.33 U/mL, respectively, were obtained with Mucor subtillissimus UCP 1262 using as culture medium 3 g wheat bran, 50% moisture at a temperature of 25°C for 72 hours. The optimum temperature for the produced enzyme was 45°C and most of its original activity was retained after being subjected to 80°C for 120 min. The protease activity was enhanced by K+, Ca+ and Mn+;but with Cu+ there was an inhibition. The specificity to chromogenic substrate and the inhibition by PMSF indicates that it is a chymotrypsin-like serine protease. Presented results suggest that this enzyme produced by solid-state fermentation is an interesting alternative as a candidate for thrombolytic therapy.

关键词： Mucor Enzyme Protease Fibrinolytic Wheat

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Effects of marine compound xyloketal B on neuroprotection and potential drug development

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Journal of Coastal Life Medicine 2015年第6期 429-432页

作者： Sammen Huang Wenliang Chen Jiyan Pang Zhong Pei Guan-Lei Wang Hong-Shuo Sun Department of Surgery Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of physiology Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of Pharmacology and Toxicology Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8 Department of Applied Chemistry School of Chemistry and Chemical EngineeringSun Yat-Sen UniversityGuangzhou 510275China Key Laboratory of Functional Moleculesfrom Oceanic microorganisms(Sun Yat-Sen University) Department of Education of Guangdong Province510080China Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China institute of Medical Science Faculty of MedicineUniversity of TorontoTorontoOntarioCanada M5S 1A8

Coastal medicine is a promising field for research and drug development,because several natural products isolated from marine organisms have been found to be therapeutically useful in a clinical *** comparison to terrestrial products,the merit of marine compounds arises from the diversity in their chemical structure and unique bioactivity.A recently discovered marine compound,xyloketal B,displays neuroprotective and antioxidative effects in in-vitro and in-vivo experimental *** elicits these beneficial effects through mitochondrial protection,free radical scavenging,reducing reactive oxygen species production and suppressing apoptotic *** addition,unpublished data from our lab revealed that transient receptor potential melastatin 7 channel activity,implicated in a myriad of neurodegenerative diseases,was inhibited following xyloketal B *** this review,the therapeutic effect of xyloketal B will be evaluated based on existing evidence and its potential for drug development will be also discussed.

关键词： Marine compound Xyloketal B Neuroprotection Antioxidative Drug development

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Synergistic combination of arbuscular mycorrhizal fungi and plant growth-promoting rhizobacteria modulates morpho-physiological characteristics and soil structure in Nitraria tangutorum *** saline soil conditions

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Research in Cold and Arid Regions 2022年第6期14卷 393-402页

作者： Jing Pan CuiHua Huang Fei Peng Tao Wang Jie Liao ShaoXiu Ma QuanGang You Xian Xue Drylands Salinization Research Station/Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Nitraria tangutorum Bobr.,a typical xero-halophyte,can be used for vegetation restoration and reconstruction in arid and semiarid regions affected by ***,global climate change and unreasonable human activity have exacerbated salinization in arid and semi-arid regions,which in turn has led to the growth inhibition of halophytes,including *** mycorrhizal fungi(AMF)and plant growth-promoting rhizobacteria(PGPR)have the potential to improve the salt tolerance of plants and their adaptation to saline soil *** this study,the effects of single and combined inoculations of AMF(Glomus mosseae)and PGPR(Bacillus amyloliquefaciens FZB42)on *** were evaluated in severe saline soil *** results indicate that AMF and PGPR alone may not adapt well to the real soil environment,and cannot ensure the effect of either growth promotion or salt-tolerance induction on *** ***,the combination of AMF and PGPR significantly promoted mycorrhizal colonization,increased biomass accumulation,improved morphological development,enhanced photosynthetic performance,stomatal adjustment ability,and the exchange of water and ***-inoculation also significantly counteracted the adverse effect of salinity on the soil structure of *** *** is concluded that the effectiveness of microbial inoculation on the salt tolerance of *** seedlings depends on the functional compatibility between plants and microorganisms as well as the specific combinations of AMF and PGPR.

关键词： Nitraria tangutorum Bobr. Arbuscular mycorrhizal fungi Plant growth-promoting rhizobacteria Morphological development Photosynthesis physiology Soil structure

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SEROLOGICAL METHODS AS AN AID TO THE CLASSIFICATION OF STREPTOMYCES SPECIES

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Science in China,Ser.A 1959年第8期 843-852页

作者：梁漱芳蔡润生沈丽君徐子渊 institute of Materia Medica Academia Sinica Shanghai

The serologic reactions applied to the genus Streptomyces are based on the same immunologic and immunochemical principles as those reactions used for classification purposes in Eubacteriales. In general the immunolo- gical reactions in the genus Streptomyces are of weaker degree man those in bacteria. The polysaccharide antigens are of different serological specificity, but contain the same carbohydrates, namely, glucosamine, glucose and arabinose. The polysaccharide antigens obtained from Streptomyces are, from the immunologic point of view, weak haptens. The specificity of immunologic reactions in this genus of microorganisms seems to be connected rather with glycoprotein antigen. By means of serologic reactions it is possible to identify strains belonging to the closely related species according to the criteria actually used for the differentiation and classification ***: The authors wish to express their sincere thanks to Professor Yin Hung-chang of the institute of Plant physiology for his helpful suggestions. The authors also offer thanks to Mr. Cheng Jyh-sing for his excellent technical assistance.

关键词： SEROLOGICAL METHODS AS AN AID TO THE CLASSIFICATION OF STREPTOMYCES SPECIES NCIB test

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Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous Martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana Monteiro Larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz institute DSMZ-German Collection of microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference Library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

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Rice(Oryza sativa L.)plant protection using dual biological control and plant growth-promoting agents:Current scenarios and future prospects

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Pedosphere 2023年第2期33卷 268-286页

作者： Debasis MITRA Sergio DE LOS SANTOS-VILLALOBOS Fannie Isela PARRA-COTA Ana María Garcia MONTELONGO Erika Lorena BLANCO Vanessa L.LIRA Adeyemi N.OLATUNBOSUN Bahman KHOSHRU Rittick MONDAL Parameswaran CHIDAMBARANATHAN Periyasamy PANNEERSELVAM Pradeep K.DAS MOHAPATRA Department of Microbiology Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Instituto Tecnológico de Sonora 5 de febrero 818.Col.CentroCd.ObregónSonora 85000(Mexico) Campo Experimental Norman E.Borlaug-Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias(INIFAP)Norman E.Borlaug Km.12C.P.Ciudad ObregónSonora 85000(Mexico) Laboratorio de Investigación en Biotecnología y Química de Polímeros Decanato de InvestigaciónUniversidad Nacional Experimental del TáchiraSan Cristóbal 5001(Venezuela) Departamento de Micologia Federal University of PernambucoRecifePE 50670-901(Brazil) Department of Plant physiology and Crop Production Federal University of AgricultureAbeokuta 111101(Nigeria) Department of Soil Science Faculty of AgricultureUniversity of TabrizTabriz 51664(Iran) Department of Sericulture Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Biotechnology Crop Improvement DivisionIndian Council of Agricultural Research(ICAR)-National Rice Research InstituteCuttackOdisha 753006(India) Microbiology Crop Production DivisionICAR-National Rice Research InstituteCuttackOdisha 753006(India) Professor A.K.Bothra Environment Conservation Centre Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India)

Various microorganisms live in association with different parts of plants and can be harmful,neutral,or beneficial to plant *** microbial inhabitants of plants can control plant diseases by contesting with,predating on,or antagonizing plant pathogens and by inducing systems for plant defense.A range of methods,including plant growth-promoting microorganisms(PGPMs)as biological control agents(BCAs)(BCA-PGPMs)are used for the biological management and control of plant *** BCAs interact with plants by inducing resistance or priming plants without direct interaction with the *** BCAs operate via nutrient competition or other mechanisms to modulate the growth conditions for the ***,PGPMs can be applied alone or together with other chemicals or carriers to control various crop *** review highlights the effective types of BCA-PGPMs and their applications,roles,carrier based-formulations,and responses to rice(Oryza sativa L.)*** plant disease management prospects are promising,and growers’increasing demand for BCA-PGPM products can be exploited as an effective approach to the management of plant diseases,as well as to improve yield,environmental protection,biological resources,and agricultural system sustainability.

关键词： biological control agent plant disease plant growth-promoting microorganism plant health plant pathogen

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