Infuence of gut microbiome on the human physiology
作者机构：Department of BiotechnologyDr.B.R.Ambedkar National Institute of TechnologyJalandharPunjab 144011India
出 版 物：《Systems Microbiology and Biomanufacturing》 (系统微生物学与生物制造（英文）)
年 卷 期：2022年第2卷第2期
页 面：217-231页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Ministry of Education India MoE
主 题：Gut microbiota Microorganisms Gastrointestinal tract Digestive system Nutrition Metabolism
摘 要：Trillions of microbes harbor the gastrointestinal tract and co-exist peacefully with the human *** diversity and composition among individuals depend upon human age,diet,and environmental *** dynamic population of the gut microbiome,majorly consisting of Bacteroidetes and Firmicutes,forms a complex ecological *** collective metabolic activities and interaction of gut microbiota with the host exert a marked infuence on human *** gut microbiota help to perform various functions,such as maintenance of intestinal mucosal integrity,production of antimicrobial peptides,protection against foreign invaders,and immunity *** addition,they also provide essential nutrients,such as enzymes and vitamins,and also take part in metabolite synthesis,which infuences both cognitive and behavioral functions of the human *** equilibrium among gut microorganisms,and between the microbes and intestinal interface of the host allows the maintenance of benefcial *** alteration or dysbiosis in gut microbial composition,due to a sedentary lifestyle or intake of an unbalanced diet,plays a crucial role in the development of diseases like systemic infammation,insulin resistance,auto-immune and metabolic *** review summarizes our current understanding of the gut microbial organization,its importance in the fundamental biological processes and the pathogenesis of various human diseases and infections,and also the prognostic,diagnostic,and therapeutic potential of the gut microbiota.
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