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Supply and quality of colonoscopy according to the characteristics of gastroenterologists in the French population-based colorectalcancer screening program

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World Journal of Gastroenterology 2023年第9期29卷 1492-1508页

作者： AkoïKoïvogui Catherine Vincelet Gaëlle Abihsera Hamou Ait-Hadad Hélène delattre Tu Le Trung Agnès Bernoux Rachel Carroll Jérôme Nicolet site de seine-Saint-denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Bondy 93146France site des Yvelines Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Le Chesnay Cedex 78153France site du Val-de-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Joinville-le-Pont 94340France site de seine-et-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Lieusaint 77763France site des hauts-de-seine Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Nanterre 92000France site du Val-d’Oise Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Cergy Saint-Christophe 95800France site de l’Essonne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Fontenay-Les-Briis 91640France Siège Paris Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Paris 75015France

BACKGROUND Since its complete roll-out in 2009,the French colorectal cancer screening program(CRCSP)experienced 3 major constraints[use of a less efficient Guaiac-test(gFOBT),stopping the supply of Fecal-Immunochemical-Test kits(FIT),and suspension of the program due to the coronavirus disease 2019(COVID-19)]affecting its *** To describe the impact of the constraints in terms of changes in the quality of screeningcolonoscopy(Quali-Colo).METHODS This retrospective cohort study included screening-colonoscopies performed by gastroenterologists between Jan-2010 and dec-2020 in people aged 50-74 living in Ile-de-France(France).The changes in Quali-colo(Proportion of colonoscopies performed beyond 7 mo(Colo_7 mo),Frequency of serious adverse events(SAE)and Colonoscopy detection rate)were described in a cohort of Gastroenterologists who performed at least one colonoscopy over each of the four periods defined according to the chronology of the constraints[gFOBT:Normal progress of the CRCSP using gFOBT(2010-2014);FIT:Normal progress of the CRCSP using FIT(2015-2018);STOP-FIT:Year(2019)during which the CRCSP experienced the cessation of the supply of test kits;COVID:Program suspension due to the COVID-19 health crisis(2020)].The link between each dependent variable(Colo_7 mo;SAE occurrence,neoplasm detection rate)and the predictive factors was analyzed in a two-level multivariate hierarchical *** The 533 gastroenterologists(cohort)achieved 21509 screening colonoscopies over gFOBT period,38352 over FIT,7342 over STOP-FIT and 7995 over COVID *** frequency of SAE did not change between periods(gFOBT:0.3%;FIT:0.3%;STOP-FIT:0.3%;and COVID:0.2%;P=0.10).The risk of Colo_7 mo doubled between FIT[adjusted odds ratio(aOR):1.2(1.1;1.2)]and STOPFIT[aOR:2.4(2.1;2.6)];then,decreased by 40%between STOP-FIT and COVID[aOR:2.0(1.8;2.2)].Regardless of the period,this Colo_7 mo’s risk was twice as high for screening colonoscopy performed in a public hospital[aOR:2.

关键词： Colorectal cancer screening Screening colonoscopy Faecal immunochemical test Guaiac faecal occult blood test Quality of colonoscopy Severity of tumor lesions

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Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

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World Journal of Gastroenterology 2021年第31期27卷 5272-5287页

作者： Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie Clerc Claire Piccotti Anne deloraine Catherine Exbrayat site de l'Ain Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-AlpesBourg-en-Bresse 01000France site de seine-Saint-denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-FranceBondy 93146France sites Savoie&Haute Savoie Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesChambery 73000France site de Drome Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesValence 26000France site Isere&Drome-Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesMeylan 38240France

BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been *** To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening *** This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and december *** between test_((-1))and test_((0))was>1year and test_((-1))result was negative(described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression *** The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of *** risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to

关键词： Colorectal cancer screening Fecal immunochemical test Fecal hemoglobin concentration Colorectal lesion severity

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Colorectal cancer fecal screening test completion after age 74,sources and outcomes in French program

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 729-740页

作者： Akoi Koivogui Christian Balamou Raushan Rymzhanova Tu Letrung Hamou Ait Hadad Zahida Brixi Stéphane Cornelis Hélène delattre-Massy Thomas Aparicio Robert Benamouzig Comité Départemental des Cancers(CDC-93) CRCDC-IDFSite de Seine-Saint-DenisBondy 93146France Office de Lutte contre les Cancers(ODLC-01) CRCDC-AURASite de l’AinBourg-en-Bresse 01000France Association pour le depistage des Cancers(AdeCA-FC) CRCDC-Bourgogne-Franche-ComteSite de Franche-ComteBesancon 25000France Prévention and Santé en Val-d’Oise(PSVO) Immeuble du CentaureCRCDCIDFSite de Val-d’OiseCergy Saint Christophe 95800France Association pour le Dépistage des Maladies Cancéreuses(ADMC91) CRCDC-IDFSite de l’EsonneCMC De BlignyBriis-sous-Forges 91640France Association de dépistage organisédes cancers(ADOC94) CRCDC-IDFSite de Val-de-MarneJoinville-le-Pont 94340France Association Icaunaise de Dépistage du Cancer(AIdeC) CRCDC-Bourgogne-Franche-ComtéSite de l’Yonne Saint-Georges-sur-Baulche 89000France Association pour le Dépistage Organisédes cancers(ADOC92) CRCDC-IDFSite des Hauts-de-SeineNanterre 92000France Service d'Hepato Gastro Enterologie Hopital Avicenne(AP-HP)Bobigny 93000France

BACKGROUND Elderly patients aged at least 75 years old(Elderly_75),represent 45%of colorectal cancer(CRC)*** others,the French Colorectal Cancer Screening Program(CRCSP)does not include Elderly_*** date,there is little evidence to justify stopping screening at 74 years of *** To describe CRC fecal screening test completion after age 74,source(CRCSP/Provider ordered)and outcomes of these *** The study concerned 18704 Elderly_75 residing in eleven French districts(Ain,Doubs,Essonne,Haute-Saone,hauts-de-seine,Jura,seine-Saint-denis,Territoire-de-Belfort,Val-de-Marne,Val-d'Oise,Yonne),having performed a CRC screening test between January 2008 and december *** tests performed in a circumstance of delayed response to a solicitation(DRS)from the local cancer screening managing center(Managing-Center)were distinguished from the tests non-solicited by the Managing-Center,performed after a recommendation by a General Practitioner(GP)or other provider ordered(RGP).DRS was any test realized by an Elderly_75 following an initial invitation from the ManagingCenter with a maximum 24 mo after this *** Non-DRS test was considered *** outcomes of these tests were described according to the circumstances of test *** Of 18995 screening-tests were performed at ages:75(83.5%),76-80(13.4%)and>80(3.1%)years ***_75 performed the screening test in a circumstance of DRS(71.9%)or RGP(28.1%).The proportion of the tests that could not be analyzed and not restarted was 13.2%.For these unanalyzed tests,the reason was age-related in 78.0%of cases,related to the laboratory's refusal to analyze the test of people aged≥*** colonoscopy completion rate was 81.3%.For those575 people with reported colonoscopy,no complication was listed.18.0%of the366 Elderly_75 with lesions had no anteriority in the *** neoplasia(124 Low-risk-polyps,159 High-risk-polyps,13 Unspecified-polyps and 70 CRCs)detection rate was 19.3/1000 Elderly_7

关键词： Colorectal cancer Fecal screening test Participation rate Colonoscopy completion rate Elderly

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Microstructure and Transformation Behavior of in-situ Shape Memory Alloys by Selective Laser Melting Ti-Ni Mixed Powder

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Journal of Materials Science & Technology 2013年第9期29卷 863-867页

作者： Baicheng Zhang Jing Chen Christian Coddet LERMPS Université de Technologie de Belfort-Montbéliard Site de Sévenans Laboratoire des Matériaux Macromoléculaires Ingénierie des Matériaux Polymères

The selective laser melting （SLM） of Ti-Ni mixed powder with atomic ratio of 1：1 was performed in the present work in order to elaborate shape memory alloy （SMA）. The martensite phase of Ti-Ni alloy can be found by X-ray diffraction （XRD） analysis under temperature field, moreover, the Ti2Ni phase at a high scanning velocity. The crystalline phase images also show that the synthesized Ti-Ni alloy possessed a refined martensite microstructure. In order to evaluate the mechanical properties, the microhardness and porosity were measured. The microhardness is relatively high about 400HVo.2 with champ temperature. Besides, the porosity is quite low due to the excellent laser energy absorptivity and meltability of Ni element. The differential scanning calorimetry （DSC） analysis shows that the transformation temperature from austenite phase to martensite phase is relatively high and stable.

关键词： Selective laser melting Microstructnre Shape memory alloy

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Antioxidant and antibacterial activities and identification of bioactive compounds of various extracts of Caulerpa racemosa from Algerian coast

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 87-94页

作者： Louiza Belkacemi Mahmoud Belalia Ali C.Djendara Youcef Bouhadda Laboratoire de Technologie Alimentaire et de Nutrition Site II EX-INES de ChimieChemin des CrêtesBP 188Abdelhamid IbnBadis UniversityMostaganemAlgeria Laboratoire de Structure Elaboration et Application des Matériaux MoléculairesSite II EX-INES de ChimieChemin des CrêtesBP 188Abdelhamid IbnBadis UniversityMostaganemAlgeria Laboratoire de Chimie Physique des Biomolécules et Interfaces Biologiques B.P.305Route de MamouniaMustapha Stambouli University MascaraAlgeria

Objective:To evaluate the antibacterial and antioxidant activities and to identify the volatile bioactive compounds present in different crude extracts of the seaweed Caulerpa racemosa ***:Caulerpa racemosa harvested from the intertidal zone of Mostaganem coast(N 35?54’37.94",E 0?3’17.37")was subjected to Soxhlet extraction using methanol,chloroform,and hexane *** properties were assessed by using 2,2’-diphenyl-1-picrylhydrazyl(DPPH),2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)andβ-carotene bleaching *** antibacterial activity was evaluated on six standard bacterial strains using the agar disc diffusion *** GC-MS analysis was performed using non-polar and polar capillary ***:The chloroform extract of Caulerpa racemosa exhibited higher contents of polyphenols[(123.91±1.46)mg gallic acid equivalent/g dry extract]and tannins[(59.28±5.43)mg catechin equivalent/g dry extract](Pdecanoate and 4-hydroxy-2 methylproline were among the most abundant volatile *** conventional fatty acids,cis-10-heptadecenoic acid,nonahexacontanoic acid,and dodecanoic acid,3-hydroxy-were *** phytosterols were identified:stigmast-5-en-3-ol-(12.9%)and ***.-ol,(24 S)-(4.57%).Conclusions:The preliminary identification of the volatile compounds reveals the presence of some new bioactive components not reported previously in Caulerpa racemosa from other geographical *** of these compounds possess an interesting potential for pharmaceutical/nutraceutical applications.

关键词： Caulerpa racemosa var.cylindracea West Algerian coast Biological activities Clionasterol 4-Hydroxy-2methylproline

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STUDY OF FREE BURNING ARC CHARACTERISTICS BY DIMENSIONAL ANALYSIS AND COMPUTER SIMULATION

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第2期3卷 69-84页

作者： GREGOIRE de IZARRA Groupe de Recherche sur l’´Energ´etique des Milieux Ionis´es UMR 6606 Universite d’Orleans CNRS Faculte des Sciences Site de Bourgesrue Gaston Berger BP 404318028 Bourges CedexFrance

This paper deals with the study of experimental current intensity/voltage characteristicsof a free burning arc that appears to be singular:At low intensity current,the arc voltagedecreases until a minimum value,corresponding to a critical current intensity *** intensities higher than Ic,there is an increase of the arc voltage with the *** analysis and Pi theorem coupled with a large set of experimentaldata allow us to evaluate the main physical processes responsible for the *** low current intensity,the plasma is mostly driven by thermal conduction effectswhile at high current intensity,it is principally governed by radiation ***,theresults obtained from dimensional analysis allow to propose a 1D numerical simulationof the plasma column that gives rather good qualitative results.

关键词： Electric discharges plasma heating by DC fields ohmic heating arcs

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HOMOGENIZATION OF SEMILINEAR PARABOLIC EQUATIONS IN PERFORATED DOMAINS

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Chinese Annals of Mathematics,Series B 2004年第2期25卷 143-156页

作者： P.DONATO A.NABIL Universite de Rouen UFR des SciencesLaboratoire de Mathematiques Raphael Salemsite Colbert76821 Mont Saint AignanFrance.Universite Ibn ZohrENSABP 33/SAgadirMaroc.

This paper is devoted to the homogenization of a semilinear parabolic equation with rapidly oscillating coefficients in a domain periodically perforated byε-periodic holes of size ε. A Neumann condition is prescribed on the boundary of the *** presence of the holes does not allow to prove a compactness of the solutions in L2. To overcome this difficulty, the authors introduce a suitable auxiliary linear problem to which a corrector result is applied. Then, the asymptotic behaviour of the semilinear problem as ε→ 0 is described, and the limit equation is given.

关键词： Periodic homogenization Perforated domains Semilinear parabolic equations

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Integrability of det▽u and Evolutionary Wente's Problem Associated to Heat Operator

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Chinese Annals of Mathematics,Series B 2007年第5期28卷 527-532页

作者： Sami BARAKET Makkia DAMMAK Mohamed JLELI Dong YE departement de mathematiques Faculte des Sciences de Tunis Campus Universitaire2092 TunisTunisie. departement de mathematiques Ecole Superieure des Sciences et Techniques de Tunis5 Avenue Taha-HusseinTunis BP 56Bab Menara 1008Tunisie. departement de mathematiques UMR8088Universite de Cergy-Pontoise site Saint-Martin BP22295302 Cergy-Pontoise cedexFrance.

In this note,the authors resolve an evolutionary Wente's problem associated to heat equation,where the special integrability of det▽u for u∈H^1(R^2,R^2)is used.

关键词： Jacobian determinant Heat equation Wente's problem

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Atmospheric photochemistry and secondary aerosol formation of urban air in Lyon,France

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Journal of Environmental Sciences 2021年第1期33卷 311-323页

作者： Salah Eddine Sbai Chunlin Li Antoinette Boreave Nicolas Charbonnel Sebastien Perrier Philippe Vernoux Farida Bentayeb Christian George Sonia Gil department of physics Laboratoires de physique des hauts Energies Modelisation et SimulationMohammed V Uniuersity in RabatRabatMorocco Universite lyon Universite Claude Bernard Lyon 1CNRSIRCELYON2 Auenue Albert Einstein69100 LyonFrance department of Earth and Planetary Sciences Weizmann Institute of Science76100 RehovotIsrael

Photochemical aging of volatile organic compounds(VOCs)in the atmosphere is an important source of secondary organic aerosol(SOA).To evaluate the formation potential of SOA at an urban site in Lyon(France),an outdoor experiment using a Potential Aerosol Mass(PAM)oxidation flow reactor(OFR)was conducted throughout entire days during JanuaryFebruary *** variation of SOA formations and their correlation with OH radical exposure(OHexp),ambient pollutants(VOCs and particulate matters,PM),Relative Humidity(RH),and temperature were explored in this *** urban air was exposed to high concentration of OH radicals with OHexp in range of(0.2-1.2)×10^12 molecule/(cm^3·sec),corresponding to several days to weeks of equivalent atmospheric photochemical *** results informed that urban air at Lyon has high potency to contribute to SOA,and these SOA productions were favored from OH radical photochemical oxidation rather than via *** SOA formation(36μg/m^3)was obtained at OHexp of about 7.4×10^11 molecule/(cm^3·sec),equivalent to approximately 5 days of atmospheric *** correlation between SOA formation and ambient environment conditions(RH&temperature,VOCs and PM)was *** was the first time to estimate SOA formation potential from ambient air over a long period in urban environment of Lyon.

关键词： Urban air Oxidation Flow Reactor(OFR) Secondary Organic Aerosol(SOA) Volatile Organic Compounds(VOC) Photochemistry Lyon

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Experimental investigation and numerical modeling of the hydration operation of date fruits

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第2期8卷 55-71页

作者： Atef Lakoud Sebastien Curet Mnasser Hassouna Ecole Superieure des Industries Alimentaires de Tunis 58 Av.Alain Savary Tunis El Khadra1003Tunisia L’UNAM Universite ONIRISCNRSGEPEAUMR 6144 site de la GeraudiereNantesF-44322France Ecole Sup´erieure des Industries Alimentaires de Tunis 58 Av.Alain Savary Tunis El Khadra1003Tunisia

Hydration represents the main unit operation in the industrial thermal process of dry *** this work,Tunisian deglet Nour dates were hydrated experimentally at a laboratory scale by using saturated air as it is commonly undertaken in *** study focuses on the modeling of this unit operation in order to control the moisture uptake phenomenon during processing.A physic-based simplified numerical model describing moisture transfer during hydration was implemented in COMSOL rMultiphysics soft*** model considers the real geometry of dates instead of approaching the fruits by simplified *** diffusivities of two types of deglet Nour dry dates characterized by different maturation stages were *** showed a good agreement between experimental and numerically computed values of average moisture *** profile in dates flesh was computed numerically using estimated moisture dif*** numerical model proposed in this work could be therefore employed as a predictive tool to simulate and optimize the hydration operation of dates.

关键词： Moisture diffusivity convective coefficient moisture profile.

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