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BnbHLH92a negatively regulates anthocyanin and proanthocyanidin biosynthesis in Brassica napus

The Crop Journal 2023年第2期11卷 374-385页

作者： Ran Hu Meichen Zhu Si Chen Chengxiang Li Qianwei Zhang Lei Gao Xueqin Liu Shulin Shen Fuyou Fu Xinfu Xu Ying Liang Liezhao Liu Kun Lu Hao Yu Jiana Li Cunmin Qu Chongqing Rapeseed Engineering Research Center College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Agriculture and Agri-Food Canada Saskatoon Research Centre107 Science PlaceSaskatoonSaskatchewan S7N 02XCanada Temasek Life Sciences Laboratory National University of SingaporeSingapore 117604Singapore

Yellow seed trait is a desirable characteristic with potential for increasing seed quality and commercial value in rapeseed,and anthocyanin and proanthocyanidins(PAs)are major seed-coat *** transcription factors involved in the regulation of anthocyanin and PAs biosynthesis have been characterized in *** this study,we identified a transcription factor gene BnbHLH92a(BnaA06T0441000ZS)in *** BnbHLH92a both in Arabidopsis and in rapeseed reduced levels of anthocyanin and ***,the expression profiles of anthocyanin and PA biosynthesis genes(TT3,BAN,TT8,TT18,and TTG1)were shown by quantitative real-time PCR to be inhibited in BnbHLH92a-overexpressing Arabidopsis seeds,indicating that BnbHLH92a represses the anthocyanin and PA biosynthesis pathway in ***92a physically interacts with the BnTTG1 protein and represses the biosynthesis of anthocyanins and PAs in ***92a also binds directly to the BnTT18 promoter and represses its *** results suggest that BnbHLH92a is a novel upstream regulator of flavonoid biosynthesis in ***.

关键词： Brassica napus L BnbHLH92a Anthocyanin Proanthocyanidins Flavonoid pathway

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What could probiotic do for us?

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Food Science and Human Wellness 2014年第2期3卷 47-50页

作者： Yuan Kun Lee Department of Microbiology Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117597Singapore

Gastrointestinal microbes play important roles in the health and disease of the *** are many documented evidences which demonstrated that disturbance of intestinal microbiota is linked to the risk of developing infectious,inflammatory and allergic *** intestine is home for a complex consortium of 1013–1014 microbial *** between the intestinal microbes,pathogens and the host lead to exclusion of toxins(mycotoxins)and pathogens(colonization resistance),interference in disease progression as demonstrated in the prevention of oral infection,dental caries,diarrhoeas(Antibiotic Associated Diarrhoea,Travellers’Diarrhoea and Rotavirus Diarrhoea),postoperative infection,respiratory infection and certain *** group of beneficial intestinal microbes termed probiotics alter intestinal epithelial cell tight junction and immunological ***,laboratory and clinical studies demonstrated gut-brain axis communication and intestinal microbial(both pathogens and probiotics)modulation of host psycho-neuroimmunological functions,in relation to depression,anxiety and memory *** open up many possibilities of probiotics supplementation for moderating intestinal microbiota as an approach in disease prevention and treatment.

关键词： prevention intestine allergic

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The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer

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Journal of Cancer Metastasis and Treatment 2017年第1期3卷 169-176页

作者： Jie Liu Han Wang Gang Chen Mo Yang Zhi-Xian Wu Russell Erick Ericksen Alice Sze Tsai Wong Weiping Han Jin-Zhang Zeng Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102FujianChina Department of Pathology Fujian Provincial Cancer HospitalFujian Medical UniversityFuzhou 350014FujianChina Department of Hepatobiliary Disease Fuzhou General Hospital(Dongfang Hospital)Xiamen UniversityFuzhou 350025FujianChina Laboratory of Metabolic Medicine Singapore Bioimaging ConsortiumAgency for ScienceTechnology and ResearchSingapore 138667Singapore School of Biological Sciences University of Hong KongHong Kong 999077China.

Aim:To study the impact of Helicobacter pylori(***)and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer(GC).Methods:GC specimens were randomly collected from 42 patients,of whom 15 had *** infection and 27 were *** RNA was extracted for reverse transcription quantitative polymerase chain reaction quantification of gene ***:The mRNA levels of interleukin(IL)-6 and leptin,which are known to regulate Th17 differentiation,were upregulated by 20 and 6 folds,respectively,in ***-infected compared to uninfected ***-17A and granulocyte-macrophage colony-stimulating factor,two cytokines produced by Th17 cells,were 5-and 6-fold higher in tumors with *** infection,***,RORγt,a transcription factor regulating Th17 differentiation,was increased 6-fold in ***-positive *** *** elevation of RORγt was seen in advanced ***-associated *** addition,*** infection was also associated with enhanced expression of CXCL1(5 folds),chemotactic factor capable of driving bone marrow-derived immature myeloid ***,we observed that ***-associated increase of IL-17A was enhanced in the group with higher plasma ***:The findings demonstrate a cross-talk and synergistic role of *** infection and abnormal lipid metabolism in GC development,at least partly via cooperative induction of Th17 differentiation and activation.

关键词： Helicobacter pylori T helper cells gastric cancer interleukin-17A RORγt

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Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

Deficiency in RNA editing enzyme ADAR2 impairs regulated exo...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术...

作者： Liu Yang Liyun Zhao Zhenji Gan Zixuan He Jingyue Xu Xiang Gao Xiaorui Wang Weiping Han Liangyi Chen Tao Xu Wenjun Li Yong Liu key Laboratory of Nutrition and Metabolism Institute for Nutritional SciencesShanghai Institutes for Biological SciencesShanghai Burnham Institute for Medical Research OrlandoUSA Department of Biology HHMIUniversity of UtahUSA Model Animal Research Center Nanjing University singapore bioimaging consortium Agency for ScienceTechnology and Research Institute of Biophysics Chinese Academy of Sciences

Mammalian RNA editing catalyzed by adenosine deaminases acting on RNA(ADARs),ADAR1 and ADAR2,plays pivotal roles in the brain through functional modifications of neurotransmitter receptors and ion *** have previously demonstrated that RNA editing by ADAR2 is metabolically regulated in pancreatic *** investigate the cellular functions of ADAR2 in professional secretory cells,we studied the effects of ADAR2 knockdown on regulated *** knockdown of ADAR2

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Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy

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Science China Chemistry 2023年第8期66卷 2329-2338页

作者： Dongyang Li Tianruo Shen Xiaoqi Xue Weijie Chen Wenjun Tao Weijie Chi Sheng Hua Liu Ying Tan Xiaogang Liu Jun Yin National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China Science Mathematics and Technology ClusterSingapore University of Technology and DesignSingapore487372Singapore State Key Laboratory of Chemical Oncogenomics Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Department of Chemistry School of ScienceHainan UniversityHaikou570228China

Changes in cellular viscosity are associated with various physiological processes and pathological *** study these cellular processes and functions,highly sensitive fluorescent probes that detect subtle changes in viscosity are urgently needed but remain *** this study,we present a series of viscosity-responsive near-infrared(NIR)fluorescent probes based on styrene-coated boron dipyrromethene(BODIPY).The probe modified with dimethylaminostyrene and piperazine at the two terminals of the BODIPY scaffold showed extremely high viscosity sensitivity values(x,around 1.54),with excellent performance for detecting viscosity below 20 c *** outstanding property is attributed to the synergistic effects of multiple rotatable bonds and hydrogen-bond ***,this probe has been successfully deployed to monitor viscosity changes in various cellular compartments(i.e.,cytoplasm)and processes(such as during autophagy).This work provides a rational molecular design strategy to construct fluorescent probes with high viscosity sensitivity for exploring cell functions.

关键词： fluorescent probe high viscosity sensitivity multiple rotors hydrogen bonds bioimaging

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Ionic Liquid-Stabilized Single-Atom Rh Catalyst Against Leaching

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CCS Chemistry 2021年第10期3卷 1814-1822页

作者： Shipeng Ding Max JHülsey Hua An Qian He Hiroyuki Asakura Min Gao Jun-ya Hasegawa Tsunehiro Tanaka Ning Yan Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585 Joint School of the National University of singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207 Department of Materials Science and Engineering National University of SingaporeSingapore 117575 Department of Molecular Engineering Graduate School of EngineeringJapan and Elements Strategy Initiative for Catalysts and Batteries(ESICB)Kyoto UniversityKyoto 615-8510615-8245 Institute for Catalysis Hokkaido UniversitySapporo 001-0021

Single-atom catalysts(SACs)are promising in some reactions typically promoted by homogeneous ***,the leaching of active species from the support in liquid-phase reactions hinders their potential ***,taking the hydroformylation reaction as an example,we report ionic liquid(IL)-induced stabilization of single Rh atoms against *** the ILs examined.

关键词： single-atom catalysts electrostatic stab ilization ionic liquid leaching

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Structured Microgels through Microfluidic Assembly and Their Biomedical Applications

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Soft 2012年第1期1卷 1-23页

作者： Rong-Cong Luo Chia-Hung Chen Department of Bioengineering National University of Singapore Singapore

Droplet based microfluidic is an effective, versatile and scalable approach which can be used to produce structured microgels with desirable features. The high degree of control endowed with microfluidics enables the formation of various functional microgels such as multicompartment encapsulations, Janus shaped particles and non spherical microgels. These microgels have aroused great interest in biological engineering aspect, since they outperform their counterparts produced from other techniques and have been applied in drug delivery, 3 Dimensional cell culture, micro tissues, single cell assay, tissue engineering and bioimaging. In this review, we will summarize the fabrication processes, technology comparisons and the usages in biomedical applications.

关键词： Droplet Microfluidic Microgels Cell Encapsulation Tissue Engineering

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Construction and regulation of imidazo[1,5-a]pyridines with AIE characteristics via iodine mediated Csp^(2)-H or Csp-H amination

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Chinese Chemical Letters 2021年第10期32卷 3083-3086页

作者： Jun Zhang Mengyao She Lang Liu Mengdi Liu Zhaohui Wang Hua Liu Wei Sun Xiaogang Liu Ping Liu Shengyong Zhang Jianli Li Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry College of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Lab of Tissue Engineering Provincial Key Laboratory of Biotechnology of ShaanxiMinistry of Education Key Laboratory of Resource Biology and Modern BiotechnologyThe College of Life SciencesFaculty of Life and Health ScienceNorthwest UniversityXi’an 710127China Fluorescence Research Group Singapore University of Technology and DesignSingapore 487372Singapore

The widespread applications of aggregation-induced emission luminogens(AIEgens)inspire the creation of AIEgens with novel structures and *** this work,we focused on the direct and efficient synthesis of a new type of AIEgens,imidazo[1,5-a]pyridicne derivatives,via iodine mediated cascade oxidative Csp^(2)–H or Csp–H amination route from phenylacetylene or styrenes under mild *** resulted compounds showed excellent AIE characteristics with tunable maximum emissions,attractive bioimaging performance,and potential anti-inflammatory activity,which exert broad application prospects in material,biology,medicine,and other relevant areas.

关键词： Aggregation-induced emission(AIE) Imidazo[1,5-a]pyridicnes Iodine bioimaging Anti-inflammatory

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Plio-Pleistocene sedimentation and palaeogeographic reconstruction in the Poso Depression,Central Sulawesi,Indonesia:from a sea channel to a land bridge

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Journal of Palaeogeography 2023年第3期12卷 331-357页

作者： Abang Mansyursyah Surya Nugraha Ramadhan Adhitama Adam D.Switzer Robert Hall Earth Observatory of singapore Nanyang Technological University50 Nanyang Ave.639798Singapore Fakultas Teknologi Kebumian dan Energi Universitas TrisaktiKampus A Gedung DJI.Kyai Tapa No.1GrogolJakarta 11441Indonesia Asian School of the Environment Nanyang Technological University50 Nanyang Ave.639798Singapore SE Asia Research Group Department of Earth SciencesRoyal Holloway University of LondonEghamSurreyTW200EXUK

The Poso Depression provides a record of Plio-Pleistocene environments and palaeogeography of Central ***-based sedimentological and provenance studies suggest that during the Pliocene the Poso Depression was a sea channel connecting Gorontalo and Bone bays formed in an asymmetric *** Pliocene history began with deposition of the Puna Formation with fan deltas at the eastern basin margin and channel complexes in the deep-water basin further *** of light and heavy minerals indicate the main sediment source was ultrabasic rocks in East Sulawesi with minor and intermittent magmatic and metamorphic input from West ***,in the Middle to Late Pliocene,carbonates of the Poso Formation accumulated on the eastern basin *** are unconformably overlain by shallow marine glaucophane-rich siliciclastics of the Pleistocene Lage Formation that are associated with the rapid exhu-mation and uplift of the Pompangeo metamorphic *** uplift led to the development of a land bridge connecting western and eastern *** terrane evolution favoured increasing the area of exposed land due to rapid tectonic uplift,which when combined with the tropical climate,contributed to faunal speciation and dispersal in Sulawesi.

关键词： Palaeogeography Poso Sulawesi Sedimentation history Provenance

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Multinational survey on the preferred approach to management of Barrett’s esophagus in the Asia-Pacific region

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 279-294页

作者： Guan Sen Kew Alex Yu Sen Soh Yeong Yeh Lee Takuji Gotoda Yan-Qing Li Yan Zhang Yiong Huak Chan Kewin Tien Ho Siah Daniel Tong Simon Ying Kit Law Andrew Ruszkiewicz Ping-Huei Tseng Yi-Chia Lee Chi-Yang Chang Duc Trong Quach Chika Kusano Shobna Bhatia Justin Che-Yuen Wu Rajvinder Singh Prateek Sharma Khek-Yu Ho Department of Gastroenterology and Hepatology University Medicine ClusterNational University Health SystemSingapore 119228Singapore Department of Gastroenterology and Hepatology National University HospitalNational University Health SystemSingapore 119074Singapore School of Medical Sciences Universiti Sains MalaysiaPenang 11800Malaysia Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineTokyo 173-8610Japan Department of Gastroenterology Laboratory of Translational GastroenterologyQilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Yong Loo Lin School of Medicine National University of SingaporeSingapore 119228Singapore Department of Surgery The University of Hong KongHong Kong PokfulamHong KongChina Department of Pathology SA PathologyAdelaide 5112Australia Department of Internal Medicine National Taiwan University HospitalTaipei 100Taiwan Department of Internal Medicine Fu Jen Catholic University HospitalTaipei 24352Taiwan Department of Internal Medicine University of Medicine and Pharmacy at Hochiminh CityVietnamHochiminh 70000Viet Nam Department of Gastroenterology Seth GS Medical College and King Edward Memorial HospitalMumbai 400012India Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Gastroenterology Lyell McEwin HospitalUniversity of AdelaideAdelaide 64128Australia Department of Gastroenterology and Hepatology Kansas City VA Medical CenterKansas CityKS 64128United States Department of Medicine National University HospitalSingapore 119074Singapore

BACKGROUND Major societies provide differing guidance on management of Barrett’s esophagus(BE),making standardization *** To evaluate the preferred diagnosis and management practices of BE among Asian *** Endoscopists from across Asia were invited to participate in an online questionnaire comprising eleven questions regarding diagnosis,surveillance and management of *** Five hundred sixty-nine of 1016(56.0%)respondents completed the survey,with most respondents from Japan(n=310,54.5%)and China(n=129,22.7%).Overall,the preferred endoscopic landmark of the esophagogastric junction was squamocolumnar junction(42.0%).Distal palisade vessels was preferred in Japan(59.0%vs 10.0%,P<0.001)while outside Japan,squamo-columnar junction was preferred(59.5%vs 27.4%,P<0.001).Only 16.3%of respondents used Prague C and M criteria all the *** was never used by 46.1%of Japanese,whereas 84.2%outside Japan,endoscopists used it to varying extents(P<0.001).Most Asian endoscopists(70.8%)would survey long-segment BE without dysplasia every two *** to Seattle protocol was poor with only 6.3%always performing it.73.2%of Japanese never did it,compared to 19.3%outside Japan(P<0.001).The most preferred(74.0%)treatment of non-dysplastic BE was proton pump inhibitor only when the patient was symptomatic or had *** BE with low-grade dysplasia,6-monthly surveillance was preferred in 61.9%within Japan vs 47.9%outside Japan(P<0.001).CONCLUSION Diagnosis and management of BE varied within Asia,with stark contrast between Japan and outside *** Asian endoscopists chose squamo-columnar junction to be the landmark for esophagogastric junction,which is *** also did not consistently use Prague criteria,and Seattle *** of standardization,education and research are possible reasons.

关键词： Barrett's esophagus Survey Asia-Pacific Asian Barrett's consortium Prague criteria Seattle protocol

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