Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis
作者单位：key Laboratory of Nutrition and MetabolismInstitute for Nutritional SciencesShanghai Institutes for Biological SciencesShanghai Burnham Institute for Medical ResearchOrlandoUSA Department of BiologyHHMIUniversity of UtahUSA Model Animal Research CenterNanjing University Singapore Bioimaging ConsortiumAgency for ScienceTechnology and Research Institute of BiophysicsChinese Academy of Sciences
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术...》
会议日期：2010年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
摘 要：Mammalian RNA editing catalyzed by adenosine deaminases acting on RNA(ADARs),ADAR1 and ADAR2,plays pivotal roles in the brain through functional modifications of neurotransmitter receptors and ion *** have previously demonstrated that RNA editing by ADAR2 is metabolically regulated in pancreatic *** investigate the cellular functions of ADAR2 in professional secretory cells,we studied the effects of ADAR2 knockdown on regulated *** knockdown of ADAR2