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Lithium-ion spontaneous exchange and synergistic transport in ceramic-liquid hybrid electrolytes for highly efficient lithium-ion transfer

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Science Bulletin 2022年第9期67卷 946-954,M0004页

作者： Kai Shi Likun Chen Zipei Wan Jie Biao Guiming Zhong Xue Li Lu Yang Jiabin Ma Wei Lv Fuzeng Ren Hongqi wang Yong Yang Feiyu Kang Yan-Bing He shenzhen Geim Graphene Center Institute of Materials Research(iMR)Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Laboratory of Advanced Spectro-electrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Liwang New Energy Co. Ltd.Dongguan 523731China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Department of ChemistryXiamen UniversityXiamen 361005China

Ceramic electrolytes are important in ceramic-liquid hybrid electrolytes(CLHEs),which can effectively solve the interfacial issues between the electrolyte and electrodes in solid-state batteries and provide a highly efficient Li-ion transfer for solid–liquid Li metal *** the ionic transport mechanisms in CLHEs and the corresponding role of ceramic electrolytes is crucial for a rational design ***,the Li-ion transfer in the ceramic electrolytes of CLHEs was confirmed by tracking the 6Li and 7Li substitution behavior through solid-state nuclear magnetic resonance *** ceramic and liquid electrolytes simultaneously participate in Li-ion transport to achieve highly efficient Li-ion transfer in CLHEs.A spontaneous Li-ion exchange was also observed between ceramic and liquid electrolytes,which serves as a bridge that connects the ceramic and liquid electrolytes,thereby greatly strengthening the continuity of Li-ion pathways in CLHEs and improving the kinetics of Li-ion *** importance of an abundant solid–liquid interface for CLHEs was further verified by the enhanced electrochemical performance in LiFePO4/Li and LiNi0.8Co0.1Mn0.1O2/Li batteries from the generated *** work provides a clear understanding of the Li-ion transport pathway in CLHEs that serves as a basis to build a universal Li-ion transport model of CLHEs.

关键词： Ceramic-liquid hybrid electrolyte Ceramic electrolyte Liquid electrolyte Li-ion exchange Li-ion transfer pathway

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The assessment of atrial function by velocity-encoded magnetic resonance imaging

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World Journal of Cardiovascular Diseases 2013年第2期3卷 18-24页

作者： Charles C. Vu John F. Heitner Igor Klem Peter J. Cawley Anna Lisa C. Crowley Manesh R. Patel Jonathan W. Weinsaft Michele A. Parker Michael Elliott Robert M. Judd Raymond J. Kim Joseph C. Greenfield Jr. Division of Cardiology New York Methodist Hospital Brooklyn USA Division of Cardiology New York Presbyterian Hospital Weill Cornell Medical Center New York USA Division of Cardiology University of Washington School of Medicine Seattle USA Duke Cardiovascular magnetic resonance Center Duke University Medical Center Durham USA Stony Brook School of Medicine Stony Brook USA

Introduction: The purpose of this study was to assess velocity-encoded cardiac magnetic resonance imaging (Ve-CMR) in a population of patients referred for cardiac magnetic resonance imaging (CMR), to determine the variability of atrial function, and to identify clinical parameters associated with left atrial function. Methods: This is a prospective study evaluating patients who were referred to our CMR center for a clinical CMR. Left atrial function was obtained via Ve-CMR thru-plane images across the mitral valve after acquiring 2 perpendicular in-plane images as “scouts”. The atrial function and mitral inflow were quantified by computer analysis (Argus, siemens). Atrial function was defined as atrial contraction (A-wave) volume divided by total inflow volume. Left atrial volumes were calculated via computer analysis. Mitral regurgitation and left ventricular ejection fractions were assessed visually. Results: Thirty-nine patients, with mean age 56 +/- 10 years, were enrolled. The mean left atrial function was 22.9% +/-14.5%;the range in left atrial function was 0% - 57%. There was a significant positive correlation between atrial function and increased left ventricular ejection fraction (r = 0.44, P < 0.01). There was a significant negative correlation between atrial function and severity of mitral regurgitation (r = -0.60, P < 0.01), as well as left atrial volume (r = -0.36, P = 0.02). Conclusion: Our results indicate a wide variability in left atrial function and a significant association between left atrial function and left ventricular ejection fraction, left atrial volume and mitral regurgitation.

关键词： Atrial Function Velocity-Encoded Cardiovascular magnetic resonance

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magnetic resonance imaging-guided focused ultrasound thalamotomy launch with remote telemedicine international proctorship

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Chronic Diseases and Translational Medicine 2024年第1期10卷 40-50页

作者： Igor V.Buzaev Rezida M.Galimova Dinara I.Nabiullina Sergey N.Illarioshkin Naufal Sh.Zagidullin Shamil M.Safin Department of Surgery Bashkir State Medical UniversityUfaRussia Intelligent Neurosurgery Clinic Ltd.International Medical Center V.S.Buzaev memorialUfaRussia Directorate Research Center of NeurologyVolokolamskoye ShosseMoscowRussia

Background: COVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the *** share our first experience of magnetic resonance imaging(MRI)-guided focused ultrasound(MRgFUS)treatment with an international remote online proctorship,and develop and evaluate the methodology of remote MRgFUS ***: This single-center,nonrandomized controlled prospective study included 94 patients:27 with essential tremor(ET)and 67 with tremor-dominant Parkinson's disease(PD).The coming of proctors was impossible,so we arranged for the remote participation of proctors from the United Kingdom,Spain,and Israel.A total of 38 patients(40.4%)received telemedicine-proctored treatment(proctor group)and 56 received their treatment independently(solo group).We used the Clinical Rating Scale for Tremor(CRST)for ET patients and the Unified Parkinson's Disease Rating Scale(UPDRS)Part III for PD ***: In patients with ET,success rates were 81.8%(proctor group)and 100%(solo group)(p=0.22).CRST reduction on the treated side was 71.43%[65.83%;80.56%](proctor group)versus 60.87%[53.99;79.58](solo group)(p=0.19).None of the patients showed worsening of tremors within 1 *** patients with PD,the success rates were 92.6%(proctor group)and 100%(solo group)(p=0.08).The UPDRS Part III improvement was 30.1%(proctor group)versus 39.9%(solo group)(p=0.003).The 1-year recurrence rate was 40%(proctor group)and 17.5%(solo group)(p=0.04).No complications were observed at 6 ***: We developed a feasible and safe methodology for telemedicine remote online-proctored MRgFUS *** significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate,effect,and long-term results;however,UPDRS Part III improvement was better in the PD solo *** study demonstrated that the MRgFUS international proctorship can be performed successfully remotely.

关键词： essential tremor MRgFUS Parkinson's disease proctor telemedicine

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Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong Rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu Xiaohong Liu Zhenghao Li Kaixian Chen Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

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Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging

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Chinese Journal of Cancer Research 2015年第3期27卷 231-238页

作者： Chenlu Feng Peiyi Gao Xiaoguang Qiu Tianyi Qian Yan Lin Jian Zhou Binbin Sui Department of Radiology Beijing Tiantan HospitalCapital Medical University Beijing Neurosurgical Institute Department of Radiotherapy Beijing Tiantan HospitalCapital Medical University MR Collaboration NE Asia Siemens Healthcare

Objective： To evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging（DCEMRI） for predicting tumor response to radiotherapy in patients with suspected primary central nervous system（CNS） germ cell tumors（GCTs）.Methods： DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic（ROC） curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC ***： A significant elevation in transfer constant（K^trans） and extravascular extracellular space（Ve）（P=0.000）, as well as a significant reduction in rate constant（Kep）（P=0.000） was observed in tumors. K^trans, relative K^trans, and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative K^trans showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value（PPV） of 95.8%, and negative predictive value（NPV） of 100%.Conclusions： Relative K^trans appeared promising in predicting tumor response to radiation therapy（RT）. It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT.

关键词： Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) extravascular extracellular space germ cell tumors (GCTs) radiosensitivity rate constant transfer constant

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PROFESSOR BRITTON CHANCE AND THE EARLY TIMES HE LIVED

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 215-219页

作者： HIDEAKI KOIZUMI Hitachi Ltd.

*** Professor Britton Chance passed away on November 16,*** on July 24,1913,he was 97 years old when he died.I was honored to have had the opportunity to meet Professor Chance and have friendly conversation at the ear... 详细信息

关键词： Chance passed conversation

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Nb_(3)Sn六极复合超导磁体测试全过程的实时分布式应变检测:从组装到励磁

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Acta Mechanica Sinica 2024年第4期40卷 78-88页

作者：王省哲杨韬略关明智辛灿杰吴北民吴魏孙良亭赵红卫周又和 Key Laboratory of Mechanics on Western Disaster and Environment Ministry of EducationCollege of Civil Engineering and MechanicsLanzhou UniversityLanzhou730000China China Southern Power Grid Technology Co. Ltd.Guangzhou510080China Institute of Modern Physics Chinese Academy of SciencesLanzhou730000China Advanced Energy science and technology Guangdong Laboratory Huizhou516000China

六极Nb_(3)Sn超导磁体系统是第四代电子回旋共振离子源(FECR)中的核心部件.这些超导磁体处于高磁场、超低温以及高应力的极端运行环境,由此关联的磁体应力/应变特征和行为的精确表征对于确保系统可靠性和最优功能实现极具重要意义.传统... 详细信息

六极Nb_(3)Sn超导磁体系统是第四代电子回旋共振离子源(FECR)中的核心部件.这些超导磁体处于高磁场、超低温以及高应力的极端运行环境,由此关联的磁体应力/应变特征和行为的精确表征对于确保系统可靠性和最优功能实现极具重要意义.传统的单点应变测量技术仅能实现局部小区域的测量,并且存在显著的电磁干扰等,这些局限性严重影响了测量精度和可靠性,使得大型复杂超导磁体极端多场下的力学测量面临着诸多挑战.本文建立了低温极端多场下的光纤测量新技术,可实现六极复合超导磁体的实时、分布式应变测量.该测量系统基于光频域反射技术(OFDR)和高空间分辨率分布式光纤技术,首次实现了超导磁体系统的组装、冷却、励磁及失超全过程中应变状态的实时监测.相关结果有效揭示了超导磁体在整个运行过程中的全局应变特性,如磁体内部全局应变状态的非对称分布现象等.本文研究对于超导磁体研制中的实时和全局力学性能监测和评估提供了有效途径.

关键词：超导磁体励磁应变状态失超力学测量分布式光纤电磁干扰应变特性

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Associating Preoperative MRI Features and Gene Expression Signatures of Early-stage Hepatocellular Carcinoma Patients using Machine Learning

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 63-71页

作者： Xiaoming Li Lin Cheng Chuanming Li Xianling Hu Xiaofei Hu Liang Tan Qing Li Chen Liu Jian Wang Department of Radiology Southwest HospitalThird Military Medical University(Army Military Medical University)Chong-qingChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Military Medical University)ChongqingChina Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina MR Collaborations Siemens Healthcare Ltd.ShanghaiChina

Background and Aims:The relationship between quanti-tative magnetic resonance imaging(MRI)imaging features and gene-expression signatures associated with the recur-rence of hepatocellular carcinoma(HCC)is not well ***:In this study,we generated multivariable regres-sion models to explore the correlation between the preoper-ative MRI features and Golgi membrane protein 1(GOLM1),SET domain containing 7(SETD7),and Rho family GTPase 1(RND1)gene expression levels in a cohort study including 92 early-stage HCC patients.A total of 307 imaging features of tumor texture and shape were computed from T2-weighted *** key MRI features were identified by performing a multi-step feature selection procedure including the cor-relation analysis and the application of RELIEFF ***,regression models were generated using kernel-based support vector machines with 5-fold ***:The features computed from higher specificity MRI better described GOLM1 and RND1 gene-expression levels,while imaging features computed from lower specificity MRI data were more descriptive for the SETD7 *** GOLM1 regression model generated with three features demon-strated a moderate positive correlation(p<0.001),and the RND1 model developed with five variables was positively as-sociated(p<0.001)with gene expression ***,RND1 regression model integrating four features was mod-erately correlated with expressed RND1 levels(p<0.001).Conclusions:The results demonstrated that MRI radiomics features could help quantify GOLM1,SETD7,and RND1 ex-pression levels noninvasively and predict the recurrence risk for early-stage HCC patients.

关键词： Hepatocellular carcinoma Gene-expression MRI Radiomics feature

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Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model

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Light(Science & Applications) 2021年第10期10卷 1863-1876页

作者： Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteMed-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China Key Lab of magnetic resonance Imaging Device and Technique Beijing 100191China Zhejiang Brainhealth Medical Technology Co. LtdHangzhou 314400China Biomedical Pioneering Innovation Center Peking UniversityBeijing 100871China School of Life Sciences Peking UniversityBeijing 100871China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Tianqiao and Chrissy Chen Institute for Clinical Translational Research Huashan HospitalShanghai 200040China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Biomedical Engineering Department Peking UniversityBeijing 100081China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142China

Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained ***,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of *** glial cells,including microglia and astrocytes,play important roles in Aβ*** results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD *** 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD ***,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβ*** study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD.

关键词： Aβ Alzheimer cerebral

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R2^(*) value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions

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World Journal of Gastroenterology 2021年第12期27卷 1182-1193页

作者： Guang-Zi Shi Hong Chen Wei-Ke Zeng Ming Gao Meng-Zhu Wang Hui-Ting Zhang Jun Shen Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina MR Scientific Marketing Siemens HealthineersGuangzhou 510120Guangdong ProvinceChina

BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are *** To investigate whether R2^(*)derived from multi-echo Dixon imaging can aid differentiating benign from malignant focal liver lesions(FLLs)and the impact of 2D region of interest(2D-ROI)and volume of interest(VOI)on the *** We retrospectively enrolled 73 patients with 108 benign or malignant *** patients underwent conventional abdominal magnetic resonance imaging and multi-echo Dixon *** radiologists independently measured the mean R2^(*)values of lesions using 2D-ROI and VOI *** Bland-Altman plot was used to determine the interobserver agreement between R2^(*)*** correlation coefficient(ICC)was used to determine the reliability between the two *** R2^(*)values were compared between benign and malignant FFLs using the nonparametric Mann-Whitney *** operating characteristic curve analysis was used to determine the diagnostic performance of R2^(*)in differentiation between benign and malignant *** compared the diagnostic performance of R2^(*)measured by 2D-ROI and VOI *** This study included 30 benign and 78 malignant *** interobserver reproducibility of R2^(*)measurements was excellent for the 2D-ROI(ICC=0.994)and VOI(ICC=0.998)***-Altman analysis also demonstrated excellent *** R2^(*)was significantly higher for malignant than benign FFLs as measured by 2D-ROI(P<0.001)and VOI(P<0.001).The area under the curve(AUC)of R2^(*)measured by 2D-ROI was 0.884 at a cut-off of 25.2/s,with a sensitivity of 84.6%and specificity of 80.0%for differentiating benign from malignant FFLs.R2^(*)measured by VOI yielded an AUC of 0.875 at a cut-off of 26.7/s in distinguishing benign from malignant FFLs,with a sensitivity of 85.9%and specificity of 76.7%.The AUCs of R2^(*)were

关键词： R2^(*) Multi-echo Dixon imaging Hypoxia Malignant lesion Benign lesion Focal liver lesion

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