R2^(*) value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions

作     者：Guang-Zi Shi Hong Chen Wei-Ke Zeng Ming Gao Meng-Zhu Wang Hui-Ting Zhang Jun Shen 

作者机构：Department of RadiologySun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina MR Scientific MarketingSiemens HealthineersGuangzhou 510120Guangdong ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第12期

页      面：1182-1193页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：R2^(*) Multi-echo Dixon imaging Hypoxia Malignant lesion Benign lesion Focal liver lesion 

摘      要：BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are *** To investigate whether R2^(*)derived from multi-echo Dixon imaging can aid differentiating benign from malignant focal liver lesions(FLLs)and the impact of 2D region of interest(2D-ROI)and volume of interest(VOI)on the *** We retrospectively enrolled 73 patients with 108 benign or malignant *** patients underwent conventional abdominal magnetic resonance imaging and multi-echo Dixon *** radiologists independently measured the mean R2^(*)values of lesions using 2D-ROI and VOI *** Bland-Altman plot was used to determine the interobserver agreement between R2^(*)*** correlation coefficient(ICC)was used to determine the reliability between the two *** R2^(*)values were compared between benign and malignant FFLs using the nonparametric Mann-Whitney *** operating characteristic curve analysis was used to determine the diagnostic performance of R2^(*)in differentiation between benign and malignant *** compared the diagnostic performance of R2^(*)measured by 2D-ROI and VOI *** This study included 30 benign and 78 malignant *** interobserver reproducibility of R2^(*)measurements was excellent for the 2D-ROI(ICC=0.994)and VOI(ICC=0.998)***-Altman analysis also demonstrated excellent *** R2^(*)was significantly higher for malignant than benign FFLs as measured by 2D-ROI(P0.001)and VOI(P0.001).The area under the curve(AUC)of R2^(*)measured by 2D-ROI was 0.884 at a cut-off of 25.2/s,with a sensitivity of 84.6%and specificity of 80.0%for differentiating benign from malignant FFLs.R2^(*)measured by VOI yielded an AUC of 0.875 at a cut-off of 26.7/s in distinguishing benign from malignant FFLs,with a sensitivity of 85.9%and specificity of 76.7%.The AUCs of R2^(*)were