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Muscle-inspired soft robots based on bilateral dielectric elastomer actuators

Microsystems & Nanoengineering 2023年第5期9卷 245-254页

作者： Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu State Key laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)ChengduPR China Chongqing Key laboratory of Materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqingPR China hong kong Centre for Cerebro-Cardiovascular Health Engineering(COCHE) Hong KongSARChina Department of Biomedical Engineering City University of Hong KongHong KongSARChina

Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot *** soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft ***,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft *** construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator *** end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation *** on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was ***,the directional steering was instantaneous and *** two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°***,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was *** bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots.

关键词： robot artificial dielectric

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From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading

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Bioactive Materials 2020年第1期5卷 17-25页

作者： Tong Yang Zeyu Du Hua Qiu Peng Gao Xin Zhao Huaiyu Wang Qiufen Tu Kaiqin Xiong Nan Huang Zhilu Yang Key laboratory of Advanced Technology for Materials of the Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical ***,the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring ***,we propose a novel concept of film engineering strategy“from surface to bulk synergetic modification”.This new concept is realized by employing the surface amine groups of plasma polymerized allylamine(PPAm)film for grafting a molecule e.g.,thrombin inhibitor,bivalirudin(BVLD),meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide(NO)gas as supplement to the functions of *** is demonstrated that such a“from surface to bulk synergetic modification”film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions,giving rise to a highly endotheliummimetic thromboresistant *** believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties,which will find broad biomedical applications in blood-contacting devices,and et ***,it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials.

关键词： Surface chemistry Amine-bearing coating Synergic modification Biomolecule grafting Nitric oxide loading

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The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit

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Psychoradiology 2023年第1期3卷 242-253页

作者： Qian Zhuang Lei Qiao Lei Xu Shuxia Yao Shuaiyu Chen Xiaoxiao Zheng Jialin Li Meina Fu Keshuang Li Deniz Vatansever Stefania Ferraro Keith M.Kendrick Benjamin Becker The Center of Psychosomatia medicine Sichuan Provincial Center for Mental HealthSichuan Provincial People's HospitalThe University of Eectronic Science and Technology of ChinaChengduSichuan Province 611731China Center for Cognition and Brain Disorders The Affliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang Province 11121 China School of Psychology Shenzhen UniversityShenzhen 518060China Institute of Brain and Psychological Sciences Sichuan Normal UniversityChengdu610068China Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Psychology and Cognitive Science East China Normal UniversityShanghai 200062China Institute of Science and Technology for Brain-Inspired Itelligence Fudan UniversityShanghai 200433China State Key laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong 99077 China Department of Psychology The University of Hong Kong Hong Kong 990777 China

Background:The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal ***,the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains ***:The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors(***)and behavioral ***:Here,we capitalize on the recent progress in robust and biologically plausible directed causal modeling(DCM-PEB)and a large response inhibition dataset(n=250)acquired with concomitant functional magnetic resonance imaging to determine key nodes,their causal regulation and modulation via biological variables(sex)and inhibitory performance in the inhibitory circuit encompassing the right inferior frontal gyrus(rIFG),caudate nucleus(rCau),globus pallidum(rGP),and thalamus(rThal).Results:The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and *** comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and *** addition,sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation,while better inhibitory performance was associated with stronger rThal to rIFG ***,control analyses did not reveal a similar key communication in a left lateralized ***:Together,these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.

关键词： response inhibition basal ganglia inferior frontal gyrus effective connectivity DCM

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Machine-learning-facilitated earthquake and anthropogenic source detections near the Weiyuan Shale Gas Blocks,sichuan,China

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Earth and Planetary Physics 2021年第6期5卷 501-519页

作者： PengCheng Zhou William L.Ellsworth hongFeng Yang Yen Joe Tan Gregory C.Beroza MinHan Sheng RiSheng Chu Key laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510301China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongSha TinHong Kong 999077China Department of Geophysics Stanford UniversityStanfordCA 94305USA State Key laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China

Seismic hazard assessment and risk mitigation depend critically on rapid analysis and characterization of earthquake *** seismicity in shale gas blocks of the sichuan Basin,China,has presented a serious challenge to monitoring and managing the seismicity *** this study,to detect events we apply a machine-learning-based phase picker(PhaseNet)to continuous seismic data collected between November 2015 and November 2016 from a temporary network covering the Weiyuan Shale Gas Blocks(SGB).Both P-and S-phases are picked and associated for *** refine the velocity model by using detected explosions and earthquakes and then relocate the detected events using our new velocity *** detections and absolute relocations provide the basis for building a high-precision earthquake *** primary catalog contains about 60 times as many earthquakes as those in the catalog of the chinese Earthquake Network Center(CENC),which used only the sparsely distributed permanent *** also measure the local magnitude and achieve magnitude completeness of *** relocate clusters of events,showing sequential migration patterns overlapping with horizontal well branches around several well pads in the Wei202 and Wei204 *** results demonstrate the applicability of a machine-learning phase picker to a dense seismic *** algorithms can facilitate rapid characterization of earthquake sequences.

关键词： induced seismicity machine learning Weiyuan Shale Gas Block

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High-resolution velocity structure and seismogenic potential of strong earthquakes in the Bamei-Kangding segment of the Xianshuihe fault zone

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Science China Earth Sciences 2023年第9期66卷 1960-1978页

作者： Yan ZHAO Junlun LI Jian XU Huajian YAO Gaohua ZHU hongfeng YANG Jinyu ZHANG Renqi LU laboratory of Seismology and Physics of the Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China Key laboratory of Marine Geology and Environment CASQingdao 266071China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongHong Kong 999077China State Key laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China

On September 5,2022,a strong MS6.8 earthquake struck the Luding area in the Kangding-Moxi segment of the Xianshuihe fault zone,which is the northern boundary of the sichuan-Yunnan rhombic block,causing considerable *** Bamei-Kangding segment of the Xianshuihe fault zone,which is located only tens of kilometers away from the Luding earthquake,has hosted frequent moderate to strong earthquakes in history and is a dangerous earthquake-prone ***,it is critical to investigate the regional seismogenic environment for strong earthquakes and to evaluate the impact of the Luding earthquake in this *** this purpose,we deployed a dense seismic array comprising over 200 short-period nodes in this region from July to August,2022 and acquired seismic ambient noise for over 30 *** the collected data,we conducted surface wave tomography and obtained a high-resolution 3-D shear wave velocity model for the regional shallow crust down to 8 km in *** key findings include:(1)the Bamei-Kangding segment of the Xianshuihe fault zone exhibits widespread stripped lowvelocity anomalies,suggesting shear movements at a relatively high temperature of the Xianshuihe fault zone;the Zheduoshan granitic pluton situated between the Zheduotang and southern Selaha faults shows a distinct low-velocity anomaly,which may be attributed to the localized high-temperature anomaly resulted by a deep magmatic heat source and the recent rapid uplift of the Zheduoshan area;(2)a ten-kilometer-wide high velocity body found below 4 km in depth near the Zhonggu area in the Bamei segment coincides with the seismic gap of moderate to strong earthquakes in this region,suggesting that the high velocity body may act as a seismic barrier;(3)the heterogeneity of the velocity structure along the Bamei-Kangding segment of the Xianshuihe fault zone corresponds to the regional changes in temperature,which reveals the reason for the spatially varying seismogenic potential in this segment;e

关键词： Xianshuihe fault zone Bamei-Kangding segment Luding earthquake Dense-array ambient noise tomography Seismogenic environment for moderate to strong earthquakes

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Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2472-2483页

作者： Lin Gao Shanze Chen Malin hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou Department of Clinical Medical Research Center The Second Clinical Medical CollegeJinan University(Shenzhen Peopled Hospital)The First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdongPR China Integrated chinese and Western medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdongPR China Department of Respiratory and Critical Care medicine First Affiliated Hospital of Southern University of Science and TechnologyThe Second Clinical Medical CollegeJinan University(Shenzhen Peopled Hospital)Shenzhen Institute of Respiratory DiseasesShenzhenGuangdongPR China Shenzhen Public Service Platform on Tumor Precision medicine and Molecular Diagnosis the Second Clinical Medical CollegeJinan University(Shenzhen People's Hospital)ShenzhenGuangdongPR China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengduPR China Guangdong Provincial Key laboratory of Regional Immunity and Diseases Department of Pharmacology and International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdongChina Department of Integrated chinese and Western medicine Jinan UniversityGuangzhouGuangdongPR China School of Life and Health Sciences The Chinese University of Kong HongShenzhenChina Warshel Institute for Computational Biology The Chinese University of HongKongShenzhenChina Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduPR China

Triple-negative breast cancer(TNBC)is the most challenging subtype of breast *** endeavor has been made to explore the molecular biology basis of ***,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in ***1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor *** functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and ***-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further ***8 depletion inhibited the tumorigenesis and progression of ***,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in ***,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of ***,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 *** together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and ***1 may be a potential molecular target for the development of TNBC treatment.

关键词： inhibited breast cancer

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Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies

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Environmental Science and Ecotechnology 2022年第1期9卷 1-9页

作者： Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang Institute of Climate Change and Sustainable Development Tsinghua UniversityBeijing100084China Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China Institute of Energy Environment and EconomyTsinghua UniversityBeijing100084China laboratory of Low Carbon Energy Tsinghua UniversityBeijing100084China Energy Research Institute Chinese Academy of Macroeconomic ResearchBeijing100038China Division of Public Policy Hong Kong University of Science and TechnologyHong KongChina

As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 *** study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each *** study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for *** comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment *** example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be *** technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough *** needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans.

关键词： China Carbon neutrality The paris agreement Transition pathway Strategy

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Inter-zone constraint modifies the stress-strain response of the constituent layer in gradient structure

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Science China Materials 2021年第12期64卷 3114-3123页

作者： Yanfei Wang Yuntian Zhu Xiaolei Wu Yueguang Wei Chongxiang Huang School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China Department of Materials Science and Engineering City University of Hong KongHong KongChina State Key laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China

How an individual constituent zone behaves during the deformation of a heterostructured metallic material is a fundamental issue for understanding heterostructure deformation, but it remains a challenge to experimentally observe it. Here we report a study on the stress-strain behavior of the nanostructured gradient layer(NGL) in an integrated gradient specimen that consists of a coarse-grained(CG)central layer sandwiched between two NGLs. Constraint from the CG central layer led to the formation of dense and dispersed stable strain bands(SBs) in the NGL, which regained dislocation hardening after initial recovery and grain coarsening. Consequently, the NGL exhibited a transient plateau of flow stress after yielding, and then regained extra strain hardening to achieve excellent uniform elongation. These unique behaviors are dramatically different from those of a freestanding NGL, indicating a fundamentally different deformation principle that is intrinsic to heterostructures, i.e.,inter-zone constraint modifies the constitutive behavior of constituent zones.

关键词： heterogeneous structure nanostructure stress-strain response strain bands strength and ductility

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Overcoming cancer therapeutic bottleneck by drug repurposing

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1449-1473页

作者： Zhe Zhang Li Zhou Na Xie Edouard CNice Tao Zhang Yongping Cui Canhua Huang State Key laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduChina Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia The School of Biological Science and Technology Chengdu Medical College610083 ChengduChina Department of Oncology The Second Affiliated Hospital of Chengdu Medical CollegeChina National Nuclear Corporation 416 HospitalChengdu610051 SichuanChina Cancer Institute Peking University Shenzhen HospitalShenzhen Peking University—the Hong Kong University of Science and Technology(PKU-HKUST)Medical Centerand Cancer InstituteShenzhen Bay Laboratory Shenzhen518035 ShenzhenChina Department of Pathology&Shanxi Key laboratory of Carcinogenesis and Translational Research on Esophageal Cancer Shanxi Medical UniversityTaiyuan030001 ShanxiChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengdu611137 SichuanChina

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic *** strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical *** an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic ***“treasure trove”of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of ***,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to *** this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination *** also summarize approaches used for drug repurposing and discuss the main barriers to its uptake.

关键词： drugs therapeutic classify

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Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges

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High Voltage 2022年第4期7卷 610-632页

作者： Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin Wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang Yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao Wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng Wang Yunlong Zi The State Key laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijingChina Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina Simpson Querrey Institute Northwestern UniversityEvanstonIllinoisUSA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Information Technology and Electrical Engineering ETH ZürichZürichSwitzerland School of Electrical and Information Engineering Tianjin UniversityTianjinChina Department of Electrical and Computer Engineering Mississippi State UniversityMississippi StateMississippiUSA Electrical and Electronic Engineering The University of ManchesterManchesterUK Department of Electrical Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiChina Key laboratory of Control of Power Transmission and Conversion(SJTU) Ministry of EducationShanghaiChina College of Electrical Engineering Sichuan UniversityChengduChina Shenzhen Institute of Advanced Technology Chinese Academy of Sciences ShenzhenShenzhenChina School of Electrical Engineering Wuhan UniversityWuhanChina School of Integrated Circuits Tsinghua UniversityBeijingChina Jiangsu Jinxin Electric Appliance Co.Ltd. YangzhouChina Tai'an Tiancheng Safety Evaluation Co. Ltd.Tai'anChina Department Electrical Electronic and Information EngineeringUniversity of BolognaBolognaItaly National Engineering laboratory for Big Data Analysis and Applications Peking UniversityBeijingChina Laplace Paul Sabatier Universityand CNRSToulouseFrance Electrical and Computer Engineering University of ConnecticutStorrsConnecticutUSA State Key laboratory of Power Transmission Equipment&System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqingChina Thrust of Sustainable Energy and Environment The Hong Kong University of Science and Technology(Guangzhou)GuangzhouChina De

The 2050 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment *** material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and *** goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first *** engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are *** materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being *** the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material *** is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality *** authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision.

关键词： neutral insulation extreme

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