Overcoming cancer therapeutic bottleneck by drug repurposing

作     者：Zhe Zhang Li Zhou Na Xie Edouard CNice Tao Zhang Yongping Cui Canhua Huang Zhe Zhang;Li Zhou;Na Xie;Edouard C.Nice;Tao Zhang;Yongping Cui;Canhua Huang

作者机构：State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduChina Department of Biochemistry and Molecular BiologyMonash UniversityClaytonVICAustralia The School of Biological Science and TechnologyChengdu Medical College610083 ChengduChina Department of OncologyThe Second Affiliated Hospital of Chengdu Medical CollegeChina National Nuclear Corporation 416 HospitalChengdu610051 SichuanChina Cancer InstitutePeking University Shenzhen HospitalShenzhen Peking University—the Hong Kong University of Science and Technology(PKU-HKUST)Medical Centerand Cancer InstituteShenzhen Bay Laboratory Shenzhen518035 ShenzhenChina Department of Pathology&Shanxi Key Laboratory of Carcinogenesis and Translational Research on Esophageal CancerShanxi Medical UniversityTaiyuan030001 ShanxiChina School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengdu611137 SichuanChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2020年第5卷第1期

页      面：1449-1473页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Chinese NSFC(nos.81821002,81790251,and 81773143) Guangdong Basic and Applied Basic Research Foundation(2019B030302012) 

主　　题：drugs therapeutic classify 

摘      要：Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic *** strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical *** an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic ***“treasure troveof non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of ***,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to *** this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination *** also summarize approaches used for drug repurposing and discuss the main barriers to its uptake.