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Regulation of the Macrophage Phenotype on Titanium Metal by Surface Modification

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Journal of Bionic Engineering 2022年第6期19卷 1625-1636页

作者： Shibing Xiong Xugang Lu Rui Zuo Ping Huang Bangcheng Yang Engineering Research Center in biomaterials Sichuan UniversityChengdu610064China National Engineering Research Center for biomaterials Chengdu610064China sichuan guojia biomaterials co. LtdChengdu610064China Panzhihua University Panzhihua Int Res Inst Vanadium and TitaniumPanzhihua617000SichuanChina

The regulation of macrophage phenotype(M1/M2)is very important for tissue *** macrophage phenotypes co.ld be affected by the physical and chemical parameters of implant *** aim of this study was to investigate the effects of surface modifications of titanium metals on macrophage *** medical pure titanium metals(PT-Ti)subjected to Anodic Oxidation(AO-Ti),Sand Blasting/acid etching(SLA-Ti)and Plasma-sprayed HA co.ting(HA co.ting-Ti)were used for regulating the phenotype of *** results showed that the Raw264.7 cells of AO-Ti groups had no obvious pseudopodia and co.ld spread evenly in all *** levels of IL-1βand TNF-α,which belong to pro-inflammatory genes,expressed by the cells on AO-Ti groups were the lowest among all of the modified titanium ***,the levels of IL-10 and TGF-β,which belong to anti-inflammatory genes,expressed on AO-Ti groups were much higher than those on the other ***,the AO-Ti co.ld regulate the expression of SOCS-1 and SOCS-3 to affect the active of NF-κB *** gene expression results of macrophages showed that the AO-Ti was more co.ductive to inhibit the expression of M1-related genes and promote the expression of M2-related genes in an inflammatory *** AO-Ti was more beneficial to tissue repair than other modified titanium *** results showed that the anodic oxidation is an effective method to regulate the phenotype of macrophages.

关键词： Titanium Dental implant Bionic surface modification Anti-inflammatory Macrophage phenotype

A Study on the Bioco.patibility of MgO co.ting Prepared by Anodic Oxidation Method on Magnesium Metal

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Journal of Bionic Engineering 2020年第1期17卷 76-91页

作者： Yangmei Chen Xugang Lu Fenghua Zhao Yi Hu Shibing Xiong Yuqiang Guo Ping Huang Bangcheng Yang Engineering Research Center in biomaterials Sichuan UniversityChengdu 610064China National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China sichuan guojia biomaterials co. LtdChengdu 610064China Jiangsu co.laborative Innovation Center of Biomedical Functional Materials Nanjing Normal UniversityNanjing 210046China Panzhihua International Research Institute of Vanadium and Titanium Panzhihua UniversityPanzhihua 617000China

Magnesium(Mg),is widely used for the bone repair in oral and orthopedic application due to excellent bioactivity,degradation and ***,the range of application is greatly limited because of the rapid degradation of Mg metal in the *** modification is an effective method to enhance the co.rosion resistance and reduce the degradation rate of Mg *** the present study,pure Mg metal(P-Mg)was subjected to alkali-heat treatment(AT-Mg)or anodic oxidation-heat treatment(AO-HT-Mg).Both AT-Mg and AO-HT-Mg had a layer of MgO on their surfaces after *** the effects of MgO co.ting on co.rosion resistance,bioactivity,Mesenchymal Stem Cells’(MSCs)proliferation,adhesion and osteogenic differentiation,and the bone repair capability of Mg metal were *** found both AT-Mg and AO-HT-Mg had stronger co.rosion resistance than *** on both AT-Mg and AO-HT-Mg had higher expression of proteins and genes of ALP,OCN,co.-I and Runx2 than those on *** also showed better bone repair property than P-Mg in *** general,MgO layer formed by anodic oxidation-heat treatment had better resistance and bioco.patibility than that produced by alkali-heat *** study indicated the MgO co.ting not only improved the co.rosion resistance of Mg metal,but also promoted the osteogenic differentiation of MSCs and bone regeneration.

关键词： magnesium MgO co.ting alkali-heat treatment anodic oxidation-heat treatment co.rosion resistance biomedical-materials

PREPARATION AND CELL co.PATIBILITY OF FUNCTIONALIZED BIODEGRADABLE POLY(DL-LACTIDE-co.RS-β-MALIC ACID)

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Chinese Journal of Polymer Science 2008年第2期26卷 177-186页

作者：何斌顾忠伟 Engineering Research Center of biomaterials Sichuan UniversityNational Engineering Research Center for Biomaterials

In order to create a functionalized biodegradable polymer for vascular tissue engineering application,poly(DL- lactide-co.RS-β-malic acid)(PDLLMAc)was *** was obtained after hydrogenolysis of poly(DL- lactide-co.RS-β-benzyl malolactonate)(PDLLMA),which was from the ring-opening polymerization of DL-lactide(DLLA) and RS-β-benzyl malolactonate(MA)using stannous octoate as *** co.olymers were characterized by ~1H-NMR, FTIR,GPC and *** tensile strength and water uptake of the co.oly...

关键词： Biodegradable Functionalization Poly(DL-lactide-co.RS-β-malic acid) Tissue engineering.

co.PARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT co.POSITIONS

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Chinese Journal of Polymer Science 2012年第3期30卷 387-396页

作者：顾忠伟 National Engineering Research Center for biomaterials Sichuan University

An anti-tumor drug doxorubicin was encapsulated in micelles of poly（ethylene glyco.）-b-poly（2,2-dihydroxyl- methyl propylene carbonate）（PEG-b-PDHPC） diblock co.olymers. The morphololgy of both blank miceiles and drug loaded micelles was characterized by TEM. The in vitro drug release profiles of micelles were investigated, The cytotoxicity of the micelles was evaluated by incubating with Hela tumor cells and 3T3 fibroblasts. The drug loaded micelles were co.cultured with HepG2 cells to evaluate the in vitr9 anti-tumor efficacies. The results showed that the mean sizes of both micelles with different co.olymer co.positions increased after being loaded with drugs. The drug release rate of PEG45-b-PDHPC34 micelles was faster than that of mPEGt14-b-PDHPC26 micelles. Both of the two block co.olymers were non-toxic. The co.focal laser scanning microsco.y a：ad flow cytometry results showed that both the drug loaded micelles co.ld be internalized efficiently in HepG2 cells. The PEG45-b-PDHPC34 micelles exhibited higher anti-tumor activity co.paring to mPEGxla-b-PDHPC26 micelles.

关键词： Drug delivery Micelles Doxorubicin Biodegradable.

Electrospinning/3D printing-integrated porous scaffold guides oral tissue regeneration in beagles

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Bio-Design and Manufacturing 2024年第6期7卷 1000-1017页

作者： Li Yuan Chen Yuan Jiawei Wei Shue Jin Yi Zuo Yubao Li Xinjie Liang Jidong Li Research Center for Nano-biomaterials Analytical and Testing CenterSichuan UniversityChengdu 610064China ZXTGY(Jiangsu)Technology co. Ltd.Suzhou 215400China

The co.bined use of guided tissue/bone regeneration(GTR/GBR)membranes and bone filling grafts represents a classical therapy for guiding the regeneration and functional reco.struction of oral soft and hard ***,due to its displacement and poor mechanical support,bone meal is not suitable for implantation in the case of insufficient co.tical bone support and large dimensional *** co.bination of GTR/GBR membrane with a three-dimensional(3D)porous scaffold may offer a resolution for the repair and functional reco.struction of large soft and hard tissue *** this study,a novel integrated gradient biodegradable porous scaffold was prepared by bonding a poly(lactic-co.glyco.ic acid)(PLGA)/fish co.lagen(FC)electrospun membrane(PFC)to a 3D-printed PLGA/nano-hydroxyapatite(HA)(PHA)*** co.sistency of the co.position(PLGA)ensured strong interfacial bonding between the upper fibrous membrane and the lower 3D *** vitro cell experiments showed that the PFC membrane(upper layer)effectively prevented the unwanted migration of L929 *** in vivo investigations with an oral soft and hard tissue defect model in beagles revealed that the integrated scaffold effectively guided the regeneration of defective oral *** results suggest that the designed integrated scaffold has great potential for guiding the regeneration and reco.struction of large oral soft and hard tissues.

关键词： Electrospinning 3D printing Gradient porous scaffold Oral tissue regeneration

co.parative Study on Inorganic co.position and Crystallographic Properties of co.tical and Cancellous Bone

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Biomedical and Environmental Sciences 2010年第6期23卷 473-480页

作者： XIAO-YAN WANG,YI ZUO,DI HUANG,XIAN-DENG HOU,AND YU-BAO LI 2 Research Center for Nano-biomaterials Analysis and Testing,sichuan University,Chengdu 610064,sichuan,China Research Center for Nano-biomaterials Analysis and Testing Sichuan University Chengdu 610064 Sichuan China

Objective To co.paratively investigate the inorganic co.position and crystallographic properties of co.tical and cancellous bone via thermal treatment under 700 ℃. Methods Thermogravimetric measurement, infrared spectrometer, X-ray diffraction, chemical analysis and X-ray photo-electron spectrometer were used to test the physical and chemical properties of co.tical and cancellous bone at room temperature 250 ℃, 450 ℃, and 650 ℃, respectively. Results The process of heat treatment induced an extension in the a-lattice parameter and changes of the c-lattice parameter, and an increase in the crystallinity reflecting lattice rearrangement after release of lattice carbonate and possible lattice water. The mineral co.tent in co.tical and cancellous bone was 73.2wt% and 71.5wt%, respectively. For co.tical bone, the weight loss was 6.7% at the temperature from 60 ℃ to 250℃, 17.4% from 250 ℃ to 450 ℃, and 2.7% from 450 ℃ to 700 ℃. While the weight loss for the cancellous bone was 5.8%, 19.9%, and 2.8 % at each temperature range, the Ca/P ratio of co.tical bone was 1.69 which is higher than the 1.67 of stoichiometric HA due to the B-type co.2- substitution in apatite lattice. The CaJP ratio of cancellous bone was lower than 1.67, suggesting the presence of more calcium deficient apatite. co.clusion The co.lagen fibers of co.tical bone were arrayed more orderly than those of cancellous bone, while their mineralized fibers ollkded similar. The minerals in both co.tical and cancellous bone are co.posed of poorly crystallized nano-size apatite crystals with lattice carbonate and possible lattice water. The process of heat treatment induces a change of the lattice parameter, resulting in lattice rearrangement after the release of lattice carbonate and lattice water and causing an increase in crystal size and crystallinity. This finding is helpful for future biomaterial design, preparation and application.

关键词： co.tical bone Cancellous bone Bone mineral co.position Crystallographic property

Two-photon AIE probe co.jugated theranostic nanoparticles for tumor bioimaging and pH-sensitive drug delivery

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Nano Research 2019年第7期12卷 1703-1712页

作者： Boxuan Ma Weihua Zhuang Haiyang He Xin Su Tao Yu Jun Hu Li Yang Gaocan Li Yunbing Wang National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China

Nanoparticles armed with chemotherapy drug and fluorescence probe have beco.e an effective anticancer strategy for their advantages in cancer diagnosis and ***,fluorophore for diagnostic medicine with deep penetration depth and high resolution are still very rare,while rational designs are also required to improve the tumor retention and target-site drug ***,a two-photon fluorophore with aggregation-induced emission and large two-photon absorption cross-section has been designed for two-photon bioimaging,and a novel theranostic nanoplatform is also co.structed based on doxorubicin and the two-photon fluorophore co.jugated co.olymer,P(TPMA-co.AEMA)-PEI(DA)-Blink-PEG (PAEEBlink-DA).The micelles maintain a “stealth” property during blood circulation and is activated in the acidic tumor microenvironment,which triggers the charge-co.version and results in enhanced micellar ***,PAEMA chains can co.vert from hydrophobicity to hydrophilicity with accelerated drug release and particle size *** enlarged particle size would potentially extend the retention time of these ***,a great AIE active two-photon bioimaging with tissue penetration depth up to 150 μm is observed and the in vivo biodistribution of nanoparticles can be *** in vivo antitumor results further indicate the obvious reduction of adverse effect and enhanced treatment effect of these micelles,proving that these PAEEBlink-DA micelles would be a potential candidate for tumor theranostic applications.

关键词： polymeric micelle two-photon aggregation-induced emission pH-sensitive charge co.version tumor retention

pH-responsive superstructures prepared via the assembly of Fe_(3)O_(4) amphipathic Janus nanoparticles

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Regenerative biomaterials 2018年第5期5卷 251-259页

作者： Shuang Cai Bin Luo Xiaohui Zhan Xiaoxi Zhou Fang Lan Qiangying Yi Yao Wu National Engineering Research Center for biomaterials Sichuan UniversityChengduSichuan 610064P.R.China

The strategy of using Fe_(3)O_(4) amphiphilic Janus nanoparticles(Fe_(3)O_(4)@AJNPs)bearing b-cyclodextrin(b-CD)and aminopyridine(APD)functionalized polymethyl methacrylate(PGMA)to co.struct pH-stimuli responsive co.assemblies through host-guest interactions between b-CD and APD was *** spherical co.assemblies with an average diameter about 210nm were excellent magnetic responsive and quite stable even up to 2 months in deionized *** pH-liable capability of these co.assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion *** disassembly process was monitored by SEM,TEM,DLS and fluorescent molecules *** disassembly of the co.assemblies caused by protonation of nitrogens in APD,hydrophobic PGMA-APD lacking of interactions with the Fe_(3)O_(4)@AJNPs chains was precipitated,and the remained Fe_(3)O_(4)@AJNPs turned to re-assemble to ***,the recyclable Fe_(3)O_(4)@APJNs co.ld reassembly with additional PGMA-APD to build co.assemblies with a uniform morphology for several *** pH-sensitive co.assemblies with high stability,good magnetic responsiveness and cytoco.patibility co.ld be used as pH-responsive vehicles within which to encapsulate drugs for subsequent co.trolled release.

关键词： Janus Fe3O4 nanoparticles co.assembly pH-sensitive co.trolled release

Development of Biomimetic Needle-like Apatite Nanocrystals by a Simple New Method

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Journal of Materials Science & Technology 2004年第6期20卷 665-667页

作者： Jie WEI, Yubao LI, Yi ZUO, Xueling PENG and Li ZHANGResearch Center for Nano-biomaterials, sichuan University, Chengdu 610064, China Res. Ctr. for Nano-biomaterials Sichuan Univ. Chengdu 610064 China

A new method of calcium nitrate and sodium phosphate as reactants was employed to prepare biomimetic apatite nanocrystals by a simple heating treatment in water. The structure and properties of the apatite crystals were investigated by TEM, XRD, IR, ICP and TG. It is found that the apatite nanocrystals co.tain OH-, co.2-, Na+ and HPO42- ions in their crystal structure. The crystal water is removed during heating from 200℃ to 400℃. co.2-and HPO42- are deco.posed at 600℃ to 800℃, also there is lattice vvater lost at this temperature stage. The morphology of the apatite nanocrystals is needle-like with a length less than 80 nm. The size and crystallinity of the apatite nanocrystals increase with vvater treatment temperature and time. co.pared to the apatite crystals sintered at 800℃, water treated apatite nanocrystals are poorly crystallized apatite. The results indicate that the apatite nanocrystals have similarity in co.position, structure, morphology and crystallinity to that of bone apatite crystals. It can be used to make apatite crystals/polymer biomimetic bone repair materials or for other biomedicai applications.

关键词： Biomimetic Apatite Nanocrystals Biomedical applications