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Journal of Materials Science & Technology 2020年第10期42卷 176-186页

作者： Lu Zhang Yuanyuan Cui Fengli Yang Quan Zhang Juhua Zhang Mengting Cao Wei-Lin Dai Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai200433China shimadzu china co.ltd. Shanghai200233China

Metallic Ni bridged Ni S@mesoporous carbon nitride hybrids were for the first time fabricated through a one-pot electroless-assisted hydrothermal *** intimate Ni bridge between the interface of mesoporous carbon nitride and Ni S was confirmed by HRTEM and in-depth XPS analysis using an Ar+-cluster sputtering gun and a possible mechanism was put forward to elucidate the formation process of the unique *** adding any noble metals as cocatalysts,the optimized catalyst 10%NiS/mCN-160-12 showed a H2 evolution rate of 1419μmol·g^-1·h^-1,which is about 34 and 14 fold higher than that of bare mesoporous carbon nitride and Ni S,*** dramatically enhanced photocatalytic performance was mainly ascribed to the synergistic effect of Ni S cocatalyst loading and the formation of metallic Ni between the interface of mesoporous carbon nitride and Ni S,which served as a charge-transfer bridge to facilitate the transfer and separation of photo-induced electron-hole pairs.

关键词： Electroless-hydrothermal method Hydrogen production NiS/mesoporous carbon nitride Hybrids photocatalysts

The flavonoids from Pentorum chinense *** ferroptosis to alleviate sorafenib-induced liver injury in BRL-3A cells

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Traditional Medicine Research 2024年第2期9卷 18-26页

作者： Di Yang Bo-Wen Zhang Shan Lei Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Xue Tang Qi Zhao Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China Chengdu Analytical Applications Center Shimadzu(China)Co.Ltd.Chengdu 610023China

Background:Drug-induced liver damage is a severe medical issue that affects people all over the *** has some side effects that cause liver injury.A dietary medicinal plant called Penthorum chinense Pursh.(PCP)has hepatoprotective *** are currently few reports on PCP’s protective impact and mechanism against sorafenib-induced liver ***:To create a liver injury model,sorafenib was administered to BRL-3A *** viability assays,immunofluorescence tests,Western blotting,real-time quantitative PCR,and high-content imaging systems were utilized to examine PCP’s effect and ***:In this study,PCP treatment mitigated the liver damage caused by sorafenib by enhancing cell survival,lowering lipid reactive oxygen species and malondialdehyde levels,and elevating glutathione *** addition,PCP can enhance the protein expression of cystine/glutamate transporter xCT and glutathione peroxidase 4,reduce iron content and alleviate mitochondrial *** mechanism studies revealed that PCP inhibited ferroptosis by promoting the production of nuclear factor E2-related factor 2 nuclear translocation and subsequently affecting target genes(HO-1 and NQO1).conclusion:Together,PCP regulates the nuclear factor E2-related factor 2 pathway,which helps to lessen ferroptosis brought on by sorafenib.

关键词： sorafenib Pentorum chinense Pursh. ferroptosis oxidative stress Nrf2

Gas-phase synthesis of Ti_(2)CCl_(2) enables an efficient catalyst for lithiumsulfur batteries

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The Innovation 2024年第1期5卷 33-40页

作者： Maoqiao Xiang Zihan Shen Jie Zheng Miao Song Qiya He Yafeng Yang Jiuyi Zhu Yuqi Geng Fen Yue Qinghua Dong Yu Ge Rui Wang Jiake Wei Weiliang Wang Haiming Huang Huigang Zhang Qingshan Zhu Chuanfang John Zhang State Key Laboratory of Multiphase complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of the Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China china Nuclear Power Engineering co. Ltd.117 West Third Ring RoadNorth SectionBeijing 100840China college of Materials Science&Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Physics Guangdong Province Key Laboratory of Display Material and TechnologyCenter for Neutron Science and TechnologySun Yat-sen UniversityGuangzhou 510275China Solid State Physics&Material Research Laboratory School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China

MXenes have aroused intensive enthusiasm because of their exotic properties and promising ***,to date,they are usually synthesized by etching *** synthetic technologies provides more opportunities for innovation and may extend unexplored ***,we report a bottom-up gas-phase synthesis of Cl-terminated MXene(Ti_(2)CCl_(2)).The gas-phase synthesis endows Ti_(2)CCl_(2) with unique surface chemistry,high phase purity,and excellent metallic conductivity,which can be used to accelerate polysulfide conversion kinetics and dramatically prolong the cyclability of Li-S ***-depth mechanistic analysis deciphers the origin of the formation of Ti_(2)CCl_(2) and offers a paradigm for tuning MXene chemical vapor *** brief,the gas-phase synthesis transforms the synthesis of MXenes and unlocks the hardly achieved potentials of MXenes.

关键词： synthesis phase lithium

UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine

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Journal of Pharmaceutical Analysis 2021年第4期11卷 458-464页

作者： Xin Wang Yue Du Cuiting Wu Ming Xu Youping Liu Xin Di Laboratory of Drug Metabolism and Pharmacokinetics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang110016PR China Shenyang Analytical Application Center Shimadzu(China)Co.Ltd.Shenyang167 Qingnian StreetShenyang110016PR China

Cyclic 3’,5’-adenosine monophosphate(cAMP)and cyclic 3’,5’-guanosine monophosphate(cGMP)are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese ***,phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in their *** the present study,a ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was developed for determination of cAMP and cGMP in rat plasma,with special consideration of their stability ex *** precipitation of proteins from plasma samples with 0.4 M perchloric acid,the analytes were chromatographed on a shimadzu Shimpack-XR-ODS II column with 2.5 mM ammonium acetate and methanol in gradient *** MS/MS detection was performed using multiple reaction monitoring in the positive electrospray ionization *** lower limit of quantification was 0.27 ng/mL for cAMP and 0.37 ng/mL for *** method was used to determine the plasma cAMP and cGMP levels in normal and Yin deficiency diabetic rats treated with or without Rehmannia *** developed method may be useful for evaluating the regulatory effects of Chinese herbal medicine on the levels of cAMP and cGMP in the body.

关键词： cAMP cGMP Plasma UHPLC-MS/MS Yin-Yang disharmony

Isoflavones’effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats

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Journal of Pharmaceutical Analysis 2020年第6期10卷 571-580页

作者： Ruirui Chang Jialin Liu Yusha Luo Taohong Huang Qiang Li Jun Wen Weidong Chen Tingting Zhou School of Pharmacy Second Military Medical UniversityShanghai200433China School of Pharmacy Anhui University of Chinese MedicineHefei230031China shimadzu china co.ltd. Shanghai200233China d Shanghai Key Laboratory for Pharmaceutical Metabolite Research School of PharmacySecond Military Medical UniversityShanghai200433China

Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions *** research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,which were administered with isolfavones from SSP for 7,14,21 and 28 consecutive days.A validated LC-MS/MS method was developed for determining shanzhiside,genipin-1-gentiobioside,geniposide and their metabolite genipin in rat *** samples were pretreated by solid-phase extraction using paeoniflorin as the internal *** chromatographic separation was performed on a Waters Atlantis T3(4.6 mm×150 mm,3 mm)column using a gradient mobile phase consisting of acetonitril and water(containing 0.06%acetic acid).The mass detection was under the multiple reaction monitoring(MRM)mode via polarity switching between negative and positive ionization *** calibration curves exhibited good linearity(r>0.997)for all *** lower limit of quantitation was in the range of 1 e10 ng/m *** intra-day and inter-day precisions(RSD)at three different levels were both less than 12.2%and the accuracies(RE)ranged fromà10.1%to 16.4%.The extraction recovery of them ranged from 53.8%to 99.7%.Pharmacokinetic results indicated the bioavailability of three iridoid glycosides and the metabolite,genipin in normal rats was higher than that in rats exposed to *** the longer time of administration of isoflavones,plasma concentrations of iridoids decreased,while genipin sulfate,the phase II metabolite of genposide and genipin-1-gentiobioside,appeared the rising *** pharmacokinetic profiles of main iridoids from GF were altered by isoflavones.

关键词： Iridoids Gardeniae fructus Isoflavones Rat Pharmacokinetics LC-MS/MS

Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

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Chinese Chemical Letters 2015年第1期26卷 36-38页

作者： Shin-ichi Kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University shimadzu Global coE for Application & Technical Development Shimadzu(China)Co.Ltd.

hloramphenicol is an antibiotic and one of the potential contaminants in ***-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in *** this work,an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive,reliable and higher throughput analysis was *** the methylcellulose-immobilized reversed-phase column,sugars in a honey sample were efficiently removed in 1 *** a result,the limit of quantitation of chloramphenicol was 20 pg/mL（0.2 μg/kg honey）.

关键词： On-line pretreatment Liquid chromatography-mass spectrometry Chloramphenicol Honey

Identification of terrigenous and autochthonous organic carbon in sediment cores from cascade reservoirs in the upper stream of Pearl River and Wujiang River,southwest china:lignin phenol as a tracer

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Acta Geochimica 2022年第5期41卷 753-764页

作者： Li Gao Xin Lin Jun Fan Ming Yang Xueping Chen FushunWang Jing Ma School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China shimadzu(Shanghai) Global Laboratory Consumables Co.LtdShanghai 200233China

Organic carbon(OC)source attribution for cascade reservoir sediments has been identified as a critical gap in understanding the effective carbon sink of inland *** this study,nine sediment cores were collected from cascade reservoirs in the Wujiang and Pearl *** analyzed lignin phenol(Λ8),total organic carbon(TOC)content,and stable carbon isotopic composition(δC)of the sediments,focusing on the changes of terrigenous OC,and the variation of OC source in cascade reservoir sediments after *** results showed that theΣ8 and TOC contents decreased from upstream to downstream reservoirs,indicating the significant interception of terrigenous OC by cascade ***,theΛ8 content in the Pearl River reservoir sediments was much higher than that in the Wujiang *** the three-end-member mixing model,we estimated that OC in reservoir sediments mainly comes from soil and *** damming,the proportion of plankton OC in TOC slightly increased in seasonal and annual regulation reservoirs due to the limnetic evolution of the *** findings suggest that the cascade damming increases the interception capacity of the river to terrigenous OC and nutrients,and that slowing of water velocity caused by damming affected primary productivity and fluvial carbon cycling.

关键词： Cascade reservoirs Terrigenous OC Lignin Autochthonous OC Three-end-member mixing model

Unraveling the difference in flavor characteristics of dry sausages inoculated with different autochthonous lactic acid bacteria

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Food Bioscience 2022年第3期47卷 1177-1188页

作者： Yingying Hu Jiawang Wang Qian Liu Yan Wang Jing Ren Qian Chen Baohua Kong college of Food Science Northeast Agricultural UniversityHarbinHeilongjiang150030China shimadzu (china) co. LTD.ShenyangLiaoning110000China

The traditional dry sausage is highly appreciated in china because of its unique flavor *** study aimed to characterize and compare the flavor profile of traditional dry sausage,inoculated with lactic acid bacteria (LAB),including Lactobacillus plantarum MDJ2,Lactobacillus sakei HRB10,Lactobacillus curvatus SYS29,Weissella hellenica HRB6,and Lactococcus lactis HRB0 using headspace solid-phase microextraction gas chromatography-mass spectrometry coupled with electronic nose (E-nose).The control (non-inoculated) sausage presented higher water activity and moisture content compared to the inoculated sausages whereas,the inoculation led to decreased pH values and increased LAB counts during fermentation of dry *** with LAB increased volatile compound contents and decreased total contents of free amino acids of sausages.E-nose and sensory analysis confirmed that inoculation with LAB,especially *** HRB6,*** HRB10,and *** SYS29 enriched the pleasant odors of dry *** analysis demonstrated that sausages inoculated with *** HRB6 and *** HRB10 showed a correlation with most of the key volatile *** conclusion,*** HRB6 and *** HRB10 are promising starter cultures to enhance the flavor characteristics of dry sausages.

关键词： Lactic acid bacteria dry fermented sausage Flavor profile Electronic nose Sensory analysis correlation analysis

Analysis of keto-enol tautomers of curcumin by liquid chromatography/mass spectrometry

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Chinese Chemical Letters 2013年第8期24卷 685-687页

作者： Shin-ichi Kawano Yusuke Inohana Yuki Hashi Jin-Ming Lin Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University shimadzu Global coE for Application & Technical Development Shimadzu(China) Co.Ltd. Global Application Development Center Shimadzu Corporation Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and Instrumentation.Tsinghua University

Keto-enol tautomers of curcumin were confirmed by reversed-phase liquid chromatography（RPLC）/ hybrid quadrupole ion trap/time-of-flight mass spectrometry（QIT/TOFMS）.Tautomers gave different MS/MS spectra in negative *** mass spectra were also obtained by hydrogen/deuterium exchange LC/MS/MS in positive *** results suggest that enol form is the major form in the solution（water/acetonitrile）.

关键词： Keto-enol tautomer Curcumin Liquid chromatography/mass spectrometry

Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS:Rg1 excretion in rat bile, urine and feces

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Acta Pharmaceutica Sinica B 2016年第6期6卷 593-599页

作者： Chiyu He Ru Feng Yupeng Sun Shifeng Chu Ji Chen Chao Ma Jie Fu Zhenxiong Zhao Min Huang Jiawen Shou Xiaoyang Li Yuzhu Wang Jinfeng Hu Yan Wang Juntian Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences Beijing Analytical Application Center Shimadzu (China) Co. Ltd.

Ginsenoside Rg1(Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry(LC–MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile,urine, and feces after oral administration(25 mg/kg). Calibration curves offered satisfactory linearity(r40.995)within the determined ranges. Both intra-day and inter-day variances were less than 15%, and the accuracy was within 80–120%. The excretion recoveries of Rg1, ginsenoside Rh1(Rh1), and protopanaxatriol(Ppt) in bile,urine, and feces combined were all greater than 70%. The fecal excretion recoveries of Rg1, Rh1, and Ppt were40.11%, 22.19%, and 22.88%, respectively, whereas 6.88% of Rg1 and 0.09% of Rh1 were excreted in *** excretion accounted for only 0.04% of Rg1. In conclusion, the observed excretion profiles for Rg1 and its metabolites after oral administration are helpful for understanding the poor oral bioavailability of Rg1 and will aid further investigations of Rg1 as a pharmacologically active component.

关键词： Ginsenoside Rg1 Ginsenoside Rh1 Protopanaxatriol Excretion LC–MS/MS