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Acupotomy alleviates knee osteoarthritis in rabbit by regulating chondrocyte mitophagy via Pink1-Parkin pathway

Journal of Traditional Chinese Medicine 2024年第3期44卷 468-477页

作者： ZHU Wenting GUO Changqing DU Mei MA Yunxuan CUI Yongqi CHEN Xilin GUO Changqing the Third Affiliated Hospital of Beijing university of Chinese Medicine Beijing 100029China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Department of Medical Technology Shijiazhuang Medical CollegeHebei 050599China

OBJECTIVE:To investigate the effect of acupotomy,on mitophagy and the Pink1-Parkin pathway in chondrocytes from rabbits with knee osteoarthritis(KOA).METHODS:A KOA model was established via the modified Videman *** were randomly divided into a control group(CON),KOA group and KOA+acupotomy group(Acu).Rabbits in the acupotomy group were subjected to acupotomy for 4 weeks after model *** behavior of the rabbits before and after intervention was *** degeneration was evaluated by optical microscopy and fluorescence *** level of mitophagy was evaluated by transmission electron microscopy,immunofluorescence and enzyme-linked immunosorbent assay(ELISA).The expression of phosphatase and tensin homolog(PTEN)-induced kinase 1(Pink1)-Parkin mitophagy pathway components was evaluated by immunofluorescence,Western blotting and real-time polymerase chain ***:In rabbits with KOA,joint pain,mobility disorders and cartilage degeneration were observed,the Mankin score was increased,collagen typeⅡ(Col-Ⅱ)expression was significantly decreased,mitophagy was inhibited,mitochondrial function was impaired,and factors associated with the Pink1-Parkin pathway were *** regulated the expression of Pink1-Parkin pathway-related proteins,the mitophagy-related protein microtubule-associated protein-1 light chain-3,the translocase of the outer membrane,and the inner mitochondrial membrane 23;increased the colocalization of mitochondria and autophagosomes;promoted the removal of damaged mitochondria;restored mitochondrial adenosine-triphosphate(ATP)production;and alleviated cartilage degeneration in rabbits with ***:Acupotomy played a role in alleviating KOA in rabbits by activating mitophagy in chondrocytes via the regulation of proteins that are related to the Pink1-Parkin pathway.

关键词： acupuncture therapy osteoarthritis knee mitophagy PTEN phosphohydrolase cartilage

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Research on the Impact of Equity Pledge on Company Value

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Proceedings of Business and Economic Studies 2024年第4期7卷 60-65页

作者： Tao Zhang Xuxu Zhu Jie Tian Hebei GEO university Shijiazhuang 050030China

This article aims to provide a literature review on the impact of equity pledges on corporate value,and to explore in depth the application of equity pledges as a financial tool in corporate governance and capital operation,as well as its multidimensional impact on corporate *** reviewing and analyzing relevant literature both domestically and internationally,this article first defines the basic concept of equity pledges and then elaborates on the impact mechanism of equity pledges on company value from both positive and negative *** terms of positive impact,this article explores how equity pledges can promote corporate financing,optimize capital structure,and enhance the control of major shareholders over the *** terms of negative impacts,the possible control risk,market risk,and potential damage to the interests of small and medium-sized shareholders brought about by equity pledges were ***,this article also discusses the differences in the impact of equity pledges on company value in different scenarios and proposes corresponding policy recommendations and research prospects.

关键词： Equity pledge Company value Financing Corporate governance Market risk

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Research on the Impact of the Digital Transformation of Commercial Banks

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Proceedings of Business and Economic Studies 2024年第5期7卷 132-137页

作者： Jinjin Gao Hebei GEO university Shijiazhuang 050030China

The development of the digital economy has presented both opportunities and challenges for the transformation of commercial *** article aims to conduct a literature review on the impact of digital transformation on commercial banks and to explore the multi-dimensional effects it *** a review and analysis of relevant domestic and international literature,this paper first defines the connotation of digital transformation in commercial *** then conducts a literature analysis and research on the strategic governance,business performance,and risk management aspects of the digital transformation of commercial banks from multiple *** on the analysis of the existing literature,the paper explores directions for future in-depth research and offers corresponding policy suggestions,providing a theoretical and practical foundation for the future digital development of commercial banks.

关键词： Commercial bank Digital transformation Bank performance

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Antihypertensive effects of whey protein hydrolysate involve reshaping the gut microbiome in spontaneously hypertension rats

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Food Science and Human Wellness 2024年第4期13卷 1974-1986页

作者： Peipei Dou Xiaoyi Li Xiaoxiao Zou Kai Wang Lei Yao Zhuo Sun Hui Hong Yongkang Luo Yuqing Tan Key Laboratory of Functional Dairy College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Hebei Dongkang Dairy Co. Ltd.Shijiazhuang 052160China

Novel angiotensin-converting enzyme(ACE)inhibitory peptides were identified from whey protein hydrolysates(WPH)in vitro in our previous study and the antihypertensive abilities of WPH in vivo were further investigated in the current *** indicated that WPH significantly inhibited the development of high blood pressure and tissue injuries caused by *** inhibited ACE activity(20.81%,P<0.01),and reduced renin concentration(P<0.05),thereby reducing systolic blood pressure(SBP)(12.63%,P<0.05)in spontaneously hypertensive *** increased Akkermansia,Bacteroides,and Lactobacillus abundance promoted high short chain fatty acid content in feces after WPH *** changes jointly contributed to low blood *** heart weight and cardiomyocyte injuries(hypertrophy and degeneration)were alleviated by *** proteomic results revealed that 19 protein expressions in the heart mainly associated with the wingless/integrated(Wnt)signaling pathway and Apelin signaling pathway were altered after WPH ***,WPH alleviated serum oxidative stress,indicated by the decreased malondialdehyde content(P<0.01),enhanced total antioxidant capacity(P<0.01)and superoxide dismutase activity(P<0.01).The current study suggests that WPH exhibit promising antihypertensive abilities in vivo and could be a potential alternative for antihypertensive dietary supplements.

关键词： Whey protein hydrolysate Antihypertension Short chain fatty acids Gut microbiome

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Spinor F=1 Bose-Einstein condensates loaded in two types of radially-periodic potentials with spin-orbit coupling

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Chinese Physics B 2021年第10期30卷 442-446页

作者： Ji-Guo Wang Yue-Qing Li Han-Zhao Tang Ya-Fei Song Department of Mathematics and Physics Shijiazhuang TieDao UniversityShijiazhuang 050043China Institute of Applied Physics Shijiazhuang TieDao UniversityShijiazhuang 050043China

We consider two-dimensional spinor F=1 Bose-Einstein condensates in two types of radially-periodic potentials with spin-orbit coupling,i.e.,spin-independent and spin-dependent radially-periodic *** the Bose-Einstein condensates in a spin-independent radially-periodic potential,the density of each component exhibits the periodic density modulation along the azimuthal direction,which realizes the necklacelike state in the ferromagnetic Bose-Einstein *** the spin-exchange interaction increases,the necklacelike state gradually transition to the plane wave phase for the antiferromagnetic Bose-Einstein condensates with larger spin-orbit *** competition of the spin-dependent radially-periodic potential,spin-orbit coupling,and spin-exchange interaction gives rise to the exotic ground-state phases when the Bose-Einstein condensates in a spin-dependent radially-periodic potential.

关键词： spinor Bose-Einstein condensates spin-orbit coupling radially-periodic potential

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High-throughput sequencing analysis of differential microRNA expression in the process of blocking the progression of chronic atrophic gastritis to gastric cancer by Xianglian Huazhuo formula(香连化浊方)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 703-712页

作者： GUO Yuxi LI Ze CHENG Nan JIA Xuemei WANG Jie MA Hongyu ZHAO Runyuan LI Bolin XUE Yucong CAI Yanru YANG Qian Department of spleen and stomach diseases First Affiliated Hospital of Hebei University of Traditional Chinese MedicineShijiazhuang 050000China Department of Traditional Chinese Medicine Hebei General HospitalShijiazhuang 050051China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China College of Integrative Medicine Hebei University of Chinese MedicineShijiazhuang 050011China

OBJECTIVE:To explore the mechanism of Xianglian Huazhuo formula(香连化浊方,XLHZ)blocking the development of chronic atrophic gastritis(CAG)to gastric cancer(GC)through bioinformatics analysis and in ***:Pathological morphology of gastric mucosa of rats were ***-throughput sequencing was used to analyze the miRNA expression profile of gastric *** miRanda,miRDB and miRWalk databases were used to predict the differential target *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for differential target ***-time quantitative reverse transcription polymerase chain reaction(qRTPCR)was used to verify the differentially expressed miRNAs and target *** blot,EdU,wound healing and flow cytometry were used to observe the effect of XLHZ on epithelial-mesenchymal transition(EMT)markers,proliferation,migration,apoptosis and cell cycle of CAG cells in ***:A total of five differentially expressed miRNAs and four differential target genes were screened in this *** analysis showed that the target genes were enriched in regulation of neuron development,regulation of transcription factor activity and regulation of RNA *** pathways database differences in gene enrichment of target genes in the Wnt signaling pathway,Phospholipase D signaling pathway and mitogen-activated protein kinase signaling *** confirmed that miRNAs and its target genes were consistent with the screening *** vitro,our study revealed that XLHZ could increase the expression of Ecadherin,decrease the expression of transforming growth factorβ1,vimentin andβ-catenin,inhibite the proliferation and migration of CAG cells,cause cell cycle arrest at G0/G1 and G2/M phase,induce the apoptosis of CAG cells,and prevent the progression of CAG to ***:This study provided a new idea for the mechanism of blocking the progression of CAG to GC by XLHZ,which may be related to the expression

关键词： high-throughput nucleotide sequencing gastritis,atrophic stomach neoplasms microRNAs Xianglian Huazhuo formula

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Cluster oscillation and bifurcation of fractional-order Duffing system with two time scales

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Acta Mechanica Sinica 2020年第4期36卷 926-932页

作者： Yanli Wang Xianghong Li Yongjun Shen Department of Mathematics and Physics Shijiazhuang Tiedao UniversityShijiazhuang 050043China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China

The dynamical behavior on fractional-order Duffing system with two time scales is investigated,and the point-cycle coupling type cluster oscillation is firstly observed *** taking the fractional order as bifurcation parameter,the dynamics of the autonomous Duffing system will become more complex than the corresponding integer-order one,and some typical phenomenon exist only in the fractional-order *** attractors exist in various parameter space,and Hopf bifurcation only happens while fractional order is bigger than 1 under certain parameter ***,the bifurcation behavior of the autonomous system may regulate dynamical phenomenon of the periodic excited *** results into the point-cycle coupling type cluster oscillation when the fractional order is bigger than *** related generation mechanism based on slow-fast analysis method is that the slow variation of periodic excitation makes the system periodically visit different attractors and critical points of different bifurcations of the autonomous system.

关键词： Fractional-order Duffing system Cluster oscillation Slow-fast analysis method Bifurcation

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Research on hunting stability and bifurcation characteristics of nonlinear stochastic wheelset system

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Applied Mathematics and Mechanics(English Edition) 2023年第3期44卷 431-446页

作者： Peng WANG Shaopu YANG Yongqiang LIU Pengfei LIU Xing ZHANG Yiwei ZHAO State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China School of Traffic and Transportation Shijiazhuang Tiedao UniversityShijiazhuang 050043China School of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China

A stochastic wheelset model with a nonlinear wheel-rail contact relationship is established to investigate the stochastic stability and stochastic bifurcation of the wheelset system with the consideration of the stochastic parametric excitations of equivalent conicity and suspension *** wheelset is systematized into a onedimensional(1D)diffusion process by using the stochastic average method,the behavior of the singular boundary is analyzed to determine the hunting stability condition of the wheelset system,and the critical speed of stochastic bifurcation is *** stationary probability density and joint probability density are derived *** on the topological structure change of the probability density function,the stochastic Hopf bifurcation form and bifurcation condition of the wheelset system are *** effects of stochastic factors on the hunting stability and bifurcation characteristics are analyzed,and the simulation results verify the correctness of the theoretical *** results reveal that the boundary behavior of the diffusion process determines the hunting stability of the stochastic wheelset system,and the left boundary characteristic value cL=1 is the critical state of hunting ***,stochastic D-bifurcation and P-bifurcation will appear in the wheelset system,and the critical speeds of the two kinds of stochastic bifurcation decrease with the increase in the stochastic parametric excitation intensity.

关键词： stochastic wheelset system stochastic average method singular boundary hunting stability stochastic Hopf bifurcation

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A Probabilistic Approach for Predicting Vessel Motion

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1877-1879页

作者： Qi Hu Jingyi Liu Zongyu Zuo 7th Research Division Beihang University(BUAA)Beijing 100191China 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Dear Editor,This letter addresses the challenge of forecasting the motion of real-world vessels over an extended period with a limited amount of available *** employing stochastic differential equation(SDE)modeling,we integrate both deterministic and stochastic components of the available ***,we establish a recursive prediction methodology based on Bayes’rule to update the model state when new measurements are ***,we develop a stochastic model tailored specifically to vessel dynamics and introduce an approximation method to tackle computational ***,we present an application example and conduct a comparative experiment to validate the effectiveness and superiority of the proposed method.

关键词： method stochastic letter

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Predictive value of positive lymph node ratio in patients with locally advanced gastric remnant cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 833-843页

作者： Meng Zhuo Lei Tian Ting Han Teng-Fei Liu Xiao-Lin Lin Xiu-Ying Xiao Department of Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Traditional lymph node stage(N stage)has limitations in advanced gastric remnant cancer(GRC)patients;therefore,establishing a new predictive stage is *** To explore the predictive value of positive lymph node ratio(LNR)according to clinicopathological characteristics and prognosis of locally advanced *** Seventy-four patients who underwent radical gastrectomy and lymphadenectomy for locally advanced GRC were retrospectively *** relationship between LNR and clinicopathological characteristics was *** survival analysis was performed using Kaplan-Meier survival curves and Cox regression *** Number of metastatic LNs,tumor diameter,depth of tumor invasion,Borrmann type,serum tumor biomarkers,and tumor-node-metastasis(TNM)stage were correlated with LNR stage and N *** analysis revealed that the factors affecting survival included tumor diameter,anemia,serum tumor biomarkers,vascular or neural invasion,combined resection,LNR stage,N stage,and TNM stage(all P<0.05).The median survival time for those with LNR0,LNR1,LNR2 and LNR3 stage were 61,31,23 and 17 mo,respectively,and the differences were significant(P=0.000).Anemia,tumor biomarkers and LNR stage were independent prognostic factors for survival in multivariable analysis(all P<0.05).CONCLUSION The new LNR stage is uniquely based on number of metastatic LNs,with significant prognostic value for locally advanced GRC,and could better differentiate overall survival,compared with N stage.

关键词： Gastric remnant cancer Positive lymph node ratio Clinicopathological characteristics Prognosis

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