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Silicon nanoparticles: Preparation, properties, and applications

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Chinese Physics B 2014年第8期23卷 23-36页

作者：常欢孙树清 shenzhen key laboratory for Minimally invasive medical technologies Graduate School at Shenzhen Tsinghua University Department of Biomedical Engineering Tsinghua University

Silicon nanoparticles have attracted great attention in the past decades because of their intriguing physical properties, active surface state, distinctive photoluminescence and biocompatibility. In this review, we present some of the recent progress in preparation methodologies and surface functionalization approaches of silicon nanoparticles. Further, their promising applications in the fields of energy and electronic engineering are introduced.

关键词： silicon nanoparticle quantum confinement effect optical performance

Advances and prospects of triboelectric nanogenerator for self-powered system

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International Journal of Smart and Nano Materials 2021年第3期12卷 233-255页

作者： Xuyao An Chunnan Wang Ruomei Shao Shuqing Suna shenzhen key laboratory for Minimal invasive medical technologies Institute of Optical Imaging and SensingDepartment of Biomedical EngineeringShenzhen International Graduate SchoolTsinghua UniversityShenzhenChina Department of Physics Tsinghua UniversityBeijing China

Self-powered technology is a novel power supply *** recent years,self-powered intelligent products have attracted much *** nanogenerators(TENGs)can convert mechanical energy into electrical energy by contact and relative motion,thus providing the possibility of self-powering for electronic ***,TENG-based self-powered technologies are limited by low power output and poor conversion *** this review,we present the development of TENG-based self-powered systems,with the emphasis on the output power of TENG and how to improve *** on the above applications,we propose the idea of TENG-driven self-powered remote robots,providing promising scenarios of small remote robots for land rescue or underwater *** to the limited power output of the current TENGs,there are still some difficulties in driving the *** at the problems of low power supply and poor conversion efficiency,we introduce the current attempts to improve the power generation efficiency from the perspectives of mechanical structure,electrode materials and auxiliary *** also outline the applications of TENGs as power supply systems in various fields such as sensing,wearable devices,and collecting Marine ***,we forecast the development prospect of TENG.

关键词： Triboelectric nanogenerator self-power sensors remote robots

POLARIZATION IMAGING AND SCATTERING MODEL OF CANCEROUS LIVER TISSUES

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Journal of Innovative Optical Health Sciences 2013年第3期6卷 91-98页

作者： DONGZHI LI HONGHUI HE NAN ZENG E DU RAN LIAO YONGHONG HE HUI MA shenzhen key laboratory for Minimal invasive medical technologies graduate school at shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China

We apply diferent polarization imaging techniques for cancerous liver tissues,and compare the relative contrasts for difference polarization imaging(DPI),degree of polarization imaging(DOPI)and rotating linear polarization imaging(RLPI).Experimental results show that a number of polarization imaging parameters are capable of differentiating cancerous cells in isotropic liver *** analyze the contrast mechanism of the cancer:-sensitive polarization imaging parameters,we propose a scattering model cont aining two types of spherical scatterers and carry on Monte Carlo simula tions based on this bi-component *** the experimental and Monte Carlo simulated results show that the RLPI technique can provide a good imaging contrast of cancerous *** bi-component scattering model provides a useful tool to ana-lyze the contrast mechanism of polarization imaging of cancerous tissues.

关键词： Polarization imaging liver cancerous tisues sca tering model Monte Carlo si mul ation

Oxygen-deficient metal oxides:Synthesis routes and applications in energy and environment

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Nano Research 2019年第9期12卷 2150-2163页

作者： Di Zu Haiyang Wang Sen Lin Gang Ou Hehe Wei Shuqing Sun Hui Wu Institute of Optical Imaging and Sensing Shenzhen Key Laboratory for Minimal Invasive Medical TechnologiesGraduate School at ShenzhenTsinghua UniversityShenzhen 518055China State key laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China

Oxyge n vaca ncies impla ntation is an efficie nt way to adjust the physical and chemical properties of metal oxide nano materials to meet the requirements for particular *** reasonable defects design,oxyge-deficient metal oxides with excellent optical and electrical properties are widely applied for environmental protection and energy *** review discusses recent advances in synthetic approaches of oxygervdeficient metal oxides and their applications in photocatalysis,electrocatalysis,and energy storage *** perspectives of oxyge n?deficie nt metal oxides for increased en ergy dema nd and en vironme ntal sustai liability are also exami ned.

关键词： oxygen vacancies metal oxides synthesis routes energy and environment

QUANTITATIVE MUELLER MATRIX POLARIMETRY TECHNIQUES FOR BIOLOGICAL TISSUES

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Journal of Innovative Optical Health Sciences 2012年第3期5卷 34-40页

作者： HONGHUI HE NAN ZENG DONGZHI LI RAN LIAO HUI MA shenzhen key laboratory for Minimal invasive medical technologies shenzhen 518055 P.R.China laboratory of Optical Imaging and Sensing Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China

We propose and conduct both the rotating linear polarization imaging(RLPI)and Mueller matrix transformation(MMT)measurements of different biological tissue samples,and testify the capability of the Mueller matrix polarimetry for the anisotropic scattering *** independent parameters extracted from the RLPI and MMT techniques are compared and *** tissue experimental results show that the parameters are closely related to the structural characteristics of the turbid scattering media,including the sizes of the scatterers,the angular distribution and order of alignment of *** results and conclusions in this paper may provide a potential method for the detection of precancerous and early stage cancerous ***,such studies represent the Mueller matrix transformation procedure which results in a set of parameters linking up the Mueller matrix elements to the structural and optical properties of the media.

关键词： Polarization scattering Mueller matrix biological tissues

A polarization method for quickly distinguishing the morphology of electro-spun ultrafine fibers

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Chinese Chemical Letters 2018年第8期29卷 1317-1320页

作者： Xiaopeng Li Yuanhuan Zhu Hui Ma Yong Sheng school of Materials Science and Engineering Sichuan University Center for Precision Medicine and Healthcare Tsinghua-Berkeley Shenzhen Institute Tsinghua University shenzhen key laboratory for Minimal invasive medical technologies Institute of Optical Imaging and Sensing Graduate School at Shenzhen Tsinghua University Department of Physics Tsinghua University

In the fields of tissue engineering and controlled drug release, electro-spun fibers are often required to have structural characteristics such as high porosity and large specific surface area. The traditional scanning electron microscope can observe the microscopic appearance of the sample clearly, but it damage to the polymer electro-spun fiber, and the detection takes a long time. In view of this, we have tested a polarization method to quickly distinguish different morphological features of the samples, such as smooth surface, microporous, and beaded microspheres using the depolarization parameter MMDD-△,which is obtained by the Mueller matrix polar decomposition. The preliminary results show that this method is simple, fast, and potentially capable of non-destructive evaluation of the microstructure properties of the object surface.

关键词： Electrospinning Ultrafine fiber Polarized light Nondestructive testing Mueller matrix

A photoacoustic imaging system with variable gain at different depths

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 1-10页

作者： Tian Guan Yao Li Muqun Yang Yong Jiang Yonghong He shenzhen key laboratory for Minimal invasive medical technologies graduate school at shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Biomedical Engineering Tsinghua University Beijing 100084P.R.China Center of Precision Medicine and Healthcare Tsinghua-Berkeley shenzhen Institute Shenzhen 518055P.R.China shenzhen Wisonic medical Technology Co. Ltd.Taoyuan StreetNanshan DistrictShenzhen 518055P.R.China

We established a photoacoustic imaging(PAI)system that can provide variable gain at different *** PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound ***-controlled attenuator was used to realize variable gain at different depths when acquiring PAI *** proof-of-concept imaging results for variable gain at different depths were achieved using specic *** resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all *** further testify the function,we imaged the sagittal section of the body of in vivo nude *** addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 *** results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all *** depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 ***,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.

关键词： Photoacoustic imaging variable gain imaging depth

Polarimetry feature parameter deriving from Mueller matrix imaging and auto-diagnostic signicance to distinguish HSIL and CSCC

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 17-28页

作者： Anli Hou Xingjian Wang Yujuan Fan Wenbin Miao Yang Dong Xuewu Tian Jibin Zou Hui Ma shenzhen key laboratory for Minimal invasive medical technologies Guangdong Engineering Center of Polarization Imaging and Sensing Technology Tsinghua shenzhen International graduate school Tsinghua University Shenzhen 518055P.R.China Department of Gynaecology University of Chinese Academy of Sciences shenzhen Hospital shenzhen 518106 P.R.China Center for Precision Medicine and Healthcare Tsinghua-Berkeley shenzhen Institute Tsinghua University Shenzhen 518071P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China Department of Pathology University of Chinese Academy of Sciences shenzhen Hospital shenzhen 518106 P.R.China

High-grade squamous intraepithelial lesion(HSIL)is regarded as a serious precancerous state of cervix,and it is easy to progress into cervical invasive carcinoma which highlights the importance of earlier diagnosis and treatment of cervical *** examine the biopsied cervical epithelial tissue through a *** pathological examination will take a long time and sometimes results in high inter-and intra-observer variability in *** imaging techniques have broad application prospects for biomedical diagnosis such as breast,liver,colon,thyroid and so *** our team,we have derived polarimetry feature parameters(PFPs)to characterize microstructural features in histological sections of breast tissues,and the accuracy for PFPs ranges from 0.82 to ***,the aim of this paper is to distinguish automatically microstructural features between HSIL and cervical squamous cell carcinoma(CSCC)by means of polarization imaging techniques,and try to provide quantitative reference index for patho-logical diagnosis which can alleviate the workload of *** images of the H&E stained histological slices were obtained by Mueller matrix *** typical path-ological structure area was labeled by two experienced *** the polarimetry basis parameter(PBP)statistics for this *** PBP statistics(stat PBPs)are screened by mutual information(MI)*** training method is based on a linear discriminant analysis(LDA)classier whichnds the most simplied linear combination from these stat PBPs and the accuracy remains constant to characterize the specic microstructural feature quantitatively in cervical squamous *** present results from 37 clinical patients with analysis regions of cervical squamous *** accuracy of PFP for recognizing HSIL and CSCC was 83.8%and 87.5%,*** work demonstrates the ability of PFP to quantitatively charac-terize the cervical squamous epithe

关键词： Polarimetry basis parameter(PBP) polarimetry feature parameter(PFP) linear discriminant analysis(LDA) mutual information(MI) high-grade squamous intraepithelial le-sion(HSIL) cervical squamous cell carcinoma(CSCC).

A saccharides sensor developed by symmetrical optical waveguide-based surface plasmon resonance

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 19-25页

作者： Ang Li Zhouyi Guo Qing Peng Chan Du Xida Han Le Liu Jun Guo Yonghong He Yanhong Ji MOE key laboratory of Laser Life Science&SATCM Third Grade laboratory of Chinese Medicine and Photonics Technology College of Biophotonics South China Normal University Guangzhou 510631P.R.China Department of Ophthalmology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092P.R.China shenzhen key laboratory for Minimal invasive medical technologies graduate school at shenzhen Tsinghua University Shenzhen 518055P.R.China MOE key laboratory of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China

We proposed a new saccharides sensor developed by symmetrical optical waveguide(SOW)-based surface plasmon resonance(SPR).This unique MgF_(2)/Au/MgF_(2)/Analyte film structure results in longer suface plasmon wave(SPW)propagation lengths and depths,leading to an increment of *** this paper,we managed to decorate the dielectric interface(MgF_(2) layer)by depositing a thin polydopamine film as surface adherent that provides a platform for secondary reactions with the probe molecule.3-Aminophenylboronic acid(3-PBA)is chosen to be the saccharides sense probe molecule in the present *** aqueous huumnor of Diabetes and Cataract patient whose blood glucose level is normal are analyzed and the results dermonstrated that this sensor shows great potential in monitoring the blood siugar and can be adapted in the field of biological monitoring in the future.

关键词： Saccharides sensor surface plasmon resonance symmetrical optical waveguide 3-Aminophenylboronic acid dopamine