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Co_(3)O_(4)/Mn_(3)O_(4) hybrid catalysts with heterointerfaces as bifunctional catalysts for Zn-air batteries

Journal of Energy Chemistry 2022年第5期31卷 679-687页

作者： Qikai Huang Xiongwei Zhong Qi Zhang Xin Wu Miaolun Jiao Biao Chen Jinzhi Sheng Guangmin Zhou shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina

Zinc-air batteries(ZABs) with high energy density and safety are promising as next-generation energy storage systems, while their applications are severely hindered by the sluggish reaction kinetic of air cathodes. Developing a bifunctional catalyst with high activity and durability is an effective strategy to address the above challenges. Herein, a Co_(3)O_(4)/Mn_(3)O_(4) nanohybrid with heterointerfaces is designed as advanced cathode catalyst for ZABs. Density functional theory calculations show the heterogeneous interface between Co_(3)O_(4)/Mn_(3)O_(4) can improve the dynamics of carrier transport and thus enhancing the catalytic activity and durability. The Co_(3)O_(4)/Mn_(3)O_(4) catalyst anchored on reduced graphene oxide(rGO)exhibits high oxygen reduction reaction(ORR) activity with a half-wave potential of 0.86 V, and excellent oxygen evolution reaction(OER) activity with the potential of 1.59 V at 10 mA cm^(-2) , which are comparable to the commercial noble metal catalysts. The improved ORR/OER catalytic activity is ascribed to the synergistic effect of heterointerfaces between Co_(3)O_(4) and Mn_(3)O_(4)as well as the improved conductivity and contact area of oxygen/catalysts/electrolytes three-phase interface by r GO. Furthermore, a home-made ZAB based on Co_(3)O_(4)/Mn_(3)O_(4)/r GO shows a high open circuit voltage of 1.54 V, a large power density of 194.6 mW cm^(-2) and good long-term cycling stability of nearly 400 h at 5 mA cm^(-2) , which affords a promising bifunctional oxygen catalyst for rechargeable ZABs.

关键词： Transition metal oxide Carbon-based catalyst Heterointerfaces Bifunctional catalyst Zn-air batteries

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Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

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Bioactive Materials 2022年第4期7卷 515-525页

作者： Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei School of Pharmaceutical Sciences(shenzhen) Sun Yat-sen UniversityShenzhen518107China Paul C.Lauterbur research Center for biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death,which has been demonstrated to be highly effective in treating malignant tumors.Sonodynamic therapy(SDT)adopts ultrasound(US)as the excitation source to induce the production of reactive oxygen species(ROS),which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety.Herein,we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO_(2) on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently(Au/BP@MS).The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO_(2)-mediated O_(2) generation and GSH depletion,thus leading to notable inhibition effect on tumor growth.Moreover,tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.

关键词： Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic

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超小二维硅量子片:一种用于脑胶质瘤原位诊疗的脑部光热纳米制剂

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Science Bulletin 2021年第2期66卷 147-157,M0004页

作者：缪昭华胡德红高笃阳范林昕马艳马腾刘新郑海荣查正宝盛宗海徐成彦 School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Paul C.Lauterbur research Center for biomedical Imaging Shenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China shenzhen Bay Laboratory Shenzhen 518107China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

提出了一种化学脱嵌和低温辅助剥离相结合的策略用于制备二维硅量子片(silicon quantum sheets,Si QSs),并证实了硅量子片能够用作高性能光热纳米制剂,在恶性程度极高的脑胶质瘤诊断和治疗上有很好的应用前景.本文制备的硅量子片横向尺... 详细信息

提出了一种化学脱嵌和低温辅助剥离相结合的策略用于制备二维硅量子片(silicon quantum sheets,Si QSs),并证实了硅量子片能够用作高性能光热纳米制剂,在恶性程度极高的脑胶质瘤诊断和治疗上有很好的应用前景.本文制备的硅量子片横向尺寸约为14.0 nm,厚度约为1.6 nm,质量消光系数和光热转换效率分别为27.5 g^(-1)cm^(-1)和47.2%,光热性能优于目前所报道的其他单元素二维材料.经尾静脉注射后,硅量子片可穿透血脑肿瘤屏障,在脑胶质瘤组织中有效蓄积,显著增强肿瘤区域的光声信号,实现了近红外光驱动的脑肿瘤靶向治疗.经激光照射5 min后,实验组小鼠的脑胶质瘤能得到有效抑制,小鼠生存期延长了1倍.该项工作拓展了二维硅在脑疾病治疗中的生物医学应用.

关键词：脑胶质瘤肿瘤区域纳米制剂生物医学应用光声信号质量消光系数脑疾病横向尺寸

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Stress proteins:the biological functions in virus infection,present and challenges for target-based antiviral drug development

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1363-1402页

作者： Qianya Wan Dan Song Huangcan Li Ming-liang He Department of biomedical Sciences City University of Hong KongKowloonHong KongChina CityU shenzhen research institute ShenzhenChina

Stress proteins(SPs)including heat-shock proteins(HSPs),RNA chaperones,and ER associated stress proteins are molecular chaperones essential for cellular homeostasis.The major functions of HSPs include chaperoning misfolded or unfolded polypeptides,protecting cells from toxic stress,and presenting immune and inflammatory cytokines.Regarded as a double-edged sword,HSPs also cooperate with numerous viruses and cancer cells to promote their survival.RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins(hnRNPs),which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II.hnRNPs involve in a large number of cellular processes,including chromatin remodelling,transcription regulation,RNP assembly and stabilization,RNA export,virus replication,histonelike nucleoid structuring,and even intracellular immunity.Dysregulation of stress proteins is associated with many human diseases including human cancer,cardiovascular diseases,neurodegenerative diseases(e.g.,Parkinson’s diseases,Alzheimer disease),stroke and infectious diseases.In this review,we summarized the biologic function of stress proteins,and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections.As SPs also attract a great interest as potential antiviral targets(e.g.,COVID-19),we also discuss the present progress and challenges in this area of HSP-based drug development,as well as with compounds already under clinical evaluation.

关键词： metabolism stabilization summarized

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Polarisation optics for biomedical and clinical applications:a review

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Light(Science & Applications) 2021年第11期10卷 2028-2047页

作者： Chao He Honghui He Jintao Chang Binguo Chen Hui Ma Martin J.Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Guangdong Engineering Center of Polarisation Imaging and Sensing Technology Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina Department of Physics Tsinghua University100084 BeijingChina Department of biomedical Engineering Tsinghua University100084 BeijingChina

Many polarisation techniques have been harnessed for decades in biological and clinical research,each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects.Various advanced vector measurement/sensing techniques,physical interpretation methods,and approaches to analyse biomedically relevant information have been developed and harnessed.In this review,we focus mainly on summarising methodologies and applications related to tissue polarimetry,with an emphasis on the adoption of the Stokes-Mueller formalism.Several recent breakthroughs,development trends,and potential multimodal uses in conjunction with other techniques are also presented.The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

关键词： clinical optics breakthrough

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二维材料厚度与片径的独立筛分

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Science China Materials 2021年第11期64卷 2739-2746页

作者：周赫元谭隽阳杨柳思王婧云丁宝福潘意坤于兴华刘闵苏杨闯丘陵成会明刘碧录 shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute&Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Laboratory for Materials Sciences Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

二维材料是当前科学研究的前沿领域.二维材料的性质与其厚度和片径密切相关,如何获得厚度和片径均匀且可调控的二维材料,是其应用的关键.本文提出了一种三步筛分法,实现了二维材料厚度与片径的独立筛分.以二维六方氮化硼为例,三步筛分... 详细信息

二维材料是当前科学研究的前沿领域.二维材料的性质与其厚度和片径密切相关,如何获得厚度和片径均匀且可调控的二维材料,是其应用的关键.本文提出了一种三步筛分法,实现了二维材料厚度与片径的独立筛分.以二维六方氮化硼为例,三步筛分法可以将其厚度和片径独立地筛分为不同组分,所得组分均具有较窄的厚度和片径分布,且厚度全部小于6 nm.本文还进一步发展了一种力场提取法,实现了二维六方氮化硼、二硫化钼和氧化石墨烯的规模化片径筛分,是二维材料片径筛分的普适方法.本工作提出的筛分方法可制备出结构均一的二维材料,对其基础研究与应用意义深远.

关键词：氧化石墨烯二维材料材料的性质筛分法二硫化钼科学研究前沿领域

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Enhanced thermoelectric performance of 3D-printed Bi2Te3-based materials via adding Te/Se

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Journal of Materiomics 2023年第2期9卷 328-337页

作者： Xuedi Zhang Jin Chen Han Zhang Pengfei Zhu Rong Wang Fu Li Bo Li institute of Materials research Tsinghua Shenzhen International Graduate SchoolShenzhen518055China School of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518055China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China

Bi_(2)Te_(3)-based materials were prepared by direct ink writing(DIW)3D printing and their microstructure and thermoelectric properties were investigated with an emphasis on the effect of the content of DMF and Te/Se addition.As the mass ratio of DMF in the composition increased from 6.5%to 8.0%(in mass),the electrical conductivity deteriorated because of the corresponding increased porosity and organic remains in the samples.However,the volatilization of DMF would reduce the fluidity of the slurry.Thus,thermoelectric slurry with 7.0%DMF is the most suitable mass ratio for 3D printing.Additionally,adding Te in the p-type Bi0.4Sb1.6Te3 and adding Se in the n-type Bi2Te2.6Se0.4 have significantly improved their electrical conductivity due to the increased carrier concentration and mobility.Combining with the moderate Seebeck coefficient(~200 mV/K),high power factors with~802 mW·m^(-1)·K^(-2)and 1266 mW·m^(-1)·K^(-2)were obtained for the n-type Bi_(2)Te_(2.6)Se_(0.4)þ10%Se and p-type Bi_(0.4)Sb_(1.6)Te_(3)þ7%Te,respectively,which result in the final relatively high zT values of 0.68 at 573 K and 0.56 at 330 K for ntype and p-type 3D-printed samples.

关键词： 3D-printing Bi_(2)Te_(3) Thermoelectric materials

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Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer

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research 2021年第1期2021卷 689-703页

作者： Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur research Center for biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis.

关键词： Internal loaded emerged

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Highly efficient labelling of extracellular vesicles for enhanced detection on a microfluidic platform

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Chinese Chemical Letters 2024年第2期35卷 441-445页

作者： Shi Hu Rui Hao Zitong Yu Huitao Zhang Hui Yang Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and analysis.However,currently available methods such as using probes to conjugate phospholipids or membrane proteins have certain limitations due to EV steric hindrance,dye aggregation,etc.Here,we present a microfluidic platform to enhance EVs’labelling efficiency and improve their detection.This platform provides excellent sample throughput and high-efficiency EV labelling at lower label concentrations with an optimized flowing rate.Flow cytometry analysis(FCM)and cellular uptake results show that EV labelling by utilizing this platform possesses the merits of a higher labelling efficiency with 64.1%relative improvement than conventional co-incubation method and a lower background noise.Moreover,this technique maintains EVs’size,morphology and biological activities.After the recipient cells uptake the EVs treated by the microfluidic platform,the spatial and temporal distribution of EVs in the cells are clearly observed.These results demonstrate that our method holds great potential in efficient labelling of EVs,which is essential to subsequent EV quantification and analysis.

关键词： Microfluidic platform Extracellular vesicles Labelling PKH dye Flow cytometry

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Advanced materials and energy technologies towards carbon neutrality

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Science China Materials 2022年第12期65卷 3187-3189页

作者： Bilu Liu Gang Liu Yongbing Tang Hui-Ming Cheng shenzhen Geim Graphene Center Tsinghua–Berkeley Shenzhen Institute and Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Faculty of Materials Science and Engineering/institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

The rapid development of human society has led to much increased consumption of energy,which results in global energy shortage as well as serious environmental concerns due to the use of non-sustainable fossil fuels.For example,the heavy relay on the use of coal and oil leads to carbon emission which is a major factor for global warming and climate change.Developing green and sustainable energy paths becomes more urgent than ever.In this regard,energy sources like sunshine,wind,and water are important to build a clean and sustainable future.For example,one could generate electricity from sun by solar cell devices.Later,such electricity can be stored either in the form of charges by batteries or supercapacitors,or stored in the form of chemicals by electrochemical catalysis conversion,which can be transported over a long distance or stored for a long time for end use.The efficiency of these new energy technologies and devices including photovoltaic,energy storage,and energy conversion,is key which determines whether they can be largescale implemented.High-performance materials play central rules in determining the efficiency of these technologies and therefore largely influence the use of these clean energy technologies and paths toward global mission of carbon neutrality.

关键词： neutral carbon sunshine

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