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Pandemic COVID-19:Current status and challenges of antiviral therapies

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Genes & Diseases 2020年第4期7卷 502-519页

作者： Winglam Chan Betsy He Xiong Wang Ming-Liang He Department of biomedical Sciences City University of Hong KongHong KongChina Rensselaer Polytechnic institute TroyNYUSA CityU shenzhen research institute NanshanShenzhenChina

The pandemic COVID-19,caused by a new coronavirus SARS-CoV-2 infection,has infected over 12 million individuals and caused more than 55,200 death worldwide.Currently,there is no specific drug to treating this disease.Here we summarized the mechanisms of antiviral therapies and the clinic findings from different countries.Antiviral chemotherapies have been conducted by in multiple cohorts in different counties.Although FDA has fast approved remdesivir for treating COVID-19,it only speeds up recovery from COVID-19 with mildly reduced mortality.The chloroquine was suggested a potential drug against SARS-CoV-2 infection due to its in vitro antiviral effects,it is imperative high-quality data from worldwide clinical trials are necessitated for an approved therapy.In terms of hydroxychloroquine(HCQ)therapy,although WHO has stopped all the clinic trials due to its strong side-effects in COVID patients,large scale clinical trials with a long-term outcome follow-up may warrant HCQ and azithromycin combination in combating the virus.Convalescent plasma(CP)therapy suggested its safety use in SARS-CoV-2 infection;but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human origin.Further research should be conducted to define the exact mechanism of SARS-CoV-2 pathogenesis,suitable animal models or ex vivo human lung tissues aid in studying replication,transmission and spread of the novel viruses,thereby facilitating highly effective therapies.

关键词： Chloroquine Convalescent plasma therapy COVID-19 Hydroxychloroquine Ivermectin Natural killer cell therapy Remdesivir SARS-CoV-2

Mild hyperthermia-enhanced chemo-photothermal synergistic therapy using doxorubicin-loaded gold nanovesicles

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Chinese Chemical Letters 2021年第8期32卷 2411-2414页

作者： Zhuoting Deng Chao Jiang Muhammad Rizwan Younis Shan Lei Yaling He Haoxing Zheng Peng Huang Jing Lin Marshall Laboratory of biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Health Science CenterShenzhen 518060China

Gold nanovesicles(GVs) with unique plasmonic property and large cavity hold great potential as a stimuli-responsive nanocarrier to deliver drugs for efficient tumor chemotherapy and other therapies synergistically.Herein,we developed doxorubicin-loaded gold nanovesicles(DGVs),offering infrared thermal(IRT) and photoacoustic(PA) dual-modal imaging guided mild hype rthermia-enhanced chemophotothermal cancer synergistic therapy.The DGVs are self-assembled by gold nanoparticles modified with amphiphilic copolymer in a predetermined concentration of doxorubicin through film rehydration method.Under the influence of laser excitation,the as-prepared DGVs exhibited good photothermal effect,which triggered the structural disruption of GVs and thus,allowed the efficient release of encapsulated DOX to enhance cell uptake for fluorescence imaging and tumor chemotherapy,respectively.In addition,DGVs also showed a strong PA and IRT signals in vivo.Our study demonstrated the potential of DGVs as stimuli-responsive drug delivery systems and cancer theranostics.

关键词： Mild hyperthermia Chemo-photothermal synergistic therapy Gold nanovesicles Doxorubicin Photoacoustic imaging

SnTe nanoparticles physicochemically encapsulated by double carbon as conversion-alloying anode materials for superior potassium-ion batteries

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Journal of Materials Science & Technology 2023年第27期158卷 86-95页

作者： Ting Li Yikun Wang Qianwen Zhou Lingling Yuan Shuangyan Qiao Meng Ma Zhengqing Liu Shaokun Chong Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China research&Development institute of Northwestern Polytechnical University in shenzhen Shenzhen 518063China

Telluride tin(SnTe)is a promising conversion-alloying anode for potassium-ion batteries(PIBs)due to its high theoretical specific capacity induced by multi-electron transport reaction and low operating voltage,whereas huge volume expansion and poor kinetics behavior become key scientific bottleneck limiting the battery performances.Herein,SnTe nanoparticles physicochemically wrapped by graphene and nitrogen-doped carbon(SnTe@rGO@NC)are proposed as anode materials for PIBs.The pre-electrostatic interaction urges the formation of Sn-C and Te-C chemical bonds between SnTe and double carbon to strengthen the interfacial stability and electron transfer,and the conductive architecture with hierarchical encapsulation effect is beneficial to maintaining the electrode integrity and electrochemical dynamics.It is demon-strated from first principles calculations and experimental results that SnTe@rGO@NC contributes fast electron transmission,strong K-ion adsorption,and superior K-ion diffusion capability.Ex-situ characteri-zations uncover that SnTe undergoes conversion-alloying dual-mechanism with the products of K_(2)Te and K_(4)Sn_(23)replied on Sn redox site(23SnTe+50K^(+)+50e^(-)↔K_(4)Sn_(23)+23K_(2)Te).Thus,the SnTe@rGO@NC electrode delivers a high initial charge specific capacity of 243.9 mAh g^(-1)at 50 mA g^(-1),superior rate performance(112.6 mAh g^(-1)at 1.0 A g^(-1)),and outstanding cyclic stability at various current densities.

关键词： Potassium-ion batteries Anode materials Tin telluride Chemical bonding Conversion-alloying mechanism

Aggregate Engineering in Supramolecular Polymers via Extensive Non-covalent Networks

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Chinese Journal of Polymer Science 2021年第10期39卷 1310-1318,I0007页

作者： Xin Huang Dong Lv Li-Qing Ai Shuk Han Cheng Xi Yao Department of biomedical Sciences City University of Hong KongHong Kong 999077China City University of Hong Kong Shenzhen Research InstituteShenzhen 518075China

Aggregate engineering of non-covalent networks endows supramolecular polymers with thermo-mechanical versatility,stimuli-responsive phase transitions and intrinsic damage-healing capabilities.However,most non-covalent networks are vulnerable at elevated temperatures,which suppresses the robustness of supramolecular polymers.Herein,ureidocytosine(UCy)motifs,which are capable of forming extensive non-covalent networks and thus robust molecular aggregates via multivalent hydrogen bonds and aromatic stackings,are proposed to enable precise programming of the thermo-mechanical versatility.Molecular simulations reveal that the enthalpic contributions from the UCy aggregates play dominant roles to compensate the entropic loss from the redistributions of polymeric spacers and stabilize the non-covalent networks over wide temperature windows.Such aggregate-level strategy offers prospects for applications which require thermo-mechanical versatility of supramolecular polymers,such as 3D printing,microfabrication and damage-healing coating.

关键词： Aggregate engineering Damage-healing Extensive non-covalent network Ureidocytosine Supramolecular polymers

Dissolution-precipitation growth of uniform and clean two dimensional transition metal dichalcogenides

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National Science Review 2021年第3期8卷 108-116页

作者： Zhengyang Cai Yongjue Lai Shilong Zhao Rongjie Zhang Junyang Tan Simin Feng Jingyun Zou Lei Tang Junhao Lin Bilu Liu Hui-Ming Cheng shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute and Tsinghua Shenzhen International Graduate SchoolTsinghua University Shenyang National Laboratory for Materials Sciences Institute of Metal ResearchChinese Academy of Sciences Department of Physics Southern University of Science and Technology

Two dimensional transition metal dichalcogenides(TMDCs) have attracted much interest and shown promise in many applications.However,it is challenging to obtain uniform TMDCs with clean surfaces,because of the difficulties in controlling the way the reactants are supplied to the reaction in the current chemical vapor deposition growth process.Here,we report a new growth approach called’dissolution-precipitation’(DP) growth,where the metal sources are sealed inside glass substrates to control their feeding to the reaction.Noteworthy,the diffusion of metal source inside glass to its surface provides a uniform metal source on the glass surface,and restricts the TMDC growth to only a surface reaction while eliminating unwanted gas-phase reaction.This feature gives rise to highly uniform monolayer TMDCs with a clean surface on centimeter-scale substrates.The DP growth works well for a large variety of TMDCs and their alloys,providing a solid foundation for the controlled growth of clean TMDCs by the fine control of the metal source.

关键词： dissolution-precipitation growth two dimensional materials transition metal dichalcogenides uniform clean

Advances and prospects of triboelectric nanogenerator for self-powered system

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international Journal of Smart and Nano Materials 2021年第3期12卷 233-255页

作者： Xuyao An Chunnan Wang Ruomei Shao Shuqing Suna shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of Optical Imaging and SensingDepartment of Biomedical EngineeringShenzhen International Graduate SchoolTsinghua UniversityShenzhenChina Department of Physics Tsinghua UniversityBeijing China

Self-powered technology is a novel power supply technology.In recent years,self-powered intelligent products have attracted much interests.Triboelectric nanogenerators(TENGs)can convert mechanical energy into electrical energy by contact and relative motion,thus providing the possibility of self-powering for electronic equipments.However,TENG-based self-powered technologies are limited by low power output and poor conversion efficiency.In this review,we present the development of TENG-based self-powered systems,with the emphasis on the output power of TENG and how to improve it.Based on the above applications,we propose the idea of TENG-driven self-powered remote robots,providing promising scenarios of small remote robots for land rescue or underwater detection.Due to the limited power output of the current TENGs,there are still some difficulties in driving the robot.Aiming at the problems of low power supply and poor conversion efficiency,we introduce the current attempts to improve the power generation efficiency from the perspectives of mechanical structure,electrode materials and auxiliary tools.We also outline the applications of TENGs as power supply systems in various fields such as sensing,wearable devices,and collecting Marine energy.Finally,we forecast the development prospect of TENG.

关键词： Triboelectric nanogenerator self-power sensors remote robots

Deep dive into anionic metal-organic frameworks based quasi-solid-state electrolytes

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Journal of Energy Chemistry 2023年第6期81卷 313-320,I0008页

作者： Tingzheng Hou Wentao Xu institute of Materials research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA

The development and application of high-capacity energy storage has been crucial to the global transition from fossil fuels to green energy.In this context,metal-organic frameworks(MOFs),with their unique 3D porous structure and tunable chemical functionality,have shown enormous potential as energy storage materials for accommodating or transporting electrochemically active ions.In this perspective,we specifically focus on the current status and prospects of anionic MOF-based quasi-solid-state-electrolytes(anionic MOF-QSSEs)for lithium metal batteries(LMBs).An overview of the definition,design,and properties of anionic MOF-QSSEs is provided,including recent advances in the understanding of their ion transport mechanism.To illustrate the advantages of using anionic MOF-QSSEs as electrolytes for LMBs,a thorough comparison between anionic MOF-QSSEs and other well-studied electrolyte systems is made.With these in-depth understandings,viable techniques for tuning the chemical and topological properties of anionic MOF-QSSEs to increase Li+conductivity are discussed.Beyond modulation of the MOFs matrix,we envisage that solvent and solid-electrolyte interphase design as well as emerging fabrication techniques will aid in the design and practical application of anionic MOF-QSSEs.

关键词： Anionic metal–organic frameworks Quasi-solid-state electrolytes Ionic conduction Lithium metal batteries Lithium-ion batteries

双金属源制备具有有序阳离子空位的非层状二维金属硫化物

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Science Bulletin 2022年第16期67卷 1649-1658,M0004页

作者：谭隽阳张宗腾曾圣锋李晟楠王经纬郑荣戌侯福臣魏印平孙宇杰张荣杰赵仕龙农慧雨陈文骏干林邹小龙赵悦林君浩刘碧录成会明 shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute and Institute of Materials ResearchShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Physics and shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China School of Electronic Information Engineering Foshan UniversityFoshan 528000China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Faculty of Materials Science and Engineering/institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

二维(2D)过渡金属硫族化合物(TMC)在纳米电子学和能源等领域中有广泛的应用前景.其中,非层状TMC由于表面不饱和悬挂键以及强大的层内和层间化学键使其2D生长极具挑战,限制了极限厚度下的物性探究.本文提出了一种普适的双金属源生长方法... 详细信息

二维(2D)过渡金属硫族化合物(TMC)在纳米电子学和能源等领域中有广泛的应用前景.其中,非层状TMC由于表面不饱和悬挂键以及强大的层内和层间化学键使其2D生长极具挑战,限制了极限厚度下的物性探究.本文提出了一种普适的双金属源生长方法,利用金属及其氯化物的混合物作为金属前驱体,实现了非层状2D TMC的可控生长.以六方Fe_(1-x)S为例,Fe_(1-x)S纳米片的厚度薄至3 nm,横向尺寸超过100μm.与MoS_(2)这类层状TMC(阴离子空位占主导)不同的是,本研究在Fe_(1-x)S中发现了有序阳离子Fe空位.低温输运测试和理论计算结果表明,2D Fe_(1-x)S是一种稳定的窄带隙半导体,其带隙宽度约为60 meV.除Fe_(1-x)S外,该方法还可用于生长其他多种具有有序阳离子空位的非层状2D TMC,包括Fe_(1-x)Se,Co_(1-x)S,Cr_(1-x)S和V_(1-x)S.本工作为非层状材料在2D厚度极限下的生长和物性表征铺平了道路.

关键词：纳米电子学双金属非层状材料可控生长悬挂键过渡金属硫族化合物金属硫化物横向尺寸

Light-induced tumor theranostics based on chemical-exfoliated borophene

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Light(Science & Applications) 2022年第12期11卷 2886-2899页

作者： Zhongjian Xie Yanhong Duo Taojian Fan Yao Zhu Shuai Feng Chuanbo Li Honglian Guo Yanqi Ge Shakeel Ahmed Weichun Huang Huiling Liu Ling Qi Rui Guo Defa Li Paras N.Prasad Han Zhang institute of Pediatrics Shenzhen Children’s HospitalShenzhenGuangdongChina shenzhen Engineering Laboratory of phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People’s Hospitalthe First Affiliated HospitalInstitute of Microscale OptoelectronicsShenzhen University518060 ShenzhenChina Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstituteStockholmSweden shenzhen Medical Ultrasound Engineering Center Department of UltrasonographyShenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityFirst Clinical Medical College of Southern University of Science and Technology518020 ShenzhenChina Optoelectronics research Center School of ScienceMinzu University of China100081 BeijingPR China Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong University226019 NantongJiangsuChina Key Laboratory of Biomaterials of Guangdong Higher Education institutes Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier DevelopmentDepartment of Biomedical EngineeringJinan University510632 GuangzhouChina Department of Core Medical Laboratory the Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuanGuang Dong ProvinceChina Department of Laboratory Medicine Shenzhen Children’s HospitalShenzhenGuangdongChina institute for Lasers Photonicsand Biophotonics and Department of ChemistryUniversity at BuffaloState University of New YorkBuffaloNYUSA

Among 2D materials(Xenes)which are at the forefront of research activities,borophene,is an exciting new entry due to its uniquely varied optical,electronic,and chemical properties in many polymorphic forms with widely varying band gaps including the lightest 2D metallic phase.In this paper,we used a simple selective chemical etching to prepare borophene with a strong near IR light-induced photothermal effect.The photothermal efficiency is similar to plasmonic Au nanoparticles,with the added benefit of borophene being degradable due to electron deficiency of boron.We introduce this selective chemical etching process to obtain ultrathin and large borophene nanosheets(thickness of ~4 nm and lateral size up to ~600 nm)from the precursor of AlB_(2).We also report first-time observation of a selective Acid etching behavior showing HCl etching of Al to form a residual B lattice,while HF selectively etches B to yield an Al lattice.We demonstrate that through surface modification with polydopamine(PDA),a biocompatible smart delivery nanoplatform of B@PDA can respond to a tumor environment,exhibiting an enhanced cellular uptake efficiency.We demonstrate that borophene can be more suitable for safe photothermal theranostic of thick tumor using deep penetrating near IR light compared to gold nanoparticles which are not degradable,thus posing longterm toxicity concerns.With about 40 kinds of borides,we hope that our work will open door to more discoveries of this top-down selective etching approach for generating borophene structures with rich unexplored thermal,electronic,and optical properties for many other technological applications.

关键词： chemical uniquely electronic