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Food Science and Human Wellness 2023年

作者： Yue Zhou Hui Xu Ka-Wing Cheng Feng Chen Qian Zhou Ming-Fu Wang shenzhen Key Laboratory of Food nutrition and health institute for Advanced Study shenzhen University

Abstract: Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs. Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure. In human umbilical vein endothelial cells (HUVECs)， we found that glycidol treatment promoted endothelial-to-mesenchymal transition (EndMT) at a lower concentration (0.5 mmol/L)， while induced apoptosis and inflammation at a higher concentration (1 mmol/L). These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species (ROS). In addition， the protective potential of 6-C-(E-2-fluorostyryl)naringenin (6-CEFN) against glycidol was evaluated and compared with naringenin. HUVECs pre-treated with 6-CEFN， but not naringenin， displayed resistance to endothelial dysfunction caused by glycidol.

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A Comparative Study of Blood Lead Levels in Urban Children in China: The China nutrition and health Survey(CNHS) 2002 and 2012

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Biomedical and Environmental Sciences 2023年第4期36卷 376-380页

作者： LIU Xiao Bing GONG Zhao Long ZHANG Yu ZHANG Hui Di WANG Jun TAN Hong Xing PIAO Jian Hua YANG Li Chen YANG Xiao Guang National institute for nutrition and health Chinese Center for Disease Control and PreventionBeijing 100050China shenzhen Polytechnic School of Food and DrugShenzhen 518000GuangdongChina shenzhen Center for Chronic Disease Control Shenzhen 518020GuangdongChina

Pb is a well-known toxic metal that has attracted considerable attention because of its ubiquitous distribution in the environment owing to the recent industrialization and rapid urbanization in China. In general, Pb from contaminated food, water, and dust enters the body through different channels,spreads throughout the body, combines with multiple amino acids, and interferes with normal physical activity.

关键词： combine interfere Blood

Increasing Trends and Species Diversity of Nontuberculous Mycobacteria in A Coastal Migrant City−shenzhen, China

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Biomedical and Environmental Sciences 2022年第2期35卷 146-150页

作者： JI Le Cai CHEN Shuai PIAO Wei HONG Chuang Yue LI Jin Li JIANG Qi Department of Tuberculosis Control Institute of Laboratory ResearchShenzhen Center for Chronic Disease ControlShenzhen 518020GuangdongChina School of Public health Wuhan UniversityWuhan 430071HubeiChina National institute for nutrition and health Chinese Center for Disease Control and PreventionKey Laboratory of Trace Element Nutrition of National Health CommissionBeijing 100050China

Nontuberculous mycobacteria(NTM)are opportunistic pathogens of environmental origin that can cause human infections in a wide variety of tissues[1].Lung involvement is the most common manifestation of NTM infection[1].The symptoms and radiographic signs are similar to those of patients with pulmonary tuberculosis(TB)who are infected with Mycobacterium tuberculosis complex(MTBC)[1].Most NTM species are naturally resistant to first-line anti-TB drugs and have different resistance profiles,thus misdiagnosis leads to inappropriate treatment and increases the risk of poor prognosis for patients with an NTM infection,and even wider spread through person-to-person contact[2].

关键词： involvement tuberculosis drugs

Salicylic acid inhibits gibberellin signaling through receptor interactions

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Molecular Plant 2022年第11期15卷 1759-1771页

作者： Xiaodong Yu Xiaoyu Cui Chong Wu Shixi Shi Shunping Yan Hubei Hongshan Laboratory Wuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhen 518000China shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureShenzhen 518000China Agricultural Genomics institute at shenzhen Chinese Academy of Agricultural SciencesShenzhen 518000China

It is well known that plants activate defense responses at the cost of growth.However,the underlying molecular mechanisms are not well understood.The phytohormones salicylic acid(SA)and gibberellin(GA)promote defense response and growth,respectively.Here we show that SA inhibits GA signaling to repress plant growth.We found that the SA receptor NPR1 interacts with the GA receptor GID1.Further biochemical studies revealed that NPR1 functions as an adaptor of ubiquitin E3 ligase to promote the polyubiquitination and degradation of GID1,which enhances the stability of DELLA proteins,the negative regulators of GA signaling.Genetic analysis suggested that NPR1,GID1,and DELLA proteins are all required for the SA-mediated growth inhibition.Collectively,our study not only uncovers a novel regulatory mechanism of growth-defense trade-off but also reveals the interaction of hormone receptors as a new mode of hormonal crosstalk.

关键词： salicylic acid gibberellin trade-off receptor growth inhibition

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Biomedical and Environmental Sciences 2021年第4期34卷 324-329页

作者： LIU Xiao Bing WANG Jun LI Ya Jie TAN Hong Xing LIU Yan Yan YU Wei ZHANG Yu YANG Li Chen PIAO Jian Hua LIU Xiao Li YANG Xiao Guang shenzhen Center for Chronic Disease Control Shenzhen 518020GuangdongChina Key Laboratory of Trace Element nutrition of National health Commission National Institute of Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Changzhi Medical College Changzhi 047500ShanxiChina

Iodine is an essential component of thyroid hormones’biosynthesis and is crucial for normal growth and healthy development[1].If the amount of dietary iodine intake cannot match the long-term requirement,regardless of whether it is excessively low or high,it can cause various thyroid dysfunctions,including hyperthyroidism,hypothyroidism,and autoimmune thyroid diseases[2].

关键词： intake diseases dietary

An Overview of Potential Cardioprotective Benefits of Xanthophylls in Atherosclerosis: An Evidence-based Review

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Food Science and Human Wellness 2023年

作者： Yuting Su Feng Chen Jiehua Chen Mingfu Wang Institution for Innovative Development of Food Industry，shenzhen University College of Civil and Transportation Engineering，shenzhen University shenzhen Key Laboratory of Food nutrition and health，shenzhen University shenzhen Key Laboratory of Marine Microbiome Engineering，institute for Advanced Study，shenzhen University

Atherosclerosis， as the most prevalent form of cardiovascular disease， is characterized by oxidized low-density lipoprotein (ox-LDL) accumulation in the vascular wall， increased inflammation of the large arteries， dysfunction of the endothelial cells (ECs) and vascular smooth muscle cells (VSMCs)， which may eventually lead to the formation of plaques. Xanthophylls， one of the main groups of carotenoids， have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective properties. However， the underlying preventive mechanism of action of xanthophylls on the pathogenesis of atherosclerosis remains unclear， and clinical evidence of the effect of xanthophylls on atherosclerosis have not yet been summarized and critically reviewed. In this regard， we conducted a comprehensive literature search in four scientific databases (PubMed， Google Scholar， ScienceDirect and Web of Science) and carefully analyzed the existing evidence to provide meaningful insights on the association between xanthophylls and atherosclerosis from various aspects. Based on the evidence from in vitro and in vivo studies， we explored several potential mechanisms， including antioxidant effect， anti-inflammatory effect， regulation of lipid metabolism， and modulation of ECs and VSMCs dysfunction， and we found that a clear picture of regulatory pathways of xanthophylls on atherosclerosis prevention and treatment is still lacking. In addition， epidemiological studies suggested the possible relationship among high dietary intake of xanthophylls， high plasma/serum xanthophylls and a reduced risk of atherosclerosis. Direct evidence from interventional studies investigating the effect of xanthophylls on atherosclerosis is very sparse， whilst indirect clinical evidence was only limited to astaxanthin and lutein. Therefore， well-designed long-term randomized controlled trials (RCTs) are highly recommended for future studies to investigate the effective dose of different xanthophyll

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Biogeographic and Evolutionary Patterns of Trace Element Utilization in Marine Microbial World

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 958-972页

作者： Yinzhen Xu Jiayu Cao Liang Jiang Yan Zhang Shanghai institute of nutrition and health Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China shenzhen Key Laboratory of Marine Bioresources and Ecology College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518055China shenzhen-Hong Kong institute of Brain Science-shenzhen Fundamental Research Institutions Shenzhen 518055China

Trace elements are required by all organisms,which are key components of many enzymes catalyzing important biological reactions.Many trace element-dependent proteins have been characterized;however,little is known about their occurrence in microbial communities in diverse environments,especially the global marine ecosystem.Moreover,the relationships between trace element utilization and different types of environmental stressors are unclear.In this study,we used metagenomic data from the Global Ocean Sampling expedition project to identify the biogeographic distribution of genes encoding trace element-dependent proteins(for copper,molybdenum,cobalt,nickel,and selenium)in a variety of marine and non-marine aquatic samples.More than 56,000 metalloprotein and selenoprotein genes corresponding to nearly 100 families were predicted,becoming the largest dataset of marine metalloprotein and selenoprotein genes reported to date.In addition,samples with enriched or depleted metalloprotein/selenoprotein genes were identified,suggesting an active or inactive usage of these micronutrients in various sites.Further analysis of interactions among the elements showed significant correlations between some of them,especially those between nickel and selenium/copper.Finally,investigation of the relationships between environmental conditions and metalloprotein/selenoprotein families revealed that many environmental factors might contribute to the evolution of different metalloprotein and/or selenoprotein genes in the marine microbial world.Our data provide new insights into the utilization and biological roles of these trace elements in extant marine microbes,and might also be helpful for the understanding of how these organisms have adapted to their local environments.

关键词： Trace element Marine metagenome Metalloprotein Selenoprotein Evolution

Altered metabolic state impedes limb regeneration in salamanders

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Zoological Research 2021年第6期42卷 772-782页

作者： Zhe-Lun Peng Bin-Xu Yin Rui-Min Ren Yin-Long Liao Hao Cai Heng Wang College of Animal Sciences and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhenGuangdong 518120China shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China

Salamanders are unique among tetrapods in their ability to regenerate the limbs throughout life.Like other poikilothermic amphibians,salamanders also show a remarkable capacity to survive long periods of starvation.Whether the physiological reserves necessary for tissue regeneration are preserved or sacrificed in starved salamanders is unknown.In the current study,we maintained Iberian ribbed newts(Pleurodeles waltl)under extreme physiological stress to assess the extent of regeneration and identify the molecular and cellular changes that may occur under such conditions.After 19 months of complete food deprivation,the animals exhibited extensive morphological and physiological adaptations but remained behaviorally active and vigilant.Autophagy was elevated in different tissues and the transformed gut microbiota indicated remodeling of the intestinal tract related to autophagy.Upon limb amputation in animals starved for 21 months,regeneration proceeded with progenitor cell proliferation and migration,leading to limb blastema formation.However,limb outgrowth and patterning were substantially attenuated.Blockage of autophagy inhibited cell proliferation and blastema formation in starved animals,but not in fed animals.Hence,tissue autophagy and the regenerative response were tightly coupled only when animals were under stress.Our results demonstrate that under adverse conditions,salamanders can exploit alternative strategies to secure blastema formation for limb regeneration.

关键词： Starvation Stress Autophagy Regeneration Salamander

Rapid detection of fluoroquinolone residues in aquatic products based on a gold-labeled microwell immunochromatographic assay

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Food Quality and Safety 2022年第4期6卷 597-607页

作者： Jiaxu Xiao Hongfei Yang Liangni Qin Jixiang Liang Long Li Xiaohui Fan Dapeng Peng National Reference Laboratory of Veterinary Drug Residues/Key Laboratory of Ministry of Agriculture for the Detection of Veterinary Drug Residues in Foods Huazhong Agricultural UniversityWuhanChina Wuhan Shangcheng Biotechnology Co. Ltd.WuhanChina Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhenChina shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina

Objectives:Fluoroquinolones(FQs)are widely used in aquaculture,and their residues have caused many problems threatening human health.Here,this study aims to develop a colloidal gold immunochromatographic strip based on gold-labeled microwells to screen the residues of FQs on site.Materials and methods:The Protein A Magarose Beads affinity chromatography method was adopted to purify the ascites against FQs.By using a strategy of heterologous coating antigen,different coating antigens are applied to detect FQs.The gold-labeled microwell immunochromatographic assay was used to improve the sensitivity of the test strip by the advanced reaction of antigen and antibody.Results:The antibodies were verified to be of high purity up to 99%,and the titer reached 1:1024000.The combination(enoxacin-OVA and the antibody)detected the 4 banned FQs(pefloxacin,PEF;norfloxacin,NOR;lomefloxacin,LOM;ofloxacin,OFL)with the 50%inhibiting concentration(IC50)values ranging from 1.3 to 2.1 ng/mL and cross-reactions ranging from 67.3%to 106.1%.The analysis of spiked crucian carp,silver carp,grass carp,and shrimp samples showed that the limit of detection for PEF,NOR,LOM,and OFL was 4μg/kg.A comparative study with liquid chromatography tandem mass spectrometry(LC-MS/MS)demonstrated that the assay provided an effective screening tool for the rapid detection of FQs residues.Conclusions:The results indicated that the test strip can realize full coverage recognition of the 4 banned FQs and has good accuracy,specifi-city,reproducibility,and stability;therefore,they are more suitable for rapid detection of FQs in aquatic products.

关键词： fluoroquinolones colloidal gold microwell purification residues

Restored intestinal integrity,nutrients transporters,energy metabolism,antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling

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Journal of Animal Science and Biotechnology 2023年第1期14卷 390-408页

作者： Chang Cui Caichi Wu Jun Wang Ziwei Ma Xiaoyu Zheng Pengwei Zhu Nuan Wang Yuhua Zhu Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China. shenzhen Kingsino Technology CO. LTDShenzhen 518107China. Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China. Agricultural Genomics institute at shenzhen Chinese Academy of Agricultural SciencesShenzhen 518116China. College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China. Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China.

Background:Intrauterine growth restriction(IUGR)is a major inducer of higher morbidity and mortality in the pig industry and catch-up growth(CUG)before weanling could significantly restore this negative influence.But there was limited knowledge about the underlying mechanism of CUG occurrence.Methods:Eighty litters of newborn piglets were divided into normal birth weight(NBW)and IUGR groups according to birth weight.At 26 d,those piglets with IUGR but over average body weight of eighty litters of weaned piglets were considered as CUG,and the piglets with IUGR still below average body weight were considered as NCUG.This study was conducted to systemically compare the intestinal difference among NBW,CUG and NCUG weaned piglets considering the crucial role of the intestine for piglet growth.Results:The results indicated that the m RNA expression of nutrients(amino acids,glucose,and fatty acids)transporters,and mitochondrial electron transport chain(ETC)I were upregulated in CUG piglets'gut with improved morphology compared with those NCUG,as well as the ratio of P-AMPK/AMPK protein expression which is the indicator of energy metabolism.Meanwhile,CUG piglet's gut showed higher antioxidative capacity with increased SOD and GSHPx activity,decreased MDA levels,as well as higher m RNA expressions of Nrf2,Keap1,SOD,and GSH-Px.Furthermore,inflammatory parameters including TNF-α,IL-1β,IL-6,and IL-12 factors,and the activation of MAPK and NF-κB signaling pathways were significantly elevated in the NCUG intestine,while the protein expression of ZO-1,Occludin and Claudin-1 was reduced.The alpha diversity of fecal microbiota was higher in CUG piglets in contrast with NCUG piglets,and the increased beneficial bacteria and decreased pathogenic bacteria was also observed in CUG piglets.Conclusions:CUG piglet's intestine showed comprehensive restoration including higher nutrients transport,energy metabolism,antioxidant capacity,and intestinal physical barrier,while lower oxidative stress,inflammatory response,and pathogenic microbi

关键词： Antioxidative capacity Catch-up growth Gut Intrauterine growth retardation Piglets