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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-zhen Qiu Wen-Long Guan sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin shen Jin Li Rui-Hua Xu Department of medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Long-term safety and absorption assessment of a novel bioresorbable nitrided iron scaffold in porcine coronary artery

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Bioactive Materials 2022年第11期7卷 496-505页

作者： Jian-Feng zheng Zi-Wei Xi Yang Li Jia-Nan Li Hong Qiu Xiao-Ying Hu Tong Luo Chao Wu Xin Wang Lai-Feng Song Li Li Hai-Ping Qi Gui Zhang Li Qin Wan-Qian Zhang Xiao-Li Shi Shu-Han Wang De-Yuan Zhang Bo Xu Run-Lin Gao Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina R&D center Biotyx Medical(Shenzhen)Co.Ltd.ShenzhenChina National and Local Joint Engineering Laboratory of Interventional medical Biotechnology and System Lifetech Scientific(Shenzhen)Co.Ltd.ShenzhenChina shen zhen testing center of medical devices ShenzhenChina Department of Cardiology and Macrovascular Disease Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

This study aimed to investigate the long-term biocompatibility, safety, and degradation of the ultrathin nitrided iron bioresorbable scaffold (BRS) in vivo, encompassing the whole process of bioresorption in porcine coronary arteries. Fifty-two nitrided iron scaffolds (strut thickness of 70 μm) and 28 Vision Co–Cr stents were randomly implanted into coronary arteries of healthy mini-swine. The efficacy and safety of the nitrided iron scaffold were comparable with those of the Vision stentwithin 52 weeks after implantation. In addition, the long-term biocompatibility, safety, and bioresorption of the nitrided iron scaffold were evaluated by coronary angiog-raphy, optical coherence tomography, micro-computed tomography, scanning electron microscopy, energy dispersive spectrometry and histopathological evaluations at 4, 12, 26, 52 weeks and even at 7 years after im-plantation. In particular, a large number of struts were almost completely absorbed in situ at 7 years follow-up, which were first illustrated in this study. The lymphatic drainage pathway might serve as the potential clearance way of iron and its corrosion products.

关键词： Bioresorbable scaffold Nitrided iron bioresorbable coronary scaffold Preclinical study Completely bioresorbable

Pressure manipulation of ultrafast carrier dynamics in monolayer WS_(2)

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Journal of Semiconductors 2023年第8期44卷 35-40页

作者： Yao Li Haiou Zhu Zongpeng Song New Materials and New Energies Shen Zhen Technology UniversityShenzhen 518118China Analysis and testing center Shen Zhen Technology UniversityShenzhen 518118China

Two-dimensional transition metal dichalcogenides(TMDs)have intriguing physic properties and offer an exciting platform to explore many features that are important for future *** this work,we synthesized monolayer WS_(2)as an example to study the optical response with hydrostatic *** Raman results show a continuous tuning of the lattice vibrations that is induced by hydrostatic *** further demonstrate an efficient pressure-induced change of the band structure and carrier dynamics via transient absorption *** found that two time constants can be attributed to the capture process of two kinds of defect states,with the pressure increasing from 0.55 GPa to 2.91 GPa,both of capture processes were accelerated,and there is an inflection point within the pressure range of 1.56 GPa to 1.89 *** findings provide valuable information for the design of future optoelectronic devices.

关键词： two-dimensional transition metal dichalcogenides hydrostatic pressure carrier dynamics band structure ultrafast spectroscopy

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

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Nano-Micro Letters 2024年第7期16卷 31-45页

作者： Tao Zhang Cheng-Hui Li Wenbo Li zhen Wang Zhongya Gu Jiapu Li Junru Yuan Jun Ou-Yang Xiaofei Yang Benpeng Zhu School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093People’s Republic of China National Institute of Dental and Craniofacial Research(NIDCR) National Institutes of Health(NIH)35A Convent DriveBethesdaMD 20892USA Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Compared with traditional piezoelectric ultrasonic devices,optoacoustic devices have unique advantages such as a simple preparation process,anti-electromagnetic interference,and wireless long-distance power ***,current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency,which seriously hinder their widespread *** this study,using a self-healing polydimethylsiloxane(PDMS,Fe-Hpdca-PDMS)and carbon nanotube composite,a flexible optoacoustic patch is developed,which possesses the self-healing capability at room temperature,and can even recover from damage induced by cutting or laser ***,this patch can generate high-intensity ultrasound(>25 MPa)without the focusing *** laser damage threshold is greater than 183.44 mJ cm^(-2),and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66×10^(-3),compared with other carbon-based nanomaterials and PDMS *** patch is also been successfully examined in the application of acoustic flow,thrombolysis,and wireless energy *** findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

关键词： Optoacoustic Self-healing PDMS Acoustic flow Thrombolytic Wireless energy harvesting

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Magnetic resonance (MR) safety and compatibility of a novel iron bioresorbable scaffold

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Bioactive Materials 2020年第2期5卷 260-274页

作者： Dong Bian Li Qin Wenjiao Lin Danni shen Haiping Qi Xiaoli Shi Gui Zhang Hongwei Liu Han Yang Jin Wang Deyuan Zhang Yufeng zheng Biotyx medical(shenzhen)Co. LtdShenzhen518110GuangdongChina Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Key Lab.of Advanced Technology for Materials of Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031SichuanChina shenzhen Advanced medical Services Co. LtdShenzhen518000GuangdongChina shen zhen testing center of medical devices Shenzhen518057GuangdongChina

Fully bioresorbable scaffolds have been designed to overcome the limitations of traditional drug-eluting stents(DESs),which permanently cage the native vessel wall and pose possible *** ultrathin-strut designed sirolimus-eluting iron bioresorbable coronary scaffold system(IBS)shows comparable mechanical properties to traditional DESs and exhibits an adaptive degradation profile during target vessel healing,which makes it a promising candidate in all-comers patient *** implanted medical devices,magnetic resonance(MR)imaging properties,including MR safety and compatibility,should be evaluated before its clinical use,especially for devices with intrinsic *** this study,MR safety and compatibility of the IBS scaffold were evaluated based on a series of well-designed in-vitro,ex-vivo and in-vivo experiments,considering possible risks,including scaffold movement,over-heating,image artifact,and possible vessel injury,under typical MR *** ASTM standards for MR safety and compatibility evaluation of intravascular devices were referred,but not only limited to *** unique time-relevant MR properties of bioresorbable scaffolds were also *** forces imposed on the scaffold during MR scanning and MR image artifacts gradually decreased along with scaffold degradation/*** experiments designed based on a scientifically based rationale revealed that the IBS scaffold is MR conditional,though not MR compatible before complete *** methodology used in the present study can give insight into the MR evaluation of magnetic scaffolds(bioresorbable)or stents(permanent).

关键词： Iron bioresorbable scaffold Magnetic resonance imaging(MRI) MR safety MR compatibility Artifact

Multicenter evaluation of a simple and sensitive nucleic acid self-testing for SARS-CoV-2

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Virologica Sinica 2023年第4期38卷 620-626页

作者： Xin-Xin shen Feng-Yu Li Meng Qin Guo-Hao Zhang Meng-Yi Zhang Hong Liu Xiu-Li Sun zhen-Jiang Xin Xue-Jun Ma NHC Key Laboratory of medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Hebei medical University Shijiazhuang050031China Fengtai District center for Disease Control and Prevention of Beijing Beijing100071China Beijing Baicare Biotechnology Co. Ltd.Beijing102206China Shandong University of Technology School of Life Sciences and MedicineZibo255000China

A rapid and accurate COVID-19 diagnosis is a prerequisite for blocking the source of infection as soon as possible and taking the appropriate medical ***,we developed GeneClick,a device for nucleic acid self-testing of SARS-CoV-2,consisting of three modules:a sampling kit,a microfluidic chip-based disposable cartridge,and an amplification *** addition,we evaluated the clinical performance of GeneClick using 2162 nasal swabs collected at three medical institutions,using three commercial RT-qPCR kits and an antigen self-test as *** to RT-qPCR,the sensitivity and specificity of the GeneClick assay were 97.93%and 99.72%,respectively,with a kappa value of 0.979(P<0.01).Of the 2162 samples,2076 were also tested for SARS-CoV-2 *** the 314 positive samples identified by GeneClick assay,63 samples were undetected by antigen ***,the GeneClick nucleic acid self-test demonstrated higher accuracy than the antigen-based *** on the additional features,including simple operation,affordable price,portable device,and reliability of smartphone APP-driven sampling and result reporting,GeneClick offers a powerful tool for field-based SARS-CoV-2 detection in primary healthcare institutions or at-home use.

关键词： Nucleic acid self-testing SARS-CoV-2 RT-qPCR Antigen-test

丹酚酸B和人参皂苷Rg1合用对卒中后出血性转化的抑制作用

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Chinese Medicine and Natural Products 2023年第2期3卷 81-89页

作者：邢荣荣王一宇王琳琳沈海生 Yi Jin 于海英刘荣霞姜宝红烟台大学药学院山东烟台264005 中国科学院上海药物研究所上海200120 shenzhen Institute for Drug Control Shenzhen Testing center of medical devicesShenzhenChina

目的:对脑卒中患者进行血管再通治疗不仅受时间窗的限制,还伴随着出血性转化的风险。本研究在小鼠大脑中动脉阻塞(MCAO)模型上观察了丹酚酸B和人参皂苷Rg1合用(Salb/Rg1)对脑缺血时间窗和出血性转化的影响。方法:通过脑梗死体积、神经... 详细信息

目的:对脑卒中患者进行血管再通治疗不仅受时间窗的限制,还伴随着出血性转化的风险。本研究在小鼠大脑中动脉阻塞(MCAO)模型上观察了丹酚酸B和人参皂苷Rg1合用(Salb/Rg1)对脑缺血时间窗和出血性转化的影响。方法:通过脑梗死体积、神经行为障碍和组织形态学检查评估SalB/Rg1的保护作用和时间窗。对MCAO小鼠进行葡萄糖刺激和再灌注考察SalB/Rg1对出血性转化的抑制。SalB/Rg1对出血性转化的抑制作用是通过免疫荧光染色和原位明胶酶谱技术来确定的。结果:通过组织病理学染色根据细胞结构进一步确定SalB/Rg1以剂量依赖的方式显著减少了梗塞体积并改善了神经行为,且SalB/Rg1对卒中的保护时间窗长达9h。其次,SalB/Rg1下调了出血评分、梗死体积并改善异常神经行为。最后,发现SalB/Rg1对出血性转化的抑制与它对神经血管单元完整性的保护相伴随。在梗死的边缘区域,SalB/Rg1减少了星形胶质细胞的激活,保持了内皮细胞之间连接蛋白(Claudin-5)的丰度,大大降低了基质金属肽酶9(MMP-9)的活性。结论:SalB/Rg1是一种很有前景的抗卒中,尤其是抗出血性转化的新策略。

关键词：卒中丹酚酸B 人参皂苷Rg1 出血性转化神经血管单元

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p.N78S and p.R161Q germline mutations of the VHL gene caused von Hippel-Lindau syndrome in two southern Chinese pedigrees

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p.N78S and p.R161Q germline mutations of the VHL gene caused...

LO2细胞3-D模型用于四种纳米银包裹的牙科合金材料毒性的检测（英文）

2013浙江省医学遗传学学术年会

作者： Xiao-Ping Qi Wen-Ting Liu Yan Zhao Ju-Ming Ma Jun Fei Feng Li Mao shen Hang-Yang Jin zhen-Guang Chen zhen-Fang Du Xiao-Ling Chen Hu-Ling Jiang Xian-Ning Zhang Department of Oncologic Surgery Department of Urologic SurgeryClinical Experimental Centerand Department of PathologyThe 117th PLA Hospital Department of Biochemistry and Genetics National Education Base for Basic Medical SciencesInstitute of Cell BiologyZhejiang University School of Medicine

von Hippel-Lindau disease(VHL) is an autosomal dominant familial cancer *** is characterized by the development of renal cell carcinoma(RCC),haemangioblastomas of the central nervous system or retina and pheochromocytoma(PCC).RCC and PCC are known to be caused by germline mutations of six and ten genes,***,two unrelated southern Chinese pedigrees with type 2A and 2C VHL syndrome containing 30 individuals were *** were clinically examined and treated by radical nephrectomy(or nephron sparing surgery) and cortical-sparing adrenalectomy,and all members of the families underwent genetic *** members presented PCC and RCC from one family and three individuals who had only hypertension were diagnosed with PCC from another *** variants of the VHL gene,C.A233G(p.N78S) within exon 1 and C.G482A(p.R161Q) within exon 3,were verified *** was performed on all the patients except a 5-year-old p.N78S boy in Family 1 who had asymptomatic,as well as genetic testing and genetic *** future,we will go on following up the cases with a focus on blood pressure and health,although they have normal blood pressure and no local recurrence and distant metastasis of VHL so *** study suggests that molecular genetic testing is helpful in the diagnosis and clinical management of VHL syndrome.

关键词： pheochromocytoma renal cell carcinoma VHL gene von Hippel-Lindau syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第2期19卷 159-167页

作者： Yi-ying ZHAO Qiang CHU Xu-er SHI Xiao-dong zhenG Xiao-ting shen Yan-zhen ZHANG Department of Food Science and Nutrition Zhejiang Key Laboratory for Agro-Food ProcessingFuli Institute of Food Science Huajiachi Dental center Stomatology Hospital Affiliated to Zhejiang University of Medicine Department of General Dentistry the Second Affiliated Hospital School of Medicine Zhejiang University

目的:应用体外三维模型模拟肝脏组织微环境,更真实地反映和评估纳米银材料和牙科合金对于人体的潜在毒性。创新点:借助中空纤维管和胶原蛋白首次构建了LO2细胞三维聚集体,并将该模型应用到医用材料毒性的评价中。方法:首先,采用扫描电... 详细信息

目的:应用体外三维模型模拟肝脏组织微环境,更真实地反映和评估纳米银材料和牙科合金对于人体的潜在毒性。创新点:借助中空纤维管和胶原蛋白首次构建了LO2细胞三维聚集体,并将该模型应用到医用材料毒性的评价中。方法:首先,采用扫描电镜观察中空纤维材料的孔径,确保营养物质的正常交换。然后,将混合有胶原蛋白的细胞悬液注入到中空纤维管的内胆,通过尿素氮和白蛋白检测,确定最佳细胞密度进行长期培养。在显微镜下观察细胞聚集体的形态,确保模型的成功建立。其次,应用水热法制作纳米银颗粒并将颗粒包裹到预先购买的合金材料上。最后,用不同牙科材料的浸提液培养细胞1、3和5天,通过MTT检测细胞死亡率,从而间接评价材料的毒性。结论:中空纤维材料的表征结果显示该材料具有较好的耐热性和细胞粘附性,孔径大小适宜营养物质交换,可以应用到三维模型的构建中。通过白蛋白和尿素氮两个指标来评价三维模型的活性,发现每毫升5×104细胞的浓度最适宜细胞生长(图4)。进一步模型评价表明,相比于传统单层培养的细胞,三维模型中的细胞能保持长期活力(图6)且可以在更短时间内对低药物浓度作出反应。

关键词： LO2细胞三维模型纳米银牙科合金毒性检测

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