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MB49小鼠膀胱癌腺病毒基因疗法模型的优化

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中国比较医学杂志 2006年第3期16卷 166-166页

作者： Loskog，A． Ninalga，C． Hedlund，T． Alimohammadi，M． Malmstrsm，P-U． Totterman，T．H．张建军 Clinical Immunology Division Rudbeck Laboratory Uppsala University Sweden Division of Molecular Medicine Uppsala University Hospital Sweden Experimental Urology Division Rudbeck LaboratoryUppsala University Sweden 不详

MRI定量肝灌注指数图:一种可能对抗肿瘤血管生成复合物BIBF1120(一种有效三联血管激酶抑制剂)治疗肿瘤效果可重复评估的方法

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国际医学放射学杂志 2008年第5期31卷 413-413页

作者： K. Miyazaki D.J. Collins S. Walker-Samuel J.N. Taylor A.R. Padhani M.O. Leach 赵艳萍（译）刘文亚（校）唐光健（校） CRUK Clinical Magnetic Resonance Research Group The Institute of Cancer Research Royal Marsden Hospital Downs Road Sutton Surrey SM2 5PT UK. 不详

肝转移灶由肝动脉供血，造成肝灌注指数（HPI）增高。本研究的目的是用动态增强MRI定量分析肝转移灶在接受一种抗血管生成新药治疗前后的灌注指数。10例已知肝转移瘤的病人接受了动态增强MR成像检查。转移灶及全肝的HPI均由感兴趣区（RO... 详细信息

肝转移灶由肝动脉供血，造成肝灌注指数（HPI）增高。本研究的目的是用动态增强MRI定量分析肝转移灶在接受一种抗血管生成新药治疗前后的灌注指数。10例已知肝转移瘤的病人接受了动态增强MR成像检查。转移灶及全肝的HPI均由感兴趣区（ROI）获取，并以像素对像素的方式定量计算钆喷酸葡胺（Gd—DTPA）的浓度改变。治疗前HPI测量误差用Bland—Ahman法分析，在应用抗血管生成药物BIBF1120治疗前后中位HPI的比较应用Wilcoxon秩和检验。治疗前，

关键词： MRI 动态肝脏成像肝灌注指数

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阿达木单抗成功治疗严重型银屑病和银屑病关节炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 28-28页

作者： Chew A.-L. Bennett A. Smith C.H. J.Barker 田中伟 Skin Therapy Research Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom Prof.

Adalimumab, a fully human-derived recombinant monoclonal antibody against tumour necrosis factor-α, has been shown to be effective for the treatment of patients with moderately to severely active rheumatoid arthritis. We report two patients with long-standing recalcitrant psoriasis and psoriatic arthritis who, after multiple treatment failures with conventional and experimental antipsoriatic medications, both responded to treatment with adalimumab. Significant clinical improvement was noted in both skin and joint disease in the two patients after several weeks of treatment with adalimumab. We are unaware of previous published reports of adalimumab therapy in patients with psoriasis and psoriatic arthritis.

关键词：银屑病关节炎严重型达木抗银屑病药物肿瘤坏死因子人源性单克隆抗体关节症状

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超声、CT、MRI及PET对于肿瘤血管生成的标准化测量的建议

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国际医学放射学杂志 2012年第5期 494-494页

作者： A.K.Dixon F.J.Gilbert 王茂雪 Department of Radiology Addenbrooke's Hospital and the University of CambridgeCambridge University Hospitals NHS Foundation TrustLevel 5Box 218Hills RoadCambridge CB2 0QQUK

摘要本文讨论了US、CT、MRI和PET4种方法评估肿瘤血管生成的标准。在肿瘤研究及临床应用中,这些方法对于评价治疗后血管的反应尤其重要。成像方法已从过去主观解释图像的形式转变为如今完全成熟的客观的科学方法,放射学专家在评价病变... 详细信息

摘要本文讨论了US、CT、MRI和PET4种方法评估肿瘤血管生成的标准。在肿瘤研究及临床应用中,这些方法对于评价治疗后血管的反应尤其重要。成像方法已从过去主观解释图像的形式转变为如今完全成熟的客观的科学方法,放射学专家在评价病变时都应该严格选择最佳的技术方法。严格采用合适的成像方案并保证影像质量,实验才会由制药公司及其他资金赞助方资助。

关键词：肿瘤血管血管新生早期试验定量灌注疗效评估

Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer

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四川生理科学杂志 2023年第8期45卷 1427-1427页

作者： Philippe A Cassier Centre Léon Bérard Departement de Recherche Clinique Centre de recherche en cancérologie de Lyon INSERM U1052-CNRS UMR5286 Université de Lyon Université Claude Bernard Lyon1 Centre Léon Bérard Lyon France Basic Medical Sciences Department Oncological Pathology Group Institut de Recerca Biomèdica de Lleida Universidad de Lleida Lleida Spain Apoptosis Cancer and Development Laboratory – Equipe labellisée ‘La Ligue’ LabEx DEVweCAN Institut PLAsCAN Centre de Recherche en Cancérologie de Lyon INSERM U1052-CNRS UMR5286 Université de Lyon Université Claude Bernard Lyon1 Centre Léon Bérard Lyon France Netris Pharma Lyon France Centre de Recherche en Cancérologie de Lyon INSERM U1052-CNRS UMR 5286 Centre Léon Bérard Claude Bernard Lyon 1 University Lyon France Institut Claudius Regaud IUCT-Oncopole Toulouse France Laboratory of Stem Cells and Cancer WEL Research Institute Université Libre de Bruxelles Brussels Belgium CRCL Core facilities Centre de Recherche en Cancérologie de Lyon (CRCL) INSERM U1052-CNRS UMR5286 Université de Lyon Université Claude Bernard Lyon1 Centre Léon Bérard Lyon France Hospices Civils de Lyon Department of Pathology Lyon France Department of Pathology IUCT-Oncopole Toulouse France DIAPath Center for microscopy and molecular Imaging Université Libre de Bruxelles Gosselies Belgium Laboratory of Image Synthesis and Analysis Ecole Polytechnique-Université libre de Bruxelles Brussels Belgium Departement of Pathology Erasme University Hospital Université Libre de Bruxelles Brussels Belgium Centre Universitaire Inter Régional d’Expertise en Anatomie pathologique hospitalière (CurePath) Jumet Belgium

Netrin-1 is upregulated in cancers as a protumoural *** we describe netrin-1 upregulation in a majority of human endometrial carcinomas(ECs)and demonstrate that netrin-1 blockade,using an anti-netrin-1 antibody(NP137),is effective in reduction of tumour progression in an EC mouse *** next examined the efficacy of NP137,as a first-in-class single agent,in a Phase I trial comprising 14 patients with advanced *** best response we observed 8 stable disease(8 out of 14,57.1%)and 1 objective response as RECIST v.1.1(partial response,1 out of 14(7.1%),51.16%reduction in target lesions at 6 weeks and up to 54.65%reduction during the following 6 months).To evaluate the NP137 mechanism of action,mouse tumour gene profiling was performed,and we observed,in addition to cell death induction,that NP137 inhibited epithelial-to mesenchymal transition(EMT).By performing bulk RNA sequencing(RNA-seq),spatial transcriptomics and single-cell RNA seq on paired pre-and on-treatment biopsies from patients with EC from the NP137 trial,we noted a net reduction in tumour *** was associated with changes in immune infiltrate and increased interactions between cancer cells and the tumour *** the importance of EMT in resistance to current standards of care2,we show in the EC mouse model that a combination of NP137 with carboplatin-paclitaxel outperformed carboplatin-paclitaxel *** results identify netrin-1 blockade as a clinical strategy triggering both tumour debulking and EMT inhibition,thus potentially alleviating resistance to standard treatments.

关键词： tumour inhibited EMT