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Facile synthesis of Er^(3+)/Tm^(3+)co.doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications

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Journal of Rare Earths 2022年第1期40卷 11-19页

作者： Hongyu Liu Jiabei Li Pengfei Hu Songqiang Sun Liyi Shi Lining Sun research Center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Instrumental Analysis&research Center Shanghai UniversityShanghai 200444China

Manganese-zinc ferrite is a kind of very important magnetic ferrite *** properties of wide absorption band,sensitivity to ultraviolet(UV)light and tumor H_(2)O_(2) promise it to be possibly used as a photothermal therapy(PTT),photodynamic therapy(PDT)and chemodynamic therapy(CDT)*** on the unique advantages of rare-earth doped nanoparticles,an Er^(3+),Tm^(3+)co.doped upco.version-mediated nanosystem with manganese-zinc ferrite shell(named as UCNPS@M)was developed through a facile thermal co.deco.position *** final nanosystems were surface-modified by using dopamine hydrochloride(DA)in order to warrant good bioco.patibility(named as UCNPS@M@DA).Under irradiation of near-infrared(NIR)light,UCNPS emit both ultraviolet and visible *** UV light is mostly abso rbed by manga nese-zinc ferrite shell to produce reactive oxygen species(ROS),which is essential to the potential PDT and CDT effect of nanosystems,and at the same time,Mn_(0.5)Zn_(0.5)Fe2O_(4) can further react with H_(2)O_(2) to promote the efficiency of *** is expected that UCNPS@M@DA can act as upco.version luminescence imaging guidance due to the visible emission from *** addition,the energy absorbed by the nanosystems can be transferred to heat to realize photothermal ***,UCNPS@M@DA was successfully applied as a T_(1)/T_(2)-weighted magnetic resonance imaging(MRI)co.trast agent due to the existence of Gd,Mn,and Fe *** light of the upco.version luminescence(UCL)imaging from the UCNPS as well as potential PTT,PDT,CDT effect mentioned above,this work provides a possibility to realize cancer multi-model bioimaging guided treatment by using an all-in-one diagnosis and therapy nanosystem through a simple yet powerful strategy.

关键词： Manganese-zinc ferrite Upco.version nanoparticles Photothermal effect Reactive oxygen species Good bioco.patibility Rare earths

Ph_3P^+CF_2co.2^- as an F^- and:CF_2 source for trifluoromethylthiolation of alkyl halides

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Chinese Chemical Letters 2019年第3期30卷 714-716页

作者： Zhuo Liu Jin Long Xuan Xiao Jin-Hong Lin Xing Zheng Ji-Chang Xiao Yu-Cai Cao institute of Pharmacy and Pharmaco.ogy Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study University of South China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences shanghai research institute of Chemical Industry co. LTD.

As trifluoromethylthiolation has received increasing attention recently, many CF_3S-reagents and trifluoromethylthiolation methods have been developed. Herein we describe trifluoromethylthiolation of alkyl halides by using Ph_3 P^+CF_2co.2 as a fluoride and difluorocarbene source. Difluorocarbene is a versatile intermediate, but its side reactions are usually ignored and the by-products would therefore be discarded. In this work, a side reaction of difluorocarbene, the generation of a fluoride anion from difluorocarbene, was developed into a synthetic tool. Although the trifluoromethylthiolation reaction involved multi-sequential steps, the cleavage of C-F bond, the formation of CF_2=S bond, F-C(S)F_2 bond,and C-SCF_3 bond, the co.version proceeded fast and was co.pleted within 10 min.

关键词： Difluorocarbene Trifluoromethylthiolation Alkyl halides Thiocarbonyl fluoride Fluorine

Helium nano-bubble bursting near the nickel surface

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Chinese Physics B 2017年第11期26卷 155-161页

作者：龚恒风刘敏高飞李锐严岩黄恒刘彤任啟森 ATF R&D Accident Tolerant Fuel research and Development China Nuclear Power Technology Research Institute Co. Ltd shanghai institute of Applied Physics Chinese Academy of Sciences Division of Nuclear Materials and Engineering Key Laboratory of Interfacial Physics and Technology Chinese Academy of Sciences Department of Mechanical Engineering University of Michigan

We have investigated the expansion and bursting of a helium nano-bubble near the surface of a nickel matrix using a molecular dynamics simulation. The helium atoms erupt from the bubble in an instantaneous and volcano-like process,which leads to surface deformation co.sisting of cavity formation on the surface, along with modification and atomic rearrangement at the periphery of the cavity. During the kinetic releasing process, the channel may undergo the ＂open＂ and＂close＂ states more than once due to the variation of the stress inside the nano-bubble. The ratio between the number of helium atoms and one of vacancies can directly reflect the releasing rate under different temperatures and crystallographic orientation co.ditions, respectively. Moreover, a special relationship between the stress and He-to-vacancy ratio is also determined. This model is tested to co.pare with the experimental result from Hastelloy N alloys implanted by helium ions and satisfactory agreement is obtained.

关键词： molecular dynamics nano-bubbles near surface

Resistivity and Radio-Frequency Properties of Two-Generation Trap-Rich Silico.-on-Insulator Substrates

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Chinese Physics Letters 2018年第4期35卷 103-107页

作者： Lei Zhu Yong-Wei Chang Nan Gao Xin Su YeMin Dong Lu Fei Xing Wei Xi Wang State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsys~em and Information Technology Chinese Academy of Sciences Shanghai 200050 School of Physical Science and Technology Shanghaitech University Shanghai 200031 University of Chinese Academy of sciences Beijing 100049 shanghai Simgui Technology co. Ltd. Shanghai 201815

Crystal morphologies and resistivity of polysilico. trap-rich layers of two-generation trap-rich silico.-on-insulator（TR-SOI） substrates are studied. It is found that the resistivity of the trap-rich layer of generation 2（TR-G2）is higher than that of generation 1（TR-G1）, although the crystal morphologies of the trap rich layers are the same. In addition, the rf performance of two-generation TR-SOI substrates is investigated by co.lanar waveguide lines and inductors. The results show that both the rf loss and the seco.d harmonic distortion of TR-G2 are smaller than those of TR-G1. These results can be attributed to the higher resistivity values of both the trap-rich layer and the high-resistivity silico.（HR-Si） substrate of TR-G2. Moreover, the rf performance of the TR-SOI substrate with thicker buried oxide is slightly better. The seco.d harmonics of various TR-SOI substrates are simulated and evaluated with the harmonic quality factor model as well. It can be predicted that the TR-SOI substrate will see further improvement in rf performance if the resistivities of both the trap-rich layer and HR-Si substrate increase.

关键词： SOI Si HR Resistivity and Radio-Frequency Properties of Two-Generation Trap-Rich Silico.-on-Insulator Substrates TR

Effect of manganese doping on the thermoelectric properties of Zintl phase EuCd_2Sb_2

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Journal of Rare Earths 2015年第10期33卷 1093-1097页

作者：闵武茂郭凯王继伟赵景泰 Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of sciences Shanghai Institute of Ceramics Chinese Academy of Sciences University of Chinese Academy of sciences School of Materials Science and Engineering Shanghai University shanghai Advanced research institute Chinese Academy of Sciences

Polycrystalline samples of Zintl phase EuCd2-xMnxSb2 （0.05≤x≤0.6） with the CaAl2Si2-type crystal structure （space group P3ml） were synthesized via a solid-state reaction followed by suitable co.ling, annealing and spark plasma sintering （SPS） processes. In samples with x=0.0, 0.1, 0.2, 0.4 and 0.6, the electrical co.ductivity, Seebeck co.fficient, and thermal co.ductivity were performed as a function of temperature from 300 to 650 K. It was found that chemical substitution of Mn failed to optimize the thermoelectric properties of p-type co.ductive EuCd2Sb2. It was because that the Mn substitution induced the minority carriers （electrons）, resulting in decreasing the electrical co.ductivity drastically despite the fact that it enlarged the Seebeck co.fficient and reduced the thermal co.ductivity synchronously.

关键词： Zintl phase co.pounds chemical substitution solid-state reaction thermoelectric properties rare earths

Efficient one-pot hydrogenolysis of biomass-derived xylitol into ethylene glyco. and 1,2-propylene glyco. over Cu–Ni–ZrO_2 catalyst without solid bases

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Journal of Energy Chemistry 2019年第1期28卷 101-106页

作者： Shenglin Li Yifan Zan Yuanyuan Sun Zhichao Tan Gai Miao L. Z. Kong Yuhan Sun CAS Key Laboratory of Low-Carbon co.version Science and Engineering Shanghai Advanced Research Institute Chinese Academy of Sciences University of Chinese Academy of sciences shanghai University

The directly selective hydrogenolysis of xylitol to ethylene glyco.(EG) and 1,2-propylene glyco.(1,2-PDO)was performed on Cu–Ni–ZrO_2 catalysts prepared by a co.precipitation method. Upon optimizing the reaction co.ditions(518 K, 4.0 MPaH_2 and 3 h), 97.0% co.version of xylitol and 63.1% yield of glyco.s were obtained in water without extra inorganic base. The catalyst still remained stable activity after six cycles and above 80% total selectivity of glyco.s was obtained when using 20.0% xylitol co.centration. XRD, TEM and ICP results indicated that Cu–Ni–ZrO_2 catalysts possess favorable stability. Cu and Ni are beneficial to the cleavage of C–O and C–H bond, respectively. To reduce the hydrogen co.sumption, isopropanol was added as in-situ hydrogen source and 96.4% co.version of xylitol with 43.6% yield of glyco.s were realized.

关键词： Hydrogenolysis Xylitol Glyco.s Cu-Ni-ZrO2 catalyst

AAV-mediated gene therapies by miniature gene editing tools

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Science China Life sciences 2024年第12期67卷 2540-2553页

作者： Xiangfeng Kong Tong Li Hui Yang shanghai institute of Materia Medica Chinese Academy of Sciences institute of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Huida Gene Therapeutics co. Ltd. shanghai Center for Brain Science and Brain-Inspired Technology

The advent of CRISPR-Cas has revolutionized precise gene editing. While pioneering CRISPR nucleases like Cas9 and Cas12 generate targeted DNA double-strand breaks(DSB) for knockout or homology-directed repair, next generation CRISPR technologies enable gene editing without DNA DSB. Base editors directly co.vert bases, prime editors make diverse alterations, and dead Cas-regulator fusions allow nuanced co.trol of gene expression, avoiding potentially risks like translocations. Meanwhile, the disco.ery of diminutive Cas12 orthologs and Obligate Mobile Element-Guided Activity(OMEGA) nucleases has overco.e cargo limitations of adeno-associated viral vectors, expanding prospects for in vivo therapeutic delivery. Here, we review the ever-evolving landscape of cutting-edge gene editing tools, focusing on miniature Cas12 orthologs and OMEGA effectors amenable to single AAV packaging. We also summarize CRISPR therapies delivered using AAV vectors, discuss challenges such as efficiency and specificity, and look to the future of this transformative field of in vivo gene editing enabled by AAV vectors delivery.

关键词： gene therapy adeno-associated viruses (AAVs) genome editing miniature CRISPR-Cas Obligate Mobile Element-Guided Activity (OMEGA)

Ultrafast joule-heating synthesis of Feco.nCuAl high-entropy-alloy nanoparticles as efficient OER electrocatalysts

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Progress in Natural Science:Materials International 2024年第5期34卷 880-887页

作者： Xindong Zhu Wen Huang Yu Lou Zhongzheng Yao Huiqiang Ying Min Dong Lan Tan Jianrong Zeng Hua Ji He Zhu Si Lan Herbert Gleiter institute of Nanoscience School of Materials Science and Engineering Nanjing University of Science and Technology shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences shanghai institute of Applied Physics Chinese Academy of Sciences Scientific research and Innovation Center Suzhou Nuclear Power Research Institute National Engineering research Center for Nuclear Power Plant Safety & Reliability

High entropy alloys（HEAs）, known for their synergistic orbital interactions among multiple elements, have been reco.nized as promising electrocatalysts for enhancing the sluggish kinetics of oxygen evolution reaction（OER）. Despite their potential, the facile and rapid preparation of HEA nanoparticles（NPs） with high electrocatalytic activity remains challenging. Here, we report an ultrafast synthesis of noble-metal-free Feco.nCuAl HEA NPs loaded on co.ductive carbon fiber networks using a Joule heating strategy. The prepared HEA NPs exhibited a face-centered cubic（FCC） structure with an average size of approximately 25 *** X-ray absorption fine structure（XAFS） and X-ray photoelectron spectrosco.y（XPS） studies were performed to investigate the atomic and electronic structures of the HEA NPs, revealing the co.presence of Fe, co. Mn, Cu and Al elements as well as their different valences across surface and internal regions. The HEA NPs showed remarkable OER performance, exhibiting an overpotential of 280 mV at 10 mA cm-2and a low Tafel slope of 76.13 mV dec-1in a 1.0 M KOH solution with high electrochemical stability, superior to co.mercial RuO2electrocatalysts. This work provides a new approach for synthesizing nanoscale noble-metal-free HEA electrocatalysts for clean energy co.version applications on a large-scale basis for practical co.mercialization.

关键词： X ray photoelectron spectrosco.y

Catechol-Bisphosphonate co.jugates: New Potential Chelating Agents for Metal Intoxication Therapy

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Chinese Chemical Letters 2004年第12期15卷 1403-1406页

作者： Guang Yu XU Chun Hao YANG Bo LIU Xi Han WU Yu Yuan XIE State Key Laboratory of Drug research, shanghai institute of Materia Medica, shanghai institutes for Biological sciences, shanghai 201203 State Key Laboratory of Drug research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences

In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, Al, oractinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized.Benzyl group was used as protecting group to avoid the breakage of amide by acid hydrolysis orimco.plete reaction in silylation-dealkylation using bromotrimethylsilane.

关键词： Bisphosphonates catechol chelating agents metal intoxication therapy.