Facile synthesis of Er^(3+)/Tm^(3+)co-doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications

作     者：Hongyu Liu Jiabei Li Pengfei Hu Songqiang Sun Liyi Shi Lining Sun Hongyu Liu;Jiabei Li;Pengfei Hu;Songqiang Sun;Liyi Shi;Lining Sun

作者机构：Research Center of Nano Science and TechnologyCollege of SciencesShanghai UniversityShanghai 200444China Department of ChemistryCollege of SciencesShanghai UniversityShanghai 200444China Institute of Nanochemistry and NanobiologySchool of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Instrumental Analysis&Research CenterShanghai UniversityShanghai 200444China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2022年第40卷第1期

页      面：11-19页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0709[理学-地质学] 0819[工学-矿业工程] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0708[理学-地球物理学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：Project supported by the National Natural Science Foundation of China(51872183) "Shuguang Program"supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(19SG38) the National Basic Research Program of China(2016YFA0201600) 

主　　题：Manganese-zinc ferrite Upconversion nanoparticles Photothermal effect Reactive oxygen species Good biocompatibility Rare earths 

摘      要：Manganese-zinc ferrite is a kind of very important magnetic ferrite *** properties of wide absorption band,sensitivity to ultraviolet(UV)light and tumor H_(2)O_(2) promise it to be possibly used as a photothermal therapy(PTT),photodynamic therapy(PDT)and chemodynamic therapy(CDT)*** on the unique advantages of rare-earth doped nanoparticles,an Er^(3+),Tm^(3+)co-doped upconversion-mediated nanosystem with manganese-zinc ferrite shell(named as UCNPS@M)was developed through a facile thermal co-decomposition *** final nanosystems were surface-modified by using dopamine hydrochloride(DA)in order to warrant good biocompatibility(named as UCNPS@M@DA).Under irradiation of near-infrared(NIR)light,UCNPS emit both ultraviolet and visible *** UV light is mostly abso rbed by manga nese-zinc ferrite shell to produce reactive oxygen species(ROS),which is essential to the potential PDT and CDT effect of nanosystems,and at the same time,Mn_(0.5)Zn_(0.5)Fe2O_(4) can further react with H_(2)O_(2) to promote the efficiency of *** is expected that UCNPS@M@DA can act as upconversion luminescence imaging guidance due to the visible emission from *** addition,the energy absorbed by the nanosystems can be transferred to heat to realize photothermal ***,UCNPS@M@DA was successfully applied as a T_(1)/T_(2)-weighted magnetic resonance imaging(MRI)contrast agent due to the existence of Gd,Mn,and Fe *** light of the upconversion luminescence(UCL)imaging from the UCNPS as well as potential PTT,PDT,CDT effect mentioned above,this work provides a possibility to realize cancer multi-model bioimaging guided treatment by using an all-in-one diagnosis and therapy nanosystem through a simple yet powerful strategy.