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Optimization oftheplanningprocesswithan in-house treatment information,management,andplanningsystem

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Radiation Medicine and Protection 2022年第3期3卷 102-107页

作者： Michael F.Moyers James Lin Jie Li Hongliang Chen Zhuangming Shen shanghai proton and heavy ion center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China

Objective:To describe the major categories of components of an in-house treatment information,management,and planning system(TIMPS■)that were designed and built to optimize the planning process.Methods:The system was designed,from the beginning,to manage the multi-user complex process of planning and delivering external beam treatments with the eventual goal of providing one-day planning,multiple radiation modality optimization,robust optimization,4D planning,daily adaptive treatments,and treatment verification and reconstruction.A Monte Carlo based track repeating algorithm was chosen for dose simulations.The user interface was based on web applications.Results:The first set of released tools included task queuing,followed by resource scheduling calendars and planning aims.Later releases included tools for image registration,manipulating motion profiles and 4D images,segmentation,PET simulation,and portal QA.Currently under testing are plan optimization and biophysical models.Conclusions:The in-house TIMPS first entered clinical service in April of 2017 with new tools added every few months.Since implementation,the time for planning has decreased simultaneously with a reduction of errors.

关键词： ion beam Treatment planning Treatment management

Comparison of pencil beam and Monte Carlo calculations with ion chamber array measurements for patient-specific quality assurance

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Radiation Medicine and Protection 2022年第3期3卷 115-122页

作者： Yu Deng Zhi Chen Qianxia Wang Pablo Yepes Zhuangming Shen Hongliang Chen Jie Li Michael F.Moyers shanghai proton and heavy ion center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China Rice University HoustonTX77005USA

Objective:To determine under what conditions and criteria comparisons between calculations made with the current clinical treatment planning system(Syngo)and an in-house built TPS(TIMPS)would allow skipping of in-beam portal-specific measurements.Methods:Measurements were made with an array of 24 ion chambers in a water phantom for 227 proton and 313 carbon ion portals with and without a range shifter(RS).These measurements were compared with calculations performed with Syngo and TIMPS using metrics of average dose difference and Gamma index.Results:For proton portals without RS,if a Gamma comparison between TIMPS and Syngo passed using criteria of 90%of tested points being within 3%and 3 mm,then 74%of measurements would agree with both TIMPS and Syngo.For proton portals with RS,more than 80%of measurements would agree with both calculations using the same criteria.For carbon ion portals without RS,if a Gamma evaluation between TIMPS and Syngo passed with criteria of 90%of tested points being within 2%and 2 mm,85%of measurements would agree with both cal-culations.For carbon ion portals with RS,if a Gamma evaluation between TIMPS and Syngo passed with criteria of 90%of tested points being within 3%and 3 mm,60%of measurements would agree with both calculations.Conclusions:Both the pencil beam algorithm in Syngo and the FDC algorithm in TIMPS can provide accurate dose calculations in water for most clinical portals.For about 75%of portals,physicists can perform comparisons of calculations instead of phantom measurements to verify Syngo calculations thereby saving a large amount of beam time.There are some portals,however,such as for low-energy protons without RS and high-energy carbon ions,where agreement between the two calculations and measurements are not yet satisfactory to allow the elimination of all measurements.

关键词： ion beam Quality assurance Monte Carlo Pencil beam

Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

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Radiation Medicine and Protection 2022年第3期3卷 131-138页

作者： Pablo Yepes Zhuangming Shen Michael F.Moyers Qianxia Wang Hongliang Chen Jie Li Yongqiang Li James Lin Rice University HoustonTX77005USA shanghai proton and heavy ion center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China

Objective:To develop and implement an ion beam teletherapy verification system based upon simulations of induced radioactivity and comparison with patient positron emission tomography(PET)scans.Methods:A Monte Carlo algorithm was integrated into an in-house built treatment,information,management,and planning system(TIMPS■)to calculate distributions of positron emitters induced by ion beams.These distribu-tions are processed to simulate PET images taking into account positron diffusion,radioactive decay,biological washout,and detector blurring.Additional tools were developed to register simulated PET images with planning CT images and perform comparisons of measured and simulated PET images.Results:Production cross-sections were generated for various isotopes and materials.Treatment plans for several different body sites were used to verify the functioning and utility of the new tools for both proton and carbon ion beams.Conclusions:Several tools have been developed to simulate PET scans of patients irradiated with ion beams and compare the simulated images to measurements.After commissioning and implementation into the clinic,the appropriate sizes for margins that account for uncertainties may be investigated.

关键词： ion beam PET Monte Carlo

Verification of an independent dose calculation method for portal-specific QA of proton and carbon ion beams

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Radiation Medicine and Protection 2022年第3期3卷 152-157页

作者： Michael F.Moyers Qianxia Wang Yu Deng Hongliang Chen Zhi Chen Xiaoli Liu Nicki Schlegel Jie Li Zhuangming Shen James Lin Pablo Yepes shanghai proton and heavy ion center Shanghai 201315China shanghai Engineering Research center of proton and heavy ion Radiation Therapy Shanghai 201315China Rice University HoustonTXUSA

Objective:To verify the accuracy of an independent dose calculation method,as incorporated into an in-house developed treatment planning system(TPS),for performing quality assurance of dose distributions delivered to a water phantom planned by a clinical TPS.Methods:A Monte Carlo based track repeating algorithm was incorporated into an in-house treatment planning system for proton and carbon ion beams.Calculations were performed in a flat water phantom for both a traditional pencil beam algorithm and a new Monte Carlo algorithm,and then compared to measurements made at multiple depths with a 2D ionization array for 44 patient portals.The comparisons utilized a Gamma analysis.Results:A total of 124 measurements were performed for proton and carbon ion patient portals.Using a small Gamma criteria of 2%/2 mm,an average of 93%and 97%of measurement points passed for each portal for pencil beam and Monte Carlo calculations,respectively.The passing rate was substantially higher for Monte Carlo calculations than for pencil beam calculations for portals that used a range shifter.Conclusions:The implemented independent method has been verified against measurements.The high passing rate with small tolerances leads to the possibility of reducing the number of required quality assurance measurements.

关键词： ion beam Quality assurance Monte Carlo ionization chamber array

Analysis of delivery and recalculation of dose using DICOM treatment records

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Radiation Medicine and Protection 2022年第3期3卷 123-130页

作者： Z.Chen M.F.Moyers Y.Deng H.L.Chen J.Li Z.M.Shen J.Lin Q.Wang P.Yepes shanghai proton and heavy ion center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai Key Laboratory of Radiation OncologyShanghai 201315China Rice University HoustonTXUnited States

Objective:A procedure has been proposed for patient-specific QA that,instead of comparing a measurement to the planned dose,compares the dose calculated by an independent system to the dose calculated by the planning system.It is still prudent,however,to check the accuracy of the beam delivery.For this purpose,the DICOM records from the first treatment fraction can be compared to the planned treatment using an in-house developed planning system.Methods:Totally 1,398 patient portals were subjected to the new QA procedure.The dose distribution for each portal was first recalculated on a water phantom by two treatment planning systems and the dose distributions were compared.When agreement was observed,the patient was allowed to start treatment without a measure-ment.The record from the first day was imported into an in-house planning system which was used to evaluate the delivery for errors and calculate the delivered dose distribution and compare it to the planned dose distribution.Results:A total of 266 portals passed a strict comparison between the clinical and QA dose calculations and directly used for treatment without measurements.For those portals,the comparison of the delivery records to the plan showed that 99%of spot positions deviated less than 0.2 mm and 99.7%of spot metersets deviated by less than 0.3%.On the other hand,64 portals showed spot size deviations greater than the tolerance of15%with some as large as25%.For 32 portals in which the record was used to calculate the delivered dose distribution,the Gamma passing rates between the planned and delivered distributions were always above 95%using a 2%dose difference and 2 mm distance-to-agreement criteria.Conclusions:The new QA process has been implemented slowly with strict constraints.The amount of beam time required has been reduced while maintaining safety.

关键词： ion beam Quality assurance Monte Carlo DICOM

Spin asymmetry and dipole moments in τ-pair production with ultraperipheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Dingyu Shao Bin Yan Shu-Run Yuan Cheng Zhang Department of Physics Center for Field Theory and Particle Physics Fudan University Key Laboratory of Nuclear Physics and ion-beam Application (MOE) Fudan University shanghai Research center for Theoretical Nuclear Physics National Natural Science Foundation of China (NSFC) and Fudan University Institute of High Energy Physics Chinese Academy of Sciences School of Physics Peking University

The anomalous magnetic(MDM) and electric(EDM) dipole moments of the τ lepton serve as crucial indicators of new physics beyond the standard model. Leveraging azimuthal angular asymmetry as a novel tool in ultraperipheral collisions(UPCs), we attain unparalleled precision in the study of these key properties. Driven by the highly linear polarization of coherent photons, this method uniquely enables both the MDM and EDM to contribute to the cos 2? angular distribution in similar magnitudes. Importantly, our approach substantially narrows the parameter space, excluding more than half of it compared to expected UPC-based measurements reliant solely on the total cross-section. This method not only provides improved constraints but also minimizes the need for additional theoretical assumptions, and offers a novel avenue to probe the EDM effects.

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PhaseⅠ/Ⅱtrial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

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Chinese Journal of Cancer 2016年第12期35卷 743-753页

作者： Lin Kong Jing Gao Jiyi Hu Weixu Hu Xiyin Guan Rong Lu Jiade J.Lu Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Shanghai Cancer HospitalShanghai 200321P.R.China. Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. Department of Outpatient Clinic Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. shanghai proton and heavy ion center 4365 Kangxin RoadPudongShanghai 201315P.R.China.

Background: After deinitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma(NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present signiicant challenges for locally recurrent NPC. Surgery, stereotactic ablative body radiotherapy, and brachytherapy have been used to treat locally recurrent NPC. However, only patients with small-volume tumors can beneit from these treatments. Re-irradiation with X-ray—based intensity-modulated radiotherapy(IMXT) has been more widely used for salvage treatment of locally recurrent NPC with a large tumor burden, but over-irradiation to the surrounding normal tissues has been shown to cause frequent and severe toxicities. Furthermore, locally recurrent NPC represents a clinical entity that is more radioresistant than its primary counterpart. Due to the inherent physical advantages of heavy-particle therapy, precise dose delivery to the target volume(s), without exposing the surrounding organs at risk to extra doses, is highly feasible with carbon-ion radiotherapy(CIRT). In addition, CIRT is a high linear energy transfer(LET) radiation and provides an increased relative biological efectiveness compared with photon and proton radiotherapy. Our prior work showed that CIRT alone to 57.5 Gy E(gray equivalent), at 2.5 Gy E per daily fraction, was well tolerated in patients who were previously treated for NPC with a deinitive dose of IMXT. The short-term response rates at 3–6 months were also acceptable. However, no patients were treated with concurrent chemotherapy. Whether the addition of concurrent chemotherapy to CIRT can beneit locally recurrent NPC patients over CIRT alone has never been addressed. It is possible that the beneits of high-LET CIRT may make radiosensitizing chemotherapy unnecessary. We therefore implemented a phase I/II clinical trial to address these questions and present our methodology and results.Methods and design: The maximal tolerated dose(MTD) of re-treatment using raster-scanning CIRT plus concurrent cisplati

关键词： Recurrent nasopharyngeal cancer Carbon ion radiotherapy Re-irradiation Salvage therapy Chemotherapy

维普期刊数据库

Secondary and activated X(γ)radiation of SPHIC particle therapy facility

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Nuclear Science and Techniques 2021年第4期32卷 84-91页

作者： Wei-Ming Sun Ning Du Wen-Dong Tian Lan Wang Department of Medical Management Shanghai Proton and Heavy Ion CenterShanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China Siemens Healthineers Ltd. Shanghai 201321China

We report the secondary X(γ)radiation from the accelerator in a normal operating state and activated X(γ)radiation from the accelerator devices when the accelerator stops operating in the cancer treatment facility of the shanghai proton and heavy ion center(SPHIC).These radiation measurements show us the structural radiation distribution along the beam lines and devices inside the accelerator room when the beam is on and off and can support the radiation protection design of the accelerator facility used for cancer treatment and help evaluate the accumulated radiation dose in the case of an emergency,such as a personal safety system failure or a radiation accident.The radiation dose rate measured in this facility shows that the facility is safe from the radiation protection point.After shooting the quality assurance(QA)beam,the radiation dose rate in the treatment room was also measured to investigate the radiation dose space distribution and decay time dependence.In addition,the time period before safely entering the treatment room after determining the shooting of the QA beam is recommended to be approximately 5 min.

关键词： Secondary radiation Activated radiation Nuclear safety and radiation protection Dose rate Accelerator

维普期刊数据库

Carbon ion radiotherapy boost in the treatment of glioblastoma:a randomized phase Ⅰ/Ⅲ clinical trial

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Cancer Communications 2019年第1期39卷 39-50页

作者： Lin Kong Jing Gao Jiyi Hu Rong Lu Jing Yang Xianxin Qiu Weixu Hu Jiade J.Lu Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Shanghai Cancer CenterShanghai 201321P.R.China Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterPudong4365 Kangxin RoadShanghai 201321P.R.China

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these mal... 详细信息

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival ions with improved treatment efficacy. Methods and design: Patients with newly diagnosed malignant gliomas will have their tumor tissue samples submitted for the analysis of the status of O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. In Phase I, the patients will undergo an induction carbon ion radiotherapy (CIRT) boost followed by 60 GyE of proton irradiation with concurrent temozolomide (TMZ) at 75 mg/m2. To determine the maximal dose of safe induction boost, the tolerance, and acute toxicity rates in a dose-escalation manner from 9 to 18 GyE in three fractions will be used. In Phase III, GBM-only patients will be randomized to receive either 60 GyE (2 GyE per fraction) of proton irradia-tion with concurrent TMZ (control arm) or a CIRT boost (dose determined in Phase I of this trial) followed by 60 GyE of proton irradiation with concurrent TMZ. The primary endpoints are overall survival (OS) and toxicity rates (acute and long-term). Secondary endpoints are progression-free survival (PFS), and tumor response (based upon assess-ment with C-methionine/fluoro-ethyl-tyrosine positron emission tomography [MET/FET PET] or magnetic resonance imaging [MRI] and detection of serologic immune markers). We hypothesize that the induction CIRT boost will result in a greater initial tumor-killing ability and prime the tumor microenvironment for enhanced immunologic tumor clearance, resulting in an expected 33% improvement in OS rates. Discussion: The prognosis of GBM remains grim. The mechanism underpinning the poor prognosis of this malig-nancy is i

关键词： Glioblastoma Anaplastic astrocytoma Carbon ion radiotherapy proton radiotherapy Temozolomide Overall survival Progression-free survival Toxicity Serologic immune response O-6-methylguanine-DNA methyltransferase