Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

作     者：Pablo Yepes Zhuangming Shen Michael F.Moyers Qianxia Wang Hongliang Chen Jie Li Yongqiang Li James Lin 

作者机构：Rice UniversityHoustonTX77005USA Shanghai Proton and Heavy Ion CenterShanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China 

出 版 物：《Radiation Medicine and Protection》 (放射医学与防护（英文）)

年 卷 期：2022年第3卷第3期

页      面：131-138页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：ion beam PET Monte Carlo 

摘      要：Objective:To develop and implement an ion beam teletherapy verification system based upon simulations of induced radioactivity and comparison with patient positron emission tomography(PET)***:A Monte Carlo algorithm was integrated into an in-house built treatment,information,management,and planning system(TIMPS■)to calculate distributions of positron emitters induced by ion *** distribu-tions are processed to simulate PET images taking into account positron diffusion,radioactive decay,biological washout,and detector *** tools were developed to register simulated PET images with planning CT images and perform comparisons of measured and simulated PET ***:Production cross-sections were generated for various isotopes and *** plans for several different body sites were used to verify the functioning and utility of the new tools for both proton and carbon ion ***:Several tools have been developed to simulate PET scans of patients irradiated with ion beams and compare the simulated images to *** commissioning and implementation into the clinic,the appropriate sizes for margins that account for uncertainties may be investigated.