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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

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Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis mechanism Neurotransmitter microRNA

液态栓塞剂栓塞脑动静脉畸形的计算流体力学建模与仿真

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Acta Mechanica Sinica 2024年第1期40卷 281-295页

作者：张博文陈曦张晓龙丁光宏葛亮王盛章 Institute for biomechanics Department of Aeronautics and AstronauticsFudan UniversityShanghai 200433China Department of Radiology Huashan HospitalFudan UniversityShanghai 200040China shanghai key laboratory for acupuncture mechanism and acupoint function Shanghai 200433China Institute of Biomedical Engineering&Technology Academy of Engineering TechnlogyFudan UniverstyShanghai 200433China

大脑动静脉畸形(AVMs)的血管内栓塞通常需要注射液态栓塞剂(LEAs)以减少畸形处的血流.在临床实践中,需要事先仔细规划注射LEAs的供血动脉以及LEAs的剂量.计算流体动力学可以模拟LEAs在畸形团内的注射过程,并在术前评估不同操作的治疗效... 详细信息

大脑动静脉畸形(AVMs)的血管内栓塞通常需要注射液态栓塞剂(LEAs)以减少畸形处的血流.在临床实践中,需要事先仔细规划注射LEAs的供血动脉以及LEAs的剂量.计算流体动力学可以模拟LEAs在畸形团内的注射过程,并在术前评估不同操作的治疗效果.应用多孔介质模型避免了AVMs的几何建模困难,并重现了血管瘤内复杂的血管网络结构.采用多相流模拟了LEAs与血液之间的相互作用.LEAs的黏度由其溶质乙烯-乙醇共聚物(EVOH)的浓度确定.通过求解物质输运方程计算了溶剂二甲基亚矾(DMSO)的扩散过程.通过构建EVOH浓度与黏度之间的关系,模拟了LEAs的凝固过程.LEAs的注射和凝固的数值模拟方法在两个特定患者的AVMs上进行了测试。计算预测了LEAs在畸形团内的流动方向。通过三维染可以很好地可视化注射的LEAs的形态.进行了定量分析,包括供血动脉和引流静脉的流量变化.利用计算流体动力学(CFD)方法可以模拟LEAs栓塞AVMs的过程,以展示不同栓塞手术规划的治疗效果,并确定最佳治疗方案.

关键词：最佳治疗方案供血动脉血管内栓塞脑动静脉畸形计算流体力学计算流体动力学注射过程血管瘤

Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

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Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao Yongjia Song Minghui Hang Hao Xu Qiang Li Pengyu Wang Tao Chen Mengxiong Xia Qi Shi Yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China key laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China shanghai Research Institute of acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

Dynamics of Calcium Signal and Leukotriene C_(4) Release in Mast Cells Network Induced by Mechanical Stimuli and Modulated by Interstitial Fluid Flow

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Advances in Applied Mathematics and Mechanics 2016年第1期8卷 67-81页

作者： Wei Yao Hongwei Yang Yabei Li Guanghong Ding shanghai key laboratory of acupuncture mechanism and acupoint function Department of Mechanics and Engineering ScienceFudan University220 Handan RoadShanghai 200433China

Mast cells(MCs)play an important role in the immune *** connective tissues,mechanical stimuli activate intracellular calcium signaling pathways,induce a variety of mediators including leukotriene C4(LTC4)release,and affect MCs’*** paper focuses on MCs’intracellular calcium dynamics and LTC4 release responding to mechanical stimuli,explores signaling pathways in MCs and the effect of interstitial fluid flow on the transport of biological messengers and feedback in the MCs *** use a mathematical model to show that(i)mechanical stimuli including shear stress induced by interstitial fluid flow can activate mechano-sensitive(MS)ion channels on MCs’membrane and allow Ca^(2+)entry,which increases intracellular Ca^(2+)concentration and leads to LTC4 release;(ii)LTC4 in the extracellular space(ECS)acts on surface cysteinyl leukotriene receptors(LTC4R)on adjacent cells,leading to Ca^(2+)influx through Ca^(2+)release-activated Ca^(2+)(CRAC)*** elevated intracellular Ca^(2+)concentration further stimulates LTC4 release and creates a positive feedback in the MCs *** findings of this study may facilitate our understanding of the mechanotransduction process in MCs induced by mechanical stimuli,contribute to understanding of interstitial flow-related mechanobiology in MCs network,and provide a methodology for quantitatively analyzing physical treatment methods including acupuncture and massage in traditional Chinese medicine(TCM).

关键词： Mast cells Ca^(2+)signaling LTC4 release interstitial fluid flow network

Mechanical effects of needle texture on acupoint tissue

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Journal of Integrative Medicine 2023年第3期21卷 254-267页

作者： Ming-zhu Sun Xin Wang Ying-chen Li Wei Yao Wei Gu shanghai key laboratory of acupuncture mechanism and acupoint function Department of Aeronautics and AstronauticsFudan UniversityShanghai 200433China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective:This study aims to clarify how the stimulation of acupuncture points is achieved by needles with different surface texture during acupuncture;it also seeks to lessen injury at the insertion site and increase the therapeutic efficacy of acupuncture,by simulating the mechanical effects of various needle surface patterns on Zusanli(ST36)without changing the radius of acupuncture ***:Five acupuncture needle models with different surface patterns,including the smooth needle,the lined needle,the ringed needle,the left-hand threaded needle and the right-hand threaded needle,and a layered model of the Zusanli acupoint were used to investigate how to reduce tissue damage and increase stimulation during acupuncture treatment,Puncturing of the skin as well as liftinginserting and twisting needle manipulations were simulated using these models,and the degree of damage and force of stimulation caused by the acupuncture needles with different surface patterns during ***:The smooth needle and the lined needle caused the least tissue damage during insertion,while the left-hand threaded and the right-hand threaded needles caused the most *** ringed needle,the left-hand threaded needle and the right-hand threaded needle stimulated the acupoint tissue more during lifting-inserting manipulations,while the lined needle and the smooth needle produced less *** stimulation of the lined needle on the acupoint tissue was the largest during twisting manipulation,whereas the left-hand threaded needle and the right-hand threaded needle had smaller *** lifting-inserting and twisting manipulations,both the left-hand threaded needle and right-hand threaded needle provided more stimulation,but the torsion direction in which they produced better stimulation was ***:According to the simulation results,the ringed pattern enhances stimulation best in the lifting-inserting manipulation,whereas the lined patter

关键词： Biomechanics Finite elementmethod acupuncture Needle roughness Mechanical effects

Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： LI Zhongzheng ZHAO Yadan Ma Weigang Zhang Yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru ZHANG Zichen WANG Songtao ZHAO Xue LIU Yangyang GUO Yi GUO Yongming Research Center of Experimental acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine acupuncture and Moxibustion Tianjin 301617China Department of acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-dependent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-dependent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state

Neuro- and immuno-modulation mediated by the cardiac sympathetic nerve: a novel insight into the anti-ischemic efficacy of acupuncture

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1058-1066页

作者： XI Hanqing LI Xia ZHANG Ziyi CUI Xiang JING Xianghong ZHU Bing GAO Xinyan Institute of acupuncture and Moxibustion China Academy of Chinese Medical Sciences

Communication between sympathetic nerves and the immune system is a crucial and active process during myocardial ischemia(MI), as myocardial damage and inflammatory stimuli concurrently occur. Sympathetic nerves undergo structural and functional changes after MI,leading to adverse left ventricular(LV) remodeling and heart failure(HF). The complex inflammatory response to MI, including local myocardial anti-inflammatory repair and systemic immune reactions, plays a key role in adverse LV remodeling. Here, we review the progressive structural and electrophysiological remodeling of the LV and the involvement of sympathetic tone in complex and dynamic processes that are susceptible to MI pathological conditions. acupuncture has been reported to effectively improve cardiac function, eliminate arrhythmia, and mitigate adverse LV remodeling via somatosensory regulation after MI. Moreover,acupuncture has an anti-inflammatory effect on the pathological process of myocardial ischemia. In this Review, we aim to summarize the involvement of sympathetic nerve activation in the neuro-immune modulation of structural and functional cardiac changes after MI. As a noninvasive method for sympathetic regulation, acupuncture is an ideal option because of its anti-ischemic efficacy. A better understanding of the neural circuitry that regulates cardiac function and immune responses following MI could reveal novel targets for acupuncture treatment.

关键词： acupuncture myocardial ischemia neuroinflammatory diseases review sympathetic nerves

A hybrid model for HIV transmission among men who have sex with men

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Infectious Disease Modelling 2020年第1期5卷 814-826页

作者： Chongpeng Zhong Mingzhu Sun Wei Yao shanghai key laboratory of acupuncture mechanism and acupoint function Department of Aeronautics and AstronauticsFudan University220 Handan RoadShanghai200433China

AIDS has spread throughout the world for *** who have sex with men(MSM)is the harder-hit sector of sexually transmitted diseases due to their physiological ***,because homosexuals suffer discrimination and exclusion in many aspects,the relevant data about the spread of HIV in this group are ***,building a network model to study and analyze this problem can provide valuable reference for the prevention of *** network can establish fixed edges between vertices,and ignores the spatial characteristics of the *** two aspects are exactly what cellular automata are good at,but cellular automata are rarely used in the problem of HIV propagation among MSM ***,we combined the advantages of these two methods,and got a new hybrid *** may provide us with some theoretical factors that affect the spread of HIV and provide guidance for the actual prevention work.

关键词： MSM HIV Complex network Cellular automata Hybrid model

Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome： a patient-blinded pilot trial with orthogonal design

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Journal of Traditional Chinese Medicine 2017年第4期37卷 538-545页

作者： Yang Ling Lu Yuan Zhang Haifeng Ma Xiaopeng Bao Chunhui Wu Huangan Zhao Chen Ding Guanghong Qi Li Zhou Shuang Department of Mechanics and Engineering Science Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Fudan University Shanghai 200433 China key laboratory of acupuncture-Moxibustion and Immunological Effects Shanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridians Shanghai 200030 China E-Institute of shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Traditional Chinese Medicine Changhai Hospital Second Military Medical University Shanghai 200433 China

OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal ***: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were *** were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final ***: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and ***: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.

关键词： Irritable bowel syndrome Diarrhea Warming moxibustion Point ST25 (Tianshu), Point CV6 (Qihai) Quality of life